Equipoise and the dilemma of randomized clinical trials

New England Journal of Medicine

Volumn 364, Issue 21, 2011, Pages 2076-2077

  Mann, Howard ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VEMURAFENIB;

CLINICAL RESEARCH; DECISION MAKING; EQUIPOISE; HUMAN; LETTER; MEDICAL CARE; MELANOMA; ORIENTATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC);

EID: 79957449264     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1102520     Document Type: Letter

References (4)

1. Miller FG, Joffe S. Equipoise and the dilemma of randomized clinical trials. N Engl J Med 2011;364:476-80.
2. Ashcroft R. Giving medicine a fair trial: trials should not second guess what patients want. BMJ 2000;320:1686.
3. Evans EL, London AJ. Equipoise and the criteria for reasonable action. J Law Med Ethics 2006;34:441-50.
4. Djulbegovic B, Kumar A, Soares HP, et al. Treatment success in cancer: new cancer treatment successes identified in phase 3 randomized controlled trials conducted by the National Cancer Institute-sponsored cooperative oncology groups, 1955 to 2006. Arch Intern Med 2008;168:632-42.