Do complex mutations of the epidermal growth factor receptor gene reflect intratumoral heterogeneity?

Journal of Thoracic Oncology

Volumn 6, Issue 6, 2011, Pages 1144-1146

  Hata, Akito ^a   Fujita, Shiro ^a   Kaji, Reiko ^a   Katakami, Nobuyuki ^a   Imai, Yukihiro ^b  

^a INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^b KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB;

AGED; CASE REPORT; COMPLEX MUTATION; COMPUTER ASSISTED TOMOGRAPHY; EGFR GENE; EXON; FEMALE; GENE; GENE MUTATION; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; LETTER; LUNG ADENOCARCINOMA; LUNG BIOPSY; MALE; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL;

EID: 79958095925     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31821b1194     Document Type: Letter

References (4)

1. Hata A, Yoshioka H, Fujita S, et al. Complex mutations in the epidermal growth factor receptor gene in non-small cell lung cancer. J Thorac Oncol 2010;5:1524-1528.
2. Sakurada A, Lara-Guerra H, Liu N, et al. Tissue heterogeneity of EGFR mutation in lung adenocarcinoma. J Thorac Oncol 2008;3:527-529. (Pubitemid 351630282)
3. Jackman DM, Yeap BY, Sequist LV, et al. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 2006;12:3908-3914. (Pubitemid 44078074)
4. Travis WD, Rekhtman N, Riley GJ, et al. Pathologic diagnosis of advanced lung cancer based on small biopsies and cytology: a paradigm shift. J Thorac Oncol 2010;5:411-414.