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Volumn 2, Issue MAY, 2010, Pages

The nuclear receptor PPARγ as a therapeutic target for cerebrovascular and brain dysfunction in Alzheimer's disease

Author keywords

Arterial reactivity; Brain metabolism; Cerebral blood flow; Inflammation; Oxidative stress; Pioglitazone; Spatial memory; Vascular fibrosis

Indexed keywords


EID: 79957953694     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2010.00021     Document Type: Review
Times cited : (57)

References (110)
  • 2
    • 0942276496 scopus 로고    scopus 로고
    • PPARγ activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with type 2 diabetes
    • Bagi, Z., Koller, A., and Kaley, G. (2004). PPARγ activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with type 2 diabetes. Am. J. Physiol. Heart. Circ. Physiol. 286, H742-H748.
    • (2004) Am. J. Physiol. Heart. Circ. Physiol. , vol.286
    • Bagi, Z.1    Koller, A.2    Kaley, G.3
  • 3
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell, R. D., and Zlokovic, B. V. (2009). Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 118, 103-113.
    • (2009) Acta Neuropathol. , vol.118 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 5
    • 0035194145 scopus 로고    scopus 로고
    • Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide
    • Butterfield, D. A., Drake, J., Pocernich, C., and Castegna, A. (2001). Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends. Mol. Med. 7, 548-554.
    • (2001) Trends. Mol. Med. , vol.7 , pp. 548-554
    • Butterfield, D.A.1    Drake, J.2    Pocernich, C.3    Castegna, A.4
  • 6
    • 10044225937 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ induces a clearance mechanism for the amyloid-β peptide
    • Camacho, I. E., Serneels, L., Spittaels, K., Merchiers, P., Dominguez, D., and De Strooper, B. (2004). Peroxisome proliferator-activated receptor γ induces a clearance mechanism for the amyloid-β peptide. J. Neurosci. 24, 10908-10917.
    • (2004) J. Neurosci. , vol.24 , pp. 10908-10917
    • Camacho, I.E.1    Serneels, L.2    Spittaels, K.3    Merchiers, P.4    Dominguez, D.5    De Strooper, B.6
  • 7
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., and Evans, R. M. (2001). PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7, 48-52.
    • (2001) Nat. Med. , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 8
    • 0027504874 scopus 로고
    • Identification of two mPPAR related receptors and evidence for the existence of five subfamily members
    • Chen, F., Law, S. W., and O'Malley, B. W. (1993). Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem. Biophys. Res. Commun. 196, 671-677.
    • (1993) Biochem. Biophys. Res. Commun. , vol.196 , pp. 671-677
    • Chen, F.1    Law, S.W.2    O'Malley, B.W.3
  • 10
    • 14844292619 scopus 로고    scopus 로고
    • Role of endothelin in fibrosis and anti-fibrotic potential of bosentan
    • Clozel, M., and Salloukh, H. (2005). Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann. Med. 37, 2-12.
    • (2005) Ann. Med. , vol.37 , pp. 2-12
    • Clozel, M.1    Salloukh, H.2
  • 11
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
    • Combs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B., and Landreth, G. E. (2000). Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J. Neurosci. 20, 558-567.
    • (2000) J. Neurosci. , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 12
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings, J. L. (2004). Alzheimer's disease. N. Engl. J. Med. 351, 59-67.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 59-67
    • Cummings, J.L.1
  • 13
    • 33748755428 scopus 로고    scopus 로고
    • Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease
    • de la Monte, S. M., Tong, M., Lester-Coll, N., Plater, M. Jr., and Wands, J. R. (2006). Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J. Alzheimers Dis. 10, 89-109.
    • (2006) J. Alzheimers Dis. , vol.10 , pp. 89-109
    • de la Monte, S.M.1    Tong, M.2    Lester-Coll, N.3    Plater Jr., M.4    Wands, J.R.5
  • 14
    • 0037076294 scopus 로고    scopus 로고
    • Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-γ
    • Diep, Q. N., El Mabrouk, M., Cohn, J. S., Endemann, D., Amiri, F., Virdis, A., Neves, M. F., and Schiffrin, E. L. (2002). Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-γ. Circulation 105, 2296-2302.
    • (2002) Circulation , vol.105 , pp. 2296-2302
    • Diep, Q.N.1    El Mabrouk, M.2    Cohn, J.S.3    Endemann, D.4    Amiri, F.5    Virdis, A.6    Neves, M.F.7    Schiffrin, E.L.8
  • 15
    • 0026517010 scopus 로고
    • Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
    • Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., and Wahli, W. (1992). Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68, 879-887.
    • (1992) Cell , vol.68 , pp. 879-887
    • Dreyer, C.1    Krey, G.2    Keller, H.3    Givel, F.4    Helftenbein, G.5    Wahli, W.6
  • 18
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • Farkas, E., and Luiten, P. G. (2001). Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64, 575-611.
    • (2001) Prog. Neurobiol. , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 20
    • 0037000396 scopus 로고    scopus 로고
    • Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier
    • Fiala, M., Liu, Q. N., Sayre, J., Pop, V., Brahmandam, V., Graves, M. C., and Vinters, H. V. (2002). Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. Eur. J. Clin. Inv. 32, 360-371.
    • (2002) Eur. J. Clin. Inv. , vol.32 , pp. 360-371
    • Fiala, M.1    Liu, Q.N.2    Sayre, J.3    Pop, V.4    Brahmandam, V.5    Graves, M.C.6    Vinters, H.V.7
  • 21
    • 0035824518 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ inhibits transforming growth factor β-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3
    • Fu, M., Zhang, J., Zhu, X., Myles, D. E., Willson, T. M., Liu, X., and Chen, Y. E. (2001). Peroxisome proliferator-activated receptor γ inhibits transforming growth factor β-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J. Biol. Chem. 276, 45888-45894.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45888-45894
    • Fu, M.1    Zhang, J.2    Zhu, X.3    Myles, D.E.4    Willson, T.M.5    Liu, X.6    Chen, Y.E.7
  • 22
    • 37549060702 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
    • Fuenzalida, K., Quintanilla, R., Ramos, P., Piderit, D., Fuentealba, R. A., Martinez, G., Inestrosa, N. C., and Bronfman, M. (2007). Peroxisome proliferator-activated receptor γ up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J. Biol. Chem. 282, 37006-37015.
    • (2007) J. Biol. Chem. , vol.282 , pp. 37006-37015
    • Fuenzalida, K.1    Quintanilla, R.2    Ramos, P.3    Piderit, D.4    Fuentealba, R.A.5    Martinez, G.6    Inestrosa, N.C.7    Bronfman, M.8
  • 24
    • 33746662942 scopus 로고    scopus 로고
    • Pioglitazone does not increase cerebral glucose utilisation in a murine model of Alzheimer's disease and decreases it in wild-type mice
    • Galea, E., Feinstein, D. L., and Lacombe, P. (2006). Pioglitazone does not increase cerebral glucose utilisation in a murine model of Alzheimer's disease and decreases it in wild-type mice. Diabetologia 49, 2153-2161.
    • (2006) Diabetologia , vol.49 , pp. 2153-2161
    • Galea, E.1    Feinstein, D.L.2    Lacombe, P.3
  • 25
    • 7244226629 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action
    • Gasparini, L., Ongini, E., and Wenk, G. (2004). Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action. J. Neurochem. 91, 521-536.
    • (2004) J. Neurochem. , vol.91 , pp. 521-536
    • Gasparini, L.1    Ongini, E.2    Wenk, G.3
  • 27
    • 0036098247 scopus 로고    scopus 로고
    • Cerebrovascular transforming growth factor-β contributes to inflammation in the Alzheimer's disease brain
    • Grammas, P., and Ovase, R. (2002). Cerebrovascular transforming growth factor-β contributes to inflammation in the Alzheimer's disease brain. Am. J. Pathol. 160, 1583-1587.
    • (2002) Am. J. Pathol. , vol.160 , pp. 1583-1587
    • Grammas, P.1    Ovase, R.2
  • 28
    • 58149265311 scopus 로고    scopus 로고
    • Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus
    • Hanyu, H., Sato, T., Kiuchi, A., Sakurai, H., and Iwamoto, T. (2009). Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus. J. Am. Geriatr. Soc. 57, 177-179.
    • (2009) J. Am. Geriatr. Soc. , vol.57 , pp. 177-179
    • Hanyu, H.1    Sato, T.2    Kiuchi, A.3    Sakurai, H.4    Iwamoto, T.5
  • 30
    • 0035800010 scopus 로고    scopus 로고
    • Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice
    • Hermann, D. M., Kilic, E., Hata, R., Hossmann, K. A., and Mies, G. (2001). Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice. Neuroscience 104, 947-955.
    • (2001) Neuroscience , vol.104 , pp. 947-955
    • Hermann, D.M.1    Kilic, E.2    Hata, R.3    Hossmann, K.A.4    Mies, G.5
  • 31
    • 0013854955 scopus 로고
    • Nature of the hepatomegalic effect produced by ethyl-chloro-phenoxy-isobutyrate in the rat
    • Hess, R., Stäubli, W., and Riess, W. (1965). Nature of the hepatomegalic effect produced by ethyl-chloro-phenoxy-isobutyrate in the rat. Nature 208, 856-858.
    • (1965) Nature , vol.208 , pp. 856-858
    • Hess, R.1    Stäubli, W.2    Riess, W.3
  • 32
    • 17644438636 scopus 로고    scopus 로고
    • Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)-correlation with simultaneous rCBF-PET measurements
    • Hock, C., Villringer, K., Müller-Spahn, F., Wenzel, R., Heekeren, H., Schuh-Hofer, S., Hofmann, M., Minoshima, S., Schwaiger, M., Dirnagl, U., and Villringer, A. (1997). Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)-correlation with simultaneous rCBF-PET measurements. Brain Res. 755, 293-303.
    • (1997) Brain Res. , vol.755 , pp. 293-303
    • Hock, C.1    Villringer, K.2    Müller-Spahn, F.3    Wenzel, R.4    Heekeren, H.5    Schuh-Hofer, S.6    Hofmann, M.7    Minoshima, S.8    Schwaiger, M.9    Dirnagl, U.10    Villringer, A.11
  • 34
    • 70349329335 scopus 로고    scopus 로고
    • PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
    • Huang, W., Eum, S. Y., András, I. E., Hennig, B., and Toborek, M. (2009). PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB J. 23, 1596-1606.
    • (2009) FASEB J. , vol.23 , pp. 1596-1606
    • Huang, W.1    Eum, S.Y.2    András, I.E.3    Hennig, B.4    Toborek, M.5
  • 36
    • 34047263780 scopus 로고    scopus 로고
    • The PPARγ ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice
    • Hwang, J., Kleinhenz, D. J., Rupnow, H. L., Campbell, A. G., Thulé, P. M., Sutliff, R. L., and Hart, C. M. (2007). The PPARγ ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice. Vasc. Pharmacol. 46, 456-462.
    • (2007) Vasc. Pharmacol. , vol.46 , pp. 456-462
    • Hwang, J.1    Kleinhenz, D.J.2    Rupnow, H.L.3    Campbell, A.G.4    Thulé, P.M.5    Sutliff, R.L.6    Hart, C.M.7
  • 37
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola, C. (2004). Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Neurosci. Rev. 5, 347-360.
    • (2004) Nat. Neurosci. Rev. , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 39
    • 13644271368 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: role of Wnt signaling
    • Inestrosa, N. C., Godoy, J. A., Quintanilla, R. A., Koenig, C. S., and Bronfman, M. (2005). Peroxisome proliferator-activated receptor γ is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: role of Wnt signaling. Exp. Cell. Res. 304, 91-104.
    • (2005) Exp. Cell. Res. , vol.304 , pp. 91-104
    • Inestrosa, N.C.1    Godoy, J.A.2    Quintanilla, R.A.3    Koenig, C.S.4    Bronfman, M.5
  • 41
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I., and Green, S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 42
    • 0027525576 scopus 로고
    • The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs
    • Issemann, I., Prince, R. A., Tugwood, J. D., and Green, S. (1993). The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J. Mol. Endocrinol. 11, 37-47.
    • (1993) J. Mol. Endocrinol. , vol.11 , pp. 37-47
    • Issemann, I.1    Prince, R.A.2    Tugwood, J.D.3    Green, S.4
  • 43
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C., Ting, A. T., and Seed, B. (1998). PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 44
    • 36949038203 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor-γ (PPARγ) in Alzheimer's disease
    • Jiang, Q., Heneka, M., and Landreth, G. E. (2008). The role of peroxisome proliferator-activated receptor-γ (PPARγ) in Alzheimer's disease. CNS Drugs 22, 1-14.
    • (2008) CNS Drugs , vol.22 , pp. 1-14
    • Jiang, Q.1    Heneka, M.2    Landreth, G.E.3
  • 45
    • 0024419325 scopus 로고
    • Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease
    • Kalaria, R. N., and Harik, S. I. (1989). Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. J. Neurochem. 53, 1083-1088.
    • (1989) J. Neurochem. , vol.53 , pp. 1083-1088
    • Kalaria, R.N.1    Harik, S.I.2
  • 46
    • 28844469924 scopus 로고    scopus 로고
    • Molecular mechanism of Nrf2 activation by oxidative stess
    • Kang, K. W., Lee, S. J., and Kim, S. G. (2005). Molecular mechanism of Nrf2 activation by oxidative stess. Antioxid. Redox Signal. 7, 1664-1673.
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 1664-1673
    • Kang, K.W.1    Lee, S.J.2    Kim, S.G.3
  • 48
    • 77951221502 scopus 로고    scopus 로고
    • Does peroxisome proliferator-activated receptor-γ (PPARγ) protect from hypertension directly through effects in the vasculature?
    • Ketsawatsomkron, P., Pelham, C. J., Groh, S., Keen, H. L., Faraci, F. M., and Sigmund, C. D. (2010). Does peroxisome proliferator-activated receptor-γ (PPARγ) protect from hypertension directly through effects in the vasculature? J. Biol. Chem. 285, 9311-9316.
    • (2010) J. Biol. Chem. , vol.285 , pp. 9311-9316
    • Ketsawatsomkron, P.1    Pelham, C.J.2    Groh, S.3    Keen, H.L.4    Faraci, F.M.5    Sigmund, C.D.6
  • 53
    • 74049099554 scopus 로고    scopus 로고
    • The relationship between Alzheimer's disease and diabetes: type 3 diabetes?
    • Kroner, Z. (2009). The relationship between Alzheimer's disease and diabetes: type 3 diabetes? Altern. Med. Rev. 14, 373-379.
    • (2009) Altern. Med. Rev. , vol.14 , pp. 373-379
    • Kroner, Z.1
  • 55
    • 46749115113 scopus 로고    scopus 로고
    • PPARγ agonists as therapeutics for the treatment of Alzheimer's disease
    • Landreth, G., Jiang, Q., Mandrekar, S., and Heneka, M. (2008). PPARγ agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics 5, 481-489.
    • (2008) Neurotherapeutics , vol.5 , pp. 481-489
    • Landreth, G.1    Jiang, Q.2    Mandrekar, S.3    Heneka, M.4
  • 56
    • 62349097513 scopus 로고    scopus 로고
    • Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
    • Alzheimer's Disease Neuroimaging Initiative.
    • Langbaum, J. B., Chen, K., Lee, W., Reschke, C., Bandy, D., Fleisher, A. S., Alexander, G. E., Foster, N. L., Weiner, M. W., Koeppe, R. A., Jagust, W. J., and Reiman, E. M.; Alzheimer's Disease Neuroimaging Initiative. (2009). Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neuroimage 45, 1107-1116.
    • (2009) Neuroimage , vol.45 , pp. 1107-1116
    • Langbaum, J.B.1    Chen, K.2    Lee, W.3    Reschke, C.4    Bandy, D.5    Fleisher, A.S.6    Alexander, G.E.7    Foster, N.L.8    Weiner, M.W.9    Koeppe, R.A.10    Jagust, W.J.11    Reiman, E.M.12
  • 57
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., and Kliewer, S. A. (1997). Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272, 3406-3410.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 58
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
    • Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995). An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 60
    • 38949208262 scopus 로고    scopus 로고
    • Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function
    • Lesné, S., Kotilinek, L., and Ashe, K. H. (2008). Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function. Neuroscience 151, 745-749.
    • (2008) Neuroscience , vol.151 , pp. 745-749
    • Lesné, S.1    Kotilinek, L.2    Ashe, K.H.3
  • 63
    • 33644687456 scopus 로고    scopus 로고
    • Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes
    • Martens, F. M., Visseren, F. L., de Koning, E. J., and Rabelink, T. J. (2005). Short-term pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes. J. Cardiovasc. Pharmacol. 46, 773-778.
    • (2005) J. Cardiovasc. Pharmacol. , vol.46 , pp. 773-778
    • Martens, F.M.1    Visseren, F.L.2    de Koning, E.J.3    Rabelink, T.J.4
  • 64
    • 0025332027 scopus 로고
    • Anti-inflammatory drugs and Alzheimer disease
    • McGeer, P. L., McGeer, E., Rogers, J., and Sibley, J. (1990). Anti-inflammatory drugs and Alzheimer disease. Lancet 335, 1037.
    • (1990) Lancet , vol.335 , pp. 1037
    • McGeer, P.L.1    McGeer, E.2    Rogers, J.3    Sibley, J.4
  • 65
    • 33646126924 scopus 로고    scopus 로고
    • A decade of modeling Alzheimer's disease in transgenic mice
    • McGowan, E., Eriksen, J., and Hutton, M. (2006). A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 22, 281-289.
    • (2006) Trends Genet. , vol.22 , pp. 281-289
    • McGowan, E.1    Eriksen, J.2    Hutton, M.3
  • 66
    • 0037154974 scopus 로고    scopus 로고
    • Combinatorial control of gene expression by nuclear receptors and coregulators
    • McKenna, N. J., and O'Malley, B. W. (2002). Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108, 465-474.
    • (2002) Cell , vol.108 , pp. 465-474
    • McKenna, N.J.1    O'Malley, B.W.2
  • 68
    • 0345118108 scopus 로고    scopus 로고
    • Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    • Moreno, S., Farioli-Vecchioli, S., and Cerù, M. P. (2004). Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience 123, 131-145.
    • (2004) Neuroscience , vol.123 , pp. 131-145
    • Moreno, S.1    Farioli-Vecchioli, S.2    Cerù, M.P.3
  • 70
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
    • Mucke, L., Masliah, E., Yu, G. Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., and McConlogue, L. (2000). High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20, 4050-4058.
    • (2000) J. Neurosci. , vol.20 , pp. 4050-4058
    • Mucke, L.1    Masliah, E.2    Yu, G.Q.3    Mallory, M.4    Rockenstein, E.M.5    Tatsuno, G.6    Hu, K.7    Kholodenko, D.8    Johnson-Wood, K.9    McConlogue, L.10
  • 71
    • 3242784885 scopus 로고    scopus 로고
    • Mechanism of the nuclear receptor molecular switch
    • Nagy, L., and Schwabe, J. W. R. (2004). Mechanism of the nuclear receptor molecular switch. Trends Biochem. Sci. 29, 317-324.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 317-324
    • Nagy, L.1    Schwabe, J.W.R.2
  • 72
    • 55249125525 scopus 로고    scopus 로고
    • Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor γ agonist
    • Nicolakakis, N., Aboulkassim, T., Ongali, B., Lecrux, C., Fernandes, P., Rosa-Neto, P., Tong, X. K., and Hamel, E. (2008). Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor γ agonist. J. Neurosci. 28, 9287-9296.
    • (2008) J. Neurosci. , vol.28 , pp. 9287-9296
    • Nicolakakis, N.1    Aboulkassim, T.2    Ongali, B.3    Lecrux, C.4    Fernandes, P.5    Rosa-Neto, P.6    Tong, X.K.7    Hamel, E.8
  • 74
    • 56649120697 scopus 로고    scopus 로고
    • Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel
    • Nomura, H., Yamawaki, H., Mukohda, M., Okada, M., and Hara, Y. (2008). Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel. J. Pharmacol. Sci. 108, 258-265.
    • (2008) J. Pharmacol. Sci. , vol.108 , pp. 258-265
    • Nomura, H.1    Yamawaki, H.2    Mukohda, M.3    Okada, M.4    Hara, Y.5
  • 78
    • 33750454798 scopus 로고    scopus 로고
    • Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats
    • Pathan, A. R., Viswanad, B., Sonkusare, S. K., and Ramarao, P. (2006). Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats. Life Sci. 79, 2209-2216.
    • (2006) Life Sci. , vol.79 , pp. 2209-2216
    • Pathan, A.R.1    Viswanad, B.2    Sonkusare, S.K.3    Ramarao, P.4
  • 80
    • 40749103882 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor γ (PPARγ) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes
    • Ramirez, S. H., Heilman, D., Morsey, B., Potula, R., Haorah, J., and Persidsky, Y. (2008). Activation of peroxisome proliferator-activated receptor γ (PPARγ) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. J. Immunol. 180, 1854-1865.
    • (2008) J. Immunol. , vol.180 , pp. 1854-1865
    • Ramirez, S.H.1    Heilman, D.2    Morsey, B.3    Potula, R.4    Haorah, J.5    Persidsky, Y.6
  • 81
    • 0016709214 scopus 로고
    • Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate
    • Reddy, J. K., and Krishnakantha, T. P. (1975). Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate. Science 190, 787-789.
    • (1975) Science , vol.190 , pp. 787-789
    • Reddy, J.K.1    Krishnakantha, T.P.2
  • 84
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., and Glass, C. K. (1998). The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 85
    • 0027332081 scopus 로고
    • β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease
    • Roher, A. E., Lowenson, J. D., Clarke, S., Woods, A. S., Cotter, R. J., Gowing, E., and Ball, M. J. (1993). β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc. Natl. Acad. Sci. USA 90, 10836-10840.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10836-10840
    • Roher, A.E.1    Lowenson, J.D.2    Clarke, S.3    Woods, A.S.4    Cotter, R.J.5    Gowing, E.6    Ball, M.J.7
  • 86
    • 31544481458 scopus 로고    scopus 로고
    • Acetylcholine esterase inhibitor donepezil improves dynamic cerebrovascular regulation in Alzheimer patients
    • Rosengarten, B., Paulsen, S., Molnar, S., Kaschel, R., Gallhofer, B., and Kaps, M. (2006). Acetylcholine esterase inhibitor donepezil improves dynamic cerebrovascular regulation in Alzheimer patients. J. Neurol. 253, 58-64.
    • (2006) J. Neurol. , vol.253 , pp. 58-64
    • Rosengarten, B.1    Paulsen, S.2    Molnar, S.3    Kaschel, R.4    Gallhofer, B.5    Kaps, M.6
  • 87
    • 1442288375 scopus 로고    scopus 로고
    • PPARγ agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice
    • Ryan, M. J., Didion, S. P., Mathur, S., Faraci, F. M., and Sigmund, C. D. (2004). PPARγ agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension 43, 661-666.
    • (2004) Hypertension , vol.43 , pp. 661-666
    • Ryan, M.J.1    Didion, S.P.2    Mathur, S.3    Faraci, F.M.4    Sigmund, C.D.5
  • 88
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β-secretase
    • Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., van Leuven, F., and Heneka, M. T. (2003). Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β-secretase. J. Neurosci. 23, 9796-9804.
    • (2003) J. Neurosci. , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3    Willson, T.M.4    Klockgether, T.5    van Leuven, F.6    Heneka, M.T.7
  • 90
    • 79959479102 scopus 로고    scopus 로고
    • Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease
    • in press. doi:10.1016/j.neurobiolaging.2009.10.009.
    • Sato, T, Hanyu, H, Hirao, K, Kanetaka, H, Sakurai, H, Iwamoto, T. (2009). Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease. Neurobiol. Aging in press. doi:10.1016/j.neurobiolaging.2009.10.009.
    • (2009) Neurobiol. Aging
    • Sato, T.1    Hanyu, H.2    Hirao, K.3    Kanetaka, H.4    Sakurai, H.5    Iwamoto, T.6
  • 91
    • 0034930107 scopus 로고    scopus 로고
    • Thiazolidinediones and liver toxicity
    • Scheen, A. J. (2001). Thiazolidinediones and liver toxicity. Diabetes Metab. (Paris) 27, 305-313.
    • (2001) Diabetes Metab. (Paris) , vol.27 , pp. 305-313
    • Scheen, A.J.1
  • 92
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe, D. J. (2001). Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 93
    • 0028241915 scopus 로고
    • Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease
    • Simpson, I. A., Chundu, K. R., Davies-Hill, T., Honer, W. G., and Davies, P. (1994). Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann. Neurol. 35, 546-551.
    • (1994) Ann. Neurol. , vol.35 , pp. 546-551
    • Simpson, I.A.1    Chundu, K.R.2    Davies-Hill, T.3    Honer, W.G.4    Davies, P.5
  • 94
    • 9644275598 scopus 로고    scopus 로고
    • Modulation of nuclear factor-κB activity by indomethacin influences Aβ levels but not Aβ precursor protein metabolism in a model of Alzheimer's disease
    • Sung, S., Yang, H., Uryu, K., Lee, E. B., Zhao, L., Shineman, D., Trojanowski, J. Q., Lee, V. M., and Praticò, D. (2004). Modulation of nuclear factor-κB activity by indomethacin influences Aβ levels but not Aβ precursor protein metabolism in a model of Alzheimer's disease. Am. J. Pathol. 165, 2197-2206.
    • (2004) Am. J. Pathol. , vol.165 , pp. 2197-2206
    • Sung, S.1    Yang, H.2    Uryu, K.3    Lee, E.B.4    Zhao, L.5    Shineman, D.6    Trojanowski, J.Q.7    Lee, V.M.8    Praticò, D.9
  • 95
    • 0013935229 scopus 로고
    • Response of hepatic microbodies to a hypolipidemic agent, ethyl chlorophenoxyisobutyrate (CPIB)
    • Svoboda, D. J., and Azarnoff, D. L. (1966). Response of hepatic microbodies to a hypolipidemic agent, ethyl chlorophenoxyisobutyrate (CPIB). J. Cell Biol. 30, 442-450.
    • (1966) J. Cell Biol. , vol.30 , pp. 442-450
    • Svoboda, D.J.1    Azarnoff, D.L.2
  • 96
    • 77249109792 scopus 로고    scopus 로고
    • Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1dE9 mouse model of Alzheimer's disease
    • Toledo, E. M., and Inestrosa, N. C. (2010). Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1dE9 mouse model of Alzheimer's disease. Mol. Psychiatry 15, 272-285.
    • (2010) Mol. Psychiatry , vol.15 , pp. 272-285
    • Toledo, E.M.1    Inestrosa, N.C.2
  • 97
    • 0032999475 scopus 로고    scopus 로고
    • Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease
    • Tong, X. K., and Hamel, E. (1999). Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience 92, 163-175.
    • (1999) Neuroscience , vol.92 , pp. 163-175
    • Tong, X.K.1    Hamel, E.2
  • 98
    • 30644465969 scopus 로고    scopus 로고
    • Vascular remodeling versus amyloid β-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease
    • Tong, X. K., Nicolakakis, N., Kocharyan, A., and Hamel, E. (2005). Vascular remodeling versus amyloid β-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease. J. Neurosci. 25, 11165-11174.
    • (2005) J. Neurosci. , vol.25 , pp. 11165-11174
    • Tong, X.K.1    Nicolakakis, N.2    Kocharyan, A.3    Hamel, E.4
  • 102
    • 0033900999 scopus 로고    scopus 로고
    • Chronic overproduction of transforming growth factor-β1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice
    • Wyss-Coray, T., Lin, C., Sanan, D. A., Mucke, L., and Masliah, E. (2000). Chronic overproduction of transforming growth factor-β1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. Am. J. Pathol. 156, 139-150.
    • (2000) Am. J. Pathol. , vol.156 , pp. 139-150
    • Wyss-Coray, T.1    Lin, C.2    Sanan, D.A.3    Mucke, L.4    Masliah, E.5
  • 103
  • 104
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters β-amyloid processing and deposition in an animal model of Alzheimer's disease
    • Yan, Q., Zhang, J., Liu, H., Babu-Khan, S., Vassar, R., Biere, A. L., Citron, M., and Landreth, G. (2003). Anti-inflammatory drug therapy alters β-amyloid processing and deposition in an animal model of Alzheimer's disease. J. Neurosci. 23, 7504-7509.
    • (2003) J. Neurosci. , vol.23 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3    Babu-Khan, S.4    Vassar, R.5    Biere, A.L.6    Citron, M.7    Landreth, G.8
  • 105
    • 35848964569 scopus 로고    scopus 로고
    • Effectiveness of treatment with donepezil hydrochloride and changes in regional cerebral blood flow in patients with Alzheimer's disease
    • Yoshida, T., Ha-Kawa, S., Yoshimura, M., Nobuhara, K., Kinoshita, T., and Sawada, S. (2007). Effectiveness of treatment with donepezil hydrochloride and changes in regional cerebral blood flow in patients with Alzheimer's disease. Ann. Nucl. Med. 21, 257-265.
    • (2007) Ann. Nucl. Med. , vol.21 , pp. 257-265
    • Yoshida, T.1    Ha-Kawa, S.2    Yoshimura, M.3    Nobuhara, K.4    Kinoshita, T.5    Sawada, S.6
  • 106
  • 107
    • 0028124577 scopus 로고
    • Effects of pioglitazone on calcium channels in vascular smooth muscle
    • Zhang, F., Sowers, J. R., Ram, J. L., Standley, P. R., and Peuler, J. D. (1994). Effects of pioglitazone on calcium channels in vascular smooth muscle. Hypertension 24, 170-175.
    • (1994) Hypertension , vol.24 , pp. 170-175
    • Zhang, F.1    Sowers, J.R.2    Ram, J.L.3    Standley, P.R.4    Peuler, J.D.5
  • 108
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • Zhao, W. Q., Chen, H., Quon, M. J., and Alkon, D. L. (2004). Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol. 490, 71-81.
    • (2004) Eur. J. Pharmacol. , vol.490 , pp. 71-81
    • Zhao, W.Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 109
    • 0027749599 scopus 로고
    • Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver
    • Zhu, Y., Alvares, K., Huang, Q., Rao, M. S., and Reddy, J. K. (1993). Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 268, 26817-26820.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26817-26820
    • Zhu, Y.1    Alvares, K.2    Huang, Q.3    Rao, M.S.4    Reddy, J.K.5


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