Improving the diagnosis of infection during out-of-hospital emergency care: Are biomarkers the next step?

Prehospital Emergency Care

Volumn 15, Issue 3, 2011, Pages 439-441

  Seymour, Christopher W ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

EMERGENCY HEALTH SERVICE; HUMAN; INFECTION; MANPOWER; METHODOLOGY; NOTE; PROFESSIONAL COMPETENCE; SEPSIS;

BIOLOGICAL MARKERS; EMERGENCY MEDICAL SERVICES; HUMANS; INFECTION; PROFESSIONAL COMPETENCE; SEPSIS; TRIAGE;

EID: 79957653518     PISSN: 10903127     EISSN: 15450066     Source Type: Journal    
DOI: 10.3109/10903127.2011.561415     Document Type: Letter

References (26)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303-10. (Pubitemid 32641789)
2. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-77.
3. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36:296-327.
4. Strehlow MC, Emond SD, Shapiro NI, Pelletier AJ, Camargo CA Jr. National Study of Emergency Department Visits for Sepsis, 1992 to 2001. Ann Emerg Med. 2006;48:326-31.
5. Wang HE, Shapiro NI, Angus DC, Yealy DM. National estimates of severe sepsis in United States emergency departments. Crit Care Med. 2007;35:1928-36. (Pubitemid 47220368)
6. Studnek JR, Artho MR, Garner CL Jr, Jones AE. The impact of emergencymedical services on the ED care of severe sepsis. Am J Emerg Med. 2010; Oct. 26 (Epub ahead of print).
7. Seymour CW, Cooke CR, Mikkelsen ME, et al. Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency department. Prehosp Emerg Care. 2010;14:145-52.
8. Seymour CW, Band RA, Cooke CR, et al. Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study. J Crit Care. 2010;25:553-62.
9. Wang HE, Weaver MD, Shapiro NI, Yealy DM. Opportunities for emergency medical services care of sepsis. Resuscitation. 2010;81:193-7.
10. Suffoletto B, Frisch A, Prabh A, Kristan J, Guyette FX, Callaway CW. Prediction of serious infection during prehospital emergency care. Prehosp Emerg Care. 2011;15
11. Seymour CW, Carlbom D, Larson J, Copass MK, Engelberg R, Rea TD. Out-of-hospital providers knowledge and awareness of sepsis [abstract]. Am J Respir Crit Care Med. 2009.
12. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010;303:739-46.
13. Otero RM, Nguyen HB, Huang DT, et al. Early goaldirected therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest. 2006;130:1579-95. (Pubitemid 44786757)
14. Goyal M, Pines JM, Drumheller BC, Gaieski DF. Point-of-care testing at triage decreases time to lactate level in septic patients. J Emerg Med. 2010;38:578-81.
15. Karon BS, Scott R, Burritt MF, Santrach PJ. Comparison of lactate values between point-of-care and central laboratory analyzers. Am J Clin Pathol. 2007;128:168-71. (Pubitemid 47121731)
16. Jones AE, Leonard MM, Hernandez-Nino J, Kline JA., Determination of the effect of in vitro time, temperature, and tourniquet use onwhole blood venous point-of-care lactate concentrations. Acad Emerg Med. 2007;14:587-91. (Pubitemid 46920979)
17. Boldt J, Kumle B, Suttner S, et al. Point-of-care (POC) testing of lactate in the intensive care patient. Accuracy, reliability, and costs of different measurement systems. Acta Anaesthesiol Scand. 2001;45:194-9. (Pubitemid 32115689)
18. Jansen TC, van Bommel J, Mulder PG, Rommes JH, Schieveld SJ, Bakker J. The prognostic value of blood lactate levels relative to that of vital signs in the pre-hospital setting: a pilot study. Crit Care. 2008;12(6):R160.
19. Jousi M, Reitala J, Lund V, Katila A, Leppäniemi A. The role of pre-hospital blood gas analysis in trauma resuscitation. World J Emerg Surg. 2010;5:10.
20. Del Portal DA, Shofer F, Mikkelsen ME, et al. Emergency department lactate is associated with mortality in older adults admitted with and without infections. Acad Emerg Med. 2010;17:260-8.
21. Pfafflin A, Schleicher E. Inflammation markers in point-of-care testing (POCT). Anal Bioanal Chem. 2009;393:1473-80.
22. Marshall JC. Biomarkers of sepsis. Curr Infect Dis Rep. 2006;8:351-7. (Pubitemid 44445708)
23. Pepe MS, Feng Z, Janes H, Bossuyt PM, Potter JD. Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: standards for study design. J Natl Cancer Inst. 2008;100:1432-8.
24. Pepe MS, Feng Z, Huang Y, et al. Integrating the predictiveness of amarkerwith its performance as a classifier. Am J Epidemiol. 2008;167:362-8. (Pubitemid 351197592)
25. Cook NR, Ridker PM. Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures. Ann Intern Med. 2009;150:795-802.
26. Steyerberg EW, Vickers AJ, Cook NR, et al. Assessing the performance of predictionmodels: a framework for traditional and novel measures. Epidemiology. 2010;21:128-38.