Alterations in pain responses in treated and untreated patients with restless legs syndrome: Associations with sleep disruption

Sleep Medicine

Volumn 12, Issue 6, 2011, Pages 603-609

  Edwards, Robert R ^a,b   Quartana, Phillip J ^b   Allen, Richard P ^b   Greenbaum, Seth ^a   Earley, Christopher J ^b   Smith, Michael T ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dopaminergic agonist; Pain; RLS; Sensitisation; Temporal Summation; Thermal; Threshold

Indexed keywords

CLONAZEPAM; DOPAMINE RECEPTOR STIMULATING AGENT; GABAPENTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FACILITATION; FEMALE; HUMAN; MALE; NOCICEPTIVE STIMULATION; PAIN; PAIN THRESHOLD; PRIORITY JOURNAL; RESTLESS LEGS SYNDROME; SLEEP DISORDER; STIMULUS RESPONSE; TEMPORAL SUMMATION; THERMAL STIMULATION;

AGED; BENZOTHIAZOLES; COLD TEMPERATURE; CROSS-SECTIONAL STUDIES; DEPRESSION; DOPAMINE AGONISTS; FEMALE; HOT TEMPERATURE; HUMANS; MALE; MIDDLE AGED; PAIN THRESHOLD; PRESSURE; PSYCHOPHYSICS; QUESTIONNAIRES; RESTLESS LEGS SYNDROME; SLEEP DISORDERS;

EID: 79957988383     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2010.09.018     Document Type: Article

References (68)

1. Gamaldo C.E., Earley C.J. Restless legs syndrome: a clinical update. Chest 2006, 130(5):1596-1604.
2. Lesage S., Earley C.J. Restless Legs Syndrome. Curr Treat Options Neurol 2004, 6(3):209-219.
3. Trenkwalder C., Paulus W. Why do restless legs occur at rest?-pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2). Clin Neurophysiol 2004, 115(9):1975-1988.
4. Zucconi M., Manconi M., Ferini S.L. Aetiopathogenesis of restless legs syndrome. Neurol Sci 2007, 28(Suppl. 1):S47-S52.
5. Potvin S., Grignon S., Marchand S. Human evidence of a supra-spinal modulating role of dopamine on pain perception. Synapse 2009, 63(5):390-402.
6. Hagelberg N., Jaaskelainen S.K., Martikainen I.K., Mansikka H., Forssell H., Scheinin H., et al. Striatal dopamine D2 receptors in modulation of pain in humans: a review. Eur J Pharmacol 2004, 500(1-3):187-192.
7. Wood P.B. Role of central dopamine in pain and analgesia. Expert Rev Neurother 2008, 8(5):781-797.
8. Yunus M.B. Role of central sensitization in symptoms beyond muscle pain, and the evaluation of a patient with widespread pain. Best Pract Res Clin Rheumatol 2007, 21(3):481-497.
9. d'Onofrio F., Bussone G., Cologno D., Petretta V., Buzzi M.G., Tedeschi G., et al. Restless legs syndrome and primary headaches: a clinical study. Neurol Sci 2008, 29 Suppl. 1:S169-S172.
10. von Spiczak S., Whone A.L., Hammers A., Asselin M.C., Turkheimer F., Tings T., et al. The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study. Brain 2005, 128(Pt 4):906-917.
11. Leutgeb U., Martus P. Regular intake of non-opioid analgesics is associated with an increased risk of restless legs syndrome in patients maintained on antidepressants. Eur J Med Res 2002, 7(8):368-378.
12. Abetz L., Allen R., Follet A., Washburn T., Earley C., Kirsch J., et al. Evaluating the quality of life of patients with restless legs syndrome. Clin Ther 2004, 26(6):925-935.
13. Stehlik R., Arvidsson L., Ulfberg J. Restless legs syndrome is common among female patients with fibromyalgia. Eur Neurol 2009, 61(2):107-111.
14. Bentley A.J., Rosman K.D., Mitchell D. Can the sensory symptoms of restless legs syndrome be assessed using a qualitative pain questionnaire?. Clin J Pain 2007, 23(1):62-66.
15. Partinen M., Hirvonen K., Jama L., Alakuijala A., Hublin C., Tamminen I., et al. Open-label study of the long-term efficacy and safety of pramipexole in patients with Restless Legs Syndrome (extension of the PRELUDE study). Sleep Med 2008, 9(5):537-541.
16. Stiasny-Kolster K., Magerl W., Oertel W.H., Moller J.C., Treede R.D. Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome. Brain 2004, 127(Pt 4):773-782.
17. Schattschneider J., Bode A., Wasner G., Binder A., Deuschl G., Baron R. Idiopathic restless legs syndrome: abnormalities in central somatosensory processing. J Neurol 2004, 251(8):977-982.
18. Bara-Jimenez W., Aksu M., Graham B., Sato S., Hallett M. Periodic limb movements in sleep: state-dependent excitability of the spinal flexor reflex. Neurology 2000, 54(8):1609-1616.
19. Edwards R.R., Sarlani E., Wesselmann U., Fillingim R.B. Quantitative assessment of experimental pain perception: multiple domains of clinical relevance. Pain 2005, 114(3):315-319.
20. Allen R.P., Picchietti D., Hening W.A., Trenkwalder C., Walters A.S., Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003, 4(2):101-119.
21. Bigatti S.M., Hernandez A.M., Cronan T.A., Rand K.L. Sleep disturbances in fibromyalgia syndrome: relationship to pain and depression. Arthritis Rheum 2008, 59(7):961-967.
22. Edwards R.R., Almeida D.M., Klick B., Haythornthwaite J.A., Smith M.T. Duration of sleep contributes to next-day pain report in the general population. Pain 2008, 137(1):202-207.
23. Kundermann B., Spernal J., Huber M.T., Krieg J.C., Lautenbacher S. Sleep deprivation affects thermal pain thresholds but not somatosensory thresholds in healthy volunteers. Psychosom Med 2004, 66(6):932-937.
24. Haack M., Mullington J.M. Sustained sleep restriction reduces emotional and physical well-being. Pain 2005, 119(1-3):56-64.
25. Hening W.A., Allen R.P., Washburn M., Lesage S., Earley C.J. Validation of the Hopkins telephone diagnostic interview for restless legs syndrome. Sleep Med 2008, 9(3):283-289.
26. Allen R.P., Earley C.J. Validation of the Johns Hopkins restless legs severity scale. Sleep Med 2001, 2(3):239-242.
27. Beck ATSRAGMG. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clinic Psychol Rev 1988; 8: 77-100.
28. Buysse D.J., Reynolds C.F., Monk T.H., Berman S.R., Kupfer D.J. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989, 28(2):193-213.
29. Ware J.E., Sherbourne C.D. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992, 30(6):473-483.
30. Herrero J.F., Laird J.M., Lopez-Garcia J.A. Wind-up of spinal cord neurones and pain sensation: much ado about something?. Prog Neurobiol 2000, 61(2):169-203.
31. Staud R., Spaeth M. Psychophysical and neurochemical abnormalities of pain processing in fibromyalgia. CNS Spectr 2008, 13(3 Suppl. 5):12-17.
32. Staud R., Robinson M.E., Price D.D. Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients. J Pain 2007, 8(11):893-901.
33. Edwards R.R., Smith M.T., Stonerock G., Haythornthwaite J.A. Pain-related catastrophizing in healthy women is associated with greater temporal summation of and reduced habituation to thermal pain. Clin J Pain 2006, 22(8):730-737.
34. Staud R., Koo E., Robinson M.E., Price D.D. Spatial summation of mechanically evoked muscle pain and painful aftersensations in normal subjects and fibromyalgia patients. Pain 2007, 130(1-2):177-187.
35. Smith M.T., Edwards R.R., McCann U.D., Haythornthwaite J.A. The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep 2007, 30(4):494-505.
36. Edwards R.R., Fillingim R.B., Ness T.J. Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults. Pain 2003, 101(1-2):155-165.
37. Preacher K.J., Hayes A.F. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 2008, 40(3):879-891.
38. Shrout P.E., Bolger N. Mediation in experimental and nonexperimental studies: new procedures and recommendations. Psychol Methods 2002, 7(4):422-445.
39. MacKinnon D.P., Lockwood C.M., Hoffman J.M., West S.G., Sheets V. A comparison of methods to test mediation and other intervening variable effects. Psychol Methods 2002, 7(1):83-104.
40. Baron R., Kenny D. The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Personal Soc Psychol 1986, 51(6):1173-1182.
41. Eide P.K. Wind-up and the NMDA receptor complex from a clinical perspective. Eur J Pain 2000, 4(1):5-15.
42. Stubhaug A., Breivik H., Eide P.K., Kreunen M., Foss A. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 1997, 41(9):1124-1132.
43. Eide P.K., Stubhaug A. Relief of trigeminal neuralgia after percutaneous retrogasserian glycerol rhizolysis is dependent on normalization of abnormal temporal summation of pain, without general impairment of sensory perception. Neurosurgery 1998, 43(3):462-472.
44. Bradley L.A., McKendree-Smith N.L., Alarcon G.S., Cianfrini L.R. Is fibromyalgia a neurologic disease?. Curr Pain Headache Rep 2002, 6(2):106-114.
45. Staud R., Craggs J.G., Perlstein W.M., Robinson M.E., Price D.D. Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls. Eur J Pain 2008, 12(8):1078-1089.
46. Staud R., Craggs J.G., Robinson M.E., Perlstein W.M., Price D.D. Brain activity related to temporal summation of C-fiber evoked pain. Pain 2007, 129(1-2):130-142.
47. Tran T.D., Wang H., Tandon A., Hernandez-Garcia L., Casey K.L. Temporal summation of heat pain in humans: Evidence supporting thalamocortical modulation. Pain 2010, 150(1):93-102.
48. Millan M.J. Descending control of pain. Prog Neurobiol 2002, 66(6):355-474.
49. Harding L.M., Kristensen J.D., Baranowski A.P. Differential effects of neuropathic analgesics on wind-up-like pain and somatosensory function in healthy volunteers. Clin J Pain 2005, 21(2):127-132.
50. Staud R., Vierck C.J., Robinson M.E., Price D.D. Effects of the N-methyl-d-aspartate receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal control subjects. J Pain 2005, 6(5):323-332.
51. Lomas L.M., Picker M.J. Behavioral assessment of temporal summation in the rat: sensitivity to sex, opioids and modulation by NMDA receptor antagonists. Psychopharmacology (Berl) 2005, 180(1):84-94.
52. Eichenberger U., Giani C., Petersen-Felix S., Graven-Nielsen T., Arendt-Nielsen L., Curatolo M. Lumbar epidural fentanyl: segmental spread and effect on temporal summation and muscle pain. Br J Anaesth 2003, 90(4):467-473.
53. Enggaard T.P., Poulsen L., Arendt-Nielsen L., Hansen S.H., Bjornsdottir I., Gram L.F., et al. The analgesic effect of codeine as compared to imipramine in different human experimental pain models. Pain 2001, 92(1-2):277-282.
54. Bradley L.A. Pathophysiology of fibromyalgia. Am J Med 2009, 122(12 Suppl):S22-S30.
55. Bachmann C.G., Rolke R., Scheidt U., Stadelmann C., Sommer M., Pavlakovic G., et al. Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome. Brain 2010, 133(Pt 3):762-770.
56. Iannaccone S., Zucconi M., Marchettini P., Ferini-Strambi L., Nemni R., Quattrini A., et al. Evidence of peripheral axonal neuropathy in primary restless legs syndrome. Mov Disord 1995, 10(1):2-9.
57. Tyvaert L., Laureau E., Hurtevent J.P., Hurtevent J.F., Derambure P., Monaca C. A-delta and C-fibres function in primary restless legs syndrome. Neurophysiol Clin 2009, 39(6):267-274.
58. Han J.K., Oh K., Kim B.J., Koh S.B., Kim J.Y., Park K.W., et al. Cutaneous silent period in patients with restless leg syndrome. Clin Neurophysiol 2007, 118(8):1705-1710.
59. Paulus W., Dowling P., Rijsman R., Stiasny-Kolster K., Trenkwalder C., de Weerd A. Pathophysiological concepts of restless legs syndrome. Mov Disord 2007, 22(10):1451-1456.
60. Walters A.S., Ondo W.G., Zhu W., Le W. Does the endogenous opiate system play a role in the Restless Legs Syndrome? A pilot post-mortem study. J Neurol Sci 2009, 279(1-2):62-65.
61. Willer J.C., Le Bars D., De Broucker T. Diffuse noxious inhibitory controls in man: involvement of an opioidergic link. Eur J Pharmacol 1990, 182(2):347-355.
62. Edwards R.R., Grace E., Peterson S., Klick B., Haythornthwaite J.A., Smith M.T. Sleep continuity and architecture: associations with pain-inhibitory processes in patients with temporomandibular joint disorder. Eur J Pain 2009, 13(10):1043-1047.
63. Walters A.S., Rye D.B. Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Sleep 2009, 32(5):589-597.
64. Pennestri M.H., Montplaisir J., Colombo R., Lavigne G., Lanfranchi P.A. Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology 2007, 68(15):1213-1218.
65. Edwards R.R., Ness T.J., Fillingim R.B. Endogenous opioids, blood pressure, and diffuse noxious inhibitory controls: a preliminary study. Percept Mot Skills 2004, 99(2):679-687.
66. Gupta A., Silman A.J., Ray D., Morriss R., Dickens C., Macfarlane G.J., et al. The role of psychosocial factors in predicting the onset of chronic widespread pain: results from a prospective population-based study. Rheumatology (Oxford) 2007, 46(4):666-671.
67. Smith M.T., Quartana P.J., Okonkwo R.M., Nasir A. Mechanisms by which sleep disturbance contributes to osteoarthritis pain: a conceptual model. Curr Pain Headache Rep 2009, 13(6):447-454.
68. Lautenbacher S., Kundermann B., Krieg J.C. Sleep deprivation and pain perception. Sleep Med Rev 2006, 10(5):357-369.