Epsilon-like waves and ventricular conduction abnormalities in subjects with type 1 ECG pattern of Brugada syndrome

Heart Rhythm

Volumn 8, Issue 6, 2011, Pages 874-878

  Letsas, Konstantinos P ^a,b   Efremidis, Michael ^a   Weber, Reinhold ^b   Korantzopoulos, Panagiotis ^c   Protonotarios, Nikos ^d   Prappa, Efstathia ^a   Kounas, Stavros P ^a   Evagelidou, Eleni N ^c   Xydonas, Sotirios ^a   Kalusche, Dietrich ^b   Sideris, Antonios ^a   Arentz, Thomas ^b  

^a EVANGELISMOS HOSPITAL   (Greece)

^b UNIVERSITY HEART CENTER FREIBURG BAD KROZINGEN   (Germany)

^c UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^d Yannis Protonotarios Foundation   (Greece)

Author keywords

Arrhythmogenic right ventricular cardiomyopathy dysplasia; Brugada syndrome; Epsilon waves

Indexed keywords

SODIUM CHANNEL BLOCKING AGENT;

ADULT; ARTICLE; BRUGADA SYNDROME; DEFIBRILLATOR; ELECTROCARDIOGRAM; EPSILON LIKE WAVE; FAMILY HISTORY; FEMALE; FOLLOW UP; HEART ELECTROPHYSIOLOGY; HEART RIGHT VENTRICLE DYSPLASIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; MALE; MEDICAL RECORD; NORMAL HUMAN; PRIORITY JOURNAL; QRS COMPLEX; RETROSPECTIVE STUDY; SUDDEN DEATH; SYNCOPE;

ADULT; BRUGADA SYNDROME; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; MALE; RETROSPECTIVE STUDIES; SODIUM CHANNEL BLOCKERS; VENTRICULAR FUNCTION, RIGHT;

EID: 79957690990     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.01.043     Document Type: Article

References (34)

1. Marcus FI, McKenna WJ, Sherrill D, et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J 2010;31:806-814.
2. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report. J Am Coll Cardiol 1992;20:1391-1396.
3. Benito B, Brugada R, Brugada J, Brugada P. Brugada syndrome. Prog Cardiovasc Dis 2008;51:1-22. (Pubitemid 351965498)
4. Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005;111:659-670.
5. Corrado D, Basso C, Buja G, Nava A, Rossi L, Thiene G. Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people. Circulation 2001;103:710-717. (Pubitemid 32144200)
6. Corrado D, Nava A, Buja G, et al. Familial cardiomyopathy underlies syndrome of right bundle branch block, ST segment elevation and sudden death. J Am Coll Cardiol 1996;27:443-448. (Pubitemid 26045511)
7. Tada H, Aihara N, Ohe T, et al. Arrhythmogenic right ventricular cardiomyopathy underlies syndrome of right bundle branch block, ST-segment elevation, and sudden death. Am J Cardiol 1998;81:519-522. (Pubitemid 28106965)
8. Peters S, Trümmel M, Denecke S, Koehler B. Results of ajmaline testing in patients with arrhythmogenic right ventricular dysplasia- cardiomyopathy. Int J Cardiol 2004;95:207-210. (Pubitemid 38757628)
9. Frustaci A, Priori SG, Pieroni M, et al. Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. Circulation 2005;112:3680-3687. (Pubitemid 43739507)
10. Cox MG, Nelen MR, Wilde AA, et al. Activation delay and VT parameters in arrhythmogenic right ventricular dysplasia/cardiomyopathy: toward improvement of diagnostic ECG criteria. J Cardiovasc Electrophysiol 2008;19:775-781. (Pubitemid 352032791)
11. Marcus FI, Zareba W. The electrocardiogram in right ventricular cardiomyopathy/dysplasia. How can the electrocardiogram assist in understanding the pathologic and functional changes of the heart in this disease? J Electrocardiol 2009;42:136.e15.
12. Corrado D, Basso C, Thiene G. Sudden cardiac death in young people with apparently normal heart. Cardiovasc Res 2001;50:399-408. (Pubitemid 32382167)
13. Zumhagen S, Spieker T, Rolinck J, et al. Absence of pathognomonic or inflammatory patterns in cardiac biopsies from patients with Brugada syndrome. Circ Arrhythm Electrophysiol 2009;2:16-23.
14. Catalano O, Antonaci S, Moro G, et al. Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities. Eur Heart J 2009;30:2241-2248.
15. Papavassiliu T, Wolpert C, Fluchter S, et al. Magnetic resonance imaging findings in patients with Brugada syndrome. J Cardiovasc Electrophysiol 2004;15:1133-1138. (Pubitemid 39426040)
16. Antzelevitch C. Brugada syndrome: historical perspectives and observations. Eur Heart J 2002;23:676.
17. Meregalli P, Wilde A, Tan H. Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? Cardiovasc Res 2005;67:367-378.
18. Wilde AA, Postema PG, Di Diego JM, et al. The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization. J Mol Cell Cardiol 2010;49:543-553.
19. Nishii N, Nagase S, Morita H, et al. Abnormal restitution property of action potential duration and conduction delay in Brugada syndrome: both repolarization and depolarization abnormalities. Europace 2010;12:544-552.
20. Tukkie R, Segaard P, Vleugels J, et al. Delay in right ventricular activation contributes to Brugada syndrome. Circulation 2004;109:1272-1277. (Pubitemid 38372786)
21. Postema P, van Dessel P, de Bakker J, et al. Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study. Circ Arrhythm Electrophysiol 2008;1:379-386.
22. Lambiase P, Ahmed A, Ciaccio E, et al. High density substrate mapping in Brugada syndrome-combined role of conduction and repolarisation heterogeneities in arrhythmogenesis. Circulation 2008;120:106-117.
23. Postema PG, van Dessel PF, Kors JA, et al. Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in Brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation. J Am Coll Cardiol 2010;55:789-797.
24. Peters S, Trummel M. Diagnosis of arrhythmogenic right ventricular dysplasiacardiomyopathy: value of standard ECG revisited. Ann Noninvasive Electrocardiol 2003;8:238-245. (Pubitemid 38569983)
25. Marcus FI, Zareba W. The electrocardiogram in right ventricular cardiomyopathy/dysplasia. How can the electrocardiogram assist in understanding the pathologic and functional changes of the heart in this disease? J Electrocardiol 2009;42:136.e15.
26. Ozeke O, Cavus UY, Atar I, Ozin B, Ilkay E. Epsilon-like electrocardiographic pattern in a patient with Brugada syndrome. Ann Noninvasive Electrocardiol 2009;14:305-308.
27. Junttila MJ, Brugada P, Hong K, et al. Differences in 12-lead electrocardiogram between symptomatic and asymptomatic Brugada syndrome patients. J Cardiovasc Electrophysiol 2008;19:380-383. (Pubitemid 351457553)
28. Nasir K, Bomma C, Tandri H, et al. Electrocardiographic features of arrhythmogenic right ventricular dysplasia/cardiomyopathy according to disease severity: a need to broaden diagnostic criteria. Circulation 2004;110:1527-1534. (Pubitemid 39297972)
29. Coronel R, Casini S, Koopmann TT, et al. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005;112:2769-2777. (Pubitemid 41641670)
30. Hoogendijk MG, Potse M, Linnenbank AC, et al. Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch. Heart Rhythm 2010;7:238-248.
31. Pérez Riera AR, Antzelevitch C, Schapacknik E, Dubner S, Ferreira C. Is there an overlap between Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy/dysplasia? J Electrocardiol 2005;38:260-263.
32. Postema PG, Wolpert C, Amin AS, et al. Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org). Heart Rhythm 2009;6:1335-1341.
33. Quarta G, Ward D, Tome Esteban MT, et al. Dynamic electrocardiographic changes in patients with arrhythmogenic right ventricular cardiomyopathy. Heart 2010;96:516-522.
34. Wang J, Yang B, Chen H, et al. Epsilon waves detected by various electrocardiographic recording methods in patients with arrhythmogenic right ventricular cardiomyopathy. Tex Heart Inst J 2010;37:405-411.