Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation

Journal of Clinical Microbiology

Volumn 49, Issue 6, 2011, Pages 2361-2364

  Frange, Pierre ^a   De Latour, Régis Peffault ^b   Arnaud, Cécile ^c   Boddaert, Nathalie ^a   Oualha, Mehdi ^a   Avettand Fenoel, Véronique ^a   Bernaudin, Françoise ^c   Aguilar, Claire ^d   Barnerias, Christine ^a   Leruez Ville, Marianne ^a   Touzot, Fabien ^a   Lortholary, Olivier ^d   Fischer, Alain ^a   Blanche, Stéphane ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIBIOTIC AGENT; BUSULFAN; CATECHOLAMINE; CIDOFOVIR; CYCLOPHOSPHAMIDE; CYCLOSPORIN; FOSCARNET; GANCICLOVIR; IMMUNOGLOBULIN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PROTEIN; STEROID; THYMOCYTE ANTIBODY; VIRUS DNA;

ACUTE RESPIRATORY FAILURE; ADENOVIRUS; ADENOVIRUS INFECTION; ADOLESCENT; ARTICLE; ARTIFICIAL VENTILATION; ASTHENIA; AUTONOMIC DYSFUNCTION; CASE REPORT; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID EXAMINATION; CHILD; CLINICAL FEATURE; CYTOMEGALOVIRUS INFECTION; DEATH; DEMENTIA; DRUG DOSE INCREASE; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENTEROVIRUS INFECTION; ERYTHROCYTE COUNT; EXTRAPYRAMIDAL SYNDROME; FEMALE; FEVER; GRAFT VERSUS HOST REACTION; HEADACHE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INTENSIVE CARE UNIT; MENINGOENCEPHALITIS; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PYRAMIDAL SIGN; SCHOOL CHILD; SEPTIC SHOCK; SICKLE CELL ANEMIA; TREATMENT OUTCOME; VASCULITIS; VIREMIA;

ADENOVIRIDAE INFECTIONS; ADENOVIRUSES, HUMAN; ADOLESCENT; BLOOD; BRAIN; CEREBROSPINAL FLUID; CHILD; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; INFANT; MAGNETIC RESONANCE IMAGING; MENINGOENCEPHALITIS; STEM CELL TRANSPLANTATION;

EID: 79957528291     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00080-11     Document Type: Article

References (23)

1. Baldwin, A., et al. 2000. Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant. 26:1333-1338. (Pubitemid 32098053)
2. Chakrabarti, S., et al. 2002. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood 100:1619-1627. (Pubitemid 34925137)
3. Cundy, K. C., et al. 1996. Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats. Drug Metab. Dispos. 24:745-752.
4. de Pagter, A. P., et al. 2009. Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients. Clin. Infect. Dis. 49:1536-1539.
5. Dubberke, E. R., et al. 2006. Acute meningoencephalitis caused by adenovirus serotype 26. J. Neurovirol. 12:235-240. (Pubitemid 44574598)
6. Gustafson, I., et al. 2008. Quantification of adenovirus DNA in unrelated donor hematopoietic stem cell transplant recipients. J. Clin. Virol. 43:79-85.
7. Hale, G. A., et al. 1999. Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant. 23:277-282. (Pubitemid 29078342)
8. Howard, D. S., et al. 1999. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 29:1494-1501.
9. Ison, M. G. 2006. Adenovirus infections in transplant recipients. Clin. Infect. Dis. 43:331-339.
10. Leen, A. M., and C. M. Rooney. 2005. Adenovirus as an emerging pathogen in immunocompromised patients. Br. J. Haematol. 128:135-144.
11. Leruez-Ville, M., et al. 2004. Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin. Infect. Dis. 38:45-52.
12. Lion, T., et al. 2003. Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood 102:1114-1120. (Pubitemid 36917814)
13. Lion, T., et al. 2010. Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation. Leukemia 24:706-714.
14. Nagasawa, H., et al. 2006. A case of non-herpetic acute limbic encephalitis associated with a type-2 adenovirus infection. Rinsho Shinkeigaku 46:322-327. (Pubitemid 44196755)
15. Ohtsuki, N., S. Kimura, and A. Nezu. 2000. Three cases with acute encephalopathy related with adenovirus type 7 infection. No To Hattatsu 32:68-72. (Pubitemid 30020523)
16. Quenelle, D. C., et al. 2010. Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies. J. Infect. Dis. 202:1492-1499.
17. Robin, M., et al. 2007. Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome. Haematologica 92:1254-1257. (Pubitemid 350144187)
18. Runde, V., et al. 2001. Adenoviral infection after allogeneic stem cell transplantation (SCT): report on 130 patients from a single SCT unit involved in a prospective multi center surveillance study. Bone Marrow Transplant. 28:51-57. (Pubitemid 32707617)
19. Schnurr, D., A. Bollen, L. Crawford-Miksza, M. E. Dondero, and S. Yagi. 1995. Adenovirus mixture isolated from the brain of an AIDS patient with encephalitis. J. Med. Virol. 47:168-171.
20. van Tol, M. J., et al. 2005. Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity. Bone Marrow Transplant. 35(Suppl. 1):S73-S76. (Pubitemid 40613928)
21. Vincentelli, C., M. J. Schniederjan, and D. J. Brat. 2010. 35-year-old HIV-positive woman with basal forebrain mass. Brain Pathol. 20:265-268.
22. Walls, T., A. G. Shankar, and D. Shingadia. 2003. Adenovirus: an increasingly important pathogen in paediatric bone marrow transplant patients. Lancet Infect. Dis. 3:79-86.
23. Zagardo, M. T., C. B. Shanholtz, G. H. Zoarski, and M. I. Rothman. 1998. Rhombencephalitis caused by adenovirus: MR imaging appearance. AJNR Am. J. Neuroradiol. 19:1901-1903.