Significance of microscopic invasion into hilar peribronchovascular soft tissue in resection specimens of primary non-small cell lung cancer

Lung Cancer

Volumn 73, Issue 1, 2011, Pages 89-95

  Sakai, Yasuhiro ^a   Ohbayashi, Chiho ^a   Kanomata, Naoki ^b   Kajimoto, Kazuyoshi ^a   Sakuma, Toshiko ^a   Maniwa, Yoshimasa ^c   Nishio, Wataru ^c   Tauchi, Shunsuke ^a   Uchino, Kazuya ^a   Yoshimura, Masahiro ^a  

^a HYOGO CANCER CENTER   (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

^c KOBE UNIVERSITY HOSPITAL   (Japan)

Author keywords

Bronchial resection margin; Hilar fat invasion; Mediastinal spread; Non small cell lung cancer; Peribronchial invasion; Prognostic factor; R classification; TNM classification

Indexed keywords

AGED; ARTICLE; ASIA; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; KAPLAN MEIER METHOD; LOBECTOMY; LOGISTIC REGRESSION ANALYSIS; LUNG HILUS; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; PREOPERATIVE CARE; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; SOFT TISSUE; STATISTICAL SIGNIFICANCE; TISSUE SECTION;

AGED; AGED, 80 AND OVER; BRONCHI; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS;

EID: 79957687431     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2010.11.002     Document Type: Article

References (31)

1. International Association for the Study of Lung Cancer. Staging manual in thoracic oncology 2009, IASLC Publication, Orange Park. Goldstraw P (Ed.).
2. International Union Against Cancer. TNM classification of malignant tumours 2009, Wiley-Blackwell, West Sussex. 7th ed. L.H. Sobin, M.K. Gospodarowicz, Wittekind C (Eds.).
3. American Joint Committee on Cancer. Cancer staging manual 2009, Springer, New York. 7th ed. S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, A. Trotti (Eds.).
4. World Health Organization Classification of Tumours. Pathology & genetics. Tumours of the lung, pleura, thymus and heart 2004, IARC Press, Lyon. W.D. Travis, E. Brambilla, H.K. Müller-Hermelink, C.C. Harris (Eds.).
5. Dawson B., Trapp R.G. Basic & clinical biostatistics 2004, McGraw-Hill, New York. 4th ed.
6. Rami-Porta R., Wittekind C., Goldstraw P. Complete resection in lung cancer surgery: proposed definition. Lung Cancer 2005, 49:25-33.
7. International Union Against Cancer. TNM classification of malignant tumours 2002, Wiley-Liss, New York. 6th ed. L.H. Sobin, C. Wittekind (Eds.).
8. Marchevsky A.M. Problems in pathologic staging of lung cancer. Arch Pathol Lab Med 2006, 130:292-302.
9. International Union Against Cancer. TNM supplement. A commentary on uniform use 2003, Wiley-Liss, New York. 3rd ed. C. Wittekind, F.L. Greene, D.E. Henson, R.V.P. Hutter, L.H. Sobin (Eds.).
10. Wittekind C., Compton C., Quirke P., Nagtegaal I., Merkel S., Hermanek P., et al. A uniform residual tumor (R) classification. Integration of the R classification and the circumferential margin status. Cancer 2009, 115:3483-3488.
11. Shields T.W. The fate of patients after incomplete resection of bronchial carcinoma. Surg Gynecol Obstet 1974, 139:569-572.
12. Soorae A.S., Stevenson H.M. Survival with residual tumor on the bronchial margin after resection for bronchogenic carcinoma. J Thorac Cardiovasc Surg 1979, 78:175-180.
13. Kaiser L.R., Fleshner P., Keller S., Martini N. Significance of extramucosal residual tumor at the bronchial resection margin. Ann Thorac Surg 1989, 47:265-269.
14. Liewald F., Hatz R.A., Dienemann H., Sunder-Plassmann L. Importance of microscopic residual disease at the bronchial margin after resection for non-small-cell carcinoma of the lung. J Thorac Cardiovasc Surg 1992, 104:408-412.
15. Massard G., Doddoli C., Gasser B., Ducrocq X., Kessler R., Schumacher C., et al. Prognostic implications of a positive bronchial resection margin. Eur J Cardiothorac Surg 2000, 17:557-565.
16. Hofmann H.S., Taege C., Lautenschläger C., Neef H., Silber R.E., Microscopic (R1) and macroscopic (R2) residual disease in patients with resected non-small cell lung cancer. Eur J Cardiothorac Surg 2002, 21:606-610.
17. Law M.R., Hodson M.E., Lennox S.C. Implications of histologically reported residual tumour on the bronchial margin after resection for bronchial carcinoma. Thorax 1982, 37:492-495.
18. Snijder R.J., Brutel de la Riviere A., Elbers H.J.J., van den Bosch J.M.M. Survival in resected stage I lung cancer with residual tumor at the bronchial resection margin. Ann Thorac Surg 1998, 65:212-216.
19. Passlick B., Sitar I., Sienel W., Thetter O., Morresi-Hauf A. Significance of lymphangiosis carcinomatosa at the bronchial resection margin in patients with non-small cell lung cancer. Ann Thorac Surg 2001, 72:1160-1164.
20. Gebitekin C., Gupta N.K., Satur C.M.R., Olgac G., Martin P.G., Saunders N.R., et al. Fate of patients with residual tumour at the bronchial resection margin. Eur J Cardiothorac Surg 1994, 8:339-344.
21. Ghiribelli C., Voltolini L., Paladini P., Luzzi L., Di Bisceglie M., Gotti G. Treatment and survival after lung resection for non-small cell lung cancer in patients with microscopic residual disease at the bronchial stump. Eur J Cardiothorac Surg 1999, 16:555-559.
22. Lequaglie C., Conti B., Brega Massone P.P., Giudice G. Unsuspected residual disease at the resection margin after surgery for lung cancer: fate of patients after long-term follow-up. Eur J Cardiothorac Surg 2003, 23:229-232.
23. Dienemann H., Trainer C., Hoffmann H., Bülzebruck H., Muley T., Kayser K., et al. Incomplete resection of lung cancer: morbidity and prognosis. Chirurg 1997, 68:1014-1019. (in German).
24. Riquet M., Achour K., Foucault C., Le Pimpec Barthes F., Dujon A., Cazes A. Microscopic residual disease after resection for lung cancer: a multifaceted but poor factor of prognosis. Ann Thorac Surg 2010, 89:870-876.
25. Thunnissen F.B.J.M., den Bakker M.A. Implications of frozen section analyses from bronchial resection margins in NSCLC. Histopathology 2005, 47:638-640.
26. Balasubramanian S., Au J., Dunning J. Should lobectomy patients with microscopic involvement of the bronchial resection margin undergo re-operation to improve their long-term survival?. Interact CardioVasc Thorac Surg 2005, 4:531-537.
27. Maygarden S.J., Detterbeck F.C., Funkhouser W.K. Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation. Mod Pathol 2004, 17:1080-1086.
28. Kara M., Sak S.D., Orhan D., Yavuzer S. Changing patterns of lung cancer; (3/4in.) 1.9cm; still a safe length for bronchial resection margin?. Lung cancer 2000, 30:161-168.
29. Cotton R.E. The bronchial spread of lung cancer. Br J Dis Chest 1959, 53:142-150.
30. Griess D.F., McDonald J.R., Clagett O.T. The proximal extension of carcinoma of the lung in the bronchial wall. J Thorac Surg 1945, 14:362-368.
31. Kayser K., Anyanwu E., Bauer H.G., Vogt-Moykopf I. Tumor presence at resection boundaries and lymph-node metastasis in bronchial carcinoma patients. Thorac Cardiovasc Surg 1993, 41:308-311.