Molecular epidemiology and antimicrobial resistance determinants of multidrug-resistant Acinetobacter baumannii in five proximal hospitals in Taiwan

Japanese Journal of Infectious Diseases

Volumn 64, Issue 3, 2011, Pages 222-227

  Lin, Ming Feng ^a,b   Chang, Kai Chih ^c   Lan, Chung Yu ^b   Chou, Juiling ^d   Kuo, Jai Wei ^d   Chang, Chih Kai ^d   Liou, Ming Li ^a  

^a Chutung Hospital   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

^d YUANPEI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BACTERIAL PROTEIN; BETA LACTAMASE AMPC; BETA LACTAMASE OXA 23; BETA LACTAMASE OXA 51 LIKE; CARBAPENEMASE; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORINASE; CIPROFLOXACIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; INTEGRASE; LEVOFLOXACIN; METALLO BETA LACTAMASE; PIPERACILLIN PLUS TAZOBACTAM; PROTEIN ABEM; PROTEIN ADEB; PROTEIN ADEJ; SULTAMICILLIN; TOBRAMYCIN; UNCLASSIFIED DRUG;

ABEM GENE; ACINETOBACTER BAUMANNII; ADEB GENE; ADEJ GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BLA AMP C GENE; BLA OXA 23 GENE; BLA OXA 51 LIKE GENE; CLONAL VARIATION; CONTROLLED STUDY; GENE EXPRESSION; INTI1 GENE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EPIDEMIOLOGY; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TAIWAN;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CLUSTER ANALYSIS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE EXPRESSION PROFILING; GENOTYPE; HOSPITALS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TAIWAN;

EID: 79958021818     PISSN: 13446304     EISSN: 18842836     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Perez, F., Hujer, A.-M., Hujer, K.-M., et al. (2007): Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother., 51, 3471-3484.
2. Valenzuela, J.-K., Thomas, L., Partridge, S.-R., et al. (2007): Horizontal gene transfer in a polyclonal outbreak of carbapenemresistant Acinetobacter baumannii. J. Clin. Microbiol., 45, 453-460.
3. Bou, G. and Martinez-Beltran, J. (2000): Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC b-lactamase in Acinetobacter bauamnnii. Antimicrob. Agents Chemother., 44, 428-432.
4. Walther-Rasmussen, J. and Høiby, N. (2006): OXA-type carbapenemases. J. Antimicrob. Chemother., 57, 373-383.
5. Heáritier, C., Poirel, L. and Nordmann, P. (2006): Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii. Clin. Microbiol. Infect., 12, 123-130.
6. Turton, J.-F., Ward, M.E., Woodford, N., et al. (2006): The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol. Lett., 258, 72-77.
7. Bratu, S., Landman, D., Martin, D.-A., et al. (2008): Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City. Antimicrob. Agents Chemother., 52, 2999-3005.
8. Nemec, A., Maixnerovaá, M., van, der Reijden T.-J., et al. (2007): Relationship between the AdeABC efflux system gene content, netilmicin susceptibility and multidrug resistance in a genotypically diverse collection of Acinetobacter baumanniistrains. J. Antimicrob. Chemother., 60, 483-489.
9. Damier-Piolle, L., Magnet, S., Breámont, S., et al. (2008): AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob. Agents Chemother., 52, 557-562.
10. Wieczorek, P., Sacha, P., Hauschild, T., et al. (2008): Multidrug resistant Acinetobacter baumannii-the role of AdeABC (RND family) efflux pump in resistance to antibiotics. Folia Histochem. Cytobiol., 46, 257-267.
11. +-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob. Agents Chemother., 49, 4362-4364.
12. Qi, C., Malczynski, M., Parker, M., et al. (2008): Characterization of genetic diversity of carbapenem-resistant Acinetobacter baumannii clinical strains collected from 2004 to 2007. J. Clin. Microbiol., 46, 1106-1109.
13. Jean, S.-S., Hsueh, P.-R., Lee, W.-S., et al. (2009): Nationwide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in intensive care units in Taiwan, SMART programme data 2005. Int. J. Antimicrob. Agents, 33, 266-271.
14. Chen, C.-M., Liu, P.-Y., Ke, S.-C., et al. (2009): Investigation of carbapenem-resistant Acinetobacter baumannii isolates in a districthospital in Taiwan. Diag. Microbiol. Infect. Dis., 63, 394-397.
15. Mendes, R.-E., Bell, J.-M., Turnidge, J.-D., et al. (2009): Emergence and widespread dissemination of OXA-23, -24/40 and -58 carbapenemases among Acinetobacter spp. in Asia-Pacific nations: report from the SENTRY Surveillance Programs. J. Antimicrob. Chemother., 63, 55-59.
16. Kuo, H.-Y., Yang, C.-M., Lin, M.-F., et al. (2010): Distribution of blaOXA-carrying imipenem-resistant Acinetobacter spp. in three hospitals in Taiwan. Diag. Microb. Infect. Dis., 66, 195-199.
17. Clinical and Laboratory Standards Institute (2009): Methods for Dilution Antimicrobial Susceptibility tests for Bacteria that Grow Areobically, Approved Standard; 8th ed. M07-A8. Clinical and Laboratory Standards Institute, Wayne, Pa.
18. Seifert, H., Dolzani, L., Bressan, R., et al. (2005): Standardization and interlaboratory reproducibility assessment of pulsedfield gel electrophoresis-generated fingerprints of Acinetobacter baumannii. J. Clin. Microbiol., 43, 4328-4335.
19. Tenover, F.-C., Arbeit, R.-D., Goering, R.-V., et al. (1995): Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol., 33, 2233-2239.
20. Woodford, N., Ellington, M.-J., Coelho, J.-M., et al. (2006): Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int. J. Antimicrob. Agents, 27, 351-353.
21. Sung, J.-Y., Kwon, K.-C., Park, J.-W., et al. (2008): Dissemination of IMP-1 and OXA type beta-lactamase in carbapenemresistant Acinetobacter baumannii. Korean J. Lab. Med., 28, 16-23.
22. Poirel, L., Figueiredo, S., Cattoir, V., et al. (2006): Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp. Antimicrob. Agents Chemother., 52, 1252-1256.
23. Koeleman, J.-G., Stoof, J., Van, Der Bijl M.-W., et al. (2001): Identification of epidemic strains of Acinetobacter baumannii by integrase gene PCR. J. Clin. Microbiol., 39, 8-13.
24. Yan, Z.-Q., Shen, D.-X., Cao, J.-R., et al. (2010): Susceptibility patterns and molecular epidemiology of multidrug-resistant Acinetobacter baumannii strains from three military hospitals in China. Int. J. Antimicrob. Agents., 35, 269-273.
25. Chen, T.-L., Siu, L.-K., Wu, R.-C., et al. (2007): Comparison of one-tube multiplex PCR, automated ribotyping and intergenic spacer (ITS) sequencing for rapid identification of Acinetobacter baumannii. Clin. Microbiol. Infect., 13, 801-806.
26. Wang, H., Guo, P., Sun, H., et al. (2007): Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Antimicrob. Agents Chemother., 51, 4022-4028.
27. Huang, L.-Y., Chen, T.-L., Lu, P.-L., et al. (2008): Dissemination of multidrug-rsistant, class 1 intergron-carrying Acinetobacter baumannii isolates in Taiwan. Clin. Microbiol. Infect., 14, 1010-1019.
28. Lu, P.-L., Doumith, M., Livermore, D.-M., et al. (2009): Diversity of carbapenem resistance mechanisms in Acinetobacter baumannii from a Taiwan hospital: spread of plasmid-borne OXA-72 carbapenemase. J. Antimicrob. Chemother., 63, 641-647.
29. Lee, M.-F., Peng, C.-F., Hsu, H.-J., et al. (2008): Molecular characterisation of the metallo-b-lactamase genes in imipenemresistant Gram-negative bacteria from a university hospital in southern Taiwan. Int. J. Antimicrob. Agents, 32, 475-480.
30. Turton, J.-F., Kaufmann, M.-E., Glover, J., et al. (2005): Detection and typing of integrons in epidemic strains of Acinetobacter baumannii found in the United Kingdom. J. Clin. Microbiol., 43, 3074-3082.
31. Lee, Y.-T., Huang, L.-Y., Chiang, D.-H., et al. (2009): Differences in phenotypic and genotypic characteristics among imipenem-non-susceptible Acinetobacter isolates belonging to different genomic species in Taiwan. Int. J. Antimicrob. Agents, 34, 580-584.
32. Hu, W.-S., Yao, S.-M., Fung, C.-P., et al. (2007): An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. Antimicrob. Agents Chemother., 51, 3844-3852.
33. Peleg, A.-Y., Adams, J. and Paterson, D.-L. (2007): Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii. Antimicrob. Agents Chemother., 51, 2065-2069.
34. Magnet, S., Courvalin, P. and Lambert, T. (2001): Resistancenodulation- cell division-type efflux pump involved inaminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents Chemother., 45, 3375-3380.