Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMP8 mice

Chinese Medical Journal

Volumn 124, Issue 10, 2011, Pages 1540-1544

  Jiang, Qing Song ^a   Liang, Zi Liang ^b   Wu, Min Jie ^c   Feng, Lin ^c   Liu, Li Li ^b   Zhang, Jian Jun ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

Author keywords

Brain derived neurotrophic factor; Learning and memory; Molarless; TrkB; Water maze

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN ENZYME; BRAIN PROTEIN; BRAIN RECEPTOR; TROPOMYOSIN RELATED KINASE B; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; BRAIN CORTEX; BRAIN LEVEL; CONTROLLED STUDY; ESCAPE BEHAVIOR; HIPPOCAMPUS; LATENT PERIOD; LEARNING; LEARNING DISORDER; LOCOMOTION; MALE; MAZE TEST; MEMORY; MOLAR TOOTH; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OPEN FIELD TEST; PROTEIN EXPRESSION; SENESCENCE ACCELERATED MOUSE; SENILE DEMENTIA; TOOTH EXTRACTION;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MOTOR ACTIVITY; PROTEIN-TYROSINE KINASES;

EID: 79957540502     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.10.019     Document Type: Article

References (12)

1. Watanabe K, Ozono S, Nishiyama K, Saito S, Tonosaki K, Fujita M, et al. The molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance. Behav Brain Res 2002; 128: 19-25.
2. Onozuka M, Watanabe K, Fujita M, Tomida M, Ozono S. Changes in the septohippocampal cholinergic system following removal of molar teeth in the aged SAMP8 mouse. Behav Brain Res 2002; 133: 197-204.
3. Kubo KY, Kojo A, Yamamoto T, Onozuka M. The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region. Neurosci Lett 2008; 441: 141-144.
4. Kubo KY, Iwaku F, Watanabe K, Fujita M, Onozuka M. Molarless induced changes of spines in hippocampal region of SAMP8 mice. Brain Res 2005; 1057: 191-195.
5. Ono Y, Kataoka T, Miyake S, Sasaguri K, Sato S, Onozuka M. Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of histamine H1 receptor. Neurosci Res 2009; 64: 385-390.
6. Cunha C, Brambilla R, Thomas KL. A simple role for BDNF in learning and memory? Front Mol Neurosci 2010; 3: 1-14.
7. Zhao WH, Yu JC, Ji XC, Feng N, Cao DX, Xu SF, et al. Learning and memory deficits in SAMP8 and their biochemical mechanisms. J Xi'an Jiaotong Univ (Med Sci) 2008; 29: 289-293.
8. Barros HM, Tannhauser MA, Tannhauser SL, Tannhauser M. Enhanced detection of hyperactivity after drug withdrawal with a simple modification of the open-field apparatus. J Pharmacol Methods 1991; 26: 269-275.
9. Pang PT, Lu B. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing Res Rev 2004; 3: 407-430.
10. Bartoletti A, Cancedda L, Reid SW, Tessarollo L, Porciatti V, Pizzorusso T, et al. Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway specific impairment of long-term potentiation but normal critical period for monocular deprivation. J Neurosci 2002; 22: 10072-10077.
11. Tsai CC, Fondell JD. Nuclear receptor recruitment of histone-modifying enzymes to target gene promoters. Vitam Horm 2004; 68: 93-122.
12. Aoki H, Kimoto K, Hori N, Hoshi N, Yamamoto T, Onozuka M. Molarless condition suppresses proliferation but not differentiation rates into neurons in the rat dentate gyrus. Neurosci Lett 2010; 469: 44-48.