Insertion-/deletion polymorphisms close to the repeat region of STR loci can cause discordant genotypes with different STR kits

Forensic Science International: Genetics

Volumn 5, Issue 4, 2011, Pages 339-341

  Rolf, Burkhard ^a   Bulander, Nicole ^a   Wiegand, Peter ^b  

^a Eurofins Medinet Inc   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Insertion deletion polymorphisms; STR loci

Indexed keywords

ARTICLE; BINDING SITE; DNA POLYMORPHISM; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC VARIABILITY; NULL ALLELE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SHORT TANDEM REPEAT;

GENE DELETION; GENOTYPE; HUMANS; MICROSATELLITE REPEATS; MUTAGENESIS, INSERTIONAL; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC;

EID: 79957641508     PISSN: 18724973     EISSN: 18780326     Source Type: Journal    
DOI: 10.1016/j.fsigen.2011.01.005     Document Type: Article

References (11)

1. A. Edwards, A. Civitello, H.A. Hammond, C.T. Caskey, DNA typing and genetic mapping with trimeric and tetrameric tandem repeats, Am. J. Hum. Genet. 49 (1991) 746-756. (Pubitemid 21891721)
2. B. Budowle, C.J. Sprecher, Concordance study on population database samples using the PowerPlex 16 kit and AmpFlSTR Profiler Plus kit and AmpFlSTR COfiler kit, J. Forensic Sci. 46 (2001) 637-641. (Pubitemid 32520589)
3. C.R. Hill, M.C. Kline, J.J. Mulero, R.E. Lagacé, C.W. Chang, L.K. Hennessy, J.M. Butler, Concordance study between the AmpFlSTR MiniFiler PCR amplification kit and conventional STR typing kits, J. Forensic Sci. 52 (2007) 870-873. (Pubitemid 46918601)
4. L. Gusmão, A. Amorim, M.J. Prata, L. Pereira, M.V. Lareu, A. Carracedo, Failed PCR amplifications of MBPSTR alleles due to polymorphism in the primer annealing region, Int. J. Legal Med. 108 (1996) 313-315.
5. U. Ricci, G. Melean, C. Robino, M. Genuardi, A single mutation in the FGA locus responsible for false homozygosities and discrepancies between commercial kits in an unusual paternity test case, J. Forensic Sci. 52 (2007) 393-396. (Pubitemid 46280521)
6. P.S. Walsh, D.A. Metzger, R. Higuchi, Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material, Biotechniques 110 (1991) 506-513.
7. K. Müller, R. Klein, E. Miltner, P. Wiegand, Q8 - a short amplicon multiplex including the German DNA database systems, Forensic Sci. Int. Genet. 1 (2007) 205-207. (Pubitemid 46760404)
8. K. Müller, G. Braunschweiger, R. Klein, E. Miltner, P. Wiegand, Validation of the short amplicon multiplex q8 including the German DNA database systems, J. Forensic Sci. 54 (2009) 862-865.
9. M.H. Polymeropoulos, D.S. Rath, H. Xiao, C.R. Merril, Tetranucleotide repeat polymorphism at the human beta-actin related pseudogene H-beta-Ac-psi-2 (ACTBP2), Nucleic Acids Res. 20 (1992) 1432.
10. B.E. Krenke, A. Tereba, S.J. Anderson, E. Buel, S. Culhane, C.J. Finis, C.S. Tomsey, J.M. Zachetti, A. Masibay, D.R. Rabbach, E.A. Amiott, C.J. Sprecher, Validation of a 16-locus fluorescent multiplex system, J. Forensic Sci. 47 (2002) 773-785. (Pubitemid 34760903)
11. C.R. Hill, D.L. Duewer, M.C. Kline, C.J. Sprecher, R.S. McLaren, D.R. Rabbach, B.E. Krenke, M.G. Ensenberger, P.M. Fulmer, D.R. Stort, J.M. Butler, Concordance and population studies along with stutter and peak height ratio analysis for the PowerPlex® ESX 17 and ESI 17 Systems, Forensic Sci. Int. Genet. (2010) (online).