Wide Disparity in Genetic Admixture Among Mexican Americans from San Antonio, TX

Annals of Human Genetics

Volumn 75, Issue 4, 2011, Pages 529-538

  Beuten, Joke ^a,b   Halder, Indrani ^c   Fowler, Sharon P ^b   Goring, Harald H H ^d   Duggirala, Ravindranath ^d   Arya, Rector ^b   Thompson, Ian M ^a   Leach, Robin J ^a,b   Lehman, Donna M ^b  

^a University of Texas Health Science Center at San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Admixture; Mexican Americans; Skin reflectance

Indexed keywords

ADULT; AMERICAN INDIAN; ARTICLE; CORRELATION ANALYSIS; FEMALE; GENETIC VARIABILITY; HISPANIC; HUMAN; MALE; POPULATION STRUCTURE; PRIORITY JOURNAL; SEX DIFFERENCE; SKIN COLOR; UNITED STATES;

EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC LINKAGE; GENETIC MARKERS; GENETICS, POPULATION; HUMANS; INDIANS, NORTH AMERICAN; MALE; MEXICAN AMERICANS; PEDIGREE; SKIN PIGMENTATION; TEXAS;

EID: 79958069577     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2011.00655.x     Document Type: Article

References (34)

1. Almasy, L. & Blangero, J. (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62, 1198-1211.
2. Boerwinkle, E., Chakraborty, R. & Sing, C. F. (1986) The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet 50, 181-194.
3. Bonilla, C., Parra, E. J., Pfaff, C. L., Dios, S., Marshall, J. A., Hamman, R. F., Ferrell, R. E., Hoggart, C. L., McKeigue, P. M. & Shriver, M. D. (2004a) Admixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mapping. Ann Hum Genet 68, 139-153.
4. Bonilla, C., Shriver, M. D., Parra, E. J., Jones, A. & Fernandez, J. R. (2004b) Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city. Hum Genet 115, 57-68.
5. Cerda-Flores, R. M., Kshatriya, G. K., Bertin, T. K., Hewett-Emmett, D., Hanis, C. L. & Chakraborty, R. (1992) Gene diversity and estimation of genetic admixture among Mexican-Americans of Starr County, Texas. Ann Hum Biol 19, 347-360.
6. Chakraborty, B. M., Fernandez-Esquer, M. E. & Chakraborty, R. (1999) Is being Hispanic a risk factor for non-insulin dependent diabetes mellitus (NIDDM)? Ethn Dis 9, 278-283.
7. Chakraborty, R. & Weiss, K. M. (1988) Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. Proc Natl Acad Sci USA 85, 9119-9123.
8. Collins-Schramm, H. E., Phillips, C. M., Operario, D. J., Lee, J. S., Weber, J. L., Hanson, R. L., Knowler, W. C., Cooper, R., Li, H. & Seldin, M. F. (2002) Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am J Hum Genet 70, 737-750.
9. Florez, J. C., Price, A. L., Campbell, D., Riba, L., Parra, M. V., Yu, F., Duque, C., Saxena, R., Gallego, N., Tello-Ruiz, M., Franco, L., Rodriguez-Torres, M., Villegas, A., Bedoya, G., Aguilar-Salinas, C. A., Tusie-Luna, M. T., Ruiz-Linares, A. & Reich, D. (2009) Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes. Diabetologia 52, 1528-1536.
10. Halder, I., Shriver, M., Thomas, M., Fernandez, J. R. & Frudakis, T. (2008) A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications. Hum Mutat 29, 648-658.
11. Halder, I. & Shriver, M. D. (2003) Measuring and using admixture to study the genetics of complex diseases. Hum Genomics 1, 52-62.
12. Hanis, C. L., Chakraborty, R., Ferrell, R. E. & Schull, W. J. (1986) Individual admixture estimates: disease associations and individual risk of diabetes and gallbladder disease among Mexican-Americans in Starr County, Texas. Am J Phys Anthropol 70, 433-441.
13. Hanis, C. L., Hewett-Emmett, D., Bertin, T. K. & Schull, W. J. (1991) Origins of U.S. Hispanics. Implications for diabetes. Diabetes Care 14, 618-627.
14. Hoggart, C. J., Parra, E. J., Shriver, M. D., Bonilla, C., Kittles, R. A., Clayton, D. G. & McKeigue, P. M. (2003) Control of confounding of genetic associations in stratified populations. Am J Hum Genet 72, 1492-1504.
15. Hunt, K. J., Lehman, D. M., Arya, R., Fowler, S., Leach, R. J., Goring, H. H., Almasy, L., Blangero, J., Dyer, T. D., Duggirala, R. & Stern, M. P. (2005) Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study. Diabetes 54, 2655-2662.
16. Jablonski, N. G. & Chaplin, G. (2000) The evolution of human skin coloration. J Hum Evol 39, 57-106.
17. Kittles, R. A., Chen, W., Panguluri, R. K., Ahaghotu, C., Jackson, A., Adebamowo, C. A., Griffin, R., Williams, T., Ukoli, F., Adams-Campbell, L., Kwagyan, J., Isaacs, W., Freeman, V. & Dunston, G. M. (2002) CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification? Hum Genet 110, 553-560.
18. Long, J. C., Williams, R. C., McAuley, J. E., Medis, R., Partel, R., Tregellas, W. M., South, S. F., Rea, A. E., McCormick, S. B. & Iwaniec, U. (1991) Genetic variation in Arizona Mexican Americans: estimation and interpretation of admixture proportions. Am J Phys Anthropol 84, 141-157.
19. Long, J. C., Williams, R. C. & Urbanek, M. (1995) An E-M algorithm and testing strategy for multiple-locus haplotypes. Am J Hum Genet 56, 799-810.
20. Madrigal, L. & Kelly, W. (2007) Human skin-color sexual dimorphism: a test of the sexual selection hypothesis. Am J Phys Anthropol 132, 470-482.
21. Mao, X., Bigham, A. W., Mei, R., Gutierrez, G., Weiss, K. M., Brutsaert, T. D., Leon-Velarde, F., Moore, L. G., Vargas, E., McKeigue, P. M., Shriver, M. D. & Parra, E. J. (2007) A genomewide admixture mapping panel for Hispanic/Latino populations. Am J Hum Genet 80, 1171-1178.
22. Marshall, J. A., Hamman, R. F., Baxter, J., Mayer, E. J., Fulton, D. L., Orleans, M., Rewers, M. & Jones, R. H. (1993) Ethnic differences in risk factors associated with the prevalence of non-insulin-dependent diabetes mellitus. The San Luis Valley Diabetes Study. Am J Epidemiol 137, 706-718.
23. Martinez-Fierro, M. L., Beuten, J., Leach, R. J., Parra, E. J., Cruz-Lopez, M., Rangel-Villalobos, H., Riego-Ruiz, L. R., Ortiz-Lopez, R., Martinez-Rodriguez, H. G. & Rojas-Martinez, A. (2009) Ancestry informative markers and admixture proportions in northeastern Mexico. J Hum Genet 54, 504-509.
24. Martinez-Marignac, V. L., Valladares, A., Cameron, E., Chan, A., Perera, A., Globus-Goldberg, R., Wacher, N., Kumate, J., McKeigue, P., O'Donnell, D., Shriver, M. D., Cruz, M. & Parra, E. J. (2007) Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors. Hum Genet 120, 807-819.
25. Parra, E. J., Hoggart, C. J., Bonilla, C., Dios, S., Norris, J. M., Marshall, J. A., Hamman, R. F., Ferrell, R. E., McKeigue, P. M. & Shriver, M. D. (2004) Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado. J Med Genet 41, e116.
26. Pfaff, C. L., Parra, E. J., Bonilla, C., Hiester, K., McKeigue, P. M., Kamboh, M. I., Hutchinson, R. G., Ferrell, R. E., Boerwinkle, E. & Shriver, M. D. (2001) Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium. Am J Hum Genet 68, 198-207.
27. Price, A. L., Patterson, N., Yu, F., Cox, D. R., Waliszewska, A., McDonald, G. J., Tandon, A., Schirmer, C., Neubauer, J., Bedoya, G., Duque, C., Villegas, A., Bortolini, M. C., Salzano, F. M., Gallo, C., Mazzotti, G., Tello-Ruiz, M., Riba, L., Aguilar-Salinas, C. A., Canizales-Quinteros, S., Menjivar, M., Klitz, W., Henderson, B., Haiman, C. A., Winkler, C., Tusie-Luna, T., Ruiz-Linares, A. & Reich, D. (2007) A genomewide admixture map for Latino populations. Am J Hum Genet 80, 1024-1036.
28. Pritchard, J. K., Stephens, M. & Donnelly, P. (2000) Inference of population structure using multilocus genotype data. Genetics 155, 945-959.
29. Relethford, J. H., Stern, M. P., Gaskill, S. P. & Hazuda, H. P. (1983) Social class, admixture, and skin color variation in Mexican-Americans and Anglo-Americans living in San Antonio, Texas. Am J Phys Anthropol 61, 97-102.
30. Shriver, M. D., Parra, E. J., Dios, S., Bonilla, C., Norton, H., Jovel, C., Pfaff, C., Jones, C., Massac, A., Cameron, N., Baron, A., Jackson, T., Argyropoulos, G., Jin, L., Hoggart, C. J., McKeigue, P. M. & Kittles, R. A. (2003) Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet 112, 387-399.
31. Sobel, E., Papp, J. C. & Lange, K. (2002) Detection and integration of genotyping errors in statistical genetics. Am J Hum Genet 70, 496-508.
32. Tang, H., Choudhry, S., Mei, R., Morgan, M., Rodriguez-Cintron, W., Burchard, E. G. & Risch, N. J. (2007) Recent genetic selection in the ancestral admixture of Puerto Ricans. Am J Hum Genet, 81, 626-633.
33. Tian, C., Hinds, D. A., Shigeta, R., Adler, S. G., Lee, A., Pahl, M. V., Silva, G., Belmont, J. W., Hanson, R. L., Knowler, W. C., Gregersen, P. K., Ballinger, D. G. & Seldin, M. F. 2007. A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping. Am J Hum Genet 80, 1014-1023.
34. Weiner, J. S. & Lourie, J. A. (1969) Human Biology: a guide to field method. IBP Handbook No. 9. Oxford: Blackwell Scientific Publication.