Role of NF-κB and PPAR-γ in lung inflammation induced by monocyte-derived microparticles

European Respiratory Journal

Volumn 37, Issue 6, 2011, Pages 1494-1502

  Neri, T ^a   Armani, C ^a   Pegoli, A ^a   Cordazzo, C ^a   Carmazzi, Y ^a   Brunelleschi, S ^b   Bardelli, C ^b   Breschi, M C ^a   Paggiaro, P ^a   Celi, A ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

15 Deoxy 12,14 prostaglandin j 2; Chemokines; Lung inflammation; Microparticles; Peroxisome proliferator activated receptors; Rosiglitazone

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; CALCIMYCIN; DRUG DERIVATIVE; IONOPHORE; PROSTAGLANDIN D2;

ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MACROPHAGE ACTIVATION; MEMBRANE MICROPARTICLE; MONOCYTE; MONOCYTE MICROPARTICLE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; UPREGULATION; BIOSYNTHESIS; BRONCHUS; CELL CULTURE; CELL LINE; DRUG POTENTIATION; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANILIDES; BRONCHI; CALCIMYCIN; CELL LINE; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; CHEMOKINE CCL2; HUMANS; INTERLEUKIN-8; IONOPHORES; MONOCYTES; NF-KAPPA B; PNEUMONIA; PPAR GAMMA; PROSTAGLANDIN D2; THIAZOLIDINEDIONES; UP-REGULATION;

EID: 79958005698     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00023310     Document Type: Article

References (28)

1. Hugel B, Martinez MC, Kunzelmann C, et al. Membrane microparticles: two sides of the coin. Physiology 2005; 20: 22-27. (Pubitemid 40363367)
2. Satta N, Toti F, Feugeas O, et al. Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide. J Immunol 1994; 153: 3245-3255. (Pubitemid 24292551)
3. Celi A, Lorenzet R, Furie BC, et al. Microparticles and a P-selectin-mediated pathway of blood coagulation. Dis Markers 2004; 20: 347-352. (Pubitemid 40392421)
4. Mesri M, Altieri DC. Endothelial cell activation by leukocyte microparticles. J Immunol 1998; 161: 4382-4387. (Pubitemid 28469024)
5. Distler JH, Jungel A, Huber LC, et al. The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles. Proc Natl Acad Sci USA 2005; 102: 2892-2897. (Pubitemid 40299887)
6. Cerri C, Chimenti D, Conti I, et al. Monocyte/macrophage-derived microparticles up-regulate inflammatory mediator synthesis by human airway epithelial cells. J Immunol 2006; 177: 1975-1980. (Pubitemid 44092538)
7. Pesci A, Balbi B, Majori M, et al. Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur Respir J 1998; 12: 380-386. (Pubitemid 28389533)
8. Mahler DA, Huang S, Tabrizi M, et al. Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Chest 2004; 126: 926-934. (Pubitemid 39258050)
9. Traves SL, Culpitt SV, Russell RE, et al. Increased levels of the chemokines GROa and MCP-1 in sputum samples from patients with COPD. Thorax 2002; 57: 590-595. (Pubitemid 34761760)
10. Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 2007; 28: 551-558. (Pubitemid 350101420)
11. Hetzel M, Walcher D, Grub M, et al. Inhibition of MMP-9 expression by PPARc activators in human bronchial epithelial cells. Thorax 2003; 58: 778-783. (Pubitemid 37094054)
12. Arnold R, Konig W. Peroxisome-proliferator-activated receptor-γ agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. Virology 2006; 346: 427-439. (Pubitemid 43357886)
13. Remels AH, Gosker HR, Schrauwen P, et al. Peroxisome proliferator- activated receptors: a therapeutic target in COPD? Eur Respir J 2008; 31: 502-508.
14. Celi A, Cianchetti S, Petruzzelli S, et al. ICAM-1-independent adhesion of neutrophils to phorbol ester-stimulated human airway epithelial cells. Am J Physiol 1999; 277: L465-L471. (Pubitemid 29459665)
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔ C(T)) method. Methods 2001; 25: 402-408. (Pubitemid 34164012)
16. Galli A, Ceni E, Crabb DW, et al. Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARγ independent mechanisms. Gut 2004; 53: 1688-1697. (Pubitemid 39434116)
17. Derlacz RA, Hyc K, Usarek M, et al. PPAR-γ-independent inhibitory effect of rosiglitazone on glucose synthesis in primary cultured rabbit kidney-cortex tubules. Biochem Cell Biol 2008; 86: 396-404.
18. Mughal RS, Warburton P, O'Regan DJ, et al. Peroxisome proliferator-activated receptor γ-independent effects of thiazolidinediones on human cardiac myofibroblast function. Clin Exp Pharmacol Physiol 2009; 36: 478-486.
19. Ardoin SP, Shanahan JC, Pisetsky DS. The role of microparticles in inflammation and thrombosis. Scand J Immunol 2007; 66: 159-165. (Pubitemid 47063209)
20. Mesri M, Altieri DC. Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway. J Biol Chem 1999; 274: 2311-2318.
21. Tesse A, Al-Massarani G, Wangensteen R, et al. Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, prevents microparticle-induced vascular hyporeactivity through the regulation of proinflammatory proteins. J Pharmacol Exp Ther 2008; 324: 539-547. (Pubitemid 351185832)
22. Bernimoulin M, Waters EK, Foy M, et al. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost 2009; 7: 1019-1028.
23. Zhang X, Wang JM, Gong WH, et al. Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2. J Immunol 2001; 166: 7104-7111. (Pubitemid 32525580)
24. Si Q, Zhao ML, Morgan AC, et al. 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. J Immunol 2004; 173: 3504-3513. (Pubitemid 39142061)
25. Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007; 176: 532-555. (Pubitemid 47403272)
26. Calverley PM, Anderson JA, Celli B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007; 356: 775-789. (Pubitemid 46294610)
27. Sabroe I, Parker LC, Calverley PM, et al. Pathological networking: a new approach to understanding COPD. Thorax 2007; 62: 733-738. (Pubitemid 47235020)
28. Belvisi MG, Hele DJ. Peroxisome proliferator-activated receptors as novel targets in lung disease. Chest 2008; 134: 152-157. (Pubitemid 352008777)