Animal studies of 99mTc-i-PIDP: A new bone imaging agent

Applied Radiation and Isotopes

Volumn 69, Issue 9, 2011, Pages 1169-1175

  Wang, Yan ^a,b   Luo, Shineng ^a   Lin, Jianguo ^a   Qiu, Ling ^a   Cheng, Wen ^a   Zhai, Haozhen ^a,b   Nan, Beibei ^a   Ye, Wanzhong ^a   Xia, Yongmei ^b  

^a JIANGSU INSTITUTE OF NUCLEAR MEDICINE   (China)

^b JIANGNAN UNIVERSITY   (China)

Author keywords

99mTc i PIDP; Biodistribution; Bone imaging agent; Preparation; SPECT

Indexed keywords

99MTC-I-PIDP; BIODISTRIBUTIONS; BONE IMAGING AGENT; PREPARATION; SPECT;

NUCLEAR MEDICINE; PHARMACOKINETICS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SODIUM; TOMOGRAPHY;

BONE;

1 HYDROXY 2 (2 ISOPROPYL 1H IMIDAZOL 1 YL)ETHYLIDENE 1,1 BISPHOSPHONIC ACID TC 99M; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BONE SCINTISCANNING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; BONE AND BONES; DIPHOSPHONATES; MALE; MICE; MICE, INBRED ICR; ORGANOTECHNETIUM COMPOUNDS; RABBITS;

EID: 79957624613     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2011.03.045     Document Type: Article

References (21)

1. Asikoglu M., Durak F.G. The rabbit biodistribution of a therapeutic dose of zoledronic acid labeled with Tc-99m. Appl. Radiat. Isot. 2009, 67:1616-1621.
2. Bevan J.A., Tofe A.J., Benedict J.J., Francis M.D., Barnett B.L. Tc-99m-HMDP (hydroxymethylene diphosphonate): a radiopharmaceutical for skeletal and acute myocardial infarct imaging II. Comparison of Tc-99m hydroxymethylene diphosphonate (HMDP) with Other technetium-labeled bone-imaging agents in a canine model. J. Nucl. Med. 1980, 21:967-970.
3. Chen C.Q., Luo S.N., Lin J.G., Yang M., Ye W.Z., Qiu L., Sang G.M., Xia Y.M. Preparation and biodistribution of 99mTc-PIDP as bone imaging agent. Nucl. Sci. Technol. 2009, 20:302-306.
4. Green J.R. Zoledronic acid: pharmacologic profile of a potent bisphosphonate. J. Org. Chem. 2005, 690:2439-2448.
5. Guo X.H., Luo S.N., Wang H.Y., Zhou L., Xie M.H., Ye W.Z., Yang M., Wang Y. Study on the preparation and biodistribution of 99mTc-HMIBP. Nucl. Sci. Technol. 2006, 17:285-288.
6. Lantto T., Vorne M., Mokka R., Vähätalo S. 99Tcm-MDP and 99Tcm-DPD in pathologic bone lesions: a visual and quantitative comparison. Acta Radiol. 1987, 28:631-633.
7. Li Q.N., Zhang X.D., Sheng R., Li W.x. Preparation of (188Re) Re-AEDP and its biodistribution studies. Appl. Radiat. Isot. 2000, 53:993-997.
8. Lin J.G., Luo S.N., Chen C.Q., Qiu L., Wang Y., Cheng W., Ye W.Z., Xia Y.M. Preparation and preclinical pharmacological study on a novel bone imaging agent 99mTc-EMIDP. Appl. Radiat. Isot. 2010, 68:1616-1622.
9. Liu R.S., Chou T.K., Chang C.H., Wu C.Y., Chang C.W., Chang T.J., Wang S.J., Lin W.J., Wang H.E. Biodistribution, pharmacokinetics and PET imaging of [18F]FMISO, [18F]FDG and [18F]FAc in a sarcoma-and inflammation-bearing mouse model. Nucl. Med. Biol. 2009, 36:305-312.
10. Luo S.N., Wang H.Y., Xie M.H., Liu X.Y., Ye W.Z., Chen Z.M., Feng Y.Y., Cao G.X. The study on the preparation and biodistribution of 99mTc-MIDP. Chin. J. Nucl. Med. 2005, 25:341-344. in Chinese.
11. Marika C., Jonsson C., Jacobsson H. Sympathotropic drugs and the distribution of 99mTc-hydroxymethylene diphosphonate experimental studies in the mouse. Acta Radiol. 1999, 40:309-313.
12. Marika C., Sääf M., Sjöberg H.E., Schnell P.O., Jacobsson H. Influence of the phosphate balance on the activity distribution of 99mTc-hydroxymethylene diphosphonate experimental studies in the mouse. Acta Radiol. 1998, 39:427-433.
13. Niu G.S., Luo S.N., Yan X.H., Yang M., Ye W.Z., Wang H.Y., Xia Y.M. The preparation and biodistribution of 99mTc-EIDP. Nucl. Technol. 2008, 31:698-701. in Chinese.
14. Ogawa K., Mukai T., Inoue Y., Ono M., Saji H. Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent. J. Nucl. Med. 2006, 47:2042-2047.
15. Subramanian G., McAfee J.G. A new complex of 99mTc for skeletal imaging. Radiology 1971, 99:192-196.
16. Subramanian G., McAfee J.G., Blair R.J., Kallfelz F.A., Thomas F.D. Technetium-99m-methylene diphosphonate-a superior agent for skeletal imaging: comparison with other technetium complexes. J. Nucl. Med. 1975, 16:744-755.
17. Wang H.Y., Luo S.N., Xie M.H., Liu X.Y., Feng Y.Y., Chen Z.M., Ye W.Z. The new bone-imaging agent: preparation and biodistribution of 99mTc-ZL. Nucl. Technol. 2006, 29:438-441. in Chinese.
18. Widler L., Jaeggi K.A., Glatt M., Müller K., Bachmann R., Bisping M., Born A.R., Cortesi R., Guiglia G., Jeker H., Klein R., Ramseier U., Schmid J., Schreiber G., Seltenmeyer Y., Green J.R. Highly potent geminal bisphosphonates. From Pamidronate Disodium (Aredia) to zoledronic acid (Zometa). J. Med. Chem. 2002, 45:3721-3738.
19. Xue F.S., Liao X., Tong S.Y., Liu J.H., Li L., Zou Q., Luo L.K. Pharmacokinetics of vecuronium during acute isovolaemic haemodilution. Brit. J. Anaesth. 1997, 79:612-616.
20. Yano Y., Mcrae J., Vandyke D.C., Anger H.O. 99mTc-labeled Sn(II)-diphosphonate: a bone scanning agent. J. Nucl. Med. 1972, 13:480.
21. Zhang J.B., Wang X.B., Lu G.X., Tang Z.G. Synthesis and biodistribution of a new 99mTc nitride complex for brain imaging. Appl. Radiat. Isot. 2001, 54:745-748.