TGF-β signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 21, 2011, Pages 8668-8673

  Cipriano, Rocky ^a   Kan, Charlene E ^b   Graham, James ^a   Danielpour, David ^a   Stampfer, Martha ^c   Jackson, Mark W ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Breast cancer; Tumor suppressor

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 2; PROTEIN P53; RAS PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BREAST EPITHELIUM; CELL AGING; CELL PROLIFERATION; DNA DAMAGE; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL AGING; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA-BINDING PROTEINS; EPITHELIAL CELLS; HUMANS; MAMMARY GLANDS, HUMAN; PROTEIN-SERINE-THREONINE KINASES; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 79957772521     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015022108     Document Type: Article

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