Evaluation of hepatoprotective effect of Omega 3-fatty acid against paracetamol induced liver injury in albino rats

Global Journal of Pharmacology

Volumn 5, Issue 1, 2011, Pages 50-53

  Meganathan, M ^a   Madhana Gopal, K ^a   Sasikala, P ^a   Mohan, J ^a   Gowdhaman, N ^a   Balamurugan, K ^b   Nirmala, P ^b   Santhakumari, Sylvia ^b   Samuel, Vanitha ^b  

^a Arupadaivedu Medical College and Hospital   (India)

^b ANNAMALAI UNIVERSITY   (India)

Author keywords

Free radicals; Hepatoprotective activity; Omega 3 Fatty acids; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; OMEGA 3 FATTY ACID; SILYMARIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVITY; LIVER INJURY; LIVER PROTECTION; LUNG INJURY; NONHUMAN; RAT;

EID: 79957650813     PISSN: 19920075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sgroc Clinard, F. and K. Ouazrir, 2002. Incidence of drug induced hepatic injuries in French population based study. Hepatol., 36: 451-455.
2. Concoran, G.B., J.R. Mitchell and Y.N. Vaishnav, 1980. Evidence that acetaminophen and N-hydroxy acetaminophen form a common arylating intermediate, N-acetyl-P-benzoquinoamine. Mol. Pharmacol., 18: 536-538.
3. Zimmerman, H.J. 1998. Chemical hepatic injury. 3rd Eds: M. Haddad, J.F. Winchester, Clinical Management of poisoning and drug over dosage, Philadelphia.
4. Farrel, G.C. 1994. Drug induced liver injury. Churchill Livingstone, New York.
5. Larry, D. 1995. Drug induced hepatitis, epidemiologic, Clinical, Diagnostic and Pathophysiology aspects. Rev. Med. Interne., 16: 752-758.
6. Danan, G. 1988. Causality assessment of drug induced liver injury. J. Hepatol., 7: 132-136.
7. Sgroc Clinard, F. and K. Ouazrir, 2002. Incidence of drug induced hepatic injuries. A French population based study. Hepatology., 36: 451-455.
8. Romagnuolo, J., D.C. Sadowski and E. Lalor, 1998. Cholestatic hepatocellular injury with azathioprine. Can. J. Gastroenterol., 12: 479-483.
9. Bang, H.O. and J. Dyerberg, 1972. Plasma lipids and lipoproteins in Greenlandic West-Coast Eskimos. Acta Med. Scand., 192: 85-94.
10. Brown, B.R. 1981. Halogenated anesthetics and hepatotoxicity. South African Med. J., 59: 422-424.
11. Bolles, K.L. and G.A. Begg, 2000. Distinction between silver hake (Merluccius bilinearis) stocks in U.S. waters of the northwest Atlantic based on whole otolith morphometrics. Fish. Bull. U.S., 98: 451-462.
12. Ellman, G.L. 1959. Arch. Bioch. Biophys., 82: 70-77.
13. Flack, C.P. and J.W. Woolln, 1984. Clin. Chem., 30: 559.
14. Forrest, J.A., J.A. Clements and L.F. Prescott, 1982. Clinical pharmacokinetics of paracetamol. Clin. Pharmacokinet, 7(2): 93-107.
15. Clissold, S.P. 1986. Paracetamol and Phenacetin. Drugs., 32(suppl 4): 46-59.
16. Dahlin, D.C., F.T. Miwa and Luay, 1984. N-acetyl-p-benzoquinoneimine; a cytochrome P-450 mediated oxidation product Proc. Natl. Acad. Sci. USA., 81(5): 1327-1331.
17. Nelson, S.D. 1990. Molecular mechanism of hepatotoxicity caused by acetaminophen. Semin liver Dis., 10(4): 267-278.