EPAS1 mRNA in plasma from colorectal cancer patients is associated with poor outcome in advanced stages

Oncology Letters

Volumn 2, Issue 4, 2011, Pages 719-724

  Mohammed, N ^a   Rodriguez, M ^a   Garcia, V ^a   Garcia, J M ^a   Dominguez, G ^a   Pena C ^a   Herrera, M ^a   Gomez, I ^a   Diaz, R ^a   Soldevilla, B ^a   Herrera, A ^a   Silva, J ^a   Bonilla, F ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Colorectal cancer; EPAS1; mRNA; Outcome; Plasma

Indexed keywords

COMPLEMENTARY DNA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NUCLEIC ACID; PROTEIN P53; UBIQUITIN CONJUGATING ENZYME;

ADULT; ADVANCED CANCER; AGED; ANGIOGENESIS; ARTICLE; CANCER PATIENT; CANCER STAGING; CONTROLLED STUDY; DISEASE FREE SURVIVAL; EPAS1 GENE; FEMALE; GENE; GENE EXPRESSION; GENOMICS; HUMAN; KAPLAN MEIER METHOD; KIAA0101 GENE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOMES RESEARCH; PLASMA; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE; UBE2D3 GENE;

EID: 79958049779     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.294     Document Type: Article

References (32)

1. Schoen RE: The case for population-based screening for colorectal cancer. Nat Rev Cancer 2: 65-70, 2002.
2. Fleischhacker M and Schmidt B: Circulating nucleic acids (CNAs) and cancer - a survey. Biochim Biophys Acta 1775: 181-232, 2007.
3. Leon SA, Shapiro B, Sklaroff DM and Yaros MJ: Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37: 646-650, 1977.
4. Shapiro B, Chakrabarty M, Cohn EM and Leon SA: Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease. Cancer 51: 2116-2120, 1983.
5. Silva JM, Rodriguez R, Garcia JM, Muñoz C, Silva J, Dominguez G, Provencio M, España P and Bonilla F: Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 50: 530-534, 2002.
6. Silva J, Silva JM, Garcia JM, Dominguez G and Bonilla F: RNA is more sensitive than DNA in identification of breast cancer patients bearing tumor nucleic acids in plasma. Gene Chromosome Cancer 3: 375-376, 2002.
7. Silva JM, Dominguez G, Silva J, Garcia JM, Sanchez A, Rodriguez O, Provencio M and Bonilla F: Detection of epithelial messenger RNA in the plasma of breast cancer patients is associated with poor prognosis tumor characteristics. Clin Cancer Res 7: 2821-2825, 2001.
8. Dasi F, Lledo S, Garcia-Granero E, Ripoll R, Marugan M, Tormo M, Garcia-Conde J and Aliño SF: Real-time quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA: a simple blood test to monitor disease in cancer patients. Lab Invest 81: 767-769, 2001.
9. Wong SC, Lo SF, Cheung MT, Ng KO, Tse CW, Lai BS, Lee KC and Lo YM: Quantification of plasma catenin mRNA in colorectal cancer and adenoma patients. Clin Cancer Res 10: 1613-1617, 2004.
10. Garcia V, Garcia JM, Peña C, Silva J, Dominguez G, Lorenzo Y, Diaz R, Espinosa P, Garcia de Sola J, Cantos B and Bonilla F: Free circulating mRNA in plasma from breast cancer patients and clinical outcome. Cancer Lett 263: 312-320, 2008.
11. Garcia V, Garcia JM, Peña C, Silva J, Dominguez G, Hurtado A, Alonso I, Rodriguez R, Provencio M and Bonilla F: Thymidylate synthase mRNA expression in plasma from colon cancer patients. Clin Cancer Res 12: 2095-2100, 2006.
12. Collado M, Garcia V, Garcia JM, Alonso I, Lombardia L, Diaz-Uriarte R, Luis Lopez Fernandez, Zaballos A, Bonilla F and Serrano M: Genomic profiling of circulating plasma RNA for the analysis of cancer. Clin Chem 53: 1860-1863, 2007.
13. Pilarsky C, Wenzig M, Specht T, Saeger HD and Grutzmann R: Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia 6: 744-750, 2004.
14. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci USA 101: 9309-9314, 2004.
15. Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M and Nagasue N: Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res 10: 8554-8560, 2004.
16. Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL and Lane DP: Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. J Biol Chem 279: 42169-42181, 2004.
17. Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K and Ciechanover A: Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. J Biol Chem 74: 14823-14830, 1999.
18. Garcia JM, Garcia V, Peña C, Dominguez G, Silva J, Diaz R, Espinosa P, Citores MJ, Collado M and Bonilla F: Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched. RNA 14: 1424-1432, 2008.
19. Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A and Rak J: Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumor cells. Nat Cell Biol 10: 619-624, 2008.
20. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654-659, 2007.
21. Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS, Krichevsky AM and Breakefield XO: Gliobastoma microvesicles transport RNA and proteins that promote tumor growth and provide diagnostic biomarkers. Nat Cell Biol 10: 1470-1476, 2008.
22. Hasselmann DO, Rappl G, Rossler M, Ugurel S, Tilgen W and Reinhold U: Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma. Oncol Res 8: 115-118, 2001.
23. Kopreski MS, Benko FA and Gocke CD: Circulating RNA as a tumor messenger in the serum of patient of malignant melanoma. Clin Cancer Res 5: 1961-1965, 1999.
24. Duffy MJ, van Dalen A, Haglund C, Hansson L and Kalapdor R: Clinical utility of biochemical markers in colorectal cancer: European Group on tumor markers (EGTM). Eur J Cancer 39: 718-727, 2003.
25. Bertout JA, Patel SA and Simon MC: The impact of O2 availability on human cancer. Nat Rev Cancer 8: 967-975, 2008.
26. Wouters BG and Koritzinsky M: Hypoxia signaling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 8: 851-864, 2008.
27. Erler JT, Bennewith KL, Nicolau M, Dornhofer N, Kong C, Le QT, Chi JT, Jeffrey SS and Giaccia AJ: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222-1226, 2006.
28. Flamme I, Krieg M and Plate KH: Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha. Am J Pathol 153: 25-29, 1998.
29. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ and Harris AL: The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157: 411-421, 2000.
30. Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS and Ogino S: HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol 176: 2292-2301, 2010.
31. Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM and Guenther T: Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1 α is associated with prognosis. Br J Cancer 100: 1666-1673, 2009.
32. Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M and Nagasue N: Prognostic impact of hypoxia-inducible factors 1α and 2α in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res 10: 8554-8560, 2004.