5 versus 10 days of treatment with ceftriaxone for bacterial meningitis in children: A double-blind randomised equivalence study

The Lancet

Volumn 377, Issue 9780, 2011, Pages 1837-1845

  Molyneux, Elizabeth ^a   Nizami, Shaikh Qamaruddin ^b   Saha, Samir ^c   Huu, Khanh Truong ^d   Azam, Matloob ^e   Bhutta, Zulfiqar Ahmad ^b   Zaki, Ramadan ^f   Weber, Martin Willi ^g   Qazi, Shamim Ahmad ^g  

^a UNIVERSITY OF MALAWI   (Malawi)

^b AGA KHAN UNIVERSITY   (Pakistan)

^c DHAKA SHISHU HOSPITAL   (Bangladesh)

^d Children's Hospital No 1   (Viet Nam)

^e National University of Medical Sciences   (Pakistan)

^f ABBASSIA FEVER HOSPITAL   (Egypt)

^g WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; DEXAMETHASONE; PLACEBO; STEROID;

ADJUVANT THERAPY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; BACTERIAL MENINGITIS; BACTERIUM CULTURE; BLOOD CULTURE; CEREBROSPINAL FLUID CULTURE; CHILD; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DOSAGE SCHEDULE COMPARISON; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HAEMOPHILUS INFLUENZAE TYPE B; HEARING IMPAIRMENT; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEISSERIA MENINGITIDIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEIZURE; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 79957799324     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(11)60580-1     Document Type: Article

References (50)

1. WHO World Health Statistics 2006 2006 World Health Organization Geneva
2. M Ramakrishnan, A Ulland, LC Sreinhardt, JC Moisi, F Were, OS Levine Sequelae due to bacterial meninigitis among African children: a systematic literature review BMC Med 7 2009 47
3. D Lehmann, W Yeka, T Rongap Aetiology and clinical signs of bacterial meningitis in children admitted to Goroka Base Hospital, Papua New Guinea, 1989-1992 Ann Trop Paediatr 19 1999 21 32 (Pubitemid 29116563)
4. A Palmer, M Weber, K Bojang, T McKay, RA Adegbola Acute bacterial meningitis in The Gambia J Trop Pediatr 45 1999 51 53
5. E Molyneux, A Walsh, A Phiri, M Molyneux Acute bacterial meningitis in children admitted to the Queen Elizabeth Central Hospital, Blantyre, Malawi in 1996-97 Trop Med Int Health 3 1998 610 618 (Pubitemid 28394590)
6. WHO Antimicrobial and support therapy for meninigitis in children 1998 World Health Organization Geneva
7. G Hussey, H Schaaf, D Hanslo Epidemiology of post-neonatal bacterial meningitis in Cape Town children S Afr Med J 87 1997 51 56 (Pubitemid 27101993)
8. KL O'Brien, LJ Wolfson, JP Watt Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates Lancet 374 2009 893 902
9. JP Watt, LJ Wolfson, KL O'Brien Burden of disease caused by Haemophilus influenzae in children younger than 5 years: global estimates Lancet 374 2009 903 911
10. CJ Murray, AD Lopez Mortality by cause for eight regions of the world: Global Burden of Disease Study Lancet 349 1997 1269 1276 (Pubitemid 27192468)
11. T Goetghebuer, TE West, V Wermenbol Outcome of meningitis caused by Streptococcus pneumoniae and Haemophilus influenzae type b in children in The Gambia Trop Med Int Health 5 2000 207 213 (Pubitemid 30196234)
12. H Goto, K Shimada, H Ikemoto, P Oguri Antimicorbial susceptibility of pathogens isolated from more than 10,000 patients with infectious respiratory diseases: a 25 year longitudinal study J Infect Chemother 15 2009 347 360
13. PA Velasquez, L Parussolo, CL Cardoso, MC Togmin, LB Garcia High prevalence of children colonized with penicillin-resistant Streptococcus pneumoniae in public day-care centers J Pediatr (Rio J) 85 2009 516 522 (in Portuguese).
14. A Kisakye, I Makumbi, D Nansera Surveillance for Streptococcus pneumoniae meningitis in children aged <5 years: implications for immunization in Uganda Clin Infect Dis 48 suppl 2 2009 S153 S161
15. S Mudhune, M Wamae Network Surveillance Pneumococcal Disease in the East African Region Report on invasive disease and meningitis due to Haemophilus influenzae and Streptococcus pneumonia from the Network for Surveillance of Pneumococcal Disease in the East African Region Clin Infect Dis 48 suppl 2 2009 S147 S152
16. KP Klugman Pneumococcal resistance to the third generation cephalosporins: clinical, laboratory and molecular aspects Int J Antimicrob Agents 4 1994 63 67 (Pubitemid 24084994)
17. E O'Neill, H Humphreys, J Phillips, EG Smyth Third-generation cephalosporin resistance among gram-negative bacilli causing meningitis in neurosurgical patients: significant challenges in ensuring effective antibiotic therapy J Antimicrob Chemother 57 2006 356 359 (Pubitemid 43160184)
18. E Martin, JR Koup, U Paravicini, K Stoeckel Pharmacokinetics of ceftriaxone in neonates and infants with meningitis J Pediatr 105 1984 475 481 (Pubitemid 14072140)
19. NI Girgis, AH Abu el Ella, Z Farid, RL Haberberger, FS Galal, JN Woody Intramuscular ceftriaxone versus ampicillin-chloramphenicol in childhood bacterial meningitis Scand J Infect Dis 20 1988 613 617 (Pubitemid 19022184)
20. M Radetsky Duration of treatment in bacterial meningitis: a historical inquiry Pediatr Infect Dis J 9 1990 2 9 (Pubitemid 20157094)
21. HP Lambert Don't keep taking the tablets? Lancet 354 1999 943 945 (Pubitemid 29424035)
22. C Visintin, MA Mugglestone, EJ Fields Management of bacterial meningitis and meningococcal septicaemia in children and young people: summary of NICE guidance BMJ 340 2010 c3209
23. RD Feigin, E Pearlman Bacterial meningitis beyond the neonatal period RD Feigin JD Cherry Textbook of Pediatric Infectious Diseases 3rd edn. 1992 WB Saunders Co Philadelphia, PA 400 430
24. N Nathan, T Borel, A Djibo Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study Lancet 366 2005 308 313 (Pubitemid 41019420)
25. K Marhoum el Filali, M Noun, A Chakib, M Zahraoui, H Himmich Ceftriaxone versus penicillin G in short-term treatment of meningococcal meningitis in adults Eur J Clin Microbiol Infect Dis 12 1993 766 768 (Pubitemid 23326557)
26. JC Auvergnat, JY Le Tallec, B Marchou, P Massip, JP Carriere, M Armengaud Shortened antibiotic therapy of menningococcal meningitis: 5-day administration of ceftriaxone Pathol Biol (Paris) 36 1988 735 737 (in French).
27. PF Viladrich, R Pallares, J Ariza, G Rufi, F Gudiol Four days of penicillin therapy for meningococcal meningitis Arch Intern Med 146 1986 2380 2382 (Pubitemid 17226093)
28. TY Lin, DF Chrane, JD Nelson, GH McCracken Jr Seven days of ceftriaxone therapy is as effective as ten days' treatment for bacterial meningitis JAMA 253 1985 3559 3563 (Pubitemid 15057007)
29. E Martin, P Hohl, T Guggi, FH Kayser, M Fernex Short course single daily ceftriaxone monotherapy for acute bacterial meningitis in children: results of a Swiss multicenter study. Part I: Clinical results Infection 18 1990 70 77 (Pubitemid 20123446)
30. I Roine, W Ledermann, LM Foncea, A Banfi, J Cohen, H Peltola Randomized trial of four vs seven days of ceftriaxone treatment for bacterial meningitis in children with rapid initial recovery Pediatr Infect Dis J 19 2000 219 222 (Pubitemid 30167442)
31. P Singhi, M Kaushal, S Singhi, P Ray Seven days vs 10 days ceftriaxone therapy in bacterial meningitis J Trop Pediatr 48 2002 273 279 (Pubitemid 35189763)
32. H Sholtz, T Hofmann, R Noack, DJ Edwards, K Stoeckel Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children Chemotherapy 44 1998 142 147 (Pubitemid 28105428)
33. I Lutsar, A Gontmachr, M Narska Five days of antibacterial therapy for bacterial meningitis in children? Infection 23 1995 113 118
34. I Lutsar, A Gontmachr, M Narska Five days of antibacterial therapy for bacterial meningitis in children? Infection 23 1995 113 118
35. T Jadavji, WD Biggar, R Gold, CG Prober Sequelae of acute bacterial meningitis in children treated for seven days Pediatrics 78 1986 21 25 (Pubitemid 16070212)
36. E Martin, P Hohl, T Guggi, FH Kayser, M Fernex Short course single daily ceftriaxone monotherapy for acute bacterial meningitis in children: results from a Swiss multicenter study. Part 1: Clinical results Infection 18 1990 70 77 (Pubitemid 20123446)
37. RJ Simeonsson, D Lollar, M Hollowell Revision of the International Classification of Impairments, Disabilities, and Handicaps: developmental issues J Clin Epidemiol 53 2000 113 124 (Pubitemid 30151216)
38. J Squires, D Bricker, LW Potter Revision of a parent-completed developmental screening tool: ages and stages questionnaires J Pediatr Psychol 22 1997 313 328 (Pubitemid 27264025)
39. WHO Chapter 5: Bacteriological media - Guidelines on Standard Operating Procedures for Microbiology 2006 World Health Organization Geneva http://www.searo.who.int/en/Section10/Section17/Section53/Section482-1782.htm (accessed April 4, 2011).
40. MA Wikler, JF Hindler, FR Cockerill Performance standards for antimicrobial disk susceptibility tests approved standard - tenth edition 2009 Clinical Laboratory Standard Institute Wayne, PA
41. AR Trunkel, WM Scheld Pathogenesis and pathophysiology of bacterial meningitis Clin Microbiol Rev 6 1993 118 136
42. DE Karageorgopoulos, PE Valkimadi, A Kapaskelis, PI Rafailidis, ME Falagas Short versus long duration of antibiotic therapy for bacterial meningitis: a meta-analysis of randomised controlled trials in children Arch Dis Child 94 2009 607 614
43. JW Kutz, LM Simon, SK Chennupati, CM Giannoni, S Manolidis Clinical predictors for hearing loss in children with bacterial meningitis Arch Otolaryngol Head Neck Surg 132 2006 941 945 (Pubitemid 44423375)
44. H Forsyth, F Kalumbi, E Mphaka Hearing loss in Malawian children after bacterial meningitis: incidence and risk factors Audiol Med 2 2004 100 107 (Pubitemid 38955059)
45. SA Qazi, MA Khan, N Mughal Dexamethasone and bacterial meningitis in Pakistan Arch Dis Child 75 1996 482 488 (Pubitemid 27008207)
46. HM Fortnum Hearing impairment after bacterial meningitis: a review Arch Dis Child 67 1992 1128 1133
47. M Eisenhut, T Meehan Risk factors for hearing loss in bacterial meningitis: delay in treatment and clinical manifestations Audiol Med 11 2002 86 97 (Pubitemid 35335121)
48. P Daza, R Banda, K Misoya The impact of routine infant immunization with Haemophilus influenzae type b conjugate vaccine in Malawi, a country with high human immunodeficiency virus prevalence Vaccine 24 2006 6232 6239 (Pubitemid 44262417)
49. EH Price, J de Louvois, MR Workman Antibiotics for Salmonella meningitis in children J Antimicrob Chemother 46 2006 653 655
50. AAP Salmonella infections G Peter Report of the Committee on Infectious Diseases 25th edn. 2000 American Academy of Pediatrics Elk Grove Village, IL