Evidence for additional functional genetic variation within the porcine IGF2 gene affecting body composition traits in an experimental Piétrain ́ Large White/Landrace cross

Animal

Volumn 5, Issue 5, 2011, Pages 672-677

  Boysen, T J ^a   Tetens, J ^a   Thaller, G ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

body composition traits; IGF2; pig; QTL; QTN

Indexed keywords

ANIMALIA; SUIDAE; SUS;

EID: 79957473314     PISSN: 17517311     EISSN: 1751732X     Source Type: Journal    
DOI: 10.1017/S1751731110002466     Document Type: Article

References (22)

1. Alexander LJ, Troyer DL, Rohrer GA, Smith TPL, Schook LB and Beattie CW 1996. Physical assignment of 68 porcine cosmid and lambda clones containing polymorphic microsatellites. Mammalian Genome 7, 368-372. (Pubitemid 126426673)
2. Borchers N, Reinsch N and Kalm E 2000. Familial cases of coat colour-change in a Pietrain cross. Journal of Animal Breeding and Genetics 117, 285-287.
3. Borchers N, Reinsch N and Kalm E 2002. Teat number, hairiness and set of ears in a Pié train cross: variation and effects on performance traits. Archiv für Tierzucht Dummerstorf 45, 465-480. (Pubitemid 35151167)
4. Borchers N, Reinsch N and Kalm E 2004. The number of ribs and vertebrae in a Pié train cross: variation, heritability and effects on performance traits. Journal of Animal Breeding and Genetics 121, 392-403. (Pubitemid 39645520)
5. Churchill GA and Doerge RW 1994. Empirical threshold values for quantitative trait mapping. Genetics 138, 963-971. (Pubitemid 24337818)
6. De Koning DJ, Rattink AP, Harlizius B, van Arendonk JAM, Brascamp EW and Groenen MAM 2000. Genome-wide scan for body composition in pigs reveales important role of imprinting. Proceedings of the National Academy of Sciences of the United States of America 97, 7947-7950. (Pubitemid 30460753)
7. Haley CS and Knott SA 1992. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69, 315-324.
8. Jeon JT, Carlborg Ö , Törnsten A, Giuffra E, Amarger V, Chardon P, Andersen- Eklund L, Andersson K, Hansson I, Lundström K and Andersson L 1999. A paternally expressed QTL affecting skeletal and cardiac muscle mass in pig maps to the IGF2 locus. Nature Genetics 21, 157-158. (Pubitemid 29070357)
9. Jungerius BJ, van Laere AS, Te Pas MF, van Oost BA, Andersson L and Groenen MA 2004. The IGF2-intron3-G3072A substitution explains a major imprinted QTL effect on backfat thickness in a Meishan3European white pig intercross. Genetics Research 842, 95-101. (Pubitemid 40081228)
10. Knoll A, Putnová L, Dvořá k J andČepica S 2000. A NciI PCR-RFLP within intron 2 of the porcine insulin-like growth factor 2 IGF2 gene. Animal Genetics 31, 150-151. (Pubitemid 30217945)
11. Knott SA, Marklund L, Haley CS, Andersson K, Davies W, Ellegren H, Fredholm M, Hansson I, Hoyheim B, Lundström K, Moller M and Andersson L 1998. Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and large white pigs. Genetics 149, 1069-1080. (Pubitemid 28283182)
12. Kühn C, Thaller G, Winter A, Bininda-Emonds OR, Kaupe B, Erhardt G, Bennewitz J, Schwerin M and Fries R 2004. Evidence for multiple alleles at the DGAT1 locus better explains a quantitative trait locus with major effect on milk fat content in cattle. Genetics 167, 1873-1881. (Pubitemid 39265923)
13. Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barré s R, Yan J, Strömberg S, De S, Pontén F, Lander ES, Carr SA, Zierath JR, Kullander K,Wadelius C, Lindblad- Toh K, Andersson G, Hjälm G and Andersson L 2009. ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS Biology 7, e1000256.
14. Nezer C, Moreau L, Brouwers B, Coppieters W, Detillieux J, Hanset R, Karim L, Kvasz A, Leroy P and Georges M 1999. An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nature Genetics 21, 155-156. (Pubitemid 29070356)
15. Rohrer GA, Alexander LJ, Keele JW, Smith TP and Beattie CW 1994. A microsatellite linkage map of the porcine genome. Genetics 136, 231-245. (Pubitemid 24016689)
16. Rohrer GA, Alexander LJ, Hu Z, Smith TPL, Kele JW and Beattie CW 1996. A comprehensive map of the porcine genome. Mammalian Genome 6, 371-391. (Pubitemid 26195762)
17. Seaton G, Hernandez J, Grunchec JA, White I, Allen J, De Koning DJ,WeiW, Berry D, Haley C and Knott S 2006. GridQTL: a grid portal for QTL mapping of compute intensive datasets. In Proceedings of the 8th World Congress on Genetics Applied to Livestock Production, August 13-18, 2006, Belo Horizonte, Brazil.
18. Stinckens A, Mathur P, Janssens S, Bruggeman V, Onagbesan OM, Schroyen M, Spincemaille G, Decuypere E, Georges M and Buys N 2010. Indirect effect of IGF2 intron3 g.3072G.A mutation on prolificacy in sows. Animal Genetics 41, 493-498.
19. Thomsen H, Lee HK, Rothschild MF, Malek M and Dekkers JCM 2004. Characterization of quantitative trait loci for growth and meat quality in a cross between commercial breeds of swine. Journal of Animal Science 82, 2213-2228. (Pubitemid 39103874)
20. Van Laere A-S, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, Archibald AL, Haley CS, Buys N, Tally M, Andersson G, Georges M and Andersson L 2003. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425, 832-836. (Pubitemid 37351466)
21. Vykoukalová Z, Knoll A, Dvorá k J andČepica S 2006. New SNPs in the IGF2 gene and association between this gene and backfat thickness and lean meat content in Large White pigs. Journal of Animal Breeding and Genetics 123, 204-207.
22. Wigginton JE and Abecasis GR 2005. PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics 2116, 3445-3447. (Pubitemid 41222458)