Herb-drug interaction between the extract of Hibiscus sabdariffa L. and hydrochlorothiazide in experimental animals

Journal of Medicinal Food

Volumn 14, Issue 6, 2011, Pages 640-644

  Ndu, Okechukwu O ^a   Nworu, Chukwuemeka S ^a   Ehiemere, Chinwendu O ^a   Ndukwe, Nichola C ^a   Ochiogu, Izuchukwu S ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Herb drug interactions; herbal beverages; Hibiscus sabdariffa; hydrochlorothiazide

Indexed keywords

BICARBONATE; CHLORIDE ION; HIBISCUS SABDARIFFA EXTRACT; HYDROCHLOROTHIAZIDE; SODIUM ION;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIURESIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; HERB DRUG INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; URINARY EXCRETION; URINE PH; URINE VOLUME;

ANIMALS; ANTIHYPERTENSIVE AGENTS; DISEASE MODELS, ANIMAL; FEMALE; HERB-DRUG INTERACTIONS; HIBISCUS; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; MALE; MICE; PLANT EXTRACTS; RABBITS; RATS; URINATION;

ANIMALIA; HIBISCUS SABDARIFFA; MALVACEAE; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 79957814913     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2010.0117     Document Type: Article

References (16)

1. Abu-Tarboush HM, Ahmed SA, Al Kahtani HA: Some nutritional and functional properties of karkade (Hibiscus sabdariffa) seed products. Cereal Chem 1997;74:352-355.
2. Haruna AK: Cathartic activity of soborodo: the aqueous extract of calyx of Hibiscus sabdariffa L. Phytother Res 1997;11:307-308.
3. Haji Faraji M, Haji Tarkhani AH: The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J Ethnopharmacol 1999;65:231-236.
4. Ali BH, Al Wabel N, Blunden G: Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res 2005;19:369-375.
5. Leung AY: Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. John Wiley, New York, 1980.
6. Odigie IP, Ettarh RR, Adigun SA: Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats. J Ethnopharmacol 2003;86:181-185.
7. Herrera-Arellano A, Flores-Romero S, Chavez Soton MA, Tortorielleo J: Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 2004;11:375-382.
8. Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR: Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol 2007;109:388-393.
9. Mojiminiyi FB, Dikko M, Muhammad BY, Ojobor PD, Ajagbonna OP, Okolo RU, Igbokwe UV, Mojiminiyi UE, Fagbemi MA, Bello SO, Anga TJ: Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa. Fitoterapia 2007;78:292-297.
10. Herrera-Arellano A, Miranda-Sánchez J, Avila-Castro P, Herrera-Alvarez S, Jimenez Ferrer JE, Zamilpa A, Roman-Ramos R, Ponce-Monter H, Tortoriello J: Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med 2007;73:6-12.
11. Harbourne JB: Phytochemical Methods: A Guide to Modern Technique of Plant Analysis, 2nd ed. Chapman and Hall, London, 1984, p. 282.
12. Lorke D: A new approach to practical acute toxicity testing. Arch Toxicol 1983;54:275-287.
13. Rowland M, Tozer TN: Clinical Pharmacokinetics: Concepts and Applications. Lippincott Williams and Wilkins, Philadelphia, 1995.
14. Galinsky RE, Svensson CK: Basic pharmacokinetics. In: Remington: The Science and Practice of Pharmacy, 20th ed. (Gennaro AR, ed.). Lippincott Williams and Wilkins, Philadelphia, 2000, pp. 1127-1144.
15. Askari A, Mirza M, Solangi MSP: Toxicological studies of herbal beverage and seeds extract of Hibiscus sabdariffa L. (Roselle). Pak J Sci Ind Res 1996;39:38-42.
16. Onyenekwe PC, Ajani, EO, Ameh DA, Gamaniel KS: Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochem Funct 1999;17:199-206.