Mechanistic toxicodynamic model for receptor-mediated toxicity of diazoxon, the active metabolite of diazinon, in Daphnia magna

Environmental Science and Technology

Volumn 45, Issue 11, 2011, Pages 4980-4987

  Kretschmann, Andreas ^a,b   Ashauer, Roman ^a   Hitzfeld, Kristina ^a   Spaak, Piet ^a,b   Hollender, Juliane ^a,b   Escher, Beate I ^a,c  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ACETYLCHOLINESTERASE ACTIVITY; ACETYLCHOLINESTERASE INHIBITION; ACTIVE METABOLITES; AQUATIC ORGANISMS; AS UPTAKE; CONTROL ACTIVITIES; DAPHNIA MAGNA; ENZYME-INHIBITOR COMPLEX; EXPOSURE TIME; HIGH SENSITIVITY; IN-VITRO; IN-VIVO; INTERNAL TARGETS; PARENT COMPOUNDS; TARGET SITES; TIME COURSE; TIME DEPENDENCY; TIME-DEPENDENT;

BIOCHEMISTRY; BIOMOLECULES; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; METABOLISM; METABOLITES; TOXICITY;

ENZYME INHIBITION;

ACETYLCHOLINESTERASE; DIAZOXON; DIMPYLATE; ENZYME; ORGANOPHOSPHATE INSECTICIDE; RECEPTOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

CRUSTACEAN; ECOTOXICOLOGY; ENZYME ACTIVITY; IMMOBILIZATION; INHIBITION; METABOLITE; MORTALITY; NUMERICAL MODEL; ORGANOPHOSPHATE; PARAMETERIZATION; POLLUTION EXPOSURE; REACTION KINETICS; TOXICITY TEST; XENOBIOTICS;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DAPHNIA; ECOTOXICITY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME KINETICS; IN VITRO STUDY; IN VIVO STUDY; METABOLITE; NONHUMAN; PARAMETRIC TEST; PRODUCT RECOVERY; TOXICODYNAMIC; TOXICOLOGICAL PARAMETERS; XENOBIOTIC METABOLISM;

ANIMALS; CHOLINESTERASE INHIBITORS; DAPHNIA; DIAZINON; KINETICS; MODELS, BIOLOGICAL; ORGANOPHOSPHORUS COMPOUNDS;

DAPHNIA MAGNA;

EID: 79957875388     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es1042386     Document Type: Article

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