메뉴 건너뛰기




Volumn 6, Issue 5, 2011, Pages 653-671

Development of the small-molecule antiviral ST-246® as a smallpox therapeutic

Author keywords

animal rule; antiviral; CBRN medical countermeasures; FDA approval; monkeypox; smallpox; strategic national stockpile; zoonotic orthopoxvirus

Indexed keywords

CIDOFOVIR; IMIQUIMOD; METISAZONE; TECOVIRIMAT;

EID: 79957582537     PISSN: 17460794     EISSN: 17460808     Source Type: Journal    
DOI: 10.2217/fvl.11.27     Document Type: Review
Times cited : (74)

References (75)
  • 2
  • 8
    • 0038621562 scopus 로고    scopus 로고
    • Smallpox vaccination campaign in the doldrums
    • Enserink M: Infectious diseases. Smallpox vaccination campaign in the doldrums. Science 300(5621), 880-881 (2003). (Pubitemid 36548840)
    • (2003) Science , vol.300 , Issue.5621 , pp. 880-881
    • Enserink, M.1
  • 11
    • 0026890916 scopus 로고
    • Biological effects of recombinant vaccinia virus-expressed interleukin 4
    • Andrew ME, Coupar BE: Biological effects of recombinant vaccinia virus-expressed interleukin 4. Cytokine 4(4), 281-286 (1992).
    • (1992) Cytokine , vol.4 , Issue.4 , pp. 281-286
    • Andrew, M.E.1    Coupar, B.E.2
  • 13
    • 0033605364 scopus 로고    scopus 로고
    • The looming threat of bioterrorism
    • Henderson DA: The looming threat of bioterrorism. Science 283(5406), 1279-1282 (1999).
    • (1999) Science , vol.283 , Issue.5406 , pp. 1279-1282
    • Henderson, D.A.1
  • 14
    • 33645222064 scopus 로고    scopus 로고
    • Bichat guidelines for the clinical management of smallpox and bioterrorism-related smallpox
    • Bossi P, Tegnell A, Baka A et al.: Bichat guidelines for the clinical management of smallpox and bioterrorism-related smallpox. Euro Surveill. 9(12), E7-E8 (2004).
    • (2004) Euro Surveill. , vol.9 , Issue.12
    • Bossi, P.1    Tegnell, A.2    Baka, A.3
  • 16
    • 3142777885 scopus 로고    scopus 로고
    • Preventing second-generation infections in a smallpox bioterror attack
    • DOI 10.1097/01.ede.0000121821.02642.a4
    • Kaplan EH: Preventing second-generation infections in a smallpox bioterror attack. Epidemiology 15(3), 264-270 (2004). (Pubitemid 40416944)
    • (2004) Epidemiology , vol.15 , Issue.3 , pp. 264-270
    • Kaplan, E.H.1
  • 17
    • 1242285024 scopus 로고    scopus 로고
    • Modelling responses to a smallpox epidemic taking into account uncertainty
    • DOI 10.1017/S0950268803001390
    • Legrand J, Viboud C, Boelle PY, Valleron AJ, Flahault A: Modelling responses to a smallpox epidemic taking into account uncertainty. Epidemiol. Infect. 132(1), 19-25 (2004). (Pubitemid 38240068)
    • (2004) Epidemiology and Infection , vol.132 , Issue.1 , pp. 19-25
    • Legrand, J.1    Viboud, C.2    Boelle, P.Y.3    Valleron, A.J.4    Flahault, A.5
  • 18
    • 0036677591 scopus 로고    scopus 로고
    • Emergency response to a smallpox attack: The case for mass vaccination
    • Kaplan EH, Craft DL, Wein LM: Emergency response to a smallpox attack: the case for mass vaccination. Proc. Natl Acad. Sci. USA 99(16), 10935-10940 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.16 , pp. 10935-10940
    • Kaplan, E.H.1    Craft, D.L.2    Wein, L.M.3
  • 19
  • 21
    • 0036518565 scopus 로고    scopus 로고
    • Expected adverse events in a mass smallpox vaccination campaign
    • Kemper AR, Davis MM, Freed GL: Expected adverse events in a mass smallpox vaccination campaign. Eff. Clin. Pract. 5(2), 84-90 (2002).
    • (2002) Eff. Clin. Pract. , vol.5 , Issue.2 , pp. 84-90
    • Kemper, A.R.1    Davis, M.M.2    Freed, G.L.3
  • 22
    • 0014861732 scopus 로고
    • Complications of smallpox vaccination, 1968: Results of ten statewide surveys
    • Lane JM, Ruben FL, Neff JM, Millar JD: Complications of smallpox vaccination, 1968: results of ten statewide surveys. J. Infect. Dis. 122(4), 303-309 (1970).
    • (1970) J. Infect. Dis. , vol.122 , Issue.4 , pp. 303-309
    • Lane, J.M.1    Ruben, F.L.2    Neff, J.M.3    Millar, J.D.4
  • 23
    • 33748366395 scopus 로고    scopus 로고
    • Frequency of adverse events after vaccination with different vaccinia strains
    • Kretzschmar M, Wallinga J, Teunis P, Xing S, Mikolajczyk R: Frequency of adverse events after vaccination with different vaccinia strains. PLoS Med. 3(8), E272 (2006).
    • (2006) PLoS Med. , vol.3 , Issue.8
    • Kretzschmar, M.1    Wallinga, J.2    Teunis, P.3    Xing, S.4    Mikolajczyk, R.5
  • 24
    • 25444519428 scopus 로고    scopus 로고
    • The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection
    • DOI 10.1016/j.virol.2005.06.043, PII S0042682205004058
    • Coulibaly S, Bruhl P, Mayrhofer J, Schmid K, Gerencer M, Falkner FG: The nonreplicating smallpox candidate vaccines defective vaccinia Lister (dVV-L) and modified vaccinia Ankara (MVA) elicit robust long-term protection. Virology 341(1), 91-101 (2005). (Pubitemid 41356718)
    • (2005) Virology , vol.341 , Issue.1 , pp. 91-101
    • Coulibaly, S.1    Bruhl, P.2    Mayrhofer, J.3    Schmid, K.4    Gerencer, M.5    Falkner, F.G.6
  • 26
    • 33645232533 scopus 로고    scopus 로고
    • Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge
    • Empig C, Kenner JR, Perret-Gentil M et al.: Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge. Vaccine 3686-3694 (2006).
    • (2006) Vaccine , pp. 3686-3694
    • Empig, C.1    Kenner, J.R.2    Perret-Gentil, M.3
  • 27
    • 2942693560 scopus 로고    scopus 로고
    • Modified vaccinia Ankara: Potential as an alternative smallpox vaccine
    • DOI 10.1086/421266
    • Mccurdy LH, Larkin BD, Martin JE, Graham BS: Modified vaccinia Ankara: potential as an alternative smallpox vaccine. Clin. Infect. Dis. 38(12), 1749-1753 (2004). (Pubitemid 38781668)
    • (2004) Clinical Infectious Diseases , vol.38 , Issue.12 , pp. 1749-1753
    • McCurdy, L.H.1    Larkin, B.D.2    Martin, J.E.3    Graham, B.S.4
  • 29
    • 33646753179 scopus 로고    scopus 로고
    • LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox
    • Saijo M, Ami Y, Suzaki Y et al.: LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox. J. Virol. 80(11), 5179-5188 (2006).
    • (2006) J. Virol. , vol.80 , Issue.11 , pp. 5179-5188
    • Saijo, M.1    Ami, Y.2    Suzaki, Y.3
  • 37
    • 38049062041 scopus 로고    scopus 로고
    • Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures
    • Duraffour S, Snoeck R, De Vos R et al.: Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures. Antivir. Ther. 12(8), 1205-1216 (2007).
    • (2007) Antivir. Ther. , vol.12 , Issue.8 , pp. 1205-1216
    • Duraffour, S.1    Snoeck, R.2    De Vos, R.3
  • 38
    • 66249115329 scopus 로고    scopus 로고
    • Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis
    • Chen Y, Honeychurch KM, Yang G et al.: Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis. Virol. J. 6, 44 (2009).
    • (2009) Virol. J. , vol.6 , pp. 44
    • Chen, Y.1    Honeychurch, K.M.2    Yang, G.3
  • 39
    • 0036932713 scopus 로고    scopus 로고
    • The formation and function of extracellular enveloped vaccinia virus
    • Smith GL, Vanderplasschen A, Law M: The formation and function of extracellular enveloped vaccinia virus. J. Gen. Virol. 83(Pt 12), 2915-2931 (2002). (Pubitemid 36054337)
    • (2002) Journal of General Virology , vol.83 , Issue.12 , pp. 2915-2931
    • Smith, G.L.1    Vanderplasschen, A.2    Law, M.3
  • 41
    • 0019199323 scopus 로고
    • Significance of extracellular enveloped virus in the in vitro and in vivo dissemination of vaccinia
    • Payne LG: Significance of extracellular enveloped virus in the in vitro and in vivo dissemination of vaccinia. J. Gen. Virol. 50(1), 89-100 (1980). (Pubitemid 11211415)
    • (1980) Journal of General Virology , vol.50 , Issue.1 , pp. 89-100
    • Payne, L.G.1
  • 42
    • 0026039370 scopus 로고
    • Extracellular vaccinia virus formation and cell-to-cell virus transmission are prevented by deletion of the gene encoding the 37,000-Dalton outer envelope protein
    • Blasco R, Moss B: Extracellular vaccinia virus formation and cell-to-cell virus transmission are prevented by deletion of the gene encoding the 37,000-Dalton outer envelope protein. J. Virol. 65(11), 5910-5920 (1991).
    • (1991) J. Virol. , vol.65 , Issue.11 , pp. 5910-5920
    • Blasco, R.1    Moss, B.2
  • 43
    • 32644454769 scopus 로고    scopus 로고
    • Pathogenicity and immunogenicity in mice of vaccinia viruses mutated in the viral envelope proteins A33R and B5R
    • DOI 10.1016/j.antiviral.2005.11.006, PII S0166354205002561
    • Gurt I, Abdalrhman I, Katz E: Pathogenicity and immunogenicity in mice of vaccinia viruses mutated in the viral envelope proteins A33R and B5R. Antiviral Res. 69(3), 158-164 (2005). (Pubitemid 43247336)
    • (2006) Antiviral Research , vol.69 , Issue.3 , pp. 158-164
    • Gurt, I.1    Abdalrhman, I.2    Katz, E.3
  • 44
    • 0029655645 scopus 로고    scopus 로고
    • Vaccinia virus glycoprotein A34R is required for infectivity of extracellular enveloped virus
    • Mcintosh AA, Smith GL: Vaccinia virus glycoprotein A34R is required for infectivity of extracellular enveloped virus. J. Virol. 70(1), 272-281 (1996). (Pubitemid 126508795)
    • (1996) Journal of Virology , vol.70 , Issue.1 , pp. 272-281
    • McIntosh, A.A.G.1    Smith, G.L.2
  • 45
    • 0027162408 scopus 로고
    • Deletion of the vaccinia virus B5R gene encoding a 42-kilodalton membrane glycoprotein inhibits extracellular virus envelope formation and dissemination
    • Wolffe EJ, Isaacs SN, Moss B: Deletion of the vaccinia virus B5R gene encoding a 42-kilodalton membrane glycoprotein inhibits extracellular virus envelope formation and dissemination. J. Virol. 67(8), 4732-4741 (1993). (Pubitemid 23215953)
    • (1993) Journal of Virology , vol.67 , Issue.8 , pp. 4732-4741
    • Wolffe, E.J.1    Isaacs, S.N.2    Moss, B.3
  • 46
    • 79952132207 scopus 로고    scopus 로고
    • Development of ST-246® for treatment of poxvirus infections
    • Jordan R, Leeds JM, Tyavanagimatt S, Hruby D: Development of ST-246® for treatment of poxvirus infections. Viruses 2, 2409-2435 (2010).
    • (2010) Viruses , vol.2 , pp. 2409-2435
    • Jordan, R.1    Leeds, J.M.2    Tyavanagimatt, S.3    Hruby, D.4
  • 47
    • 71249115159 scopus 로고    scopus 로고
    • ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation
    • Berhanu A, King DS, Mosier S et al.: ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation. Antimicrob. Agents Chemother. 53(12), 4999-5009 (2009).
    • (2009) Antimicrob. Agents Chemother. , vol.53 , Issue.12 , pp. 4999-5009
    • Berhanu, A.1    King, D.S.2    Mosier, S.3
  • 48
    • 76249114760 scopus 로고    scopus 로고
    • Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice
    • Grosenbach DW, Berhanu A, King DS et al.: Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice. Proc. Natl Acad. Sci. USA 107(2), 838-843 (2010).
    • (2010) Proc. Natl Acad. Sci. USA 107 , vol.2 , pp. 838-843
    • Grosenbach, D.W.1    Berhanu, A.2    King, D.S.3
  • 51
    • 43649089767 scopus 로고    scopus 로고
    • Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model
    • Nalca A, Hatkin JM, Garza NL et al.: Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model. Antiviral Res. 79(2), 121-127 (2008).
    • (2008) Antiviral Res. , vol.79 , Issue.2 , pp. 121-127
    • Nalca, A.1    Hatkin, J.M.2    Garza, N.L.3
  • 52
    • 67049136160 scopus 로고    scopus 로고
    • Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246
    • Huggins J, Goff A, Hensley L et al.: Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Antimicrob. Agents Chemother. 53(6), 2620-2625 (2009).
    • (2009) Antimicrob. Agents Chemother. , vol.53 , Issue.6 , pp. 2620-2625
    • Huggins, J.1    Goff, A.2    Hensley, L.3
  • 53
    • 66149119341 scopus 로고    scopus 로고
    • ST-246 antiviral efficacy in a nonhuman primate monkeypox model: Determination of the minimal effective dose and human dose justification
    • Jordan R, Goff A, Frimm A et al.: ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification. Antimicrob. Agents Chemother. 53(5), 1817-1822 (2009).
    • (2009) Antimicrob. Agents Chemother. , vol.53 , Issue.5 , pp. 1817-1822
    • Jordan, R.1    Goff, A.2    Frimm, A.3
  • 54
    • 0035206041 scopus 로고    scopus 로고
    • The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis)
    • Zaucha GM, Jahrling PB, Geisbert TW, Swearengen JR, Hensley L: The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis). Lab. Invest. 81(12), 1581-1600 (2001). (Pubitemid 33144422)
    • (2001) Laboratory Investigation , vol.81 , Issue.12 , pp. 1581-1600
    • Zaucha, G.M.1    Jahrling, P.B.2    Geisbert, T.W.3    Swearengen, J.R.4    Hensley, L.5
  • 56
    • 33947170378 scopus 로고    scopus 로고
    • Adjuvant-enhanced antibody responses to recombinant proteins correlates with protection of mice and monkeys to orthopoxvirus challenges
    • DOI 10.1016/j.vaccine.2006.12.037, PII S0264410X06013673
    • Fogg CN, Americo JL, Lustig S et al.: Adjuvant-enhanced antibody responses to recombinant proteins correlates with protection of mice and monkeys to orthopoxvirus challenges. Vaccine 25(15), 2787-2799 (2007). (Pubitemid 46412575)
    • (2007) Vaccine , vol.25 , Issue.15 , pp. 2787-2799
    • Fogg, C.N.1    Americo, J.L.2    Lustig, S.3    Huggins, J.W.4    Smith, S.K.5    Damon, I.6    Resch, W.7    Earl, P.L.8    Klinman, D.M.9    Moss, B.10
  • 59
    • 37849005004 scopus 로고    scopus 로고
    • Clonal vaccinia virus grown in cell culture fully protects monkeys from lethal monkeypox challenge
    • Marriott KA, Parkinson CV, Morefield SI, Davenport R, Nichols R, Monath TP: Clonal vaccinia virus grown in cell culture fully protects monkeys from lethal monkeypox challenge. Vaccine 26(4), 581-588 (2008).
    • (2008) Vaccine , vol.26 , Issue.4 , pp. 581-588
    • Marriott, K.A.1    Parkinson, C.V.2    Morefield, S.I.3    Davenport, R.4    Nichols, R.5    Monath, T.P.6
  • 62
    • 66149153445 scopus 로고    scopus 로고
    • CDC: Progressive vaccinia in a military smallpox vaccinee - United States, 2009
    • CDC: Progressive vaccinia in a military smallpox vaccinee - United States, 2009. MMWR Morb. Mortal. Wkly Rep. 58(19), 532-536 (2009).
    • (2009) MMWR Morb. Mortal. Wkly Rep. , vol.58 , Issue.19 , pp. 532-536
  • 65
    • 77958012660 scopus 로고    scopus 로고
    • Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo
    • Rimoin AW, Mulembakani PM, Johnston SC et al.: Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc. Natl Acad. Sci. USA 107(37), 16262-16267 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.37 , pp. 16262-16267
    • Rimoin, A.W.1    Mulembakani, P.M.2    Johnston, S.C.3
  • 68
    • 0035349885 scopus 로고    scopus 로고
    • Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997
    • Hutin YJ, Williams RJ, Malfait P et al.: Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerg. Infect. Dis. 7(3), 434-438 (2001).
    • (2001) Emerg. Infect. Dis. , vol.7 , Issue.3 , pp. 434-438
    • Hutin, Y.J.1    Williams, R.J.2    Malfait, P.3
  • 69
    • 34248679286 scopus 로고    scopus 로고
    • Human monkeypox: An emerging zoonotic disease
    • DOI 10.2217/17460913.2.1.17
    • Parker S, Nuara A, Buller RM, Schultz DA: Human monkeypox: an emerging zoonotic disease. Future Microbiol. 2, 17-34 (2007). (Pubitemid 46766996)
    • (2007) Future Microbiology , vol.2 , Issue.1 , pp. 17-34
    • Parker, S.1    Nuara, A.2    Buller, R.M.L.3    Schultz, D.A.4
  • 71
    • 21444459872 scopus 로고    scopus 로고
    • Biological activity of an intravenous preparation of human vaccinia immune globulin in mouse models of vaccinia virus infection
    • DOI 10.1128/AAC.49.7.2634-2641.2005
    • Shearer JD, Siemann L, Gerkovich M, House RV: Biological activity of an intravenous preparation of human vaccinia immune globulin in mouse models of vaccinia virus infection. Antimicrob. Agents Chemother. 49(7), 2634-2641 (2005). (Pubitemid 40917572)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.7 , pp. 2634-2641
    • Shearer, J.D.1    Siemann, L.2    Gerkovich, M.3    House, R.V.4
  • 72
    • 23044457366 scopus 로고    scopus 로고
    • Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate
    • DOI 10.1128/AAC.49.8.3153-3162.2005
    • Magee WC, Hostetler KY, Evans DH: Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrob. Agents Chemother. 49(8), 3153-3162 (2005). (Pubitemid 41060553)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.8 , pp. 3153-3162
    • Magee, W.C.1    Hostetler, K.Y.2    Evans, D.H.3
  • 74
    • 38649123346 scopus 로고    scopus 로고
    • Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination
    • Grosenbach DW, Jordan R, King DS et al.: Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination. Vaccine 26(7), 933-946 (2008).
    • (2008) Vaccine , vol.26 , Issue.7 , pp. 933-946
    • Grosenbach, D.W.1    Jordan, R.2    King, D.S.3
  • 75
    • 78649698396 scopus 로고    scopus 로고
    • Impact of ST-246® on ACAM2000 smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice
    • Berhanu A, King DS, Mosier S et al.: Impact of ST-246® on ACAM2000 smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice. Vaccine 29(2), 289-303 (2010).
    • (2010) Vaccine , vol.29 , Issue.2 , pp. 289-303
    • Berhanu, A.1    King, D.S.2    Mosier, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.