Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-D-aspartate receptor 3α5β-pregnanolone glutamate

Neuropharmacology

Volumn 61, Issue 1-2, 2011, Pages 61-68

  Rambousek, Lukas ^a,c,e   Bubenikova Valesova, Vera ^a,c   Kacer, Petr ^e   Syslova, Kamila ^e   Kenney, Jana ^a   Holubova, Kristina ^a   Najmanova, Vera ^e   Zach, Petr ^d   Svoboda, Jan ^a   Stuchlik, Ales ^a   Chodounska, Hana ^b   Kapras, Vojtech ^b   Adamusova, Eva ^a   Borovska, Jirina ^a   Vyklicky, Ladislav ^a   Vales, Karel ^a,c  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

Author keywords

3 5 Pregnanolone glutamate; Cognitive function; Glutamate excitotoxicity; Neuroactive steroid; Neuroprotectivity

Indexed keywords

20 OXO 5BETA PREGNAN 3ALPHA YL GLUTAMYL 1 ESTER; 3ALPHA 5BETA PREGNANOLONE GLUTAMATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR DISORDER; BLOOD BRAIN BARRIER; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; EXCITOTOXICITY; HIPPOCAMPUS; LOCOMOTION; MALE; MAXIMUM PLASMA CONCENTRATION; NERVE CELL LESION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SENSORY GATING; STARTLE REFLEX; SUBICULUM; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; MALE; MOTOR ACTIVITY; NEURONS; PREGNANOLONE; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS; RECEPTORS, N-METHYL-D-ASPARTATE; STEROIDS;

EID: 79957803675     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.02.018     Document Type: Article

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