SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism

Journal of Neuroscience Research

Volumn 89, Issue 8, 2011, Pages 1259-1266

  Chu, Hong Yuan ^a   Wu, Qianqian ^a   Zhou, Shanglin ^a   Cao, Xiaohua ^b   Zhang, Ao ^a   Jin, Guo Zhang ^a   Hu, Guo Yuan ^a   Zhen, Xuechu ^a,c  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Excitatory postsynaptic potential; Neuroprotection; Parkinson's disease; SKF83959; Voltage gated Na+ channel

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 3 METHYL 1 (3 METHYLPHENYL) 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR; DOPAMINE RECEPTOR; GLUTAMIC ACID; GUANOSINE DIPHOSPHATE; GUANOSINE DIPHOSPHATE BETA; MESULERGINE; PHOSPHATIDYLINOSITOL; PRAZOSIN; RACLOPRIDE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIALYSIS; DRUG ANTAGONISM; DRUG EFFECT; HIPPOCAMPUS; IC 50; MALE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SYNAPTIC TRANSMISSION;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ANIMALS; BENZAZEPINES; CELLS, CULTURED; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; MALE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE; SYNAPTIC TRANSMISSION;

EID: 79957800248     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22653     Document Type: Article

References (47)

1. 2+ channels of the cell membrane as targets of neuroprotective substances. Adv Exp Med Biol 513: 161-181.
2. Andersen P, Silfvenius H, Sundberg SH, Sveen O, Wigström H. 1978. Functional characteristics of unmyelinated fibres in the hippocampal cortex. Brain Res 144: 11-18.
3. 1 receptor antagonist in primate cells and interacts with other receptors. Eur J Pharmacol 364: 33-41.
4. 1 antagonist SKF 83959 in bilaterally MPTP-treated rhesus monkeys: stable therapeutic effects and wearing-off dyskinesia. Psychopharmacology 146: 328-334.
5. + channel blocker in the hippocampus. Nature 349: 67-69.
6. 1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. Eur J Pharmacol 213: 259-267.
7. Braunewell KH, Manahan-Vaughan D. 2001. Long-term depression: a cellular basis for learning? Rev Neurosci 12: 121-140.
8. 2+-dependent intracellular signaling. J Neurophysiol 97: 2448-2464.
9. + channel: a potential mechanism for their neuroprotective effects. PLoS ONE 4: e5811.
10. Christian H. 1999. Synaptic plasticity and learning and memory: LTP and beyond. J Neurosci Res 58: 62-75.
11. Chu HY, Gu Q, Jin GZ, Hu GY, Zhen X. 2010. Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects. PLoS One 5: e13118.
12. 1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology 42: 237-245.
13. Gao Z-B, Chen X-Q, Hu G-Y. 2006. Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus. Brain Res 1111: 41-47.
14. Gasparini S, DiFrancesco D. 1997. Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons. Pflugers Arch 435: 99-106.
15. + channels. Nat Neurosci 12: 577-584.
16. 1-type dopamine receptor activation. J Neurosci 29: 15001-15016.
17. Hsu KS. 1996. Characterization of dopamine receptors mediating inhibition of excitatory synaptic transmission in the rat hippocampal slice. J Neurophysiol 76: 1887-1895.
18. 1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc Natl Acad Sci U S A 89: 11988-11992.
19. Ito HT, Schuman EM. 2007. Frequency-dependent gating of synaptic transmission and plasticity by dopamine. Front Neural Circuits 1: 1-13.
20. Jay TM. 2003. Dopamine: a potential substrate for synaptic plasticity and memory mechanisms. Prog Neurobiol 69: 375-390.
21. 1 dopamine receptors in rat brain. J Neurochem 85: 378-386.
22. Kobayashi K, Suzuki H. 2007. Dopamine selectively potentiates hippocampal mossy fiber to CA3 synaptic transmission. Neuropharmacology 52: 552-561.
23. Kress GJ, Mennerick S. 2009. Action potential initiation and propagation:upstream influences on neurotransmission. Neuroscience 158: 211-222.
24. + channel blockers. Brain Res 637: 349-355.
25. 1 dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses. Neuropharmacology 57: 164-171.
26. Magee JC. 1998. Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J Neurosci 18: 7613-7624.
27. 2 dopamine receptor mRNA in rat brain. Proc Natl Acad Sci U S A 86: 7625-7628.
28. Meador-Woodruff JH, Mansour A, Grandy DK, Damask SP, Civelli O, Watson SJJr. 1992. Distribution of D5 dopamine receptor mRNA in rat brain. Neurosci Lett 145: 209-212.
29. Meeks JP, Mennerick S. 2004. Selective effects of potassium elevations on glutamate signaling and action potential conduction in hippocampus. J Neurosci 24: 197-206.
30. Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Ruther E, Huether G. 2000. Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood. Brain Res Dev Brain Res 119: 251-257.
31. 1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol 474: 137-140.
32. 1-like receptor. Neuroscience 138: 475-485.
33. 1-like receptors: behavioural topography. Eur J Pharmacol 486: 273-280.
34. Otmakhova NA, Lisman JE. 1999. Dopamine selectively inhibits the direct cortical pathway to the CA1 hippocampal region. J Neurosci 19: 1437-1445.
35. 35S]GTP-γ-S binding and phosphoinositide hydrolysis in rat and monkey brain. Neuropharmacology 40: 826-837.
36. Rosenkranz JA, Johnston D. 2006. Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex. JNeurosci 26: 3229-3244.
37. 1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons. J Physiol 581: 981-1000.
38. Rothstein JD, Kuncl RW. 1995. Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J Neurochem 65: 643-651.
39. Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW. 1993. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci U S A 90: 6591-6595.
40. Sahu A, Tyeryar KR, Vongtau HO, Sibley DR, Undieh AS. 2008. D5 dopamine receptors are required for dopaminergic activation of phospholipase C. Mol Pharmacol 75: 447-453.
41. Taft WC, Clifton GL, Blair RE, DeLorenzo RJ. 1989. Phenytoin protects against ischemia-produced neuronal cell death. Brain Res 483: 143-148.
42. + channels as targets for neuroprotective drugs. Trends Pharmacol Sci 16: 309-316.
43. Thomson AM. 2000. Facilitation, augmentation and potentiation at central synapses. Trends Neurosci 23: 305-312.
44. Yu FH, Catterall WA. 2003. Overview of the voltage-gated sodium channel family. Genome Biol 4: 207.
45. 1 receptor-dependent inhibition of glycogen synthase kinase-3β; and a receptor-independent anti-oxidative action. J Neurochem 104: 946-956.
46. Zhang H, Ma L, Wang F, Chen J, Zhen X. 2007. Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. Neuropharmacology 53: 125-133.
47. Zucker RS. 1989. Short-term synaptic plasticity. Annu Rev Neurosci 12: 13-31.