메뉴 건너뛰기




Volumn 10, Issue 8, 2011, Pages 460-463

Does polymorphysm of genes coding for pro-inflammatory mediators predict the clinical response to tnf alpha blocking agents? A review analysis of the literature

Author keywords

Anti TNF blockers; Polymorphism; Rheumatoid arthritis

Indexed keywords

ADALIMUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; INFLIXIMAB; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

EID: 79957665365     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2011.01.010     Document Type: Review
Times cited : (21)

References (41)
  • 1
    • 0035883897 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • Lee D.M., Weinblatt M.E. Rheumatoid arthritis. Lancet 2001, 358:903-911.
    • (2001) Lancet , vol.358 , pp. 903-911
    • Lee, D.M.1    Weinblatt, M.E.2
  • 3
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy E.H., Panayi G.S. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001, 344:907-916.
    • (2001) N Engl J Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 4
    • 0034780515 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis in the third millennium
    • Skapenko A., Kalden J.R., Schulze-Koops H. Treatment of rheumatoid arthritis in the third millennium. Scand J Rheumatol 2001, 30:249-254.
    • (2001) Scand J Rheumatol , vol.30 , pp. 249-254
    • Skapenko, A.1    Kalden, J.R.2    Schulze-Koops, H.3
  • 6
    • 77956933003 scopus 로고    scopus 로고
    • Predictive factors of response to rituximab therapy in rheumatoid arthritis: what do we know today?
    • Benucci M., Manfredi M., Puttini P.S., Atzeni F. Predictive factors of response to rituximab therapy in rheumatoid arthritis: what do we know today?. Autoimmun Rev 2010, 9:801-803.
    • (2010) Autoimmun Rev , vol.9 , pp. 801-803
    • Benucci, M.1    Manfredi, M.2    Puttini, P.S.3    Atzeni, F.4
  • 7
    • 0033179534 scopus 로고    scopus 로고
    • Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis
    • Charles P., Elliott M.J., Davis D., Potter A., Kalden J.R., Antoni C., et al. Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis. J Immunol 1999, 163:1521-1528.
    • (1999) J Immunol , vol.163 , pp. 1521-1528
    • Charles, P.1    Elliott, M.J.2    Davis, D.3    Potter, A.4    Kalden, J.R.5    Antoni, C.6
  • 8
    • 33751416149 scopus 로고    scopus 로고
    • Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register
    • Hyrich K.L., Watson K.D., Silman A.J., Symmons D.P. Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology (Oxford) 2006, 45:1558-1565.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1558-1565
    • Hyrich, K.L.1    Watson, K.D.2    Silman, A.J.3    Symmons, D.P.4
  • 10
    • 77952743228 scopus 로고    scopus 로고
    • Strategies after the failure of the first anti-tumor necrosis factor alpha agent in rheumatoid arthritis
    • Papagoras C., Voulgari P.V., Drosos A.A. Strategies after the failure of the first anti-tumor necrosis factor alpha agent in rheumatoid arthritis. Autoimmun Rev 2010, 9:574-582.
    • (2010) Autoimmun Rev , vol.9 , pp. 574-582
    • Papagoras, C.1    Voulgari, P.V.2    Drosos, A.A.3
  • 11
    • 77950300568 scopus 로고    scopus 로고
    • Switching TNF-alpha antagonists in rheumatoid arthritis: the experience of the LORHEN registry
    • Caporali R., Sarzi-Puttini P., Atzeni F., Gorla R., Filippini M., Marchesoni A., et al. Switching TNF-alpha antagonists in rheumatoid arthritis: the experience of the LORHEN registry. Autoimmun Rev 2010, 9:465-469.
    • (2010) Autoimmun Rev , vol.9 , pp. 465-469
    • Caporali, R.1    Sarzi-Puttini, P.2    Atzeni, F.3    Gorla, R.4    Filippini, M.5    Marchesoni, A.6
  • 12
    • 4444236600 scopus 로고    scopus 로고
    • The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    • Criswell L.A., Lum R.F., Turner K.N., Woehl B., Zhu Y., Wang J., et al. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum 2004, 50:2750-2756.
    • (2004) Arthritis Rheum , vol.50 , pp. 2750-2756
    • Criswell, L.A.1    Lum, R.F.2    Turner, K.N.3    Woehl, B.4    Zhu, Y.5    Wang, J.6
  • 13
    • 33846138651 scopus 로고    scopus 로고
    • Association of TNF-alpha -308G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis
    • Lee Y.H., Rho Y.H., Choi S.J., Ji J.D., Song G.G. Association of TNF-alpha -308G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatol Int 2006, 27:157-161.
    • (2006) Rheumatol Int , vol.27 , pp. 157-161
    • Lee, Y.H.1    Rho, Y.H.2    Choi, S.J.3    Ji, J.D.4    Song, G.G.5
  • 14
    • 4444239006 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha (TNF-alpha) levels and influence of -308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis
    • Cuchacovich M., Ferreira L., Aliste M., Soto L., Cuenca J., Cruzat A., et al. Tumour necrosis factor-alpha (TNF-alpha) levels and influence of -308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis. Scand J Rheumatol 2004, 33:228-232.
    • (2004) Scand J Rheumatol , vol.33 , pp. 228-232
    • Cuchacovich, M.1    Ferreira, L.2    Aliste, M.3    Soto, L.4    Cuenca, J.5    Cruzat, A.6
  • 15
    • 33947610407 scopus 로고    scopus 로고
    • Tumour necrosis factor (TNF)alpha -308G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis
    • Cuchacovich M., Soto L., Edwardes M., Gutierrez M., Llanos C., Pacheco D., et al. Tumour necrosis factor (TNF)alpha -308G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Scand J Rheumatol 2006, 35:435-440.
    • (2006) Scand J Rheumatol , vol.35 , pp. 435-440
    • Cuchacovich, M.1    Soto, L.2    Edwardes, M.3    Gutierrez, M.4    Llanos, C.5    Pacheco, D.6
  • 16
    • 37349093406 scopus 로고    scopus 로고
    • Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis
    • Guis S., Balandraud N., Bouvenot J., Auger I., Toussirot E., Wendling D., et al. Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis. Arthritis Rheum 2007, 57:1426-1430.
    • (2007) Arthritis Rheum , vol.57 , pp. 1426-1430
    • Guis, S.1    Balandraud, N.2    Bouvenot, J.3    Auger, I.4    Toussirot, E.5    Wendling, D.6
  • 17
    • 33144459772 scopus 로고    scopus 로고
    • The shared epitope is a marker of severity associated with selection for, but not with response to, infliximab in a large rheumatoid arthritis population
    • Marotte H., Pallot-Prades B., Grange L., Tebib J., Gaudin P., Alexandre C., et al. The shared epitope is a marker of severity associated with selection for, but not with response to, infliximab in a large rheumatoid arthritis population. Ann Rheum Dis 2006, 65:342-347.
    • (2006) Ann Rheum Dis , vol.65 , pp. 342-347
    • Marotte, H.1    Pallot-Prades, B.2    Grange, L.3    Tebib, J.4    Gaudin, P.5    Alexandre, C.6
  • 18
    • 0038681582 scopus 로고    scopus 로고
    • Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis
    • Mugnier B., Balandraud N., Darque A., Roudier C., Roudier J., Reviron D. Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis. Arthritis Rheum 2003, 48:1849-1852.
    • (2003) Arthritis Rheum , vol.48 , pp. 1849-1852
    • Mugnier, B.1    Balandraud, N.2    Darque, A.3    Roudier, C.4    Roudier, J.5    Reviron, D.6
  • 19
    • 0038823966 scopus 로고    scopus 로고
    • Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis
    • Padyukov L., Lampa J., Heimburger M., Ernestam S., Cederholm T., Lundkvist I., et al. Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis. Ann Rheum Dis 2003, 62:526-529.
    • (2003) Ann Rheum Dis , vol.62 , pp. 526-529
    • Padyukov, L.1    Lampa, J.2    Heimburger, M.3    Ernestam, S.4    Cederholm, T.5    Lundkvist, I.6
  • 20
    • 33845595254 scopus 로고    scopus 로고
    • The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients
    • Seitz M., Wirthmuller U., Moller B., Villiger P.M. The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients. Rheumatology (Oxford) 2007, 46:93-96.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 93-96
    • Seitz, M.1    Wirthmuller, U.2    Moller, B.3    Villiger, P.M.4
  • 21
    • 5644233733 scopus 로고    scopus 로고
    • Investigation of the prognostic value of TNF-alpha gene polymorphism among patients treated with infliximab, and the effects of infliximab therapy on TNF-alpha production and apoptosis
    • Balog A., Klausz G., Gal J., Molnar T., Nagy F., Ocsovszky I., et al. Investigation of the prognostic value of TNF-alpha gene polymorphism among patients treated with infliximab, and the effects of infliximab therapy on TNF-alpha production and apoptosis. Pathobiology 2004, 71:274-280.
    • (2004) Pathobiology , vol.71 , pp. 274-280
    • Balog, A.1    Klausz, G.2    Gal, J.3    Molnar, T.4    Nagy, F.5    Ocsovszky, I.6
  • 22
    • 36148992942 scopus 로고    scopus 로고
    • Tumour necrosis factor a -308 promoter polymorphism in patients with rheumatoid arthritis
    • Rezaieyazdi Z., Afshari J.T., Sandooghi M., Mohajer F. Tumour necrosis factor a -308 promoter polymorphism in patients with rheumatoid arthritis. Rheumatol Int 2007, 28:189-191.
    • (2007) Rheumatol Int , vol.28 , pp. 189-191
    • Rezaieyazdi, Z.1    Afshari, J.T.2    Sandooghi, M.3    Mohajer, F.4
  • 23
    • 20244363493 scopus 로고    scopus 로고
    • Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics
    • Fonseca J.E., Carvalho T., Cruz M., Nero P., Sobral M., Mourao A.F., et al. Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics. Ann Rheum Dis 2005, 64:793-794.
    • (2005) Ann Rheum Dis , vol.64 , pp. 793-794
    • Fonseca, J.E.1    Carvalho, T.2    Cruz, M.3    Nero, P.4    Sobral, M.5    Mourao, A.F.6
  • 24
    • 43949122575 scopus 로고    scopus 로고
    • Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor
    • Marotte H., Arnaud B., Diasparra J., Zrioual S., Miossec P. Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor. Arthritis Rheum 2008, 58:1258-1263.
    • (2008) Arthritis Rheum , vol.58 , pp. 1258-1263
    • Marotte, H.1    Arnaud, B.2    Diasparra, J.3    Zrioual, S.4    Miossec, P.5
  • 25
    • 54949146894 scopus 로고    scopus 로고
    • Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis
    • Maxwell J.R., Potter C., Hyrich K.L., Barton A., Worthington J., Isaacs J.D., et al. Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Hum Mol Genet 2008, 17:3532-3538.
    • (2008) Hum Mol Genet , vol.17 , pp. 3532-3538
    • Maxwell, J.R.1    Potter, C.2    Hyrich, K.L.3    Barton, A.4    Worthington, J.5    Isaacs, J.D.6
  • 26
    • 41849134745 scopus 로고    scopus 로고
    • A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis
    • Miceli-Richard C., Comets E., Verstuyft C., Tamouza R., Loiseau P., Ravaud P., et al. A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis. Ann Rheum Dis 2008, 67:478-484.
    • (2008) Ann Rheum Dis , vol.67 , pp. 478-484
    • Miceli-Richard, C.1    Comets, E.2    Verstuyft, C.3    Tamouza, R.4    Loiseau, P.5    Ravaud, P.6
  • 27
    • 38149118006 scopus 로고    scopus 로고
    • Polymorphisms in genes encoding tumor necrosis factor-alpha and HLA-DRB1 are not associated with response to infliximab in patients with rheumatoid arthritis
    • Pinto J.A., Rego I., Rodriguez-Gomez M., Canete J.D., Fernandez-Lopez C., Freire M., et al. Polymorphisms in genes encoding tumor necrosis factor-alpha and HLA-DRB1 are not associated with response to infliximab in patients with rheumatoid arthritis. J Rheumatol 2008, 35:177-178.
    • (2008) J Rheumatol , vol.35 , pp. 177-178
    • Pinto, J.A.1    Rego, I.2    Rodriguez-Gomez, M.3    Canete, J.D.4    Fernandez-Lopez, C.5    Freire, M.6
  • 28
    • 67349101771 scopus 로고    scopus 로고
    • TNF-alpha-308G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis
    • O'Rielly D.D., Roslin N.M., Beyene J., Pope A., Rahman P. TNF-alpha-308G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis. Pharmacogenomics J 2009, 9:161-167.
    • (2009) Pharmacogenomics J , vol.9 , pp. 161-167
    • O'Rielly, D.D.1    Roslin, N.M.2    Beyene, J.3    Pope, A.4    Rahman, P.5
  • 29
    • 77953701245 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha -308G->A polymorphism is not associated with response to TNFalpha blockers in Caucasian patients with rheumatoid arthritis: systematic review and meta-analysis
    • Pavy S., Toonen E.J., Miceli-Richard C., Barrera P., van Riel P.L., Criswell L.A., et al. Tumour necrosis factor alpha -308G->A polymorphism is not associated with response to TNFalpha blockers in Caucasian patients with rheumatoid arthritis: systematic review and meta-analysis. Ann Rheum Dis 2010, 69:1022-1028.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1022-1028
    • Pavy, S.1    Toonen, E.J.2    Miceli-Richard, C.3    Barrera, P.4    van Riel, P.L.5    Criswell, L.A.6
  • 30
    • 0036138727 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha gene polymorphism in severe and mild-moderate rheumatoid arthritis
    • Fabris M., Di P.E., D'Elia A., Damante G., Sinigaglia L., Ferraccioli G. Tumor necrosis factor-alpha gene polymorphism in severe and mild-moderate rheumatoid arthritis. J Rheumatol 2002, 29:29-33.
    • (2002) J Rheumatol , vol.29 , pp. 29-33
    • Fabris, M.1    Di, P.E.2    D'Elia, A.3    Damante, G.4    Sinigaglia, L.5    Ferraccioli, G.6
  • 31
    • 34447296681 scopus 로고    scopus 로고
    • Combined tumour necrosis factor-alpha and tumour necrosis factor receptor genotypes could predict rheumatoid arthritis patients' response to anti-TNF-alpha therapy and explain controversies of studies based on a single polymorphism
    • Chatzikyriakidou A., Georgiou I., Voulgari P.V., Venetsanopoulou A.I., Drosos A.A. Combined tumour necrosis factor-alpha and tumour necrosis factor receptor genotypes could predict rheumatoid arthritis patients' response to anti-TNF-alpha therapy and explain controversies of studies based on a single polymorphism. Rheumatology (Oxford) 2007, 46:1034-1035.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 1034-1035
    • Chatzikyriakidou, A.1    Georgiou, I.2    Voulgari, P.V.3    Venetsanopoulou, A.I.4    Drosos, A.A.5
  • 32
    • 47949130787 scopus 로고    scopus 로고
    • The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis
    • Toonen E.J., Coenen M.J., Kievit W., Fransen J., Eijsbouts A.M., Scheffer H., et al. The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis. Ann Rheum Dis 2008, 67:1174-1177.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1174-1177
    • Toonen, E.J.1    Coenen, M.J.2    Kievit, W.3    Fransen, J.4    Eijsbouts, A.M.5    Scheffer, H.6
  • 33
    • 18744365197 scopus 로고    scopus 로고
    • The influence of a polymorphism at position -857 of the tumour necrosis factor alpha gene on clinical response to etanercept therapy in rheumatoid arthritis
    • Kang C.P., Lee K.W., Yoo D.H., Kang C., Bae S.C. The influence of a polymorphism at position -857 of the tumour necrosis factor alpha gene on clinical response to etanercept therapy in rheumatoid arthritis. Rheumatology (Oxford) 2005, 44:547-552.
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 547-552
    • Kang, C.P.1    Lee, K.W.2    Yoo, D.H.3    Kang, C.4    Bae, S.C.5
  • 34
    • 18444395237 scopus 로고    scopus 로고
    • Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors
    • van Heel D.A., Udalova I.A., De Silva A.P., McGovern D.P., Kinouchi Y., Hull J., et al. Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors. Hum Mol Genet 2002, 11:1281-1289.
    • (2002) Hum Mol Genet , vol.11 , pp. 1281-1289
    • van Heel, D.A.1    Udalova, I.A.2    De Silva, A.P.3    McGovern, D.P.4    Kinouchi, Y.5    Hull, J.6
  • 35
    • 0035317243 scopus 로고    scopus 로고
    • Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter
    • Hohjoh H., Tokunaga K. Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter. Genes Immun 2001, 2:105-109.
    • (2001) Genes Immun , vol.2 , pp. 105-109
    • Hohjoh, H.1    Tokunaga, K.2
  • 36
    • 0031573549 scopus 로고    scopus 로고
    • TNF and lymphotoxin-alpha polymorphisms associated with common variable immunodeficiency: role in the pathogenesis of granulomatous disease
    • Mullighan C.G., Fanning G.C., Chapel H.M., Welsh K.I. TNF and lymphotoxin-alpha polymorphisms associated with common variable immunodeficiency: role in the pathogenesis of granulomatous disease. J Immunol 1997, 159:6236-6241.
    • (1997) J Immunol , vol.159 , pp. 6236-6241
    • Mullighan, C.G.1    Fanning, G.C.2    Chapel, H.M.3    Welsh, K.I.4
  • 37
    • 34249796662 scopus 로고    scopus 로고
    • Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial
    • Burmester G.R., Mariette X., Montecucco C., Monteagudo-Saez I., Malaise M., Tzioufas A.G., et al. Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial. Ann Rheum Dis 2007, 66:732-739.
    • (2007) Ann Rheum Dis , vol.66 , pp. 732-739
    • Burmester, G.R.1    Mariette, X.2    Montecucco, C.3    Monteagudo-Saez, I.4    Malaise, M.5    Tzioufas, A.G.6
  • 38
    • 77953697163 scopus 로고    scopus 로고
    • Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment
    • Tan R.J., Gibbons L.J., Potter C., Hyrich K.L., Morgan A.W., Wilson A.G., et al. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment. Ann Rheum Dis 2010, 69:1029-1035.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1029-1035
    • Tan, R.J.1    Gibbons, L.J.2    Potter, C.3    Hyrich, K.L.4    Morgan, A.W.5    Wilson, A.G.6
  • 39
    • 78049524433 scopus 로고    scopus 로고
    • Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis
    • Hassan B., Maxwell J.R., Hyrich K.L., Barton A., Worthington J., Isaacs J.D., et al. Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. Rheumatology (Oxford) 2010, 49:43-47.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 43-47
    • Hassan, B.1    Maxwell, J.R.2    Hyrich, K.L.3    Barton, A.4    Worthington, J.5    Isaacs, J.D.6
  • 40
    • 55049089081 scopus 로고    scopus 로고
    • Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
    • Liu C., Batliwalla F., Li W., Lee A., Roubenoff R., Beckman E., et al. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Mol Med 2008, 14:575-581.
    • (2008) Mol Med , vol.14 , pp. 575-581
    • Liu, C.1    Batliwalla, F.2    Li, W.3    Lee, A.4    Roubenoff, R.5    Beckman, E.6
  • 41
    • 77949694141 scopus 로고    scopus 로고
    • Interleukin 10 and tumor necrosis factor-alpha genotypes in rheumatoid arthritis-association with clinical response to glucocorticoids
    • de Paz B., peri-Lopez M., Ballina-Garcia F.J., Prado C., Mozo L., Gutierrez C., et al. Interleukin 10 and tumor necrosis factor-alpha genotypes in rheumatoid arthritis-association with clinical response to glucocorticoids. J Rheumatol 2010, 37:503-511.
    • (2010) J Rheumatol , vol.37 , pp. 503-511
    • de Paz, B.1    peri-Lopez, M.2    Ballina-Garcia, F.J.3    Prado, C.4    Mozo, L.5    Gutierrez, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.