A comparison of the effect of aprotinin and ε-aminocaproic acid on renal function in children undergoing cardiac surgery

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 25, Issue 3, 2011, Pages 402-406

  Leyvi, Galina ^a   Nelson, Olivia ^a   Yedlin, Adam ^a   Pasamba, Michelle ^a   Belamarich, Peter F ^a   Nair, Singh ^a   Cohen, Hillel W ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

acute kidney injury; antifibrinolytic agents; creatinine; pediatric cardiac surgery

Indexed keywords

AMINOCAPROIC ACID; APROTININ; CREATININE; FRESH FROZEN PLASMA;

ACUTE KIDNEY FAILURE; AGE; AORTA SURGERY; AORTOPULMONARY SHUNT; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BODY FLUID; BODY WEIGHT; CARDIOPULMONARY BYPASS; CHILD; COMPARATIVE STUDY; CONTINUOUS INFUSION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG FATALITY; HEART SURGERY; HUMAN; INCIDENCE; INFANT; KIDNEY FAILURE; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; OPERATION DURATION; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; THROMBOCYTE; TUBE; VOLUMETRY;

6-AMINOCAPROIC ACID; ACUTE KIDNEY INJURY; AGE FACTORS; APROTININ; CARDIAC SURGICAL PROCEDURES; CHILD; CHILD, PRESCHOOL; CREATINE; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INFANT; KIDNEY FUNCTION TESTS; MALE; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 79957784206     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2011.01.015     Document Type: Article

References (18)

1. Mangano D, Tudor IC, Deitzel C: The risk associated with aprotinin in cardiac surgery. N Engl J Med 354:353-365, 2006 (Pubitemid 43145060)
2. Mangano DT, Miao Y, Vuylsteke A, et al: Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 297:471-479, 2007
3. Backer CL, Kelle AM, Stewart RD, et al: Aprotinin is safe in pediatric patients undergoing cardiac surgery. J Thorac Cardiovasc Surg 134:1421-1428, 2007 (Pubitemid 350110450)
4. Szekely A, Sapi E, Breuer T, et al: Aprotinin and renal dysfunction after pediatric cardiac surgery. Pediatr Anesth 18:151-159, 2008
5. Williams GD, Ramamoorthy C, Pentcheva K, et al: A randomized, controlled trial of aprotinin in neonates undergoing open-heart surgery. Pediatr Anesth 18:812-819, 2008
6. Kramer HJ, Dusing R, Glanzer K, et al: Effects of aprotinin on renal function. Contrib Nephrol 42:233-241, 1984
7. Manrique A, Jooste EH, Kuch BA, et al: The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass. Anesth Analg 109:45-52, 2009
8. Zappitelli M, Bernier P-L, Saczkowski RS, et al: A small postoperative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery. Kidney Int 76:885-892, 2009
9. Bayer Healthcare Pharmaceuticals communication (Leverkussen GaWH, CT). Available at: http://www.trasylol.com. Accessed July 2009
10. Williams GD, Bratton SL Riley EC, et al: Efficacy of ε-aminocaproic acid in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 13:304-308, 1999 (Pubitemid 29283382)
11. Ricci Z, Cruz D, Ronco C: The RIFLE criteria and mortality in acute kidney injury: A systematic review. Kidney Int 73:538-546, 2008 (Pubitemid 351264114)
12. Venkataraman R, Kellum JA: Defining acute renal failure: The RIFLE criteria. J Intensive Care Med 22:187-193, 2007 (Pubitemid 47094112)
13. Akcan-Arikan A, Zappitelli M, Loftis LL, et al: Modified RIFLE criteria in critically ill child with acute kidney injury. Kidney Int 71:1028-1035, 2007 (Pubitemid 46741996)
14. Guzzetta NA, Evans FM, Rosenberg ES, et al: The impact of aprotinin on postoperative renal dysfunction in neonates undergoing cardiopulmonary bypass: A retrospective analysis. Anesth Analg 108:448-455, 2009
15. Mak RH: Acute kidney injury in children: The dawn of a new era. Pediatr Nephrol 23:2147-2149, 2008
16. Askenazi DJ, Bunchman TE: Pediatric acute kidney injury: The use of the RIFLE criteria. Kidney Int 71:963-964, 2007 (Pubitemid 46741997)
17. Askenazi DJ, Feig DI, Graham NM, et al: 3-5 year longitudinal follow-up of pediatric patients after acute renal failure. Kidney Int 69:184-189, 2006 (Pubitemid 43117757)
18. Shaw NJ, Brocklebank JT, Dickinson DF, et al: Long-term outcome for children with acute renal failure following cardiac surgery. Int J Cardiol 31:161-165, 1991