Inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target

PLoS Neglected Tropical Diseases

Volumn 5, Issue 5, 2011, Pages

  Zhang, Wenbao ^a   Li, Jun ^a   Duke, Mary ^a   Jones, Malcolm K ^a,b   Kuang, Ling ^a   Zhang, Jianfeng ^a   Blair, David ^c   Li, Yuesheng ^a,d   McManus, Donald P ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c JAMES COOK UNIVERSITY   (Australia)

^d HUNAN INSTITUTE OF PARASITIC DISEASES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; SCHISTOSOMA JAPONICUM TETRASPANIN 2E; SCHISTOSOMA MANSONI TETRASPANIN 2; SCHISTOSOMA VACCINE; UNCLASSIFIED DRUG; HELMINTH ANTIBODY; HELMINTH PROTEIN; IMMUNOGLOBULIN G; PARASITE ANTIGEN; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFICACY; DRUG SCREENING; DRUG TARGETING; ESCHERICHIA COLI; FEMALE; GENE; GENE CLUSTER; GENETIC POLYMORPHISM; HUMAN; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE IDENTIFICATION; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; SCHISTOSOMA JAPONICUM; SCHISTOSOMIASIS JAPONICA; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; TETRASPANIN 2 GENE; TREMATODE LIFE CYCLE STAGE; VACCINATION; WESTERN BLOTTING; ANIMAL; BLOOD; CBA MOUSE; CLUSTER ANALYSIS; CROSS PROTECTION; GENETICS; IMMUNOLOGY; METHODOLOGY; PARASITOLOGY;

ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; CLUSTER ANALYSIS; CROSS PROTECTION; FEMALE; HELMINTH PROTEINS; HUMANS; IMMUNOGLOBULIN G; MALE; MICE; MICE, INBRED CBA; POLYMORPHISM, GENETIC; SCHISTOSOMA JAPONICUM; SCHISTOSOMIASIS JAPONICA; VACCINATION; VACCINES;

EID: 79957975544     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001166     Document Type: Article

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