Variation in the ADH1B proximal promoter affects expression

Chemico-Biological Interactions

Volumn 191, Issue 1-3, 2011, Pages 38-41

  Pochareddy, Sirisha ^a   Edenberg, Howard J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol dehydrogenase 1B; Alcoholism; Gene expression; Haplotype; Polymorphism; Promoter; SNP

Indexed keywords

ADH1B GENE; ALCOHOLISM; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENETIC TRANSFECTION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION SITE;

ALCOHOL DEHYDROGENASE; ALLELES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HAPLOTYPES; HEP G2 CELLS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 79957556304     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.12.007     Document Type: Conference Paper

References (31)

1. A.J. Birley, et al., Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci, Behav. Genet. 35 (2005) 509-524.
2. D.W. Goodwin, et al., Alcohol problems in adoptees raised apart from alcoholic biological parents, Arch. Gen. Psychiatry 28 (1973) 238-243.
3. D.W. Goodwin, et al., Drinking problems in adopted and nonadopted sons of alcoholics, Arch. Gen. Psychiatry 31 (1974) 164-169.
4. K.S. Kendler, et al., Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949, Arch. Gen. Psychiatry 54 (1997) 178-184.
5. R.D. Mayfield, R.A. Harris, M.A. Schuckit, Genetic factors influencing alcohol dependence, Br. J. Pharmacol. 154 (2008) 275-287.
6. M. McGue, A behavioral-genetic perspective on children of alcoholics, Alcohol Health Res. World 21 (1997) 210-217.
7. M. McGue, The behavioral genetics of alcoholism, Curr. Dir. Psychol. Sci. 8 (1999) 109-115.
8. J.I. Nurnberger Jr., et al., A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands, Arch. Gen. Psychiatry 61 (2004) 1246-1256.
9. C.A. Prescott, S.H. Aggen, K.S. Kendler, Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins, Alcohol Clin. Exp. Res. 23 (1999) 1136-1144. (Pubitemid 29352799)
10. C.A. Prescott, K.S. Kendler, Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins, Am. J. Psychiatry 156 (1999) 34-40. (Pubitemid 29034877)
11. H.J. Edenberg, Regulation of the mammalian alcohol dehydrogenase genes, Prog. Nucleic Acid Res. Mol. Biol. 64 (2000) 295-341.
12. T.D. Hurley, H.J. Edenberg, T.-K. Li, Pharmacogenomics of alcoholism, in: M.-L.W. Julio Licinio (Ed.), Pharmacogenomics: The Search for Individualized Therapies, Culinary and Hospitality Industry Publications Services, 2002, pp. 417-441.
13. H.J. Edenberg, The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants, Alcohol Res. Health 30 (2007) 5-13.
14. Y.L. Xu, et al., Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification, Genomics 2 (1988) 209-214.
15. H.R. Thomasson, et al., Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men, Am. J. Hum. Genet. 48 (1991) 677-681. (Pubitemid 21891610)
16. J.B. Whitfield, Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease, Alcohol Alcohol. 32 (1997) 613-619. (Pubitemid 27483199)
17. E. Borras, et al., Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1, Hepatology 31 (2000) 984-989. (Pubitemid 30169947)
18. J.B. Whitfield, Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations, Am. J. Hum. Genet. 71 (2002) 1247-1250 (author reply 1250-1241).
19. S.E. Luczak, S.J. Glatt, T.L. Wall, Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians, Psychol. Bull. 132 (2006) 607-621.
20. C.C. Chen, et al., Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism, Am. J. Hum. Genet. 65 (1999) 795-807.
21. H.J. Edenberg, R.E. Jerome, M. Li, Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression, Pharmacogenetics 9 (1999) 25-30. (Pubitemid 29176720)
22. C. Guindalini, et al., Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients, Am. J. Psychiatry 162 (2005) 1005-1007. (Pubitemid 40684468)
23. H.J. Chen, H. Tian, H.J. Edenberg, Natural haplotypes in the regulatory sequences affecthumanalcohol dehydrogenase1C(ADH1C) gene expression,Hum.Mutat. 25 (2005) 150-155.
24. H.J. Edenberg, T. Foroud, The genetics of alcoholism: identifying specific genes through family studies, Addict. Biol. 11 (2006) 386-396.
25. H.J. Edenberg, et al., Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis, Hum. Mol. Genet. 15 (2006) 1539-1549.
26. S. Macgregor, P.A. Lind, K.K. Bucholz, N.K. Hansell, P.A. Madden, M.M. Richter, G.W. Montgomery, N.G. Martin, A.C. Heath, J.B. Whitfield, Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis, Hum. Mol. Genet. 18 (2009) 580-593.
27. X. Luo, H.R. Kranzler, L. Zuo, B.Z. Yang, J. Lappalainen, J. Gelernter, ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies, Pharmacogenet. Genomics 15 (2005) 755-768. (Pubitemid 41531725)
28. S.K. Nordeen, Luciferase reporter gene vectors for analysis of promoters and enhancers, Biotechniques 6 (1988) 454-458.
29. C.J. Brown, L. Zhang, H.J. Edenberg, Tissue-specific differences in the expression of the human ADH2 alcohol dehydrogenase gene and in binding of factors to cis-acting elements in its promoter, DNA Cell Biol. 13 (1994) 235-247. (Pubitemid 24296985)
30. C.J. Brown, L. Zhang, H.J. Edenberg, Gene expression in a young multigene family: tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3, DNA Cell Biol. 15 (1996) 187-196.
31. D. Farre, et al., Identification of patterns in biological sequences at the ALGGEN server, PROMO and MALGEN, Nucleic Acids Res. 31 (2003) 3651-3653.