Serum fetuin-A levels are associated with vascular calcifications and predict cardiovascular events in renal transplant recipients

Clinical Journal of the American Society of Nephrology

Volumn 6, Issue 5, 2011, Pages 974-985

  Maréchal, Céline ^a   Schlieper, Georg ^b   Nguyen, Pauline ^a   Krüger, Thilo ^b   Coche, Emmanuel ^a   Robert, Annie ^c   Floege, Jorgen ^b   Goffin, Eric ^a   Jadoul, Michel ^a   Devuyst, Olivier ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHOLESTEROL; FETUIN A;

ADULT; AGED; ALLELE; ARTICLE; BLOOD VESSEL CALCIFICATION; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GENETIC VARIABILITY; HUMAN; INFLAMMATION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING;

ADULT; AORTIC DISEASES; BIOLOGICAL MARKERS; BLOOD PROTEINS; CALCINOSIS; CHOLESTEROL; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KAPLAN-MEIER ESTIMATE; KIDNEY TRANSPLANTATION; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 79957821770     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.06150710     Document Type: Article

References (45)

1. Kasiske BL, Maclean JR, Snyder JJ: Acute myocardial infarction and kidney transplantation. J Am Soc Nephrol 17: 900- 907, 2006
2. Ojo AO: Cardiovascular complications after renal transplantation and their prevention. Transplantation 82: 603-611, 2006
3. Schwarz U, Buzello M, Ritz E, Stein G, Raabe G, Wiest G, Mall G, Amann K: Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure. Nephrol Dial Transplant 15: 218-223, 2000
4. London GM, Marchais SJ, Guérin AP, Métivier F: Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia. Curr Opin Nephrol Hypertens 14: 525-531, 2005
5. Moe SM, Chen NX: Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 19: 213-216, 2008
6. Moe SM, O'Neill KD, Reslerova M, Fineberg N, Persohn S, Meyer CA: Natural history of vascular calcification in dialysis and transplant patients. Nephrol Dial Transplant 19: 2387-2393, 2004
7. Rosas SE, Mensah K, Weinstein RB, Bellamy SL, Rader DJ: Coronary artery calcification in renal transplant recipients. Am J Transplant 5: 1942-1947, 2005
8. Oschatz E, Benesch T, Kodras K, Hoffmann U, Haas M: Changes of coronary calcification after kidney transplantation. Am J Kidney Dis 48: 307-313, 2006
9. Schankel K, Robinson J, Bloom RD, Guerra C, Rader D, Joffe M, Rosas SE: Determinants of coronary artery calcification progression in renal transplant recipients. Am J Transplant 7: 2158-2164, 2007
10. Blacher J, Guerin AP, Panner B, Marchais SJ, London GM: Arterial calcifications, arterial stiffness and cardiovascular risk in end-stage renal disease. Hypertension 38: 938-942, 2001
11. Oh J, Wunch R, Turzer M, Bahner M, Raggi P, Querfeld U, Mehls O, Schaefer: Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation 106: 100-105, 2002
12. Wang A, Wang M, Woo J, Lam CW, Li PK, Lui SJ, Sanderson JE: Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients. J Am Soc Nephrol 14: 159-168, 2003
13. Nguyen P, Henrard S, Coche E, Goffin E, Devuyst O, Jadoul M: Coronary artery calcification: A strong predictor of cardiovascular events in renal transplant recipients. Nephrol Dial Transplant 25: 3773-3778, 2010
14. Shroff RC, McNair R, Skepper JN, Figg N, Schurgers LJ, Deanfield J, Rees L, Shanahan CM: Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. J Am Soc Nephrol 21: 103-112, 2010
15. Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM: Human vascular smooth muscle cells undergo vesiclemediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcifications in ESRD. J Am Soc Nephrol 15: 2857-2867, 2004
16. Amann K: Media calcification and intima calcification are distinct entities in CKD. Clin J Am Soc Nephrol 3: 1599-1605, 2008
17. Schlieper G, Westenfeld R, Brandenburg V, Ketteler M: Inhibitors of calcification in blood and urine. Semin Dial 20: 113-121, 2007
18. Triffit JT, Gebauer I, Ashton BA, Owen ME, Reynolds JJ: Origin of plasma alpha2HS-glycoprotein and its accumulation in bone. Nature 262: 226-227, 1976
19. Lebreton JP, Joisel F, Raoult JP, Lannuzel B, Rogez JP, Humbert G: Serum concentration of human alpha 2 HS glycoprotein during the inflammatory process: Evidence that alpha 2 HS glycoprptein is a negative acute-phase reactant. J Clin Invest 64: 1118-1129, 1979
20. Schafer C, Heiss A, Schwarz A, Westenfeld R, Ketteler M, Floege J, Muller-Esterl W, Schinke T, Jahnen-Dechent W: The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin- A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 112: 357-366, 2003
21. Westenfeld R, Schfer C, Krüger T, Haarmann C, Schurgers LJ, Reutelingsperger C et al. Fetuin-A protects against atherosclerotic calcification in CKD. J Am Soc Nephrol 20: 1264-1274, 2009
22. Price PA, Lim JE: The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin mineral complex. J Biol Chem 278: 22144-22152, 2003
23. Reynolds JL, Skepper JN, McNair R, Kasama T, Gupta K, Weissberg PL, Jahnen-Dechent W, Shanahan CM: Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol 16: 2920-2930, 2005
24. Ketteler M, Bongartz P, Westenfeld R, Wildberger JE, Mahnken AH, Böhm R, Metzger T, Wanner C, Jahnen-Dechent W, Floege J: Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: A cross-sectional study. Lancet 361: 827-833, 2003
25. Stenvinkel P, Wang K, Qureshi AR, Axelsson J, Pecoits-Filho R, Gao P, Barany P, Lindholm B, Jogestrand T, Heimburger O, Holmes C, Schalling M, Nordfors L: Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int 67: 2383-2392, 2005
26. Wang AYM, Woo J, Lam CWK, Wang M, Chan IH, Gao P, Lui SF, Li PK, Sanderson JE: Associations of serum fetuin-A with malnutrition atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial Transplant 20: 1676-1685, 2005
27. Hermans MMH, Brandenburg V, Ketteler M, Kooman JP, van der Sande FM, Boeschoten EW, Leunissen KM, Krediet RT, Dekker FW; Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD): Association of serum fetuin-A levels with mortality in dialysis patients. Kidney Int 72: 202-207, 2007
28. Nguyen PT, Coche E, Goffin E, Beguin C, Vlassenbroek A, Devuyst O, Robert A, Jadoul M: Prevalence and determinants of coronary and aortic calcifications assessed by chest CT in renal transplant recipients. Am J Nephrol 27: 329-335, 2007
29. Kasiske BL, Guijarro C, Massy ZA, Wiederkehr MR, Ma JZ: Cardiovascular disease after renal transplantation. J Am Soc Nephrol 7: 158-165, 1996
30. van Summeren MJ, Hameleers JM, Schurgers LJ, Hoeks AP, Uiterwall CS, Kruger T, Vermeer C, Kuis W, Lilien MR: Circulating calcification inhibitors and vascular properties in children after renal transplantation. Pediatr Nephrol 23: 985- 993, 2008
31. Urbanová M, Kalousová M, Zima T, Skibová J, Wohlfahrt P, Viklický O: Fetuin-A early after renal transplantation. Kidney Blood Press Res 32: 217-222, 2009
32. Metry G, Stenvinkel P, Qureshi AR, Carrero JJ, Yilmaz MI, Barany P, Snaedal S, Heimberger O, Lindholm B, Suliman ME: Low serum fetuin-A concentration predicts poor outcomeonly in the presence of inflammation in prevalent haemodialysis patients. Eur J Clin Invest 38: 804-811, 2008
33. Weikert C, Stefan N, Schulze MB, Pischon T, Berger K, Joost HG, Haring HU, Boeing H, Fritsche A: Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation 118: 2555-2562, 2008
34. Chen HY, Chiu YL, Hsu SP, Pai MF, Lai CF, Peng YS, Kao TW, Hung KY, Tsai TJ, Wu KD: Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients. Eur J Endocrinol 160: 777-783, 2009
35. Jenkins NT, McKenzie JA, Hagberg JM, Witkowski S: Plasma fetuin-A concentrations in young and older high- and lowactive men. Metabolism, 2010 March 2 [Epub ahead of print]
36. Mehrotra R, Westenfeld R, Christenson P, Budoff M, Ipp E, Takasu J, Gupta A, Norris K, Ketteler M, Adler S: Serum fetuin- A in non dialyzed patients with diabetic nephropathy: Relationship with coronary artery calcification. Kidney Int 67: 1070-1077, 2005
37. Reinehr T, Roth CL: Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab 93: 4479-4485, 2008
38. El-Zayadi AR: Heavy smoking and liver. World J Gastroenterol 12: 6098-6101, 2006
39. Mehrota R: Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int 72: 137-140, 2007
40. Shroff RC, Shah V, Hiorns MP, Schoppet M, Hofbauer LC, Hawa G, Schurgers LJ, Singhal A, Merryweather I, Brogan P, Shanahan C, Deanfield J, Rees L: The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis. Nephrol Dial Transplant 23: 3263-3271, 2008
41. Wang AY, Lam CW, Chan IH, Wang M, Lui SF, Sanderson JE: Long-term mortality and cardiovascular risk stratification of peritoneal dialysis patients using a combination of inflammation and calcification markers. Nephrol Dial Transplant 24: 3826-3833, 2009
42. Schlieper G, Aretz A, Verberckmoes SC, Krü ger T, Behets GJ, Ghadimi R, Weirich TE, Rohrmann D, Langer S, Tordoir JH, Amann K, Westerfeld R, Brandenburg VM, D'Haese PC, Mayer J, Ketteler M, McKee MD, Floege J: Ultrastructural analysis of vascular calcifications in uremia. J Am Soc Nephrol 21: 689-696, 2010
43. Post W, Bielak LF, Ryan KA, Cheng YC, Shen H, Rumberger JA, Sheedy PF II, Shuldner AR, Peyser PA, Mitchell BD: Determinants of coronary artery and aortic calcification in the Old Order Amish. Circulation 115: 717-724, 2007
44. de Mattos AM, Prather J, Olyaei AJ, Shibagaki Y, Keith DS, Mori M, Norman DJ, Becker T: Cardiovascular events following renal transplantation: Role of traditional and transplantspecific risk factors. Kidney Int 70: 757-764, 2006
45. Verhave JC, Gansevoort RT, Hillege HL, De Zeeuw D, Curhan GC, De Jong PE: Drawbacks of the use of indirect estimates of renal function to evaluate the effect of risk factors on renal function. J Am Soc Nephrol 15: 1316-1322, 2004