Does vitamin E and C supplementation improve the recovery from anterior cruciate ligament surgery?

Journal of Evidence-Based Complementary and Alternative Medicine

Volumn 16, Issue 1, 2011, Pages 114-128

  Barker, Tyler ^a   Traber, Maret G ^b  

^a Orthopedic Specialty Hospital   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Anterior cruciate ligament; Antioxidants; Cytokines; Knee; Oxidative stress; Skeletal muscle; Vitamin C; Vitamin E

Indexed keywords

EID: 79957929121     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (214)

1. Robson AW. VI. Ruptured crucial ligaments and their repair by operation. Ann Surg. 1903;37:716-718.
2. Lange F. Uber die Sehnenplastik. Verh Dtsch Orthop Ges. 1903;2: 10-12.
3. Hey Groves EW. Operation for the repair of the crucial ligaments. Lancet. 1917;2:674-675.
4. Lyman S, Koulouvaris P, Sherman S, et al. Epidemiology of anterior cruciate ligament reconstruction: trends, readmissions, and subsequent knee surgery. J Bone Joint Surg Am. 2009;91: 2321-2328.
5. Anderson JL, Lamb SE, Barker KL, et al. Changes in muscle torque following anterior cruciate ligament reconstruction. Acta Orthop Scand. 2002;73:546-552.
6. Arangio GA, Chen C, Kalady M, et al. Thigh muscle size and strength after anterior cruciate ligament reconstruction and rehabilitation. J Orthop Sports Phys Ther. 1997;26:238-243.
7. Arvidsson I, Arvidsson H, Eriksson E, et al. Prevention of quadriceps wasting after immobilization: an evaluation of the effect of electrical stimulation. Orthopedics. 1986;9:1519-1528.
8. Barker T, Leonard SW, Hansen J, et al. Vitamin E and C supplementation does not ameliorate muscle dysfunction following anterior cruciate ligament surgery. Free Radic Biol Med. 2009; 47:1611-1618.
9. Elmqvist L-G, Lorentzon R, Johansson C, et al. Knee extensor muscle function before and after reconstruction of anterior cruciate ligament tear. Scand J Rehabil Med Suppl. 1989;21:131-139.
10. Eriksson K, Hamberg P, Jansson E, et al. Semitendinosus muscle in anterior cruciate ligament surgery: morphology and function. Arthroscopy. 2001;17:808-817.
11. Gerber JP, Marcus RL, Dibble LE, et al. Effects of early progressive eccentric exercise on muscle structure after anterior cruciate ligament reconstruction. J Bone Joint Surg Am. 2007; 89:559-570.
12. Gerber JP, Marcus RL, Dibble LE, et al. Effects of early progressive eccentric exercise on muscle size and function after anterior cruciate ligament reconstruction: a 1-year follow-up study of a randomized clinical trial. Phys Ther. 2009;89:51-59.
13. Hamada M, Shino K, Horibe S, et al. Single-versus bi-socket anterior cruciate ligament reconstruction using autogenous multiple-stranded hamstring tendons with EndoButton femoral fixation: a prospective study. Arthroscopy. 2001;17:801-807.
14. Jarvela T, Kannus P, Latvala K, et al. Simple measurements in assessing muscle performance after an ACL reconstruction. Int J Sports Med. 2002;23:196-201.
15. Konishi Y, Aihara Y, Sakai M, et al. Gamma loop dysfunction in the quadriceps femoris of patients who underwent anterior cruciate ligament reconstruction remains bilaterally. Scand J Med Sci Sports. 2007;17:393-399.
16. Konishi Y, Ikeda K, Nishino A, et al. Relationship between quadriceps femoris muscle volume and muscle torque after anterior cruciate ligament repair. Scand J Med Sci Sports. 2007;17:656-661.
17. Mattacola CG, Perrin DH, Gansneder BM, et al. Strength, functional outcome, and postural stability after anterior cruciate ligament reconstruction. J Athl Train. 2002;37:262-268.
18. McHugh MP, Tyler TF, Gleim GW, et al. Preoperative indicators of motion loss and weakness following anterior cruciate ligament reconstruction. J Orthop Sports Phys Ther. 1998;27:407-411.
19. McHugh MP, Tyler TF, Nicholas SJ, et al. Electromyographic analysis of quadriceps fatigue after anterior cruciate ligament reconstruction. J Orthop Sports Phys Ther. 2001;31:25-32.
20. Rosenberg TD, Franklin JL, Baldwin GN, et al. Extensor mechanism function after petallar tendon graft harvest for anterior cruciate ligament reconstruction. Am J Sports Med. 1992;20:519-526.
21. Snyder-Mackler L, Binder-MaCleod SA, Williams PR. Fatig-ability of human quadriceps femoris muscle following anterior cruciate ligament reconstruction. Med Sci Sports Exerc. 1993; 25:783-789.
22. Snyder-Mackler L, Delitto A, Stralka SW, et al. Use of electrical stimulation to enhance recovery of quadriceps femoris muscle force production in patients following anterior cruciate ligament reconstruction. Phys Ther. 1994;74:901-907.
23. Urbach D, Nebelung W, Weiler H-T, et al. Bilateral deficit of voluntary quadriceps muscle activation after unilateral ACL tear. Med Sci Sports Exerc. 1999;31:1691-1696.
24. Mikesky AE, Mazzuca SA, Brandt KD, et al. Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum. 2006;55:690-699.
25. Holm L, Esmarck B, Mizuno M, et al. The effect of protein and carbohydrate supplementation on strength training outcome of rehabilitation in ACL patients. J Orthop Res. 2006;24: 2114-2123.
26. Fang Y-Z, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18:872-879.
27. Meucci E, Mele MC. Amino acids and plasma antioxidant capacity. Amino Acids. 1997;12:373-377.
28. Newham DJ, Jones DA, Clarkson PM. Repeated high-force eccentric exercise: effects on muscle pain and damage. J Appl Physiol. 1987;63:1381-1386.
29. Friden J, Sjostrom M, Ekblom B. A morphological study of delayed muscle soreness. Experientia. 1981;37:506-507.
30. Newham DJ, McPhail G, Mills KR, et al. Ultrastructural changes after concentric and eccentric contractions of human muscle. J Neurol Sci. 1983;61:109-122.
31. Friden J, Sjostrom M, Ekblom B. Myofibrillar damage following intense eccentric exercise in man. Int J Sports Med. 1983;4: 170-176.
32. Cannon JG, Fielding RA, Fiatoarone MA, et al. Increased inter-leukin 1b in human skeletal muscle after exercise. Am J Physiol Regul Integr Comp Physiol. 1989;257:R451-R455.
33. Fielding RA, Manfredi TJ, Ding W, et al. Acute phase response in exercise: III. Neutrophil and IL-1 beta accumulation in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 1993;265:R166-R172.
34. Petersen EW, Ostrowski K, Ibfelt T, et al. Effect of vitamin supplementation on cytokine response and on muscle damage after strenuous exercise. Am J Physiol Cell Physiol. 2001;280: C1570-C1575.
35. Toft AD, Jensen LB, Bruunsgaard H, et al. Cytokine response to eccentric exercise in young and elderly humans. Am J Physiol Cell Physiol. 2002;283:C289-C295.
36. Close GL, Ashton T, Cable T, et al. Eccentric exercise, isokinetic muscle torque and delayed onset muscle soreness: the role of reactive oxygen species. Eur J Appl Physiol. 2004;91:615-621.
37. Hellsten Y, Frandsen U, Orthenblad N, et al. Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation. J Physiol. 1997;498:239-248.
38. Radak Z, Pucsok J, Mecseki S, et al. Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle. Free Radic Biol Med. 1999;26:1059-1063.
39. Traber MG, Atkinson J. Vitamin E, antioxidant and nothing more. Free Radic Biol Med. 2007;43:4-15.
40. Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr. 2007;27:347-362.
41. Azzi A, Gysin R, Kempna P, et al. Vitamin E mediates cell signaling and regulation of gene expression. Ann N Y Acad Sci. 2004; 1031:86-95.
42. Carr A, Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 1999;13:1007-1024.
43. Bonetto A, Penna F, Muscaritoli M, et al. Are antioxidants useful for treating skeletal muscle atrophy? Free Radic Biol Med. 2009; 47:906-916.
44. Sies H, Jones DP. Oxidative stress. In: Fink G, ed. Encyclopedia of Stress. 2nd ed. New York, NY: Elsevier; 2007;45-48.
45. Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Phy-siol Rev. 2008;88:1243-1276.
46. Tidball JG, Villalta SA. Regulatory interactions between muscle and the immune system during muscle regeneration. Am J Physiol Regul Integr Comp Physiol. 2010.
47. Hawke TJ, Garry DJ. Myogenic satellite cells: physiology to molecular biology. J Appl Physiol. 2001;91:534-551.
48. Charge SB, Rudnicki MA. Cellular and molecular regulation of muscle regeneration. Physiol Rev. 2004;84:209-238.
49. Glass DJ. Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol. 2005;37:1974-1984.
50. Jackman RW, Kandarian SC. The molecular basis of skeletal muscle atrophy. Am J Physiol Cell Physiol. 2004;287:C834-C843.
51. Powers SK, Kavazis AN, McClung JM. Oxidative stress and disuse muscle atrophy. J Appl Physiol. 2007;102:2389-2397.
52. Fitts RH. The cross-bridge cycle and skeletal muscle fatigue. J Appl Physiol. 2008;104:551-558.
53. Spindler KP, Wright RW. Clinical practice: anterior cruciate ligament tear. N Engl J Med. 2008;359:2135-2142.
54. Palmieri-Smith RM, Thomas AC. A Neuromuscular mechanism of posttraumatic osteoarthritis associated with ACL injury. Exerc Sport Sci Rev. 2009;37:147-153.
55. Frei B, England L, Ames BN. Ascorbate is an outstanding antiox-idant in human blood plasma. Proc Natl Acad Sci U S A. 1989;86: 6377-6381.
56. Bergman M, Salman H, Djaldetti M, et al. In vitro immune response of human peripheral blood cells to vitamins C and E. J Nutr Biochem. 2004;15:45-50.
57. Bruno RS, Leonard SW, Atkinson J, et al. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med. 2006;40:689-697.
58. Englard S, Seifter S. The biochemical functions of ascorbic acid. Annu Rev Nutr. 1986;6:365-406.
59. Reiter E, Jiang Q, Christen S. Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol Aspects Med. 2007;28: 668-691.
60. McLaughlin PJ, Weihrauch JL. Vitamin E content of foods. J Am Diet Assoc. 1979;75:647-665.
61. Lehmann J, Martin HL, Lashley EL, et al. Vitamin E in foods from high and low linoleic acid diets. J Am Diet Assoc. 1986; 86:1208-1216.
62. Burton GW, Doba T, Gabe EJ, et al. Autoxidation of biological molecules: 4. Maximizing the antioxidant activity of phenols. J Am Chem Soc. 1985;107:7053-7065.
63. Devaraj S, Li D, Jialal I. The effects of alpha tocopherol supplementation on monocyte function: decreased lipid oxidation, interleukin 1beta secretion, and monocyte adhesion to endothe-lium. J Clin Invest. 1996;98:756-763.
64. Devaraj S, Leonard S, Traber MG, et al. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med. 2008;44: 1203-1208.
65. Devaraj S, Jialal I. Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Free Radic Biol Med. 2000;29:790-792.
66. Jiang Q, Ames BN. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J. 2003;17:816-822.
67. Wiser J, Alexis NE, Jiang Q, et al. In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects. Free Radic Biol Med. 2008;45:40-49.
68. Cooney RV, Franke AA, Harwood PJ, et al. Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-toco-pherol. Proc Natl Acad Sci U S A. 1993;90:1771-1775.
69. Traber MG, Kayden HJ. Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins. Am J Clin Nutr. 1989;49:517-526.
70. Traber MG, Rudel LL, Burton GW, et al. Nascent VLDL from liver perfusions of cynomolgus monkeys are preferentially enriched in RRR- compared with SRR-alpha-tocopherol: studies using deuterated tocopherols. J Lipid Res. 1990;31:687-694.
71. Traber MG, Sokol RJ, Burton GW, et al. Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver. J Clin Invest. 1990;85:397-407.
72. Traber MG, Burton GW, Hughes L, et al. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J Lipid Res. 1992;33:1171-1182.
73. Bartali B, Frongillo EA, Guralnik JM, et al. Serum micronutrient concentrations and decline in physical function among older persons. JAMA. 2008;299:308-315.
74. Ble A, Cherubini A, Volpato S, et al. Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2006;61:278-283.
75. Cesari M, Pahor M, Bartali B, et al. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr. 2004;79:289-294.
76. Thompson D, Bailey DM, Hill J, et al. Prolonged vitamin C supplementation and recovery from eccentric exercise. Eur J Appl Physiol. 2004;92:133-138.
77. Shafat A, Butler P, Jensen RL, et al. Effects of dietary supplementation with vitamins C and E on muscle function during and after eccentric contractions in humans. Eur J Appl Physiol. 2004;93: 196-202.
78. Jakeman P, Maxwell S. Effect of antioxidant vitamin supplementation on muscle function after eccentric exercise. Eur J Appl Physiol Occup Physiol. 1993;67:426-430.
79. Thompson D, Williams C, Garcia-Roves P, et al. Post-exercise vitamin C supplementation and recovery from demanding exercise. Eur J Appl Physiol. 2003;89:393-400.
80. Close GL, Ashton T, Cable T, et al. Ascorbic acid supplementation does not attenuate post-exercise muscle soreness following muscle-damaging exercise but may delay the recovery process. Br J Nutr. 2006;95:976-981.
81. Beaton LJ, Allan DA, Tarnopolsky MA, et al. Contraction-induced muscle damage is unaffected by vitamin E supplementation. Med Sci Sports Exerc. 2002;34:798-805.
82. Demiryurek S, Babul A. Effects of vitamin E and electrical stimulation on the denervated rat gastrocnemius muscle malon-dialdehyde and glutathione levels. Int J Neurosci. 2004;114: 45-54.
83. Servais S, Letexier D, Favier R, et al. Prevention of unloading-induced atrophy by vitamin E supplementation: links between oxidative stress and soleus muscle proteolysis? Free Radic Biol Med. 2007;42:627-635.
84. Kondo H, Miura M, Itokawa Y. Oxidative stress in skeletal muscle atrophied by immobilization. Acta Physiol Scand. 1991;142: 527-528.
85. Kondo H, Miura M, Nakagaki I, et al. Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization. Am J Physiol Endocrinol Metab. 1992;262:E583-E590.
86. Kondo H, Kodama J, Kishibe T, et al. Oxidative stress during recovery from muscle atrophy. FEBS J. 1993;326:189-191.
87. Appell HJ, Duarte JAR, Soares JMC. Supplementation of vitamin E may attenuate skeletal muscle immobilization atrophy. Int J Sports Med. 1997;18:157-160.
88. Koesterer TJ, Dodd SL, Powers S. Increased antioxidant capacity does not attenuate muscle atrophy caused by unweighting. J Appl Physiol. 2002;93:1959-1965.
89. Ikemoto M, Okamura Y, Kano M, et al. A relative high dose of vitamin E does not attenuate unweighting-induced oxidative stress and ubiquitination in rat skeletal muscle. J Physiol Anthro-pol Appl Human Sci. 2002;21:257-263.
90. Whidden MA, Smuder AJ, Wu M, et al. Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm. J Appl Physiol. 2010;108:1376-1382.
91. McClung JM, Kavazis AN, Whidden MA, et al. Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB/Akt) signaling. J Physiol. 2007;585:203-215.
92. Mastaloudis A, Morrow JD, Hopkins DW, et al. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med. 2004;36:1329-1341.
93. Mastaloudis A, Yu T-W, O'Donnell RP, et al. Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med. 2004;36:966-975.
94. Howard C, Ferrucci L, Sun K, et al. Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol. 2007;103:17-20.
95. Semba RD, Ferrucci L, Sun K, et al. Oxidative stress and severe walking disability among older women. Am J Med. 2007;120: 1084-1089.
96. Bernard S, LeBlanc P, Whittom F, et al. Peripheral muscle weakness in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;158:629-634.
97. Hambrecht R, Adams V, Gielen S, et al. Exercise intolerance in patients with chronic heart failure and increased expression of inducible nitric oxide synthase in the skeletal muscle. J Am Coll Cardiol. 1999;33:174-179.
98. Szentesi P, Bekedam MA, Beek-Harmsen BJ, et al. Depression of force production and ATPase activity in different types of human skeletal muscle fibers from patients with chronic heart failure. J Appl Physiol. 2005;99:2189-2195.
99. Minotti JR, Pillay P, Oka R, et al. Skeletal muscle size: relationship to muscle function in heart failure. J Appl Physiol. 1993;75: 373-381.
100. Lanone S, Mebazaa A, Heymes C, et al. Muscular contractile failure in septic patients: role of the inducible nitric oxide synthase pathway. Am J Respir Crit Care Med. 2000;162: 2308-2315.
101. Sayer AA, Dennison EM, Syddall HE, et al. Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care. 2005;28:2541-2542.
102. Slemenda C, Heilman DK, Brandt KD, et al. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum. 1998;41: 1951-1959.
103. Petterson SC, Barrance P, Buchanan T, et al. Mechanisms underlying quadriceps weakness in knee osteoarthritis. Med Sci Sports Exerc. 2008;40:422-427.
104. Ogilvie AC, Groeneveld AB, Straub JP, et al. Plasma lipid peroxides and antioxidants in human septic shock. Intensive Care Med. 1991;17:40-44.
105. Tkacova R, Kluchova Z, Joppa P, et al. Systemic inflammation and systemic oxidative stress in patients with acute exacerbations of COPD. Respir Med. 2007;101:1670-1676.
106. Barreiro E, de la PB, Minguella J, et al. Oxidative stress and respiratory muscle dysfunction in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005;171:1116-1124.
107. Riede UN, Forstermann U, Drexler H. Inducible nitric oxide synthase in skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 1998;32:964-969.
108. Ayilavarapu S, Kantarci A, Fredman G, et al. Diabetes-induced oxidative stress is mediated by Ca2{thorn}-independent phospholi-pase A2 in neutrophils. J Immunol. 2010;184:1507-1515.
109. Altindag O, Erel O, Aksoy N, et al. Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis. Rheumatol Int. 2007;27:339-344.
110. Surapaneni KM, Venkataramana G. Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritis. Indian J Med Sci. 2007;61:9-14.
111. Pinto S, Rao AV, Rao A. Lipid peroxidation, erythrocyte antiox-idants and plasma antioxidants in osteoarthritis before and after homeopathic treatment. Homeopathy. 2008;97:185-189.
112. Andrade FH, Reid MR, Allen DG, et al. Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibers from the mouse. J Physiol. 1998;509:565-575.
113. Moopanar TR, Allen DG. Reactive oxygen species reduce myo-fibrillar Ca2{thorn} sensitivity in fatiguing mouse skeletal muscle at 37 degrees C. J Physiol. 2005;564:189-199.
114. Reid MB, Stokic DS, Koch SM, et al. N-acetylcysteine inhibits muscle fatigue in humans. J Clin Invest. 1994;94:2468-2474.
115. Barker T, Leonard SW, Trawick RH, et al. Modulation of inflammation by vitamin E and C supplementation prior to anterior cruciate ligament surgery. Free Radic Biol Med. 2009; 46:599-606.
116. Barker T, Leonard SW, Trawick RH, et al. Antioxidant supplementation lowers circulating IGF-1 but not F2-isoprostanes immediately following ACL surgery. Redox Rep. 2009;14:221-226.
117. Kondo H, Miura M, Kodama J, et al. Role of iron in oxidative stress in skeletal muscle atrophied by immobilization. Pflugers Arch. 1992;421:295-297.
118. Kondo H, Nakagaki I, Sasaki S, et al. Mechanism of oxidative stress in skeletal muscle atrophied by immobilization. Am J Phy-siol Endocrinol Metab. 1993;28:E839-E844.
119. Kondo H, Nishino K, Itokawa Y. Hydroxyl radical generation in skeletal muscle atrophied by immobilization. FEBS Lett. 1994; 349:169-182.
120. Lawler JM, Song W, Demaree SR. Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle. Free Radic Biol Med. 2003;35:9-16.
121. Zergeroglu MA, McKenzie MJ, Shanely RA, et al. Mechanical ventilation-induced oxidative stress in the diaphragm. J Appl Physiol. 2003;95:1116-1124.
122. Liu MJ, Li JX, Lee KM, et al. Oxidative stress after muscle damage from immobilization and remobilization occurs locally and systemically. Clin Orthop Relat Res. 2005;434:246-250.
123. Selsby JT, Dodd SL. Heat treatment reduces oxidative stress and protects muscle mass during immobilization. Am J Physiol Regul Integr Comp Physiol. 2005;289:R134-R139.
124. Arbogast S, Smith J, Matuszczak Y, et al. Bowman-Birk inhibitor concentrate prevents atrophy, weakness, and oxidative stress in soleus muscle of hindlimb-unloaded mice. J Appl Physiol. 2006;102:956-964.
125. Falk DJ, DeRuisseau KC, Van Gammeren DL, et al. Mechanical ventilation promotes redox status alterations in the diaphragm. J Appl Physiol. 2006;101:1017-1024.
126. Suzuki N, Motohashi N, Uezumi A, et al. NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS. J Clin Invest. 2007;117:2468-2476.
127. Dodd SL, Gagnon BJ, Senf SM, et al. Ros-mediated activation of NF-kappaB and Foxo during muscle disuse. Muscle Nerve. 2009;41:110-113.
128. Brocca L, Pellegrino MA, Desaphy JF, et al. Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A pro-teomic approach in hindlimb unloaded mice. Exp Physiol. 2009; 95:331-350.
129. Kavazis AN, Talbert EE, Smuder AJ, et al. Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production. Free Radic Biol Med. 2009;46: 842-850.
130. Whidden MA, McClung JM, Falk DJ, et al. Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction. J Appl Physiol. 2009;106:385-394.
131. Abruzzo PM, di Tullio S, Marchionni C, et al. Oxidative stress in the denervated muscle. Free Radic Res. 2010;44:563-576.
132. Hudson NJ, Lehnert SA, Ingham AB, et al. Lessons from an estivating frog: sparing muscle protein despite starvation and disuse. Am J Physiol Regul Integr Comp Physiol. 2006;290: R836-R843.
133. Barker T, Traber MG. From animals to humans: evidence linking oxidative stress as a causative factor in muscle atrophy. J Physiol. 2007;583:421-422.
134. Barker T, Traber MG. Response to the letter to the editor by Rennie et al. J Physiol. 2008;586:309-310.
135. Rennie MJ, Atherton P, Selby A, et al. Letter to the editor on the journal club article by Barker and Traber. J Physiol. 2008;586: 307-308.
136. Levine S, Nguyen T, Taylor N, et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008;358:1327-1335.
137. Dalla LL, Ravara B, Gobbo V, et al. A transient antioxidant stress response accompanies the onset of disuse atrophy in human skeletal muscle. J Appl Physiol. 2009;107:549-557.
138. Brocca L, Borina E, Pellegrino MA, et al. Qualitative and quantitative adaptations of muscle fibers and muscle protein pattern to 35-days bed rest. Basic Appl Myol. 2009;19:117-126.
139. Glover EI, Yasuda N, Tarnopolsky MA, et al. Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy. Appl Phy-siol Nutr Metab. 2010;35:125-133.
140. Frost RA, Nystrom GJ, Lang CH. Tumor necrosis factor-alpha decreases insulin-like growth factor-I messenger ribonucleic acid expression in C2C12 myoblasts via a Jun N-terminal kinase pathway. Endocrinology. 2003;144:1770-1779.
141. Mallat Z, Heymes C, Ohan J, et al. Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. Arterioscler Thromb Vasc Biol. 1999;19:611-616.
142. Adams V, Jiang H, Yu J, et al. Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. J Am Coll Cardiol. 1999;33:959-965.
143. Qi WN, Chen LE, Zhang L, et al. Reperfusion injury in skeletal muscle is reduced in inducible nitric oxide synthase knockout mice. J Appl Physiol. 2004;97:1323-1328.
144. Zhang L, Looney CG, Qi W-N, et al. Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. J Appl Physiol. 2003;94:1473-1478.
145. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87:315-424.
146. Beckman JS, Ischiropoulos H, Zhu L, et al. Kinetics of superox-ide dismutase- and iron-catalyzed nitration of phenolics by per-oxynitrite. Arch Biochem Biophys. 1992;298:438-445.
147. Beckmann JS, Ye YZ, Anderson PG, et al. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem Hoppe Seyler. 1994; 375:81-88.
148. Ischiropoulos H, Zhu L, Beckman JS. Peroxynitrite formation from macrophage-derived nitric oxide. Arch Biochem Biophys. 1992;298:446-451.
149. Ischiropoulos H, Zhu L, Chen J, et al. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Bio-chem Biophys. 1992;298:431-437.
150. Phillips L, Toledo AH, Lopez-Neblina F, et al. Nitric oxide mechanism of protection in ischemia and reperfusion injury. J Invest Surg. 2009;22:46-55.
151. Takano H, Manchikalapudi S, Tang XL, et al. Nitric oxide synthase is the mediator of late preconditioning against myo-cardial infarction in conscious rabbits. Circulation. 1998;98: 441-449.
152. Guo Y, Jones WK, Xuan YT, et al. The late phase of ischemic preconditioning is abrogated by targeted disruption of the indu-cible NO synthase gene. Proc Natl Acad Sci U S A. 1999;96: 11507-11512.
153. Xi L, Jarrett NC, Hess ML, et al. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardio-protection: evidence from pharmacological inhibition and gene knockout mice. Circulation. 1999;99:2157-2163.
154. Li G, Labruto F, Sirsjo A, et al. Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase. Eur J Cardiothorac Surg. 2004;26:968-973.
155. Chen CH, Chuang JH, Liu K, et al. Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase. Shock. 2008;30:241-249.
156. Huang J, Forsberg NE. Role of calpain in skeletal-muscle protein degradation. Proc Natl Acad Sci U S A. 1998;95: 12100-12105.
157. Smith IJ, Dodd SL. Calpain activation causes a proteasome dependent increase in protein degradation and inhibits the Akt signaling pathway in rat diaphragm muscle. Exp Physiol. 2007;92:561-573.
158. McClung JM, Judge AR, Talbert EE, et al. Calpain-1 is required for hydrogen peroxide-induced myotube atrophy. Am J Physiol Cell Physiol. 2009;296:C363-C371.
159. Smuder AJ, Kavazis AN, Hudson MB, et al. Oxidation enhances myofibrillar protein degradation via calpain and caspase-3. Free Radic Biol Med. 2010;49:1152-1160.
160. Betters JL, Criswell DS, Shanely RA, et al. Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis. Am J Respir Crit Care Med. 2004;170: 1179-1184.
161. Ikegami K, Lalonde C, Young YK, et al. Comparison of plasma reduced glutathione and oxidized glutathione with lung and liver tissue oxidant and antioxidant activity during acute inflammation. Shock. 1994;1:307-312.
162. Jiang Q, Lykkesfeldt J, Shigenaga MK, et al. Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free Radic Biol Med. 2002;33: 1534-1542.
163. Lang CH, Frost RA, Nairn AC, et al. TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol Endocrinol Metab. 2002;282: E336-E347.
164. Li W, Moylan JS, Chambers MA, et al. Interleukin-1 stimulates catabolism in C2C12 myotubes. Am J Physiol Cell Physiol. 2009;297:C706-C714.
165. Strle K, Broussard SR, McCusker RH, et al. Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology. 2004;145:4592-4602.
166. Broussard SR, McCusker RH, Novakofski JE, et al. Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. Endocrinology. 2003;144: 2988-2996.
167. Wilcox PG, Wakai Y, Walley KR, et al. Tumor necrosis factor a decreases in vivo diaphragm contractility in dogs. Am J Respir Crit Care Med. 1994;150:1368-1373.
168. Li X, Moody MR, Engel D, et al. Cardiac-specific overex-pression of tumor necrosis factor-a causes oxidative stress and contractile dysfunction in mouse diaphragm. Circulation. 2000;102:1690-1696.
169. Hardin BJ, Campbell KS, Smith JD, et al. TNF-{alpha} acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle. J Appl Physiol. 2008;104:694-699.
170. Divangahi M, Demoule A, Danialou G, et al. Impact of IL-10 on diaphragmatic cytokine expression and contractility during Pseudomonas infection. Am J Respir Cell Mol Biol. 2007;36: 504-512.
171. Meador BM, Krzyszton CP, Johnson RW, et al. Effects of IL-10 and age on IL-6, IL-1beta, and TNF-alpha responses in mouse skeletal and cardiac muscle to an acute inflammatory insult. J Appl Physiol. 2008;104:991-997.
172. Krzyszton CP, Sparkman NL, Grant RW, et al. Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1109-R1114.
173. Yende S, Waterer GW, Tolley EA, et al. Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax. 2006;61:10-16.
174. Adams V, Nehrhoff B, Spate U, et al. Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study. Cardiovasc Res. 2002;54: 95-104.
175. Niebauer J, Pflaum CD, Clark AL, et al. Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation. J Am Coll Cardiol. 1998;32:393-397.
176. Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990;323:236-241.
177. Larsen AI, Lindal S, Aukrust P, et al. Effect of exercise training on skeletal muscle fibre characteristics in men with chronic heart failure: correlation between skeletal muscle alterations, cyto-kines and exercise capacity. Int J Cardiol. 2002;83:25-32.
178. Meduri GU, Headley S, Kohler G, et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS.Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest. 1995;107:1062-1073.
179. Cavallo MG, Pozzilli P, Bird C, et al. Cytokines in sera from insulin-dependent diabetic patients at diagnosis. Clin Exp Immunol. 1991;86:256-259.
180. Smith MD, Triantafillou S, Parker A, et al. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol. 1997;24:365-371.
181. Cannon JG, Meydani SN, Fielding RA, et al. Acute phase response in exercise. II. Associations between vitamin E, cyto-kines, and muscle proteolysis. Am J Physiol Regul Integr Comp Physiol. 1991;260:R1235-R1240.
182. Devaraj S, Tang R, Adams-Huet B, et al. Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr. 2007;86: 1392-1398.
183. Fischer CP, Hiscock NJ, Penkowa M, et al. Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiol. 2004;558:633-645.
184. Li YP, Schwartz RJ, Waddell ID, et al. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-{kappa}B activation in response to tumor necrosis factor {alpha}. FASEB J. 1998;12:871-880.
185. Buck M, Chojkier M. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. EMBO J. 1996;15:1753-1765.
186. Goodman MN. Tumor necrosis factor induces skeletal muscle protein breakdown in rats. Am J Physiol Endocrinol Metab. 1991;260:E727-E730.
187. Li YP, Reid MB. NF-kB mediates the protein loss induced by TNF-a in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1165-R1170.
188. Haddad F, Zaldivar F, Cooper DM, et al. IL-6-induced muscle atrophy. J Appl Physiol. 2005;98:911-917.
189. Cameron M, Buchgraber A, Passler H, et al. The natural history of the anterior cruciate ligament-deficient knee: changes in synovial fluid cytokine and keratan sulfate concentrations. Am J Sports Med. 1997;25:751-754.
190. Irie K, Uchiyama E, Iwaso H. Intraarticular inflammatory cyto-kines in acute anterior cruciate ligament injured knee. Knee. 2003;10:93-96.
191. Higuchi H, Shirakura K, Kimura M, et al. Changes in biochemical parameters after anterior cruciate ligament injury. Int Orthop. 2006;30:43-47.
192. Elsaid KA, Fleming BC, Oksendahl HL, et al. Decreased lubri-cin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum. 2008;58:1707-1715.
193. Willy C, Dahouk S, Starck C, et al. DNA damage in human leukocytes after ischemia/reperfusion injury. Free Radic Biol Med. 2000;28:1-12.
194. Saricaoglu F, Dal D, Salman AE, et al. Effect of low-dose n-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery. Acta Anaesthesiol Scand. 2005;49:847-851.
195. Le Moine O, Louis H, Stordeur P, et al. Role of reactive oxygen intermediates in interleukin 10 release after cold liver ischemia and reperfusion in mice. Gastroenterology. 1997;113: 1701-1706.
196. Haddad JJ, Fahlman CS. Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine? Biochem Biophys Res Commun. 2002;297:163-176.
197. Wanidworanun C, Strober W. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. J Immunol. 1993;151:6853-6861.
198. Tilg H, Atkins MB, Dinarello CA, et al. Induction of circulating interleukin 10 by interleukin 1 and interleukin 2, but not interleu-kin 6 immunotherapy. Cytokine. 1995;7:734-739.
199. Daftarian PM, Kumar A, Kryworuchko M, et al. IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha. J Immunol. 1996;157:12-20.
200. Garcia CA, Wang H, Benakanakere MR, et al. c-Jun controls the ability of IL-12 to induce IL-10 production from human memory CD4{thorn} T cells. J Immunol. 2009;183:4475-4482.
201. Jeschke MG, Barrow RE, Suzuki F, et al. IGF-I/IGFBP-3 equilibrates ratios of pro- to anti-inflammatory cytokines, which are predictors for organ function in severely burned pediatric patients. Mol Med. 2002;8:238-246.
202. Warzecha Z, Dembinski A, Ceranowicz P, et al. IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis. J Physiol Pharmacol. 2003;54:575-590.
203. Kooijman R, Coppens A. Insulin-like growth factor-I stimulates IL-10 production in human T cells. J Leukoc Biol. 2004;76: 862-867.
204. Zysk SP, Fraunberger P, Veihelmann A, et al. Tunnel enlargement and changes in synovial fluid cytokine profile following anterior cruciatae ligament reconstruction with petallar tendon and hamstring tendon autografts. Knee Surg Sports Traumatol Arthrosc. 2004;12:98-103.
205. Ling PR, Schwartz JH, Bistrian BR. Mechanisms of host wasting induced by administration of cytokines in rats. Am J Physiol Endocrinol Metab. 1997;272:E333-E339.
206. Langen RCJ, Schols AMWJ, Kelders MCJM, et al. Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-{kappa}B. FASEB J. 2001;15:1169-1180.
207. Bodine SC, Latres E, Baumhueter S, et al. Identification of ubi-quitin ligases required for skeletal muscle atrophy. Science. 2001;294:1704-1708.
208. Broussard SR, McCusker RH, Novakofski JE, et al. IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts. J Immunol. 2004;172:7713-7720.
209. Elliott S, Hays E, Mayor M, et al. The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. Arthritis Res Ther. 2003;5:R285-R291.
210. Pfander D, Heinz N, Rothe P, et al. Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis. Ann Rheum Dis. 2004;63:240-244.
211. Fan Z, Bau B, Yang H, et al. Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chon-drocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum. 2005;52:136-143.
212. Darabos N, Hundric-Haspl Z, Haspl M, et al. Correlation between synovial fluid and serum IL-1beta levels after ACL surgery-preliminary report. Int Orthop. 2009;33:413-418.
213. Daniel DM, Stone ML, Dobson BE, et al. Fate of the ACL-injured patient. Am J Sports Med. 1994;22:632-644.
214. Ferretti A, Conteduca F, De Carli A, et al. Osteoarthritis of the knee after ACL reconstruction. Int Orthop. 1991;15:367-371.