Chronic alcoholism in rats induces a compensatory response, preserving brain thiamine diphosphate, but the brain 2-oxo acid dehydrogenases are inactivated despite unchanged coenzyme levels

Journal of Neurochemistry

Volumn 117, Issue 6, 2011, Pages 1055-1065

  Parkhomenko, Yulia M ^a   Kudryavtsev, Pavel A ^b   Pylypchuk, Svetlana Yu ^a   Chekhivska, Lilia I ^a   Stepanenko, Svetlana P ^a   Sergiichuk, Andrej A ^a   Bunik, Victoria I ^b  

^a PALLADIN INSTITUTE OF BIOCHEMISTRY   (Ukraine)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

2 oxoacid dehydrogenases; alcoholism; brain; mitochondria; thiamine diphosphate; thiamine diphosphokinase

Indexed keywords

2 OXOACID DEHYDROGENASE; COCARBOXYLASE; OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; THIAMINE; THIAMINE PHOSPHATE; THIOL DERIVATIVE;

ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; MALE; NERVE DEGENERATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SYNAPTOSOME; THIAMINE DEFICIENCY;

ALCOHOLISM; ANIMALS; BRAIN; COENZYMES; KETOGLUTARATE DEHYDROGENASE COMPLEX; MALE; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; THIAMINE PYROPHOSPHATE;

RATTUS;

EID: 79957999673     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07283.x     Document Type: Article

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