Synthesis, in vitro antioxidant, anthelmintic and molecular docking studies of novel dichloro substituted benzoxazole-triazolo-thione derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 3078-3084

  Satyendra, R V ^a,c   Vishnumurthy, K A ^a   Vagdevi, H M ^b   Rajesh, K P ^b   Manjunatha, H ^b   Shruthi, A ^b  

^a Department of PG Studies and Research in Industrial Chemistry   (India)

^b KUVEMPU UNIVERSITY   (India)

^c BASF India Ltd   (India)

Author keywords

Tubulin; Anthelmintic activity; Benzoxazole; In vitro antioxidant; Molecular docking; Triazole

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 5,7 DICHLORO 2 HYDRAZINYL 1,3 BENZOXAZOLE; 6,8 DICHLORO 2 [[(4 NITROPHENYL)AMINO]METHYL] [1,2,4]TRIAZOLO [3,4 B] [1,3]BENZOXAZOLE 3(2H) THIONE; 6,8 DICHLORO [1,2,4]TRIAZOLO [3,4 B] [1,3]BENZOXAZOLE 3(2H) THIONE; ANTIOXIDANT; ANTIPARASITIC AGENT; BENZOXAZOLE TRIAZOLO THIONE DERIVATIVE; BETA TUBULIN; ETHYL 6 DEOXY 3,5 DI O METHYL 6 (3 METHYL 3 NITROSOUREIDO) ALPHA GLUCOFURANOSIDE; ETHYL [(5,7 DICHLORO 1,3 BENZOXAZOL 2 YL)SULFANYL]ACETATE; ETHYL [(6,8 DICHLORO [1,2,4]TRIAZOLO [3,4 B] [1,3] BENZOXAZOL 2 YL)SULFANYL]ACETATE; HYDRAZINE; UNCLASSIFIED DRUG; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; ANTHELMINTIC AGENT; BENZOXAZOLE DERIVATIVE; BIPHENYL DERIVATIVE; CHLORIDE; HELMINTH PROTEIN; HYDRAZINE DERIVATIVE; PICRIC ACID; THIOKETONE; TRIAZOLE DERIVATIVE; TUBULIN; TUBULIN MODULATOR;

ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG BINDING; DRUG SYNTHESIS; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR DOCKING; NONHUMAN; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION; ANIMAL; ANNELID; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THERMODYNAMICS;

ANIMALS; ANNELIDA; ANTHELMINTICS; ANTIOXIDANTS; BENZOXAZOLES; BIPHENYL COMPOUNDS; CHLORIDES; HELMINTH PROTEINS; HYDRAZINES; MOLECULAR DOCKING SIMULATION; PICRATES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THIONES; TRIAZOLES; TUBULIN; TUBULIN MODULATORS;

EID: 79957520370     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.017     Document Type: Article

References (19)

1. R.K. Prichard Vet. Parasitol. 54 1994 259 268
2. N.G. Birendra, C.S.K. Jiban, and N.B. Jogendra J. Heterocycl. Chem. 21 1984 1225
3. P.J. Kothari, M.A. Mehlhoff, S.P. Singh, S.S. Parmar, and V.I. Stenberg J.Heterocycl. Chem. 17 1980 1369
4. P.J. Kothari, S.P. Singh, S.S. Parmar, and V.I. Stenberg J. Heterocycl. Chem. 17 1980 1393
5. A.K. Sengupta, and H.K. Misra J. Indian Chem. Soc. 8 1981 508
6. S.C. Sarmah, and S.C. Bahel J. Indian Chem. Soc. 59 1982 877
7. P.A. Friedman, and E.G. Platzer Biochim. Biophys. Acta 544 1978 605 614
8. P. Kohler, and R. Bachmann Mol. Biochem. Parasitol. 4 1981 325 336
9. E. Lacey Int. J. Parasitol. 18 1988 885 936
10. B.M. Basavaraja, H.M. Vagdevi, L.P. Srikrishna, B.S. Shubha, and V.P. Vaidya Ind. J. Heterocycl. Chem. 18 2008 05 08
11. Y. Zhang, R.Z. Qiao, C. Dai, P.F. Xu, and Z.Y. Zhang Chin. Chem. Lett. 13 2002 287 289
12. P. Prieto, M. Pineda, and M. Aguilar Anal. Biochem. 269 1999 337 341
13. M. Oyaizu Jpn. J. Nutr. 44 1986 307 315
14. A. Braca, Nunziatina Tommasi, Lorenzo De Bari, Cosimo Di Pizza, Mateo Politi, and Ivano Morelli J. Nat. Prod. 64 2001 892 895
15. Z. Vigar Atlas of Medical Parasitology second ed. 1984 P.G. Publishing House Singapore 242
16. G.K. Dash, P. Suresh, D.M. Kar, S. Ganpaty, and S.B. Panda J. Nat. Rem. 2 2002 182 185
17. Y.M. Shivkumar, and V.L. Kumar Pharma. Biol. 41 2003 263 265
18. W. Mark, Robinson, N. McFerran, A. Trudgett, Liz Hoey, and I. Fairweather J. Mol. Graphics Modell 23 2004 275 284
19. E.O. Ajaiyeoba, P.A. Onocha, and O.T. Olarenwaju Pharm. Biol. 39 2001 217 220