Treatment of gastrointestinal angiodysplasia and unmet needs

Digestive and Liver Disease

Volumn 43, Issue 7, 2011, Pages 515-522

  Dray, Xavier ^a,b   Camus, Marine ^a,b   Coelho, Jessica ^a   Ozenne, Violaine ^a   Pocard, Marc ^a,b   Marteau, Philippe ^a,b  

^a HÔPITAL LARIBOISIÈRE   (France)

^b Hôpital Lariboisière   (France)

Author keywords

Angiodysplasia; Argon plasma coagulation; Cryotherapy; Elastic band ligation; Electrocoagulation; Laser; Octreotide; Oestrogen; Sclerotherapy; Thalidomide

Indexed keywords

AMINOCAPROIC ACID; DANAZOL; ESTROGEN; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS NORETHISTERONE; OCTREOTIDE; PROGESTERONE; RECOMBINANT ERYTHROPOIETIN; THALIDOMIDE; TRANEXAMIC ACID;

ANGIODYSPLASIA; ARGON PLASMA COAGULATION; BLOOD CLOTTING DISORDER; CONGENITAL BLOOD VESSEL MALFORMATION; CRYOTHERAPY; DIARRHEA; ELECTROCOAGULATION; GASTROINTESTINAL DISEASE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL MALFORMATION; HUMAN; LIGATION; LOW LEVEL LASER THERAPY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REVIEW; VALVULAR HEART DISEASE;

ANGIODYSPLASIA; CRYOTHERAPY; ELECTROCOAGULATION; ESTROGENS; GASTROINTESTINAL AGENTS; GASTROINTESTINAL HEMORRHAGE; HUMANS; LASER COAGULATION; LIGATION; OCTREOTIDE; SCLEROTHERAPY; TREATMENT OUTCOME;

EID: 79957618066     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2010.12.007     Document Type: Review

References (89)

1. Athanasoulis C.A., Galdabini J.J., Waltman A., et al. Angiodysplasia of the colon. Cardiovasc Radiol 1978, 1:3-13.
2. Gordon F.H., Watkinson A., Hodgson H. Vascular malformations of the gastrointestinal tract. Best Pract Res Clin Gastroenterol 2001, 15:41-58.
3. Howard O.M., Buchanan J.D., Hunt R.H. Angiodysplasia of the colon, Experience of 26 cases. Lancet 1982, 2:16-19.
4. Boley S.J., Brandt L.J. Vascular ectasias of the colon-1986. Dig Dis Sci 1986, 31:26S-42S.
5. Rockey D.C., Koch J., Cello J.P., et al. Relative frequency of upper gastrointestinal and colonic lesions in patients with positive fecal occult-blood tests. N Engl J Med 1998, 339:153-159.
6. Longstreth G.F. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol 1997, 92:419-424.
7. Foutch P.G., Rex D.K., Lieberman D.A. Prevalence and natural history of colonic angiodysplasia among healthy asymptomatic people. Am J Gastroenterol 1995, 90:564-567.
8. Duchini A, Godino J, Wong P. Angiodysplasia of the colon. In: Patti MG, Talavera F, Achord JL, Mechaber AJ, Katz J, editors. e-Medicine; 2006.
9. Richter J.M., Christensen M.R., Colditz G.A., et al. Angiodysplasia. Natural history and efficacy of therapeutic interventions. Dig Dis Sci 1989, 34:1542-1546.
10. Junquera F., Feu F., Papo M., et al. A multicenter, randomized, clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia. Gastroenterology 2001, 121:1073-1079.
11. Junquera F., Saperas E., Videla S., et al. Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. Am J Gastroenterol 2007, 102:254-260.
12. Gupta N., Longo W.E., Vernava A.M. Angiodysplasia of the lower gastrointestinal tract: an entity readily diagnosed by colonoscopy and primarily managed nonoperatively. Dis Colon Rectum 1995, 38:979-982.
13. Cappell M.S., Gupta A. Changing epidemiology of gastrointestinal angiodysplasia with increasing recognition of clinically milder cases: angiodysplasia tend to produce mild chronic gastrointestinal bleeding in a study of 47 consecutive patients admitted from 1980-1989. Am J Gastroenterol 1992, 87:201-206.
14. Canard J.M., Vedrenne B. Clinical application of argon plasma coagulation in gastrointestinal endoscopy: has the time come to replace the laser?. Endoscopy 2001, 33:353-357.
15. Askin M.P., Lewis B.S. Push enteroscopic cauterization: long-term follow-up of 83 patients with bleeding small intestinal angiodysplasia. Gastrointest Endosc 1996, 43:580-583.
16. Rolachon A., Papillon E., Fournet J. Is argon plasma coagulation an efficient treatment for digestive system vascular malformation and radiation proctitis?. Gastroenterol Clin Biol 2000, 24:1205-1210.
17. Olmos J.A., Marcolongo M., Pogorelsky V., et al. Argon plasma coagulation for prevention of recurrent bleeding from GI angiodysplasias. Gastrointest Endosc 2004, 60:881-886.
18. Olmos J.A., Marcolongo M., Pogorelsky V., et al. Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. Dis Colon Rectum 2006, 49:1507-1516.
19. Kwan V., Bourke M.J., Williams S.J., et al. Argon plasma coagulation in the management of symptomatic gastrointestinal vascular lesions: experience in 100 consecutive patients with long-term follow-up. Am J Gastroenterol 2006, 101:58-63.
20. Suzuki N., Arebi N., Saunders B.P. A novel method of treating colonic angiodysplasia. Gastrointest Endosc 2006, 64:424-427.
21. Rogers H.G., Adler F. Hemangiomas of the cecum. Colonoscopic diagnosis and therapy. Gastroenterology 1976, 71:1079-1082.
22. Rogers B.H. Endoscopic diagnosis and therapy of mucosal vascular abnormalities of the gastrointestinal tract occurring in elderly patients and associated with cardiac, vascular, and pulmonary disease. Gastrointest Endosc 1980, 26:134-138.
23. Trudel J.L., Fazio V.W., Sivak M.V. Colonoscopic diagnosis and treatment of arteriovenous malformations in chronic lower gastrointestinal bleeding. Clinical accuracy and efficacy. Dis Colon Rectum 1988, 31:107-110.
24. Cottone C., Disclafani G., Genova G., et al. Use of BICAP in a case of colon angiodysplasia. Surg Endosc 1991, 5:99-100.
25. Foutch P.G., Sawyer R., Sanowski R.A. Push-enteroscopy for diagnosis of patients with gastrointestinal bleeding of obscure origin. Gastrointest Endosc 1990, 36:337-341.
26. Jensen D., Jutabha R., Kovacs T. A randomized prospective study of endoscopic hemostasis with argon plasma coagulator compared to Gold Probe for bleeding GI angiomas. Gastrointest Endosc 1999, 49:AB167.
27. Naveau S., Leger-Ravet M.B., Houdayer C., et al. Nonhereditary colonic angiodysplasias: histomorphometric approach to their pathogenesis. Dig Dis Sci 1995, 40:839-842.
28. Sudry P., Brunetaud J.M., Paris J.C., et al. Treatment of digestive angiomas with argon laser; about 15 cases. Gastroenterol Clin Biol 1981, 5:426-432.
29. Bowers J., Dixon J. Argon laser photocoagulation of vascular malformations in the GI tract. Short term results. Gastrointest Endosc 1982, 28:126.
30. Waitman A., Graut D., Chateau F. Argon laser photocoagulation treatments of patients with acute and chronic bleeding secondary to telangiectasia. Gastrointest Endosc 1982, 28:A153.
31. Jensen D.M., Machicado G.A., Silpa M. Treatment of GI angiomas with laser argon, heater probe, or bipolar electrocoagulation. Gastrointest Endosc 1984, 30:A134.
32. Maunoury V., Brunetaud J., Cochelard D., et al. Le traitement par laser des malformations vasculaires du tube digestif. Acta Endosc 1988, 18:73-80.
33. Feydy P., Aazib L., Driguez E., et al. Treatment with laser Nd YAG of digestive angiodysplasias in dialysed patients with chronic kidney failure. Gastroenterol Clin Biol 1993, 17:772-773.
34. Pavey D.A., Craig P.I. Endoscopic therapy for upper-GI vascular ectasias. Gastrointest Endosc 2004, 59:233-238.
35. Rutgeerts P., Van Gompel F., Geboes K., et al. Long term results of treatment of vascular malformations of the gastrointestinal tract by neodymium Yag laser photocoagulation. Gut 1985, 26:586-593.
36. Cello J.P., Grendell J.H. Endoscopic laser treatment for gastrointestinal vascular ectasias. Ann Intern Med 1986, 104:352-354.
37. Gostout C.J., Bowyer B.A., Ahlquist D.A., et al. Mucosal vascular malformations of the gastrointestinal tract: clinical observations and results of endoscopic neodymium: yttrium-aluminum-garnet laser therapy. Mayo Clin Proc 1988, 63:993-1003.
38. Johnston C.M., Schoenfeld L.P., Mysore J.V., et al. Endoscopic spray cryotherapy: a new technique for mucosal ablation in the esophagus. Gastrointest Endosc 1999, 50:86-92.
39. Pasricha P.J., Hill S., Wadwa K.S., et al. Endoscopic cryotherapy: experimental results and first clinical use. Gastrointest Endosc 1999, 49:627-631.
40. Kantsevoy S.V., Cruz-Correa M.R., Vaughn C.A., et al. Endoscopic cryotherapy for the treatment of bleeding mucosal vascular lesions of the GI tract: a pilot study. Gastrointest Endosc 2003, 57:403-406.
41. Jaspersen D., Korner T., Schorr W., et al. Diagnosis and treatment control of bleeding colorectal angiodysplasias by endoscopic Doppler sonography: a preliminary study. Gastrointest Endosc 1994, 40:40-44.
42. Bemvenuti G.A., Julich M.M. Ethanolamine injection for sclerotherapy of angiodysplasia of the colon. Endoscopy 1998, 30:564-569.
43. Tseng C., Burke S., Connors P., et al. Endoscopic band ligation for treatment of non-variceal upper gastrointestinal bleeding. Endoscopy 1991, 23:297-298.
44. Campo R., Brullet E. Endoscopic treatment of gastric angiodysplasia with elastic band ligation. Gastrointest Endosc 1996, 43:502-504.
45. Abi-Hanna D., Williams S.J., Gillespie P.E., et al. Endoscopic band ligation for non-variceal non-ulcer gastrointestinal hemorrhage. Gastrointest Endosc 1998, 48:510-514.
46. Jo Y., Matsumoto T., Aoyagi K., et al. Endoscopic band ligation device for bleeding gastric angiodysplasia. Gastrointest Endosc 1999, 50:599.
47. Junquera F., Brullet E., Campo R., et al. Usefulness of endoscopic band ligation for bleeding small bowel vascular lesions. Gastrointest Endosc 2003, 58:274-279.
48. Campo R., Brullet E., Montane J.M., et al. Elastic band ligation in the bowel: is it really safe?. Gastrointest Endosc 1998, 47:105-106.
49. Ljubicic N. Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up. Gastrointest Endosc 2004, 59:420-423.
50. Moparty B., Raju G.S. Role of hemoclips in a patient with cecal angiodysplasia at high risk of recurrent bleeding from antithrombotic therapy to maintain coronary stent patency: a case report. Gastrointest Endosc 2005, 62:468-469.
51. Cheng M., Madanick R., Barkin J. Pharmacologic management of obscure gastrointestinal bleeding. Tech Gastrointest Endosc 2003, 5:142-145.
52. Lewis B.S., Salomon P., Rivera-MacMurray S., et al. Does hormonal therapy have any benefit for bleeding angiodysplasia?. J Clin Gastroenterol 1992, 15:99-103.
53. Vase P. Estrogen treatment of hereditary hemorrhagic telangiectasia. A double-blind controlled clinical trial. Acta Med Scand 1981, 209:393-396.
54. Granieri R., Mazzulla J.P., Yarborough G.W. Estrogen-progesterone therapy for recurrent gastrointestinal bleeding secondary to gastrointestinal angiodysplasia. Am J Gastroenterol 1988, 83:556-558.
55. Bellucci S., Zini J.M., Bitoun P., et al. Diffuse severe digestive angiodysplasia in Bernard-Soulier syndrome. Improvement of bleeding by oestroprogestative therapy. Thromb Haemost 1995, 74:1610-1612.
56. Moshkowitz M., Arber N., Amir N., et al. Success of estrogen-progesterone therapy in long-standing bleeding gastrointestinal angiodysplasia. Report of a case. Dis Colon Rectum 1993, 36:194-196.
57. Yuksel O., Koklu S., Ucar E., et al. Severe recurrent gastrointestinal bleeding due to angiodysplasia in a Bernard-Soulier patient: an onerous medical concomitance. Dig Dis Sci 2004, 49:885-887.
58. Van Cutsem E., Rutgeert P., Vantrappen G. Long-term effect of hormonal therapy for bleeding gastrointestinal vascular malformations. Eur J Gastroenterol Hepatol 1993, 5:439-443.
59. Barkin J.S., Ross B.S. Medical therapy for chronic gastrointestinal bleeding of obscure origin. Am J Gastroenterol 1998, 93:1250-1254.
60. Van Cutsem E., Rutgeerts P., Vantrappen G. Treatment of bleeding gastrointestinal vascular malformations with oestrogen-progesterone. Lancet 1990, 335:953-955.
61. Hodgson H. Hormonal therapy for gastrointestinal angiodysplasia. Lancet 2002, 359:1630-1631.
62. Torsoli A., Annibale B., Viscardi A., et al. Treatment of bleeding due to diffuse angiodysplasia of the small intestine with somatostatine analogue. Eur J Gastroenterol Hepatol 1991, 3:785-787.
63. Rossini F.P., Arrigoni A., Pennazio M. Octreotide in the treatment of bleeding due to angiodysplasia of the small intestine. Am J Gastroenterol 1993, 88:1424-1427.
64. Andersen M.R., Aaseby J. Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. Scand J Gastroenterol 1996, 31:1037-1039.
65. Plessevaux H., Coremans G., Rutgeert P., et al. Octreotide in the treatment of bleeding gastrointestinal vascular malformations. Gastroenterology 1996, 110:A353.
66. Bowers M., McNulty O., Mayne E. Octreotide in the treatment of gastrointestinal bleeding caused by angiodysplasia in two patients with von Willebrand's disease. Br J Haematol 2000, 108:524-527.
67. Orsi P., Guatti-Zuliani C., Okolicsanyi L. Long-acting octreotide is effective in controlling rebleeding angiodysplasia of the gastrointestinal tract. Dig Liver Dis 2001, 33:330-334.
68. Nordquist L.T., Wallach P.M. Octreotide for gastrointestinal bleeding of obscure origin in an anticoagulated patient. Dig Dis Sci 2002, 47:1514-1515.
69. Blich M., Fruchter O., Edelstein S., Edoute Y. Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. Scand J Gastroenterol 2003, 38:801-803.
70. Coppola A., De Stefano V., Tufano A., et al. Long-lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3-year pharmacological management. J Intern Med 2002, 252:271-275.
71. Nardone G., Rocco A., Balzano T., et al. The efficacy of octreotide therapy in chronic bleeding due to vascular abnormalities of the gastrointestinal tract. Aliment Pharmacol Ther 1999, 13:1429-1436.
72. Scaglione G., Pietrini L., Russo F., et al. Long-acting octreotide as rescue therapy in chronic bleeding from gastrointestinal angiodysplasia. Aliment Pharmacol Ther 2007, 26:935-942.
73. Bauditz J., Schachschal G., Wedel S., et al. Thalidomide for treatment of severe intestinal bleeding. Gut 2004, 53:609-612.
74. Shurafa M., Kamboj G. Thalidomide for the treatment of bleeding angiodysplasias. Am J Gastroenterol 2003, 98:221-222.
75. De Koning D.B., Drenth J.P., Friederich P., et al. Thalidomide for the treatment of recurrent gastrointestinal blood loss due to intestinal angiodysplasias. Ned Tijdschr Geneeskd 2006, 150:1994-1997.
76. Heidt J., Langers A.M., van der Meer F.J., et al. Thalidomide as treatment for digestive tract angiodysplasias. Neth J Med 2006, 64:425-428.
77. Kirkham S.E., Lindley K.J., Elawad M.A., et al. Treatment of multiple small bowel angiodysplasias causing severe life-threatening bleeding with thalidomide. J Pediatr Gastroenterol Nutr 2006, 42:585-587.
78. Dabak V., Kuriakose P., Kamboj G., et al. A pilot study of thalidomide in recurrent GI bleeding due to angiodysplasias. Dig Dis Sci. 2008, 53(6):1632-1635.
79. Kamalaporn P., Saravanan R., Cirocco M., et al. Thalidomide for treatment of chronic gastrointestinal bleeding from angiodysplasias: a case series. Eur J Gastroenter Hepatol 2009, 21(12):1347-1350.
80. Zaharia-Czeizler V. Erythropoietin stops chronic diffuse transfusion-dependent gastrointestinal bleeding. Ann Intern Med 2001, 135:933.
81. Meijer K., Peters F.T., van der Meer J. Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa. Blood Coagul Fibrinolysis 2001, 12:211-213.
82. Zanon E., Vianello F., Casonato A., et al. Early transfusion of factor VIII/von Willebrand factor concentrates seems to be effective in the treatment of gastrointestinal bleeding in patients with von Willebrand type III disease. Haemophilia 2001, 7:500-503.
83. Vujkovac B., Lavre J., Sabovic M. Successful treatment of bleeding from colonic angiodysplasias with tranexamic acid in a hemodialysis patient. Am J Kidney Dis 1998, 31:536-538.
84. De Leusse A., Landi B., Edery J., et al. Video capsule endoscopy for investigation of obscure gastrointestinal bleeding: feasibility, results, and interobserver agreement. Endoscopy 2005, 37:617-621.
85. Akerman P., Cantero D. Spiral enteroscopy push enteroscopy. Gastrointest Endosc Clin N Am 2009, 19(3):357-369.
86. Sharma R., Gorbien M.J. Angiodysplasia and lower gastrointestinal tract bleeding in elderly patients. Arch Intern Med 1995, 155:807-812.
87. Nguyen N., Croser D., Madigan D., et al. Embolotherapy for small bowel angiodysplasia. Gastrointest Endosc 2003, 58:797-800.
88. Douard R., Wind P., Panis Y., et al. Intraoperative enteroscopy of diagnosis and management of unexplained gastrointestinal bleeding. Am J Surg 2000, 180:181-184.
89. Lewis B.S. Obscure GI bleeding in the world of capsule endoscopy, push, and double balloon enteroscopies. Gastrointest Endosc 2007, 66:S66-S68.