SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Sharma, Kulbhushan ^a   Åkerström, Sara ^b   Sharma, Anuj Kumar ^c   Chow, Vincent T K ^d   Teow, Shumein ^e   Abrenica, Bernard ^e   Booth, Stephanie A ^e,f   Booth, Timothy F ^e,f   Mirazimi, Ali ^b   Lal, Sunil K ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^c JAWAHARLAL NEHRU UNIVERSITY   (India)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^f UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

9B PROTEIN; CASPASE 3; EXPORTIN 1; UNCLASSIFIED DRUG; VIRUS PROTEIN; CELL RECEPTOR; EXPORTIN 1 PROTEIN; KARYOPHERIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HALF LIFE TIME; HOST CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEOTIDE SEQUENCE; PASSIVE TRANSPORT; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SARS CORONAVIRUS; ACTIVE TRANSPORT; ANIMAL; BIOLOGICAL MODEL; CERCOPITHECUS; DIFFUSION; INTRACELLULAR SPACE; METABOLISM; NUCLEAR EXPORT SIGNAL; PROTEIN PROCESSING; VERO CELL;

SARS CORONAVIRUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL CYCLE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; DIFFUSION; INTRACELLULAR SPACE; KARYOPHERINS; MODELS, BIOLOGICAL; NUCLEAR EXPORT SIGNALS; NUCLEAR LOCALIZATION SIGNALS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SARS VIRUS; TRANSFECTION; VERO CELLS; VIRAL PROTEINS;

EID: 79957611537     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019436     Document Type: Article

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