On-chip solid phase extraction and enzyme digestion using cationic PolyE-323 coatings and porous polymer monoliths coupled to electrospray mass spectrometry

Journal of Chromatography A

Volumn 1218, Issue 26, 2011, Pages 4039-4044

  Hua, Yujuan ^a   Jemere, Abebaw B ^b   Harrison, D Jed ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Mass spectrometry; Microfluidics; Monolithic column; Solid phase extraction; Trypsin digestion

Indexed keywords

CAPILLARY WALL; CATIONIC CHARGES; CYTOCHROME C; ELECTROKINETIC; ELECTROOSMOTIC FLOW; ELECTROSPRAY MASS SPECTROMETRY; ELECTROSPRAYS; ENZYME DIGESTION; GLASS CHIPS; HIGH QUALITY; IONIZATION MASS SPECTROMETRY; LINEAR CALIBRATION CURVE; MIGRATION TIME; MODEL PROTEINS; MONOLITHIC COLUMN; MONOLITHIC COLUMNS; MONOLITHIC POLYMERS; ON CHIPS; PEPTIDE ADSORPTION; POLYMER MONOLITHS; POROUS POLYMER MONOLITHS; POROUS POLYMERS; PRE-CONCENTRATION; PROTEIN ADSORPTION; SOLID PHASE EXTRACTION; SOLID-PHASE EXTRACTION COLUMNS; SOLUTION PHASE; STOP FLOW; SURFACE COATINGS; TRYPSIN DIGESTION;

ADSORPTION; CHLORINE COMPOUNDS; ELECTROOSMOSIS; ELECTROPHORESIS; ELECTROSPRAY IONIZATION; ION CHROMATOGRAPHY; MASS SPECTROMETRY; MICROFLUIDICS; MONOLITHIC INTEGRATED CIRCUITS; PEPTIDES; PLASTIC COATINGS; POLYMERS;

EXTRACTION;

CATION; METHACRYLIC ACID; POLYE 323; POLYMER; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; CALIBRATION; CAPILLARY ELECTROPHORESIS; ELECTROOSMOSIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME DEGRADATION; HYDROPHOBICITY; MATERIAL COATING; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION;

ELECTROOSMOSIS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, ELECTRON, SCANNING; PEPTIDE FRAGMENTS; POLYMERIZATION; POLYMETHACRYLIC ACIDS; PROTEINS; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPSIN;

EID: 79957874206     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.04.027     Document Type: Article

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