The discovery of endothelin: The power of bioassay and the role of serendipity in the discovery of endothelium-derived vasocative substances

Pharmacological Research

Volumn 63, Issue 6, 2011, Pages 448-454

  Rubanyi, Gabor M ^a  

^a Cardium Therapeutics Inc   (United States)

Author keywords

EDCF; EDRF; Endothelin; Endothelium; NO

Indexed keywords

ACETYLCHOLINE; AMBRISENTAN; BOSENTAN; ENDOTHELIN; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; ENDOTHELIUM DERIVED RELAXING FACTOR;

ARTERY CONSTRICTION; BIOASSAY; CULTURE MEDIUM; ENDOTHELIUM CELL; HUMAN; IN VIVO STUDY; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN SECRETION; PULMONARY HYPERTENSION; REVIEW; SEQUENCE ANALYSIS; SMOOTH MUSCLE RELAXATION; VASODILATATION;

EID: 79958044627     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.08.004     Document Type: Article

References (26)

1. Florey HW. The endothelial cell. Br Med J 1966;2:487-90.
2. Moncada S, Gryglewski R, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976;263:663-5.
3. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6. (Pubitemid 11169009)
4. DeMey JG, Vanhoutte PM. Anoxia and endothelium-dependent reactivity of the canine femoral artery. J Physiol (Lond) 1983;335:65-74.
5. Rubanyi GM, Vanhoutte PM. Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J Physiol (Lond) 1985;364:45-56.
6. Hickey KA, Rubanyi GM, Paul R, Highsmith RF. Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol 1985;248:C550-5.
7. Rubanyi GM, Lorenz RR, Vanhoutte PM. Bioassay of endothelium-derived relaxing factor(s): inactivation by catecholamines. Am J Physiol 1985;249:H95-101.
8. Holden WE, McCall E. Hypoxic vasoconstriction of porcine pulmonary artery strips in vitro requires intact endothelium. Am Rev Respir Dis 1983;127:301 [abstract].
9. Holden WE, McCall E. Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium. Exp Lung Res 1984;7:101-72 [abstract].
10. Rubanyi GM, Vanhoutte PM. Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. Circulation 1984;70:122 [abstract].
11. Furchgott RF, Bhadrakom S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Therap 1953;108:129.
12. Furchgott RF. Spiral-cut strip of rabbit aorta for in vitro studies of responses of arterial smooth muscle. In: Bruner HD, editor. Methods in medical research, vol. 177. Yearbook Publishers Inc; 1960. p. 8.
13. Warner TD, De Nucci G, Vane JR. Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat. Eur J Pharmacol 1989;159:325-6. (Pubitemid 19032169)
14. Rubanyi GM, Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol Rev 1994;46:325-415.
15. Highsmith RF. From endotensin to endothel: the discovery and characterization of an endothelial cell-derived constricting factor. In: Rubanyi GM, editor. Endothelin. Oxford/New York: Oxford University Press; 1992. p. 17-30.
16. Hom GJ, Highsmith RF, Pang DC. In vivo hemodynamic effects of endothelium-derived constricting factor in the dog. Drug Dev Res 1989;18:145-51.
17. Agricola K, Rubanyi G, Paul RJ, Highsmith RF. Characterization of a potent coronary vasoconstrictor produced by endothelial cells in culture. Federation Proc 1984;43:899 [abstract].
18. Gillespie MN, Owasoyo JO, McMurtry IF, O'Brien RF. Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmacol Exp Ther 1986;236:339-43. (Pubitemid 16184223)
19. O'Brien RF, Robbins RJ, McMurtry IF. Endothelial cells in culture produce a vasoconstrictor substance. J Cell Physiol 1987;132:263-70. (Pubitemid 17151479)
20. Masaki T, Rubanyi GM. Introduction: the discovery of endothelin. In: Rubanyi GM, editor. Endothelin. Oxford/New York: Oxford University Press; 1992. p. xi-xiii.
21. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-5. (Pubitemid 18090241)
22. Kloog Y, Sokolovsky M. Similarities in mode and sites of action of sarafotoxins and endothelins. Trends Pharmacol Sci 1989;10:212-4. (Pubitemid 19146390)
23. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, et al. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci USA 1989;86:2863-7. (Pubitemid 19112640)
24. Inoue A, Yanagisawa M, Takuwa Y, Mitsui Y, Kobayashi M, Masaki T. The human preproendothelin 1 gene. Complete nucleotide sequence and regulation of expression. J Biol Chem 1989;264:14954-9. (Pubitemid 19237323)
25. AraiH, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature 1990;348:730-2. (Pubitemid 120015147)
26. Sakurai T, Yanagisawa M, TakuwaY, Miyazaki H, Kimura S, Mitsui Y, et al. Cloning of a cDNA encoding a non isopeptide selective subtype of the endothelin receptor. Nature 1990;348:732-5. (Pubitemid 120015148)