The growth hormone receptor (GHR) exon 3 polymorphism and its correlation with metabolic profiles in obese Chinese children

Pediatric Diabetes

Volumn 12, Issue 4 PART 2, 2011, Pages 429-434

  Gao, Lingling ^a,c   Zheng, Zhangqian ^a   Cao, Lingfeng ^a   Shen, Shuixian ^a   Yang, Yi ^a   Zhao, Zhuhui ^a   Zhi, Dijing ^a   Cheng, Ruoqian ^a   Pei, Zhou ^a   Yongfu, Yu ^b   Luo, Feihong ^a  

^a CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Children; Exon 3; GHR; Obesity; Polymorphism

Indexed keywords

CHOLESTEROL; GENOMIC DNA; GROWTH HORMONE RECEPTOR; INSULIN; TRIACYLGLYCEROL;

ARTICLE; BODY MASS; CHILD; CHILDHOOD OBESITY; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; BODY MASS INDEX; CHILD; CHOLESTEROL; EXONS; FEMALE; GENE DELETION; GENE FREQUENCY; GENOTYPE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; OVERWEIGHT; POLYMORPHISM, GENETIC; RECEPTORS, SOMATOTROPIN;

EID: 79957497637     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2010.00747.x     Document Type: Article

References (28)

1. Godowski PJ, Leung DW, Meacham LR et al. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism. Proc Natl Acad Sci U S A 1989: 86: 8083-8087.
2. Sobrier ML, Duquesnoy P, Duriez B, Amselem S, Goossens M. Expression and binding properties of two isoforms of the human growth hormone receptor. FEBS Lett 1993: 319: 16-20.
3. Dos Santos C, Essioux L, Teinturier C, Tauber M, Goffin V, Bougnères P. A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone. Nat Genet 2004: 36: 720-724.
4. Meyer S, Schaefer S, Stolk L et al. Association of the exon 3 deleted/full-length GHR polymorphism with recombinant growth hormone dose in growth hormone-deficient adults. Pharmacogenomics 2009: 10: 1599-1608.
5. Carrascosa A, Audí L, Fernández-Cancio M et al. The exon 3-deleted/full-length growth hormone receptor polymorphism did not influence growth response to growth hormone therapy over two years in prepubertal short children born at term with adequate weight and length for gestational age. J Clin Endocrinol Metab 2008: 93: 764-770.
6. Wassenaar MJ, Dekkers OM, Pereira AM et al. Impact of the exon 3-deleted growth hormone (GH) receptor polymorphism on baseline height and the growth response to recombinant human GH therapy in GH-deficient (GHD) and non-GHD children with short stature: a systematic review and meta-analysis. J Clin Endocrinol Metab 2009: 94: 3721-3730.
7. van der Klaauw AA, van der Straaten T, Baak-Pablo R et al. Influence of the d3-growth hormone (GH) receptor isoform on short-term and long-term treatment response to GH replacement in GH-deficient adults. J Clin Endocrinol Metab 2008: 93: 2828-2834.
8. Jørgensen JO, Krag M, Jessen N et al. Growth hormone and glucose metabolism. Horm Res 2004: 62: 51-55.
9. Mericq V, Roman R, Iñiguez G et al. Relationship between nocturnal growth hormone concentrations, serum IGF-I/IGFBP-3 levels, insulin sensitivity and GH receptor allelic variant in small for gestational age children. Horm Res 2007: 68: 132-138.
10. Audi L, Carrascosa A, Esteban C et al. The exon 3-deleted/full-length growth hormone receptor polymorphism does not influence the effect of puberty or growth hormone therapy on glucose homeostasis in short non-growth hormone-deficient small-for-gestational-age children: results from a two-year controlled prospective study. J Clin Endocrinol Metab 2008: 93: 2709-2715.
11. Strawbridge RJ, Kärvestedt L, Li C et al. GHR exon 3 polymorphism: Association with type 2 diabetes mellitus and metabolic disorder. Growth Horm IGF Res 2007: 17: 392-398.
12. Cole TJ, Bellizzl MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000: 320: 1240-1243.
13. Binder G, Trebar B, Baur F, Schweizer R, Ranke MB. Homozygosity of the d3-growth hormone receptor polymorphism is associated with a high total effect of GH on growth and a low BMI in girls with Turner syndrome. Clin Endocrinol (Oxf) 2008: 68: 567-572.
14. Montefusco L, Filopanti M, Ronchi CL et al. d3-growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype. Clin Endocrinol (Oxf) 2010: 72: 661-667.
15. Jorgensen JO, Moller L, Krag M, Billestrup N, Christiansen JS. Effects of growth hormone on glucose and fat metabolism in human subjects. Endocrinol Metab Clin North Am 2007: 36: 75-87.
16. CDC. Trends in intake of energy and macronutrients - United States, 1971-2000. MMWR Morb Mortal Wkly Rep 2004: 53: 80-82.
17. Stock S, Miranda C, Evans S et al. Healthy buddies: a novel, peer-led health promotion program for the prevention of obesity and eating disorders in children in elementary school. Pediatrics 2007: 120: e1059-e1068.
18. Peterson KE, Fox MK. Addressing the epidemic of childhood obesity through school-based interventions: what has been done and where do we go from here. J Law Med Ethics 2007: 35: 113-130.
19. Sørensen K, Aksglaede L, Munch-Andersen T et al. Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-1 levels during puberty. J Clin Endocrinol Metab 2009: 94: 2966-2969.
20. Schreiner F, Gohlke B, Stutte S et al. Growth hormone receptor d3-variant, insulin-like growth factor binding protein-1-575G/A polymorphism and postnatal catch-up growth: association with parameters of glucose homeostasis in former extremely low birth weight preterm infants. Growth Horm IGF Res 2010: 20: 201-204.
21. Kairamkonda VR, Khashu M. Controversies in the management of hyperglycemia in the ELBW infant. Indian Pediatr 2008: 45: 29-38.
22. Dominici FP, Turyn D. Growth hormone induced alterations in the insulin-signaling system. Exp Biol Med (Maywood) 2002: 227: 149-157.
23. Binder G, Baur F, Schweizer R, Ranke MB. The d3-growth hormone (GH) receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short small-for-gestational-age children. J Clin Endocrinol Metab 2006: 91: 659-664.
24. Audí L, Esteban C, Carrascosa A, Espadero R et al. Exon 3-deleted/full-length growth hormone receptor polymorphism genotype frequencies in Spanish short small-for-gestational-age (SGA) children and adolescents (n = 247) and in an adult control population (n = 289) show increased fl/fl in short SGA. J Clin Endocrinol Metab 2006: 91: 5038-5043.
25. Qiu XS, Tang NL, Yeung HY, Qiu Y, Cheng JC. Genetic association study of growth hormone receptor and idiopathic scoliosis. Clin Orthop Relat Res 2007: 462: 53-58.
26. Ihara K, Inuo M, Kuromaru R, Miyako K, Kohno H, Kinukawa N et al. The Leu544Ile polymorphism of the growth hormone receptor gene affects the serum cholesterol levels during GH treatment in children with GH deficiency. Clin Endocrinol (Oxf) 2007: 67: 212-217.
27. Ko JM, Park JY, Yoo HW. Common exon 3 polymorphism of the GH receptor (GHR) gene and effect of GH therapy on growth in Korean children with idiopathic short stature (ISS). Clin Endocrinol (Oxf) 2009: 70: 82-87.
28. Ko JM, Kim JM, Cheon CK et al. The common exon 3 polymorphism of the growth hormone receptor gene and the effect of growth hormone therapy on growth in Korean patients with Turner syndrome. Clin Endocrinol (Oxf) 2010: 72: 196-202.