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Volumn 12, Issue 2, 2011, Pages 126-135

BEYOND KRAS: Other markers and potential treatment strategies for KRAS mutant and wild-type patients

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANTINEOPLASTIC AGENT; B RAF KINASE; B RAF KINASE INHIBITOR; BEVACIZUMAB; CETUXIMAB; CIXUTUMUMAB; CONATUMUMAB; DALOTUZUMAB; FLUOROURACIL; FOLINIC ACID; GANITUMAB; IRINOTECAN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; MUTANT PROTEIN; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN PIK3CA; RILOTUMUMAB; SORAFENIB; STA 9090; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEMURAFENIB; VISMODEGIB;

EID: 79958050915     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-011-0147-3     Document Type: Article
Times cited : (2)

References (35)
  • 1
    • 0036817040 scopus 로고    scopus 로고
    • Epithelial growth factor receptor interacting agents
    • DOI 10.1016/S0889-8588(02)00055-2, PII S0889858802000552
    • J Baselga J Albanell 2002 Epithelial growth factor receptor interacting agents Hematol Oncol Clin North Am 16 1041 1063 12512382 10.1016/S0889-8588(02) 00055-2 (Pubitemid 35462913)
    • (2002) Hematology/Oncology Clinics of North America , vol.16 , Issue.5 , pp. 1041-1063
    • Baselga, J.1    Albanell, J.2
  • 2
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • J Baselga 2002 Why the epidermal growth factor receptor? The rationale for cancer therapy Oncologist 7 Suppl 4 2 8 12202782 10.1634/theoncologist.7- suppl-4-2 1:CAS:528:DC%2BD38XnsFOiurw%3D (Pubitemid 34977157)
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 3
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • 7612182 10.1016/1040-8428(94)00144-I 1:STN:280:DyaK2Mzjs1KgsQ%3D%3D
    • DS Salomon R Brandt F Ciardiello, et al. 1995 Epidermal growth factor-related peptides and their receptors in human malignancies Crit Rev Oncol Hematol 19 183 232 7612182 10.1016/1040-8428(94)00144-I 1:STN:280: DyaK2Mzjs1KgsQ%3D%3D
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3
  • 4
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan is active in CPT-11 refractory colorectal cancer that expresses epidermal growth factor (abstract)
    • Saltz LB RM, Hochester H: Cetuximab plus irinotecan is active in CPT-11 refractory colorectal cancer that expresses epidermal growth factor (abstract). J Clin Oncol. 20, 2001
    • (2001) J Clin Oncol , vol.20
    • Saltz, L.B.1    Hochester, H.2
  • 5
    • 0001407135 scopus 로고    scopus 로고
    • Single agent IMC-C225 (Erbitux) has activity in CPT-11 refractory colorectal cancer that expresses epidermal growth factor receptor (abstract)
    • Saltz LB MN, Loeher PJ, et al: Single agent IMC-C225 (Erbitux) has activity in CPT-11 refractory colorectal cancer that expresses epidermal growth factor receptor (abstract). J Clin Oncol 21, 2002
    • (2002) J Clin Oncol , vol.21
    • Saltz, L.B.1    Loeher, P.J.2
  • 7
    • 11344268358 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor
    • ER Camp J Summy TW Bauer, et al. 2005 Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor Clin Cancer Res 11 397 405 15671571 1:CAS:528:DC%2BD2MXhtVegtbw%3D (Pubitemid 40075820)
    • (2005) Clinical Cancer Research , vol.11 , Issue.1 , pp. 397-405
    • Camp, E.R.1    Summy, J.2    Bauer, T.W.3    Liu, W.4    Gallick, G.E.5    Ellis, L.M.6
  • 8
    • 6344272498 scopus 로고    scopus 로고
    • ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis (abstract)
    • Hecht JR PA, Malik I, et al: ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): an updated analysis (abstract). J Clin Oncol 22, 2004
    • (2004) J Clin Oncol , vol.22
    • Hecht Jr., P.A.1    Malik, I.2
  • 9
    • 79958063146 scopus 로고    scopus 로고
    • Panitumumab antitumor activity in patients with metastatic colorectal cancer (mCRC expressing >10% epidermal growth factor receptor (EGFr) (abstract)
    • Berlin J NM, Swanson P, et al: Panitumumab antitumor activity in patients with metastatic colorectal cancer (mCRC expressing >10% epidermal growth factor receptor (EGFr) (abstract).. J Clin Oncol 24, 2006
    • (2006) J Clin Oncol , vol.24
    • Jnm, B.1    Swanson, P.2
  • 13
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • 18316791 10.1200/JCO.2007.14.7116 1:CAS:528:DC%2BD1cXltlWhsrw%3D The study demonstarted the resistance to anti-EGFR therapy in KRAS mutated mcrc.
    • RG Amado M Wolf M Peeters, et al. 2008 Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer J Clin Oncol 26 1626 1634 18316791 10.1200/JCO.2007.14.7116 1:CAS:528:DC%2BD1cXltlWhsrw%3D The study demonstarted the resistance to anti-EGFR therapy in KRAS mutated mcrc.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 14
    • 51649120733 scopus 로고    scopus 로고
    • KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or wihtout cetuximab: The CRYSTAL experience
    • Van Cutsem E LI, D'haens G, Moiseyenko V, Zaluski J, Folprecht G, Tejpar S, et al: KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or wihtout cetuximab: The CRYSTAL experience. J Clin Oncol. 26, 2008.
    • (2008) J Clin Oncol , vol.26
    • Van Cutsem, E.L.I.1    D'Haens, G.2    Moiseyenko, V.3    Zaluski, J.4    Folprecht, G.5    Tejpar, S.6
  • 15
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • 19114683 10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D
    • C Bokemeyer I Bondarenko A Makhson, et al. 2009 Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer J Clin Oncol 27 663 671 19114683 10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 16
    • 79958047314 scopus 로고    scopus 로고
    • Randomized phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colrectal cancer (ACC), the CAIRO2 study if the Dutch Colorectal Cancer Group (DCCG)
    • Punt CJTJ, Rodenburg CJ, Cats A, Creemers G, Schrama JG, Erdkamp FL, et al: Randomized phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colrectal cancer (ACC), the CAIRO2 study if the Dutch Colorectal Cancer Group (DCCG). J Clin Oncol. 26, 2008
    • (2008) J Clin Oncol , vol.26
    • Cjtj, P.1    Rodenburg, C.J.2    Cats, A.3    Creemers, G.4    Schrama, J.G.5    Erdkamp, F.L.6
  • 17
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p.G13D Mutation with Outcome in Patients with Chemotherapy-Refractory Metastatic Colorectal Cancer Treated with Cetuximab
    • 20978259 10.1001/jama.2010.1535
    • W De Roock DJ Jonker F Di Nicolantonio A Sartore-Bianchi 2010 Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab JAMA. 304 16 1812 1820 20978259 10.1001/jama.2010.1535
    • (2010) JAMA. , vol.304 , Issue.16 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3    Sartore-Bianchi, A.4
  • 18
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • 19001320 10.1200/JCO.2008.18.0786 the study showed resistance to anti-EGFR therapy in BRAF mutated mcrc
    • F Di Nicolantonio M Martini F Molinari, et al. 2008 Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer J Clin Oncol 26 5705 5712 19001320 10.1200/JCO.2008.18.0786 the study showed resistance to anti-EGFR therapy in BRAF mutated mcrc
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 19
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
    • 19603018 10.1038/sj.bjc.6605177 1:CAS:528:DC%2BD1MXpvFyisb0%3D
    • F Loupakis A Ruzzo C Cremolini, et al. 2009 KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer Br J Cancer 101 715 721 19603018 10.1038/sj.bjc.6605177 1:CAS:528:DC%2BD1MXpvFyisb0%3D
    • (2009) Br J Cancer , vol.101 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3
  • 21
    • 78650755609 scopus 로고    scopus 로고
    • Association of BRAF mutations and EGFR Intron-1 L/L genotype with ersistance to cetuximab plus irinotecan treatment in KRAS wild-type metastatic colorectal cancer patients
    • 10.1200/JCO.2008.21.7695 suppl; abstr 4058
    • A Ruzzo C Cremolini F Loupakis D Fornaro B Santini 2009 Association of BRAF mutations and EGFR Intron-1 L/L genotype with ersistance to cetuximab plus irinotecan treatment in KRAS wild-type metastatic colorectal cancer patients J Clin Oncol 27 15s 10.1200/JCO.2008.21.7695 suppl; abstr 4058
    • (2009) J Clin Oncol , vol.27
    • Ruzzo, A.1    Cremolini, C.2    Loupakis, F.3    Fornaro, D.4    Santini, B.5
  • 23
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS and PIK3CA mutationson the efficacy of cetuximab plus chemotherapy in chemotehrapy-refractory metastatic colorectal cancer: A retropsective consortium analysis
    • 20619739 10.1016/S1470-2045(10)70130-3
    • W De Roock B Claes D Bernasconi J De Schutter B Biesmans, et al. 2010 Effects of KRAS, BRAF, NRAS and PIK3CA mutationson the efficacy of cetuximab plus chemotherapy in chemotehrapy-refractory metastatic colorectal cancer: a retropsective consortium analysis Lancet Oncol 11 8 753 762 20619739 10.1016/S1470-2045(10)70130-3
    • (2010) Lancet Oncol , vol.11 , Issue.8 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5
  • 24
    • 78649739337 scopus 로고    scopus 로고
    • Cetuximab with chemotehrapy (CT) as first-line treatment for metastatic colorectal cancer (mCRC): Analysis of the CRYSTAL and OPUS studies according to KRAS and BRAF mutation status
    • 10.1200/JCO.2009.25.9937 This study is the first to demonstrate efficacy of dual targeted therapy in mcrc.
    • C Bokemeyer C Kohne P Rougier C Stroh M Schlichting 2010 Cetuximab with chemotehrapy (CT) as first-line treatment for metastatic colorectal cancer (mCRC): Analysis of the CRYSTAL and OPUS studies according to KRAS and BRAF mutation status J Clin Oncol 28 7s 10.1200/JCO.2009.25.9937 This study is the first to demonstrate efficacy of dual targeted therapy in mcrc.
    • (2010) J Clin Oncol , vol.28
    • Bokemeyer, C.1    Kohne, C.2    Rougier, P.3    Stroh, C.4    Schlichting, M.5
  • 25
    • 79958057528 scopus 로고    scopus 로고
    • http://www.nelm-web.lbi.co.uk/en/NeLM-Area/News/2009 - -July/01/Phase-III-study-of-sunitinib-Sutent-in-metastatic-colorectal-cancer- discontinued/
  • 26
    • 78649723255 scopus 로고    scopus 로고
    • PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors
    • Kopetz S, Desai J, Chan E, Hecht R, O'Dweyer, Lee RJ, et al: PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors. Abstract 3534 JCO vol 28, No 15 suppl 2010; 3534.
    • Abstract 3534 JCO , vol.28 , Issue.15 SUPPL. 2010 , pp. 3534
    • Kopetz, S.1    Desai, J.2    Chan, E.3    Hecht, R.4    O'Dweyer5    Lee, R.J.6
  • 27
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • 19223544 10.1158/0008-5472.CAN-08-2466 1:CAS:528:DC%2BD1MXisFSrt7Y%3D
    • A Sartore-Bianchi M Martini F Molinari, et al. 2009 PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies Cancer Res 69 1851 1857 19223544 10.1158/0008-5472.CAN-08- 2466 1:CAS:528:DC%2BD1MXisFSrt7Y%3D
    • (2009) Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3
  • 29
    • 54249155585 scopus 로고    scopus 로고
    • Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type-1 insulin-like growth factor receptor and epidermal growth factor receptor
    • 18829558 10.1158/0008-5472.CAN-08-0280 1:CAS:528:DC%2BD1cXhtF2msLrI
    • YP Hu SB Patil M Panasiewicz, et al. 2008 Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type-1 insulin-like growth factor receptor and epidermal growth factor receptor Cancer Res 68 8004 8013 18829558 10.1158/0008-5472.CAN-08-0280 1:CAS:528: DC%2BD1cXhtF2msLrI
    • (2008) Cancer Res , vol.68 , pp. 8004-8013
    • Hu, Y.P.1    Patil, S.B.2    Panasiewicz, M.3
  • 30
    • 77957962308 scopus 로고    scopus 로고
    • Rnadomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with ot without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer
    • 20713879 10.1200/JCO.2010.30.4154 1:CAS:528:DC%2BC3cXhsVSksr7I
    • DL Reidy E Vakiani MG Fakih LB Saltz 2010 Rnadomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with ot without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer J Clin Oncol. 28 27 4240 4246 20713879 10.1200/JCO.2010.30. 4154 1:CAS:528:DC%2BC3cXhsVSksr7I
    • (2010) J Clin Oncol. , vol.28 , Issue.27 , pp. 4240-4246
    • Reidy, D.L.1    Vakiani, E.2    Fakih, M.G.3    Saltz, L.B.4
  • 31
    • 79958051585 scopus 로고    scopus 로고
    • A Randomized Phase I/II Trial of AMG 102 or AMG 479 in combination with panitumumab (pmab) compared with pmab alone in patients with wild type KRAS metastatic colorectal cancer: Safety and efficacy results
    • abstr 366
    • VanCutsem E, Eng C, Tabernero J, Nowara E, et al: A Randomized Phase I/II Trial of AMG 102 or AMG 479 in combination with panitumumab (pmab) compared with pmab alone in patients with wild type KRAS metastatic colorectal cancer: Safety and efficacy results. J Clin Oncol 29: 2011 (suppl 4; abstr 366).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4
    • Vancutsem, E.1    Eng, C.2    Tabernero, J.3    Nowara, E.4
  • 33
    • 84872606115 scopus 로고    scopus 로고
    • A phase 2, randomized, double-blind, placebo-controlled study of hedgehog pathway inhibitor (HPI) GDC-0449 in patients with previously untreated metastatic colorectal cancer (mCRC)
    • abstract
    • Berlin J. A phase 2, randomized, double-blind, placebo-controlled study of hedgehog pathway inhibitor (HPI) GDC-0449 in patients with previously untreated metastatic colorectal cancer (mCRC), abstract ESMO 2010 https://www.webges.com/cslide/library/esmo/mylibrary/search/session/0/509
    • ESMO 2010
    • Berlin, J.1
  • 34
    • 3342894130 scopus 로고    scopus 로고
    • Targeting death receptors in cancer with Apo2L/TRAIL
    • DOI 10.1016/j.coph.2004.02.006, PII S1471489204000840
    • S Kelly A Ashkenazi 2004 Targeting death receptors in cancer with Apo2L/TRAIL Curr Opin Pharmacol 4 333 339 10.1016/j.coph.2004.02.006 (Pubitemid 38987058)
    • (2004) Current Opinion in Pharmacology , vol.4 , Issue.4 , pp. 333-339
    • Kelley, S.K.1    Ashkenazi, A.2
  • 35
    • 72449176627 scopus 로고    scopus 로고
    • Fuchs Safety and efficacy of AMG 655 plus modified FOLFOX6 (mFOLFOX6) and bevacizumab (B) for the first-line treatment of patients (pts) with metastatic colorectal cancer (mCRC)
    • 10.1200/JCO.2008.21.7695 suppl; abstr 4079
    • L Saltz J Infante L Schwartzberg J Stephenson C Rocha-Lima F Galimi, et al. 2009 Fuchs Safety and efficacy of AMG 655 plus modified FOLFOX6 (mFOLFOX6) and bevacizumab (B) for the first-line treatment of patients (pts) with metastatic colorectal cancer (mCRC) J Clin Oncol 27 15s 10.1200/JCO.2008.21.7695 suppl; abstr 4079
    • (2009) J Clin Oncol , vol.27
    • Saltz, L.1    Infante, J.2    Schwartzberg, L.3    Stephenson, J.4    Rocha-Lima, C.5    Galimi, F.6


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