Interstitial cystitis is associated with vulvodynia and sexual dysfunction-A case-control study

Journal of Sexual Medicine

Volumn 8, Issue 6, 2011, Pages 1726-1734

  Gardella, Barbara ^a   Porru, Daniele ^b   Nappi, Rossella E ^a   Daccò, Maria Diletta ^a,b   Chiesa, Alessia ^a   Spinillo, Arsenio ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Bladder and Vulvar Pain; Interstitial Cystitis; Menopause; Oral Contraceptives; Sexual Pain; Vulvodynia

Indexed keywords

ORAL CONTRACEPTIVE AGENT;

ADULT; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DRUG USE; ENDOMETRIOSIS; FEMALE; FEMALE SEXUAL DYSFUNCTION; GYNECOLOGICAL EXAMINATION; HUMAN; INTERSTITIAL CYSTITIS; MENOPAUSE; PAPANICOLAOU TEST; PRIORITY JOURNAL; SEMI STRUCTURED INTERVIEW; SEXUAL FUNCTION; SOCIAL ASPECT; UROGENITAL ENDOSCOPY; VULVODYNIA;

EID: 79957881473     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2011.02251.x     Document Type: Article

References (52)

1. Clemens JQ, Meenan RT, Rosetti MC, Gao SY, Calhoun EA. Prevalence and incidence of interstitial cystitis in a managed care population. J Urol 2005;173:98-102.
2. Hanno P, Lin A, Nordling J, Nyberg L, van Ophoven A, Ueda T, Wein A. Bladder pain syndrome committee of the international consultation on incontinence. Neurourol Urodyn 2010;29:191-8.
3. Parsons CL, Dell J, Stanford EJ, Bullen M, Kahn BS, Willems JJ. The prevalence of interstitial cystitis in gynecologic patients with pelvic pain, as detected by intravesical potassium sensitivity. Am J Obstet Gynecol 2002;187:1395-400.
4. Stanford EJ, Dell JR, Parsons CL. The emerging presence of interstitial cystitis in gynecologic patients with chronic pelvic pain. Urology 2007;69(4 suppl):53-9.
5. Dell JR, Mokrzycki ML, Jayne CJ. Differentiating interstitial cystitis from similar conditions commonly seen in gynecologic practice. Eur J Obstet Gynecol Reprod Biol 2009;144:105-9.
6. Clemens J, Meenan R, O'Keeffe Rosetti M, Kimes T, Calhoun E. Case-control study of medical comorbidities in women with interstitial cystitis. J Urol 2008;179:2222-5.
7. Kahn BS, Tatro C, Parsons CL, Willems JJ. Prevalence of interstitial cystitis in vulvodynia patients detected by bladder potassium sensitivity. J Sex Med 2010;7:996-1002.
8. Goldstein AT, Burrows L. Vulvodynia. J Sex Med 2008;5:5-14.
9. Edwards L. New concepts in vulvodynia. Am J Obstet Gynecol 2003;189(3 suppl):S24-30.
10. Stewart DE, Reicher AE, Gerulath AH, Boydell KM. Vulvodynia and psychological distress. Obstet Gynecol 1994;84:587-90.
11. Nickel JC, Tripp DA, Pontari M, Moldwin R, Mayer R, Carr LK, Doggweiler R, Yang CC, Mishra N, Nordling J. Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: A case control study. J Urol 2010;183:167-72.
12. Whitemore K, Siegel F, Kellog-Spadt S. Interstitial cystitis/painful bladder syndrome as a cause of sexual pain in women: A diagnosis to consider. J Sex Med 2007;4:720-7.
13. Bogart LM, Berry SH, Clemens JQ. Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: A systematic review. J Urol 2007;177:450-6.
14. Wehbe SA, Whitmore K, Kellogg-Spadt S. Urogenital complaints and female sexual dysfunction (part 1). J Sex Med 2010;7:1704-13. quiz 1703, 1714-5.
15. Gardella B, Porru D, Ferdeghini F, Martinotti E, Nappi RE, Rovereto B, Spinillo A. Insight into urogynecologic features of women with interstitial cystitis/painful bladder syndrome. Eur Urol 2008;54:1145-53.
16. Butrick CW. Interstitial cystitis and chronic pelvic pain: New insights in neuropathology, diagnosis, and treatment. Clin Obstet Gynecol 2003;46:811-23.
17. Burrows LJ, Klingman D, Pukall CF, Goldstein AT. Umbilical hypersensitivity in women with primary vestibulodynia. J Reprod Med 2008;53:413-6.
18. Fenton BW. Limbic associated pelvic pain: A hypothesis to explain the diagnostic relationships and features of patients with chronic pelvic pain. Med Hypotheses 2007;69:282-6.
19. Harlow BL, Vitonis AF, Stewart EG. Influence of oral contraceptive use on the risk of adult-onset vulvodynia. J Reprod Med 2008;53:102-10.
20. Hand JR. Interstitial cystitis: Report of 223 cases (204 women and 19 men). J Urol 1949;61:291-310.
21. Powell-Boone T, Ness TJ, Cannon R, Lloyd LK, Weigent DA, Fillingim RB. Menstrual cycle affects bladder pain sensation in subjects with interstitial cystitis. J Urol 2005;174:1832-6.
22. O'Leary MP, Sant GR, Fowler FJ, Whitmore KE, Spolarich-Kroll J. The interstitial cystitis symptom index and problem index. Urology 1997;49(5A suppl):58-63.
23. Gillenter JY, Wein AJ. Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Disease workshop on Interstitial Cystitis, National Institute of Health, Bethesda, Maryland, August 28-29, 1987. J Urol 1988;140:203-6.
24. Rosen RC, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'Agostino R Jr. The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000;26:191-208.
25. Moyal-Barracco M, Lynch PJ. 2003 ISSVD terminology and classification of vulvodynia: A historical perspective. J Reprod Med 2004;49:772-7.
26. Bergeron S, Binik YM, Khalifé S, Pagidas K, Glazer HI. Vulvar vestibulitis syndrome: Reliability of diagnosis and evaluation of current diagnostic criteria. Obstet Gynecol 2001;98:45-51.
27. Pukall CF, Binik YM, Khalifé S, Amsel R, Abbott FV. Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome. Pain 2002;96:163-75.
28. Bachmann GA, Notevolitz M, Kelly SJ. Long-term non hormonal treatment of vaginal dryness. Clin Pract Sex 1992;8:3-8.
29. Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK. Nonspecific vaginitis: Diagnostic criteria and microbial and epidemiologic associations. Am J Med 1983;74:14-22.
30. Melchers WJ, Bakkers JM, Wang J, de Wilde PC, Boonstra H, Quint WG, Hanselaar AG. Short fragment polymerase chain reaction reverse hybridization line probe assay to detect and genotype a broad spectrum of human papilloma virus types. Am J Pathol 1999;155:1473-8.
31. Birder L, de Groat W, Mills I, Morrison J, Thor K, Drake M. Neural control of the lower urinary tract: Peripheral and spinal mechanisms. Neurourol Urodyn 2010;29:128-39.
32. Theoharides TC, Whitmore K, Stanford E, Moldwin R, O'Leary MP. Interstitial cystitis: Bladder pain and beyond. Expert Opin Pharmacother 2008;9:2979-94.
33. Ustinova EE, Fraser MO, Pezzone MA. Cross-talk and sensitization of bladder afferent nerves. Neurourol Urodyn 2010;29:77-81.
34. Acar D, Cayan S, Aktaş S, Tek M, Akbay E. The effect of tamoxifen on bladder functions and histology, and the role of estrogen receptor beta in a rat chemical cystitis model. Neurourol Urodyn 2007;26:309-16.
35. Imamov O, Yakimchuk K, Morani A, Schwend T, Wada-Hiraike O, Razumov S, Warner M, Gustafsson JA. Estrogen receptor beta-deficient female mice develop a bladder phenotype resembling human interstitial cystitis. Proc Natl Acad Sci U S A 2007;104:9806-9.
36. Cheng Y, Keast JR. Effects of estrogens and bladder inflammation on mitogen-activated protein kinases in lumbosacral dorsal root ganglia from adult female rats. BMC Neurosci 2009;10:156.
37. Sant GR, Kempuraj D, Marchand JE, Theoharides TC. The mast cell in interstitial cystitis: Role in pathophysiology and pathogenesis. Urology 2007;69(4 suppl):34-40.
38. Theoharides TC, Pang X, Letourneau R, Sant GR. Interstitial cystitis: A neuroimmunoendocrine disorder. Ann N Y Acad Sci 1998;840:619-34.
39. Bjorling DE, Wang ZY. Estrogen and neuroinflammation. Urology 2001;57(1 suppl):40-6.
40. Nappi RE, Polatti F. The use of estrogen therapy in women's sexual functioning (CME). J Sex Med 2009;6:603-16.
41. Lachowsky M, Nappi RE. The effects of oestrogen on urogenital health. Maturitas 2009;63:149-51.
42. Bouchard C, Brisson J, Fortier M, Morin C, Blanchette C. Use of oral contraceptive pills and vulvar vestibulitis: A case-control study. Am J Epidemiol 2002;156:254-61.
43. Bohm-Starke N, Johannesson U, Hilliges M, Rylander E, Torebjörk E. Decreased mechanical pain threshold in the vestibular mucosa of women using oral contraceptives: A contributing factor in vulvar vestibulitis? J Reprod Med 2004;49:888-92.
44. Bohm-Starke N, Hilliges M, Falconer C, Rylander E. Increased intraepithelial innervation in women with vulvar vestibulitis syndrome. Gynecol Obstet Invest 1998;46:256-60.
45. Westrom LV, Willen R. Vestibular nerve fiber proliferation in vulvar vestibulitis syndrome. Obstet Gynecol 1998;91:572-6.
46. Bornstein J, Goldschmid N, Sabo E. Hyperinnervation and mast cell activation may be used as histopathologic diagnostic criteria for vulvar vestibulitis. Gynecol Obstet Invest 2004;58:171-8.
47. Rodríguez MA, Afari N, Buchwald DS, National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Urological Chronic Pelvic Pain. Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol 2009;182:2123-31.
48. Peters KM, Killinger KA, Carrico DJ, Ibrahim IA, Diokno AC, Graziottin A. Sexual function and sexual distress in women with interstitial cystitis: A case-control study. Urology 2007;70:543-7.
49. Nappi RE, Albani F, Vaccaro P, Gardella B, Salonia A, Chiovato L, Spinillo A, Polatti F. Use of the Italian translation of the sexual function index (FSFI) in routine gynecological practice. Gynecol Endocrinol 2008;24:214-9.
50. Parsons CL, Dell J, Stanford EJ, Bullen M, Kahn BS, Waxell T, Koziol JA. Increased prevalence of interstitial cystitis: Previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity. Urology 2002;60:573-8.
51. Peters KM, Kalinowski SE, Carrico DJ, Ibrahim IA, Diokno AC. Fact or fiction-Is abuse prevalent in patients with interstitial cystitis? Results from a community survey and clinic population. J Urol 2007;178(3 Pt 1):891-5.
52. Rothock NE, Lutgendorf SK, Hoffman A, Kreader KJ. Depression symptoms and quality of life in patient with interstitial cystitis. J Urol 2002;167:1763-7.