Arbutin inhibits TCCSUP human bladder cancer cell proliferation via up-regulation of p21

Pharmazie

Volumn 66, Issue 4, 2011, Pages 306-309

  Li, Hailan ^a   Jeong, Yun Mi ^a   Kim, Su Yeon ^a   Kim, Myo Kyoung ^b   Kim, Dong Seok ^a  

^a Chung Ang University College of Medicine   (South Korea)

^b UNIVERSITY OF THE PACIFIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ARBUTIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; MITOGEN ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; CANCER CELL; CELL CYCLE REGULATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

ACTINS; ARBUTIN; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLORING AGENTS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENTIAN VIOLET; HUMANS; NEOPLASM PROTEINS; TETRAZOLIUM SALTS; THIAZOLES; UP-REGULATION; URINARY BLADDER NEOPLASMS;

EID: 79957656706     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2011.0785     Document Type: Article

References (20)

1. Blagosklonny MV, Pardee AB (2002) The restriction point of the cell cycle. Cell Cycle 1: 103-110.
2. Blaut M, Braune A, Wunderlich S, Sauer P, Schneider H, Glatt H (2006) Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria. Food Chem Toxicol 44: 1940-1947. (Pubitemid 44894156)
3. Blenis J (1993) Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci U S A 90: 5889-5892.
4. Blumer KJ, Johnson GL (1994) Diversity in function and regulation of MAP kinase pathways. Trends Biochem Sci 19: 236-240. (Pubitemid 24184162)
5. Cheng SL, Liu RH, Sheu JN, Chen ST, Sinchaikul S, Tsay GJ (2007) Toxicogenomics of A375 human malignant melanoma cells treated with arbutin. J Biomed Sci 14: 87-105. (Pubitemid 46295276)
6. Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268: 14553-14556.
7. Ertam I, Mutlu B, Unal I, Alper S, Kivcak B, Ozer O (2008) Efficiency of ellagic acid and arbutin in melasma: a randomized, prospective, open-label study. J Dermatol 35: 570-574.
8. Gartel AL, Tyner AL (2002) The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1: 639-649.
9. Jeong YM, Lee JE, Kim SY, Yun HY, Baek KJ, Kwon NS, Kim DS (2009) Enhanced effects of citrate on UVB-induced apoptosis of B16 melanoma cells. Pharmazie 64: 829-833.
10. Kamei H, Koide T, Kojima T, Hashimoto Y, Hasegawa M (1998) Inhibition of cell growth in culture by quinones. Cancer Biother Radiopharm 13: 185-188. (Pubitemid 28359721)
11. Kiely PA, Sant A, O'Connor R (2002) RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. J Biol Chem 277: 22581-22589. (Pubitemid 34967235)
12. Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athear M (2006) Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways. Exp Dermatol 15: 538-546. (Pubitemid 43834489)
13. Maeda K, Fukuda M (1996) Arbutin: mechanism of its depigmenting action in human melanocyte culture. J Pharmacol Exp Ther 276: 765-769. (Pubitemid 126660519)
14. Pébay A, Toutant M, Premont J, Calvo CF, Venance L, Cordier J, Glowinshi J, Tencé H (2001) Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. Eur J Neurosci 13: 2067-2076.
15. Prietzsch H, Brock J, Kleine HD, Liebe S, Jaster R (2002) Interferon-alpha inhibits cell cycle progression by Ba/F3 cells through the antagonisation of interleukin-3 effects on key regulators of G(1)/S transition. Cell Signal 14: 751-759. (Pubitemid 34597182)
16. Schindler G, Patzak U, Brinkhaus B, von Niecieck A, Wittig J, Kráhmer N, Glo{combining double acute accent}ckl J, Veit M (2002) Urinary excretion and metabolism of arbutin after oral administration of Arctostaphylos uvae ursi extract as film-coated tablets and aqueous solution in healthy humans. J Clin Pharmacol 42: 920-927.
17. Sugimoto K, Nishimura T, Nomura K, Kuriki T (2004) Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model. Biol Pharm Bull 27: 510-514. (Pubitemid 41701835)
18. Tang PP, Hsieh SC, Wang FF (2002) Modulation of caspase activation and p27(Kip1) degradation in the p53-induced apoptosis in IW32 erythroleukemia cells. Cell Signal 14: 961-968.
19. Weiss RH, Randour CJ (2000) The permissive effect of p21(Waf1/Cip1) on DNA synthesis is dependent on cell type: effect is absent in p53-inactive cells. Cell Signal 12: 413-418. (Pubitemid 30417605)
20. Zieger K (2008) High throughput molecular diagnostics in bladder cancer - on the brink of clinical utility. Mol Oncol 1: 384-394.