Detecting cell death with optical coherence tomography and envelope statistics

Journal of Biomedical Optics

Volumn 16, Issue 2, 2011, Pages

  Farhat, Golnaz ^a,b,c   Yang, Victor X D ^b,d   Czarnota, Gregory J ^a,b,e   Kolios, Michael C ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d RYERSON UNIVERSITY   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Apoptosis; Cell death; Envelope statistics; Integrated backscatter; Optical coherence tomography; Treatment monitoring

Indexed keywords

ACUTE MYELOID LEUKEMIA; CELLULAR LEVELS; ENVELOPE STATISTICS; FIRST ORDER; GENERALIZED GAMMA DISTRIBUTION; HIGH FREQUENCY ULTRASOUNDS; HIGH-FREQUENCY ULTRASOUND IMAGING; IN-VITRO; INTEGRATED BACKSCATTER; MITOTIC ARREST; MORPHOLOGICAL CHANGES; NECROTIC CELLS; NONINVASIVE METHODS; QUANTITATIVE METHOD; SIGNAL ENVELOPE; STRUCTURAL CHANGE; TREATMENT MONITORING;

BACKSCATTERING; CELL DEATH; DISEASES; INTEGRATION; MORPHOLOGY; NONINVASIVE MEDICAL PROCEDURES; TOMOGRAPHY; ULTRASONIC IMAGING; ULTRASONICS;

POPULATION STATISTICS;

ACUTE GRANULOCYTIC LEUKEMIA; ALGORITHM; APOPTOSIS; ARTICLE; COMPUTER ASSISTED DIAGNOSIS; HUMAN; IMAGE ENHANCEMENT; METHODOLOGY; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE;

ALGORITHMS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LEUKEMIA, MYELOID, ACUTE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 79957876199     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3544543     Document Type: Article

References (24)

1. F. J. Esteva and G. N. Hortobagyi, "Can early response assessment guide neoadjuvant chemotherapy in early-stage breast cancer?," J. Natn. Cancer Inst. 100, 521 (2008).
2. M. A. Pantaleo, M. Nannini, A. Maleddu, S. Fanti, V. Ambrosini, C. Nanni, S. Boschi, and G. Biasco, "Conventional and novel PET tracers for imaging in oncology in the era of molecular therapy," Cancer Treat Rev. 34 103-121 (2008).
3. M. J. Paulus, S. S. Gleason, M. E. Easterly, and C. J. Foltz, "High resolution x-ray computed tomography: an emerging tool for small animal cancer research," Neoplasia 2(1-2), 62-70 (2001).
4. J. S. Lewis, J. M. Connett, J. R. Garbow, T. L. Buettner, Y. Fujibayashi, J. W. Fleshman, and M. J. Welch, "Copper-64-pyruvaldehyde-bis(N(4)- methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imaging," Cancer Res. 62, 445-449 (2002).
5. Z. He, J. L. Evelhoch, R. M. Mohammad, N. V. Adsay, G. R. Pettit, V. K. Vaitkevicius, and F. H. Sarkar, "Magnetic resonance imaging to measure therapeutic response using an orthotopic model of human pancreatic cancer," Pancreas 21, 69-76 (2000).
6. J. K. Willmann, N. van Bruggen, L.M. Dinkelborg, and S. S. Gambhir, "Molecular imaging in drug development," Nat. Rev. Drug Discovery 7, 591-607 (2008).
7. G. J. Czarnota, M. C. Kolios, J. Abraham, M. Portnoy, F. P. Ottensmeyer, J.W. Hunt, and M.D. Sherar, "Ultrasound imagingofapoptosis: high-resolution non-invasive monitoring of programmed cell death in vitro, in situ and in vivo," Br. J. Cancer 81, 520-527 (1999).
8. F. L. Lizzi, M. Ostromogilsky, E. J. Feleppa, M. C. Rorke, and M. M. Yaremko, "Relationship of ultrasonic spectral parameters to features of tissue microstructure," IEEE Trans. Ultrason. Ferroelectr. Freq. Control UFFC-33(3), 319-329 (1986).
9. M. C. Kolios, G. J. Czarnota, M. Lee, J. W. Hunt, and M. D. Sherar, "Ultrasonic spectral parameter characterization of apoptosis," Ultrasound Med. Biol. 28, 589-597 (2002).
10. A. S. Tunis, G. J. Czarnota, A. Giles, M. D. Sherar, J. W. Hunt, and M. C. Kolios, "Monitoring structural changes in cells with high-frequency ultrasound signal statistics," Ultrasound Med. Biol. 31, 1041-1049 (2005).
11. V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Muller, Q. Zhang, G. Zonios, E. Kline, and T. McGillican, "Detection of preinvasive cancer cells," Nature 406, 35 (2000).
12. A. L. Oldenburg, C. Xu, and S. A. Boppart, "Spectroscopic optical coherence tomography and microscopy," IEEE J. Sel. Top. Quantum Electron. 13, 1629-1640 (2007).
13. F. J. van der Meer, D. J. Faber, M. C. Aalders, A. A. Poot, I. Vermes, and T. G. van Leeuwen, "Apoptosis- and necrosis-induced changes in light attenuation measured by optical coherence tomography," Lasers Med. Sci. 25, 259-267 (2010).
14. B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, "Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219-1223 (2009).
15. V. X. D. Yang, G. J. Czarnota, I. A. Vitkin, M. Kolios, M. Sherar, J. de Boer, B. Tromberg, and B. C. Wilson, "Ultrasound backscatter microscopy/spectroscopy and optical coherence (Doppler) tomography for mechanism-specific monitoring of photodynamic therapy in vivo and in vitro," in Proc. SPIE 4612, 128 (2002).
16. R. M. Vlad, N. M. Alajez, A. Giles, M. C. Kolios, and G. J. Czarnota, "Quantitative ultrasound characterization of cancer radiotherapy effects in vitro," Int. J. Radiat. Oncol., Biol., Phys. 72, 1236-1243 (2008).
17. G. J. Czarnota, M. C. Kolios, H. Vaziri, S. Benchimol, F. P. Ottensmeyer, M. D. Sherar, and J. W. Hunt, "Ultrasonic biomicroscopy of viable, dead and apoptotic cells," Ultrasound Med. Biol. 23, 961-965 (1997).
18. M. Karbowski and R. J. Youle, "Dynamics of mitochondrial morphology in healthy cells and during apoptosis," Cell Death Differ 10, 870-880 (2003).
19. S. L. Fink and B. T. Cookson, "Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells," Infect. Immun. 73, 1907 (2005).
20. G. Majno and I. Joris, "Apoptosis, oncosis, and necrosis. An overview of cell death," Am. J. Pathol. 146(1), 3-15 (1995).
21. D. B. Zamble and S. J. Lippard, "Cisplatin and DNA repair in cancer chemotherapy," Trends Biochem. Sci. 20, 435-439 (1995).
22. P. Dustin, "Microtubules," Sci. Am. 243, 66-76 (1980).
23. P. M. Shankar, "Ultrasonic tissue characterization using a generalized Nakagami model," IEEE Trans. Ultrason. Ferroelectr. Freq. Control 48, 1716-1720 (2001).
24. J. M. Schmitt, A. Knuttel, M. Yadlowsky, and M. A. Eckhaus, "Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994).