Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention

Cancer Research

Volumn 71, Issue 11, 2011, Pages 3904-3911

  Paonessa, Joseph D ^a   Ding, Yi ^a   Randall, Kristen L ^b   Munday, Rex ^c   Argoti, Dayana ^b   Vouros, Paul ^b   Zhang, Yuesheng ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

4 BIPHENYLAMINE; 5,6 DIHYDROCYCLOPENTA[C][1,2] DITHIOLE 3(4H) THIONE; ANTINEOPLASTIC AGENT; BIPHENYL DERIVATIVE; CARCINOGEN; DNA; GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE; N (DEOXYGUANOSIN 8 YL) 4 AMINOBIPHENYL; TOBACCO SMOKE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CANCER; CANCER INHIBITION; CANCER PREVENTION; CARCINOGEN DNA INTERACTION; CELL PROTECTION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DETOXIFICATION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG TARGETING; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CANCER; LIVER CELL; LIVER PROTECTION; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; URINARY EXCRETION;

AMINOBIPHENYL COMPOUNDS; ANIMALS; CARCINOGENS; CELL LINE, TUMOR; CHEMOPREVENTION; CYTOPROTECTION; DNA ADDUCTS; DNA DAMAGE; GLUCURONOSYLTRANSFERASE; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; SULFHYDRYL COMPOUNDS; THIONES; TUMOR CELLS, CULTURED; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 79957883557     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-0396     Document Type: Article

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