Intra-articular epithelioid sarcoma showing mixed classic and proximal-type features: Report of 2 cases, with immunohistochemical and molecular cytogenetic INI-1 study

American Journal of Surgical Pathology

Volumn 35, Issue 6, 2011, Pages 891-897

  Kosemehmetoglu, Kemal ^a   Kaygusuz, Gulsah ^b   Bahrami, Armita ^c   Raimondi, Susana C ^c   Kilicarslan, Kasim ^a   Yildiz, Yusuf ^b   Folpe, Andrew L ^d  

^a ATATURK TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d MAYO CLINIC   (United States)

Author keywords

epithelioid sarcoma; INI 1; intra articular; synovium

Indexed keywords

DNA BINDING PROTEIN; NONHISTONE PROTEIN; SMARCB1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR MARKER;

ADULT; AMPUTATION; ARTICLE; CASE REPORT; DIFFERENTIAL DIAGNOSIS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KNEE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PIGMENTED VILLONODULAR SYNOVITIS; SARCOMA; SOFT TISSUE TUMOR; SPORT INJURY; TREATMENT OUTCOME;

AMPUTATION; ATHLETIC INJURIES; CHROMOSOMAL PROTEINS, NON-HISTONE; DIAGNOSIS, DIFFERENTIAL; DNA-BINDING PROTEINS; FEMALE; GENE DELETION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; KNEE JOINT; MALE; MIDDLE AGED; SARCOMA; SOFT TISSUE NEOPLASMS; SYNOVITIS, PIGMENTED VILLONODULAR; TRANSCRIPTION FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 79957995245     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318215f732     Document Type: Article

References (28)

1. Beckers C, Foidart J, Thiry A, et al. Synovial metastases from colonic cancer presenting as arthritis of the knee. Characterization by 18FDG PET scan. Rev Med Liege. 2002;57:467-474.
2. Benhamou CL, Tourliere D, Brigant S, et al. Synovial metastasis of an adenocarcinoma presenting as a shoulder monoarthritis. J Rheumatol. 1988;15:1031-1033.
3. Bertoni F, Unni KK, Beabout JW, et al. Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). Am J Surg Pathol. 1997;21:153-163. (Pubitemid 27084054)
4. Bhadra AK, Pollock R, Tirabosco RP, et al. Primary tumours of the synovium: a report of four cases of malignant tumour. J Bone Joint Surg Br. 2007;89:1504-1508. (Pubitemid 350273248)
5. Chase DR, Enzinger FM. Epithelioid sarcoma: diagnosis, prognostic indicators, and treatment. Am J Surg Pathol. 1985;9:241-263. (Pubitemid 15037676)
6. Enzinger FM. Epithelioid sarcoma: a sarcoma simulating a granuloma or a carcinoma. Cancer. 1970;26:1029-1041.
7. Enzinger FM, Weiss SW. Soft Tissue Tumors. St Louis:Mosby; 1983.
8. Fletcher CD, ed. WHO Classification of Tumours; Pathology and Genetics, Tumours of Soft Tissue and Bone. France: IARC Press, Lyons; 2002.
9. Gleason BC, Fletcher CD. Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases. Am J Surg Pathol. 2007;31:1813-1824. (Pubitemid 350175808)
10. Guillou L, Wadden C, Coindre JM, et al. "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features: clinicopathologic, immunohistochemical, and ultrastructural study of a series. American Journal of Surgical Pathology. 1997;21:130-146. (Pubitemid 27084052)
11. Hornick JL, Dal Cin P, Fletcher CD. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol. 2009;33:542-550.
12. Hurtado RM, McCarthy E, Frassica F, et al. Intraarticular epithelioid sarcoma. Skeletal Radiol. 1998;27:453-456. (Pubitemid 28434656)
13. Judkins AR. Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology. Adv Anat Pathol. 2007;14:335-339. (Pubitemid 47312288)
14. Kohashi K, Izumi T, Oda Y, et al. Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. Hum Pathol. 2009;40:349-355.
15. Koplin SA, Nielsen GP, Hornicek FJ, et al. Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases. Int J Surg Pathol. 2010;18:207-212.
16. Koss SD, Johnson KH. Metastatic lung cancer to ankle synovium: a case report. Foot Ankle Int. 1996;17:51-53. (Pubitemid 26026902)
17. Medjkane S, Novikov E, Versteege I, et al. The tumor suppressor hSNF5/INI1 modulates cell growth and actin cytoskeleton organization. Cancer Res. 2004;64:3406-3413. (Pubitemid 38657912)
18. Meinkoth JH, Rochat MC, Cowell RL. Metastatic carcinoma presenting as hind-limb lameness: diagnosis by synovial fluid cytology. J Am Anim Hosp Assoc. 1997;33:325-328. (Pubitemid 127511893)
19. Modena P, Lualdi E, Facchinetti F, et al. SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res. 2005;65:4012-4019. (Pubitemid 40775637)
20. Muchardt C, Yaniv M. When the SWI/SNF complex remodelsythe cell cycle. Oncogene. 2001;20:3067-3075. (Pubitemid 32553561)
21. Orrock JM, Abbott JJ, Gibson LE, et al. INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics. Am J Dermatopathol. 2009;31:152-156.
22. Philipson JD, Birkhead R, Phillips PE. Arthritis of the elbow caused by metastatic bronchogenic carcinoma. Clin Exp Rheumatol. 1983;1:165-169.
23. Raoux D, Peoc'h M, Pedeutour F, et al. Primary epithelioid sarcoma of bone: report of a unique case, with immunohistochemical and fluorescent in situ hybridization confirmation of INI1 deletion. Am J Surg Pathol. 2009;33:954-958.
24. Ter Borg EJ, Slee PH, Seldenrijk CA.Monoarthritis of the elbow due to metastatic colon carcinoma: diagnosis based on the presence of adenocarcinoma cells in synovial fluid. Rheumatol Int. 2008;28: 1177-1178.
25. Vandecandelaere P, Sciot R, Westhovens R, et al. Malignant involvement of the knee synovium in a patient with metastastic oesophageal adenocarcinoma. Acta Clin Belg. 2010;65:48-50.
26. Versteege I, Medjkane S, Rouillard D, et al. A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle. Oncogene. 2002;21:6403-6412. (Pubitemid 35155445)
27. von Hochstetter AR, Cserhati MD. Epithelioid sarcoma presenting as chronic synovitis and mistaken for osteosarcoma. Skeletal Radiol. 1995;24:636-638.
28. Weiss SW, Goldblum JR. Enzinger & Weiss's Soft Tissue Tumors. New York, NY: Mosby, Elsevier; 2008.