The frequency of meconium-stained amniotic fluid increases as a function of the duration of labor

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 24, Issue 7, 2011, Pages 880-885

  Lee, Kyung A ^a   Mi Lee, Seung ^a   Jin Yang, Hye ^a   Park, Chan Wook ^a   Mazaki Tovi, Shali ^b   Hyun Yoon, Bo ^a   Romero, Roberto ^b,c  

^a Seoul National University College of Medicine   (South Korea)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fetal bowel function; first stage of labor; pregnancy

Indexed keywords

ADULT; AMNION FLUID; ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HUMAN; LABOR; LABOR ONSET; LABOR STAGE 1; LABOR STAGE 2; MAJOR CLINICAL STUDY; MECONIUM; NEWBORN; PARITY; PREMATURE FETUS MEMBRANE RUPTURE; PRIORITY JOURNAL;

ADULT; AMNIOTIC FLUID; FEMALE; HUMANS; INFANT, NEWBORN; LABOR, OBSTETRIC; MECONIUM; PREGNANCY; TERM BIRTH; TIME FACTORS;

EID: 79958054611     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2010.531329     Document Type: Article

References (56)

1. Katz VL, Bowes WA Jr. Meconium aspiration syndrome: reflections on a murky subject. Am J Obstet Gynecol 1992;166:171-183.
2. Blackwell SC, Moldenhauer J, Hassan SS, Redman ME, Refuerzo JS, Berry SM, Sorokin Y. Meconium aspiration syndrome in term neonates with normal acid-base status at delivery: is it different? Am J Obstet Gynecol 2001;184:1422- 1425; discussion 5-6.
3. Vain NE, Szyld EG, Prudent LM, Wiswell TE, Aguilar AM, Vivas NI. Oropharyngeal and nasopharyngeal suctioning of meconium-stained neonates before delivery of their shoulders: multicentre, randomised controlled trial. Lancet 2004;364: 597-602. (Pubitemid 39094177)
4. Fraser WD, Hofmeyr J, Lede R, Faron G, Alexander S, Goffinet F, Ohlsson A, Goulet C, Turcot-Lemay L, Prendiville W, et al. Amnioinfusion for the prevention of the meconium aspiration syndrome. N Engl J Med 2005;353:909-917. (Pubitemid 41247930)
5. Ziadeh SM, Sunna E. Obstetric and perinatal outcome of pregnancies with term labour and meconium-stained amniotic fluid. Arch Gynecol Obstet 2000;264:84-87.
6. Greenwood C, Lalchandani S, MacQuillan K, Sheil O, Murphy J, Impey L.Meconium passed in labor: how reassuring is clear amniotic fluid? Obstet Gynecol 2003;102:89-93. (Pubitemid 36792128)
7. Ahanya SN, Lakshmanan J, Morgan BL, Ross MG. Meconium passage in utero: mechanisms, consequences, and management. Obstet Gynecol Surv 2005;60:45-56; quiz 73-74. (Pubitemid 40039863)
8. David AN, Njokanma OF, Iroha E. Incidence of and factors associated with meconium staining of the amniotic fluid in a Nigerian University Teaching Hospital. J Obstet Gynaecol 2006;26:518-520. (Pubitemid 44454457)
9. Oyelese Y, Culin A, Ananth CV, Kaminsky LM, Vintzileos A, Smulian JC. Meconium-stained amniotic fluid across gestation and neonatal acid-base status. Obstet Gynecol 2006; 108:345-349. (Pubitemid 44305676)
10. Becker S, Solomayer E, Dogan C, Wallwiener D, Fehm T. Meconium-stained amniotic fluid - perinatal outcome and obstetrical management in a low-risk suburban population. Eur J Obstet Gynecol Reprod Biol 2007;132:46-50. (Pubitemid 46635967)
11. de Beaufort AJ. Early human development at the perinatal interface: meconium stained amniotic fluid (MSAF) and meconium aspiration syndrome (MAS). Early Hum Dev 2009;85:605.
12. Berkus MD, Langer O, Samueloff A, Xenakis EM, Field NT, Ridgway LE. Meconium-stained amniotic fluid: increased risk for adverse neonatal outcome. Obstet Gynecol 1994;84:115-120. (Pubitemid 24202969)
13. Alchalabi H, Abu-Heija AT, El-Sunna E, Zayed F, Badria LF, Obeidat A. Meconium-stained amniotic fluid in term pregnancies - a clinical view. J Obstet Gynaecol 1999;19:262-264. (Pubitemid 29271656)
14. Spinillo A, Fazzi E, Capuzzo E, Stronati M, Piazzi G, Ferrari A. Meconium-stained amniotic fluid and risk for cerebral palsy in preterm infants. Obstet Gynecol 1997;90:519-523. (Pubitemid 27407389)
15. Romero R, Hanaoka S, Mazor M, Athanassiadis AP, Callahan R, Hsu YC, Avila C, Nores J, Jimenez C. Meconium-stained amniotic fluid: a risk factor for microbial invasion of the amniotic cavity. Am J Obstet Gynecol 1991;164:859-862.
16. Rao S, Pavlova Z, Incerpi MH, Ramanathan R. Meconiumstained amniotic fluid and neonatal morbidity in near-term and term deliveries with acute histologic chorioamnionitis and/or funisitis. J Perinatol 2001;21:537-540. (Pubitemid 34055853)
17. Tran SH, Caughey AB, Musci TJ. Meconium-stained amniotic fluid is associated with puerperal infections. Am J Obstet Gynecol 2003;189:746-750. (Pubitemid 37194098)
18. Maymon E, Chaim W, Furman B, Ghezzi F, Shoham Vardi I, Mazor M. Meconium stained amniotic fluid in very low risk pregnancies at term gestation. Eur J Obstet Gynecol Reprod Biol 1998;80:169-173. (Pubitemid 28414445)
19. Williams MK, Chames MC. Risk factors for the breakdown of perineal laceration repair after vaginal delivery. Am J Obstet Gynecol 2006;195:755-759. (Pubitemid 44292148)
20. Cheng YW, Hopkins LM, Laros RK Jr, Caughey AB. Duration of the second stage of labor in multiparous women: maternal and neonatal outcomes. Am J Obstet Gynecol 2007;196:585 e1-585 e6.
21. Burgess AM, Hutchins GM. Inflammation of the lungs, umbilical cord and placenta associated with meconium passage in utero. Review of 123 autopsied cases. Pathol Res Pract 1996;192:1121-1128.
22. Lee SM, Lee KA, Lee J, Park CW, Yoon BH. 'Early rupture of membranes' after the spontaneous onset of labor as a risk factor for cesarean delivery. Eur J Obstet Gynecol Reprod Biol 2010;148:152-157.
23. Grammatopoulos DK, Hillhouse EW. Role of corticotropinreleasing hormone in onset of labour. Lancet 1999;354:1546-1549. (Pubitemid 29502118)
24. Lakshmanan J, Oyachi N, Ahanya SA, Liu G, Mazdak M, Ross MG. Corticotropin-releasing factor inhibition of sheep fetal colonic contractility: mechanisms to prevent meconium passage in utero. Am J Obstet Gynecol 2007;196:357 e1-357 e7.
25. Miller NM, Fisk NM, Modi N, Glover V. Stress responses at birth: determinants of cord arterial cortisol and links with cortisol response in infancy. BJOG 2005;112:921-926. (Pubitemid 40896958)
26. Oh SY, Romero R, Shim SS, Park JS, Jun JK, Yoon BH. Fetal plasma cortisol and dehydroepiandrosterone sulfate concentrations in pregnancy and term parturition. J Matern Fetal Neonatal Med 2006;19:529-536. (Pubitemid 44373604)
27. Mears K, McAuliffe F, Grimes H, Morrison JJ. Fetal cortisol in relation to labour, intrapartum events and mode of delivery. J Obstet Gynaecol 2004;24:129-132. (Pubitemid 38234068)
28. Lakshmanan J, Ahanya SN, Rehan V, Oyachi N, Ross MG. Elevated plasma corticotrophin release factor levels and in utero meconium passage. Pediatr Res 2007;61:176-179. (Pubitemid 46146875)
29. Ciftci AO, Tanyel FC, Bingol-Kologlu M, Sahin S, Buyukpamukcu N. Fetal distress does not affect in utero defecation but does impair the clearance of amniotic fluid. J Pediatr Surg 1999;34:246-250. (Pubitemid 29091425)
30. Gursoy T, Tekinalp G, Yigit S, Kirazli S, Korkmaz A, Gurgey A. Thrombin activatable fibrinolysis inhibitor activity (TAFIa) levels in neonates with meconium-stained amniotic fluid. J Matern Fetal Neonatal Med 2008;21:123-128. (Pubitemid 351196235)
31. Simsek A, Celen S, Islimye M, Danisman N, Buyukkagnici U. A long-standing incomprehensible matter of obstetrics: meconium-stained amniotic fluid, a new approach to reason. Arch Gynecol Obstet 2008;278:559-563.
32. Yoon BH, Kim SW. The effect of labor on the normal values of umbilical blood acid-base status. Acta Obstet Gynecol Scand 1994;73:555-561. (Pubitemid 24275519)
33. Ramon y Cajal CL, Martinez RO. Defecation in utero: a physiologic fetal function. Am J Obstet Gynecol 2003;188: 153-156.
34. Ramon YCCL, Martinez RO. In-utero defecation between weeks 14 and 22 of gestation: stools are whitish. Ultrasound Obstet Gynecol 2004;23:94-95.
35. Ciftci AO, Tanyel FC, Karnak I, Buyukpamukcu N, Hicsonmez A. In-utero defecation: fact or fiction? Eur J Pediatr Surg 1999;9:376-380. (Pubitemid 30022334)
36. Malkiel A, Pnina M, Aloni H, Gdansky E, Grisaru-Granovsky S. Primiparity: a traditional intrapartum obstetric risk reconfirmed. Isr Med Assoc J 2008;10:508-511.
37. Liu BY, Wang CC, Lau TK, Chu CY, Phil M, Pang CP, Rogers MS, Leung TN. Meconium-stained liquor during labor is associated with raised neonatal cord blood 8-isoprostaglandin F2a concentration. Am J Obstet Gynecol 2005;192:289-294. (Pubitemid 40164255)
38. Myles TD, Santolaya J. Maternal and neonatal outcomes in patients with a prolonged second stage of labor. Obstet Gynecol 2003;102:52-58. (Pubitemid 36792123)
39. Schiessl B, Janni W, Jundt K, Rammel G, Peschers U, Kainer F. Obstetrical parameters influencing the duration of the second stage of labor. Eur J Obstet Gynecol Reprod Biol 2005;118:17-20. (Pubitemid 39647016)
40. Cheng YW, Hopkins LM, Caughey AB. How long is too long: does a prolonged second stage of labor in nulliparous women affect maternal and neonatal outcomes? Am J Obstet Gynecol 2004;191:933-938. (Pubitemid 39298136)
41. BursteinE,Sheiner E,MazorM,CarmelE, LevyA,Hershkovitz R. Identifying risk factors for premature rupture of membranes in small for gestational age neonates: a population-based study. JMatern Fetal Neonatal Med 2008;21:816-820.
42. Savasan ZA, Romero R, Chaiworapongsa T, Kusanovic JP, Kim SK, Mazaki-Tovi S, Vaisbuch E, Mittal P, Ogge G, Madan I, et al. Evidence in support of a role for antiangiogenic factors in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2010;23:828-841.
43. Cruciani L, Romero R, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Mazaki-Tovi S, Mittal P, Ogge G, Gotsch F, Erez O, et al. Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation. J Perinat Med 2010;38:161-171.
44. Cruciani L, Romero R, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Mazaki-Tovi S, Dong Z, Kim SK, Ogge G, Yeo L, et al. Pentraxin 3 in maternal circulation: an association with preterm labor and preterm PROM, but not with intraamniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:1097-1105.
45. Kusanovic JP, Romero R, Jodicke C, Mazaki-Tovi S, Vaisbuch E, Erez O, Mittal P, Gotsch F, Chaiworapongsa T, Edwin SS, et al. Amniotic fluid soluble human leukocyte antigen-G in term and preterm parturition, and intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2009;22:1151-1166.
46. DiGiulio DB, Romero R, Kusanovic JP, Gomez R, Kim CJ, Seok KS, Gotsch F, Mazaki-Tovi S, Vaisbuch E, Sanders K, et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010;64:38-57.
47. DiGiulio DB, Romero R, Amogan HP, Kusanovic JP, Bik EM, Gotsch F, Kim CJ, Erez O, Edwin S, Relman DA. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS One 2008;3:e3056.
48. Kusanovic JP, Romero R, Chaiworapongsa T, Mittal P, Mazaki-Tovi S, Vaisbuch E, Erez O, Gotsch F, Than NG, Edwin SS, et al. Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:34-47.
49. Kim SK, Romero R, Kusanovic JP, Erez O, Vaisbuch E, Mazaki-Tovi S, Gotsch F, Mittal P, Chaiworapongsa T, Pacora P, et al. The prognosis of pregnancy conceived despite the presence of an intrauterine device (IUD). J Perinat Med 2010;38:45-53.
50. Lee SE, Romero R, Lee SM, Yoon BH. Amniotic fluid volume in intra-amniotic inflammation with and without culture-proven amniotic fluid infection in preterm premature rupture of membranes. J Perinat Med 2010;38: 39-44.
51. Mazaki-Tovi S, Romero R, Vaisbuch E, Chaiworapongsa T, Erez O, Mittal P, Kim SK, Gotsch F, Lamont R, Ogge G, et al. Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection. J Perinat Med 2010;38:9-17.
52. Mittal P, Romero R, Mazaki-Tovi S, Tromp G, Tarca AL, Kim YM, Chaiworapongsa T, Kusanovic JP, Erez O, Than NG, et al. Fetal membranes as an interface between inflammation and metabolism: increased aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis. J Matern Fetal Neonatal Med 2009;22:1167-1175.
53. Erez O, Romero R, Tarca AL, Chaiworapongsa T, Kim YM, Than NG, Vaisbuch E, Draghici S, Tromp G. Differential expression pattern of genes encoding for anti-microbial peptides in the fetal membranes of patients with spontaneous preterm labor and intact membranes and those with preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med 2009;22:1103-1115.
54. Melamed N, Hadar E, Ben-Haroush A, Kaplan B, Yogev Y. Factors affecting the duration of the latency period in preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2009;22:1051-1056.
55. Deutsch A, Deutsch E, Totten C, Downes K, Haubner L, Belogolovkin V. Maternal and neonatal outcomes based on the gestational age of midtrimester preterm premature rupture of membranes. J Matern Fetal Neonatal Med 2010;23:1429-34.
56. Seong HS, Lee SE, Kang JH, Romero R, Yoon BH. The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor. Am J Obstet Gynecol 2008;199:375 e1-375 e5.