Feasibility of 62Cu-ATSM PET for evaluation of brain ischaemia and misery perfusion in patients with cerebrovascular disease

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 38, Issue 6, 2011, Pages 1075-1082

  Isozaki, Makoto ^a   Kiyono, Yasushi ^b   Arai, Yoshikazu ^a   Kudo, Takashi ^b   Mori, Tetsuya ^b   Maruyama, Rikiya ^b   Kikuta, Ken Ichiro ^a   Okazawa, Hidehiko ^b  

^a Faculty of Medical Sciences   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

15O PET; Cerebral ischaemic change; Cerebrovascular disease; Cu ATSM; Oxygen extraction fraction

Indexed keywords

CARBON MONOXIDE; CARBON MONOXIDE O 15; DIACETYLBIS(N4 METHYLTHIOSEMICARBAZONE) COPPER CU 62; OXYGEN 15; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG; WATER O 15; COPPER (II) DIACETYL DI(N(4) METHYLTHIOSEMICARBAZONE); COPPER (II) DIACETYL-DI(N(4)-METHYLTHIOSEMICARBAZONE); DIAGNOSTIC AGENT; ORGANOMETALLIC COMPOUND;

ADULT; AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN ISCHEMIA; BRAIN PERFUSION; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; FEASIBILITY STUDY; FEMALE; HEMISPHERE; HEMODYNAMICS; HUMAN; MALE; OXYGEN EXTRACTION FRACTION; POSITRON EMISSION TOMOGRAPHY; BRAIN CIRCULATION; CASE CONTROL STUDY; MIDDLE AGED; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; SCINTISCANNING;

ADULT; AGED; ARTERIAL OCCLUSIVE DISEASES; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CEREBROVASCULAR CIRCULATION; FEASIBILITY STUDIES; FEMALE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; ORGANOMETALLIC COMPOUNDS; POSITRON-EMISSION TOMOGRAPHY; THIOSEMICARBAZONES;

EID: 79958068141     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-011-1734-z     Document Type: Article

References (32)

1. RL Grubb Jr CP Derdeyn SM Fritsch DA Carpenter KD Yundt TO Videen, et al. 1998 Importance of hemodynamic factors in the prognosis of symptomatic carotid occlusion JAMA 280 1055 1060 9757852 10.1001/jama.280.12.1055 (Pubitemid 28449534)
2. H Yamauchi H Fukuyama Y Nagahama H Nabatame M Ueno S Nishizawa, et al. 1999 Significance of increased oxygen extraction fraction in five-year prognosis of major cerebral arterial occlusive diseases J Nucl Med 40 1992 1998 10616876 1:STN:280:DC%2BD3c%2FotlWltA%3D%3D (Pubitemid 30022012)
3. H Okazawa T Kudo 2009 Clinical impact of hemodynamic parameter measurement for cerebrovascular disease using positron emission tomography and (15)O-labeled tracers Ann Nucl Med 23 217 227 19353235 10.1007/s12149-009-0235-7 1:CAS:528:DC%2BD1MXps1Ogsrs%3D
4. M Takasawa RR Moustafa JC Baron 2008 Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke Stroke 39 1629 1637 18369176 10.1161/STROKEAHA.107.485938 1:CAS:528:DC%2BD1cXkvVeit7g%3D
5. R Markus DC Reutens S Kazui S Read P Wright BR Chambers, et al. 2003 Topography and temporal evolution of hypoxic viable tissue identified by 18F-fluoromisonidazole positron emission tomography in humans after ischemic stroke Stroke 34 2646 2652 14563970 10.1161/01.STR.0000094422.74023.FF 1:STN:280:DC%2BD3srisl2jtQ%3D%3D (Pubitemid 37392759)
6. AS Sarrafzadeh A Nagel M Czabanka T Denecke P Vajkoczy M Plotkin 2010 Imaging of hypoxic-ischemic penumbra with (18)F-fluoromisonidazole PET/CT and measurement of related cerebral metabolism in aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab 30 36 45 19773799 10.1038/jcbfm.2009.199 1:CAS:528:DC%2BC3cXos1Sm
7. SJ Read T Hirano DF Abbott JI Sachinidis HJ Tochon-Danguy JG Chan, et al. 1998 Identifying hypoxic tissue after acute ischemic stroke using PET and 18F-fluoromisonidazole Neurology 51 1617 1621 9855512 1:STN:280: DyaK1M%2FntFWmtg%3D%3D
8. SJ Read T Hirano DF Abbott R Markus JI Sachinidis HJ Tochon-Danguy, et al. 2000 The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke Ann Neurol 48 228 235 10939574 10.1002/1531-8249(200008)48:2<228::AID-ANA13>3.0.CO;2-B 1:STN:280:DC%2BD3cvhs1OmtQ%3D%3D (Pubitemid 30617042)
9. R Markus DC Reutens S Kazui S Read P Wright DC Pearce, et al. 2004 Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival Brain 127 1427 1436 15130953 10.1093/brain/awh162 1:STN:280:DC%2BD2c3mslKitw%3D%3D (Pubitemid 38745520)
10. R Markus G Donnan S Kazui S Read D Reutens 2004 Penumbral topography in human stroke: methodology and validation of the 'Penumbragram' Neuroimage 21 1252 1259 15050553 10.1016/j.neuroimage.2003.11.020 (Pubitemid 38446556)
11. M Bruehlmeier U Roelcke PA Schubiger SM Ametamey 2004 Assessment of hypoxia and perfusion in human brain tumors using PET with 18F- fluoromisonidazole and 15O-H2O J Nucl Med 45 1851 1859 15534054 (Pubitemid 47618442)
12. Y Fujibayashi H Taniuchi Y Yonekura H Ohtani J Konishi A Yokoyama 1997 Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential J Nucl Med 38 1155 1160 9225812 1:CAS:528:DyaK2sXltFChsL8%3D (Pubitemid 27339632)
13. N Takahashi Y Fujibayashi Y Yonekura MJ Welch A Waki T Tsuchida, et al. 2000 Evaluation of 62Cu labeled diacetyl-bis(N4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer Ann Nucl Med 14 323 328 11108159 10.1007/BF02988690 1:CAS:528:DC%2BD3MXkvFWnuw%3D%3D
14. F Dehdashti MA Mintun JS Lewis J Bradley R Govindan R Laforest, et al. 2003 In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM Eur J Nucl Med Mol Imaging 30 844 850 12692685 10.1007/s00259-003-1130-4 1:CAS:528:DC%2BD3sXjvF2lsLw%3D (Pubitemid 36734203)
15. F Dehdashti PW Grigsby JS Lewis R Laforest BA Siegel MJ Welch 2008 Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4- methylthiosemicarbazone) J Nucl Med 49 201 205 18199612 10.2967/jnumed.107.048520 1:CAS:528:DC%2BD1cXivVOltLw%3D (Pubitemid 351225657)
16. TG Lohith T Kudo Y Demura Y Umeda Y Kiyono Y Fujibayashi, et al. 2009 Pathophysiologic correlation between 62Cu-ATSM and 18F-FDG in lung cancer J Nucl Med 50 1948 1953 19910425 10.2967/jnumed.109.069021
17. Y Fujibayashi CS Cutler CJ Anderson DW McCarthy LA Jones T Sharp, et al. 1999 Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats Nucl Med Biol 26 117 121 10096511 10.1016/S0969-8051(98)00049-3 1:CAS:528:DyaK1MXjvFOjtg%3D%3D (Pubitemid 29030531)
18. N Takahashi Y Fujibayashi Y Yonekura MJ Welch A Waki T Tsuchida, et al. 2001 Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia Ann Nucl Med 15 293 296 11545205 10.1007/BF02987849 1:STN:280:DC%2BD3Mvps12qtg%3D%3D (Pubitemid 32679229)
19. A Obata E Yoshimi A Waki JS Lewis N Oyama MJ Welch, et al. 2001 Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent Cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells Ann Nucl Med 15 499 504 11831397 10.1007/BF02988502 1:CAS:528:DC%2BD38XitFKjs7s%3D (Pubitemid 34131947)
20. M Ikawa H Okazawa K Arakawa T Kudo H Kimura Y Fujibayashi, et al. 2009 PET imaging of redox and energy states in stroke-like episodes of MELAS Mitochondrion 9 144 148 19460295 10.1016/j.mito.2009.01.011 1:CAS:528: DC%2BD1MXjsFWksLs%3D
21. WJ Powers 1991 Cerebral hemodynamics in ischemic cerebrovascular disease Ann Neurol 29 231 240 2042939 10.1002/ana.410290302 1:STN:280: DyaK3M3lsVSjsQ%3D%3D
22. TR DeGrado TG Turkington JJ Williams CW Stearns JM Hoffman RE Coleman 1994 Performance characteristics of a whole-body PET scanner J Nucl Med 35 1398 1406 8046501 1:STN:280:DyaK2czit1WjtQ%3D%3D (Pubitemid 24243158)
23. K Matsumoto Y Fujibayashi Y Yonekura K Wada Y Takemura J Konishi, et al. 1992 Application of the new zinc-62/copper-62 generator: an effective labeling method for 62Cu-PTSM Int J Rad Appl Instrum B 19 39 44 1577613 1:CAS:528:DyaK38XhsVOjsLg%3D
24. H Okazawa H Yamauchi K Sugimoto M Takahashi H Toyoda Y Kishibe, et al. 2001 Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: positron emission tomography study using 15O-gas and water J Cereb Blood Flow Metab 21 793 803 11435791 10.1097/00004647-200107000-00004 1:STN:280:DC%2BD3MznvFWisA%3D%3D (Pubitemid 32613533)
25. H Okazawa T Tsuchida M Kobayashi Y Arai M Pagani M Isozaki, et al. 2007 Can the detection of misery perfusion in chronic cerebrovascular disease be based on reductions in baseline CBF and vasoreactivity? Eur J Nucl Med Mol Imaging 34 121 129 16896662 10.1007/s00259-006-0192-5 (Pubitemid 44885562)
26. Okazawa H, Kishibe Y, Sugimoto K, Takahashi M, Yamauchi H, et al. Delay and dispersion correction for a new coincidental radioactivity detector, Pico-Count, in quantitative PET studies. In: Senda M, editor. Brain imaging using PET. San Diego: Academic; 2002. p. 15-21.
27. ME Raichle WR Martin P Herscovitch MA Mintun J Markham 1983 Brain blood flow measured with intravenous H2(15)OO. II. Implementation and validation J Nucl Med 24 790 798 6604140 1:STN:280:DyaL3s3ptlGqug%3D%3D (Pubitemid 14234679)
28. MA Mintun ME Raichle WR Martin P Herscovitch 1984 Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography J Nucl Med 25 177 187 6610032 1:CAS:528:DyaL2cXhtlGisrg%3D (Pubitemid 14187475)
29. M Isozaki Y Arai T Kudo Y Kiyono M Kobayashi T Kubota, et al. 2010 Clinical implication and prognosis of normal baseline cerebral blood flow with impaired vascular reserve in patients with major cerebral artery occlusive disease Ann Nucl Med 24 371 377 20238185 10.1007/s12149-010-0367-9
30. M Kobayashi T Kudo T Tsujikawa M Isozaki Y Arai Y Fujibayashi, et al. 2008 Shorter examination method for the diagnosis of misery perfusion using count-based oxygen extraction fraction elevation in 15O-gas PET J Nucl Med 49 242 246 18199611 10.2967/jnumed.107.047118 (Pubitemid 351225662)
31. K Saita M Chen NJ Spratt MJ Porritt GT Liberatore SJ Read, et al. 2004 Imaging the ischemic penumbra with 18F-fluoromisonidazole in a rat model of ischemic stroke Stroke 35 975 980 15017016 10.1161/01.STR.0000121647.01941.ba 1:CAS:528:DC%2BD2cXitlWktLk%3D (Pubitemid 38419813)
32. M Takasawa JS Beech TD Fryer YT Hong JL Hughes K Igase, et al. 2007 Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study J Cereb Blood Flow Metab 27 679 689 17033692 (Pubitemid 46474626)