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Volumn 11, Issue 10, 2011, Pages 853-865

Methylated genes in breast cancer: Associations with clinical and histopathological features in a familial breast cancer cohort

Author keywords

BRCA1; BRCA2; Breast cancer; DNA methylation; Epigenetic; Familial; Methylation specific PCR; Protective; QM MSP; Risk

Indexed keywords

APC PROTEIN; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA2 PROTEIN; CYCLIN D2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN RAR BETA; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 79957438722     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.11.10.15177     Document Type: Article
Times cited : (43)

References (68)
  • 2
    • 77956186851 scopus 로고    scopus 로고
    • UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer
    • Jin W, Chen L, Chen Y, Xu SG, Di GH, Yin WJ, et al. UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer. Breast Cancer Res Treat 2010; 123:359-73.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 359-373
    • Jin, W.1    Chen, L.2    Chen, Y.3    Xu, S.G.4    Di, G.H.5    Yin, W.J.6
  • 4
    • 47549090640 scopus 로고    scopus 로고
    • Estrogen receptor alpha, BRCA1 and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers
    • Wei M, Xu J, Dignam J, Nanda R, Sveen L, Fackenthal J, et al. Estrogen receptor alpha, BRCA1 and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers. Breast Cancer Res Treat 2008; 111:113-20.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 113-120
    • Wei, M.1    Xu, J.2    Dignam, J.3    Nanda, R.4    Sveen, L.5    Fackenthal, J.6
  • 5
    • 33745184403 scopus 로고    scopus 로고
    • Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid
    • Fackler MJ, Malone K, Zhang Z, Schilling E, Garrett-Mayer E, Swift-Scanlan T, et al. Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid. Clin Cancer Res 2006; 12:3306-10.
    • (2006) Clin Cancer Res , vol.12 , pp. 3306-3310
    • Fackler, M.J.1    Malone, K.2    Zhang, Z.3    Schilling, E.4    Garrett-Mayer, E.5    Swift-Scanlan, T.6
  • 8
    • 54449085718 scopus 로고    scopus 로고
    • Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
    • Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci USA 2008; 105:14867-72.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14867-14872
    • Dumont, N.1    Wilson, M.B.2    Crawford, Y.G.3    Reynolds, P.A.4    Sigaroudinia, M.5    Tlsty, T.D.6
  • 9
    • 33748122556 scopus 로고    scopus 로고
    • Cancer-linked DNA hypomethylation and its relationship to hypermethylation
    • DNA Methylation: Development, Genetic Disease and Cancer
    • Ehrlich M. Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr Top Microbiol Immunol 2006; 310:251-74. (Pubitemid 47400293)
    • (2006) Current Topics in Microbiology and Immunology , vol.310 , pp. 251-274
    • Ehrlich, M.1
  • 10
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich M. DNA hypomethylation in cancer cells. Epigenomics 2009; 1:239-59.
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 11
    • 77149135270 scopus 로고    scopus 로고
    • Breast cancer epigenetics: From DNA methylation to microRNAs
    • Veeck J, Esteller M. Breast cancer epigenetics: from DNA methylation to microRNAs. J Mammary Gland Biol Neoplasia 2010; 15:5-17.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 5-17
    • Veeck, J.1    Esteller, M.2
  • 12
    • 33645515174 scopus 로고    scopus 로고
    • Perinatal exposures and breast cancer risk in the western New York Exposures and Breast Cancer (WEB) Study
    • Barba M, McCann SE, Nie J, Vito D, Stranges S, Fuhrman B, et al. Perinatal exposures and breast cancer risk in the western New York Exposures and Breast Cancer (WEB) Study. Cancer Causes Control 2006; 17:395-401.
    • (2006) Cancer Causes Control , vol.17 , pp. 395-401
    • Barba, M.1    McCann, S.E.2    Nie, J.3    Vito, D.4    Stranges, S.5    Fuhrman, B.6
  • 13
    • 26944473246 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer 1975-2002, featuring population-based trends in cancer treatment
    • Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LA, et al. Annual report to the nation on the status of cancer 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 2005; 97:1407-27.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1407-1427
    • Edwards, B.K.1    Brown, M.L.2    Wingo, P.A.3    Howe, H.L.4    Ward, E.5    Ries, L.A.6
  • 14
    • 9644310201 scopus 로고    scopus 로고
    • Molecular portraits of breast cancer: Tumour subtypes as distinct disease entities
    • DOI 10.1016/j.ejca.2004.08.021, PII S0959804904007099
    • Sorlie T. Molecular portraits of breast cancer: tumour subtypes as distinct disease entities. Eur J Cancer 2004; 40:2667-75. (Pubitemid 39574720)
    • (2004) European Journal of Cancer , vol.40 , Issue.18 , pp. 2667-2675
    • Sorlie, T.1
  • 15
    • 79960922226 scopus 로고    scopus 로고
    • Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors
    • In press
    • Trujillo KA, Heaphy CM, Mai M, Vargas KM, Jones AC, Vo P, et al. Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors. Int J Cancer 2010; In press.
    • (2010) Int J Cancer
    • Trujillo, K.A.1    Heaphy, C.M.2    Mai, M.3    Vargas, K.M.4    Jones, A.C.5    Vo, P.6
  • 16
    • 35148823283 scopus 로고    scopus 로고
    • Methodological approach to study the genomic profile of the human breast
    • Balogh GA, Heulings R, Mailo D, Wang R, Li YS, Hardy R, et al. Methodological approach to study the genomic profile of the human breast. Int J Oncol 2007; 31:253-60.
    • (2007) Int J Oncol , vol.31 , pp. 253-260
    • Balogh, G.A.1    Heulings, R.2    Mailo, D.3    Wang, R.4    Li, Y.S.5    Hardy, R.6
  • 17
    • 66649087110 scopus 로고    scopus 로고
    • Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge
    • Fackler MJ, Rivers A, Teo WW, Mangat A, Taylor E, Zhang Z, et al. Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge. Clin Cancer Res 2009; 15:3802-11.
    • (2009) Clin Cancer Res , vol.15 , pp. 3802-3811
    • Fackler, M.J.1    Rivers, A.2    Teo, W.W.3    Mangat, A.4    Taylor, E.5    Zhang, Z.6
  • 18
    • 58149154845 scopus 로고    scopus 로고
    • Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis
    • Lee JS, Fackler MJ, Teo WW, Lee JH, Choi C, Park MH, et al. Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis. Cancer Biol Ther 2008; 7:1398-406.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1398-1406
    • Lee, J.S.1    Fackler, M.J.2    Teo, W.W.3    Lee, J.H.4    Choi, C.5    Park, M.H.6
  • 19
    • 33645528784 scopus 로고    scopus 로고
    • Two-color quantitative multiplex methylation-specific PCR
    • DOI 10.2144/000112097
    • Swift-Scanlan T, Blackford A, Argani P, Sukumar S, Fackler MJ. Two-color quantitative multiplex methylation-specific PCR. Biotechniques 2006; 40:210-9. (Pubitemid 46542642)
    • (2006) BioTechniques , vol.40 , Issue.2 , pp. 210-219
    • Swift-Scanlan, T.1    Blackford, A.2    Argani, P.3    Sukumar, S.4    Fackler, M.J.5
  • 20
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • DOI 10.1038/5947
    • Jones PA, Laird PW. Cancer epigenetics comes of age. NatGenet 1999; 21:163-7. (Pubitemid 29070360)
    • (1999) Nature Genetics , vol.21 , Issue.2 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 21
    • 33846422373 scopus 로고    scopus 로고
    • HTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site
    • DOI 10.1158/0008-5472.CAN-06-3396
    • Zinn RL, Pruitt K, Eguchi S, Baylin SB, Herman JG. hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site. Cancer Res 2007; 67:194-201. (Pubitemid 46142775)
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 194-201
    • Zinn, R.L.1    Pruitt, K.2    Eguchi, S.3    Baylin, S.B.4    Herman, J.G.5
  • 23
    • 52449133362 scopus 로고    scopus 로고
    • Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model
    • Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR. Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Res 2008; 6:1365-74.
    • (2008) Mol Cancer Res , vol.6 , pp. 1365-1374
    • Morey Kinney, S.R.1    Smiraglia, D.J.2    James, S.R.3    Moser, M.T.4    Foster, B.A.5    Karpf, A.R.6
  • 25
    • 77950680545 scopus 로고    scopus 로고
    • TWIST1 hypermethylation is observed frequently in colorectal tumors and its over-expression is associated with unfavorable outcomes in patients with colorectal cancer
    • Okada T, Suehiro Y, Ueno K, Mitomori S, Kaneko S, Nishioka M, et al. TWIST1 hypermethylation is observed frequently in colorectal tumors and its over-expression is associated with unfavorable outcomes in patients with colorectal cancer. Genes Chromosomes Cancer 2010; 49:452-62.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 452-462
    • Okada, T.1    Suehiro, Y.2    Ueno, K.3    Mitomori, S.4    Kaneko, S.5    Nishioka, M.6
  • 28
    • 49249136904 scopus 로고    scopus 로고
    • Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors
    • Tapia T, Smalley SV, Kohen P, Munoz A, Solis LM, Corvalan A, et al. Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors. Epigenetics 2008; 3:157-63.
    • (2008) Epigenetics , vol.3 , pp. 157-163
    • Tapia, T.1    Smalley, S.V.2    Kohen, P.3    Munoz, A.4    Solis, L.M.5    Corvalan, A.6
  • 29
    • 0033680062 scopus 로고    scopus 로고
    • Epigenetic lesions causing genetic lesions in human cancer: Promoter hypermethylation of DNA repair genes
    • Esteller M. Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes. Eur J Cancer 2000; 36:2294-300.
    • (2000) Eur J Cancer , vol.36 , pp. 2294-2300
    • Esteller, M.1
  • 30
    • 33847355994 scopus 로고    scopus 로고
    • Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2 and XRCC5 in non-small cell lung cancer
    • Lee MN, Tseng RC, Hsu HS, Chen JY, Tzao C, Ho WL, et al. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2 and XRCC5 in non-small cell lung cancer. Clin Cancer Res 2007; 13:832-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 832-838
    • Lee, M.N.1    Tseng, R.C.2    Hsu, H.S.3    Chen, J.Y.4    Tzao, C.5    Ho, W.L.6
  • 33
    • 34447100205 scopus 로고    scopus 로고
    • Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients
    • DOI 10.1016/j.lfs.2007.05.012, PII S0024320507003748
    • Mirza S, Sharma G, Prasad CP, Parshad R, Srivastava A, Gupta SD, et al. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci 2007; 81:280-7. (Pubitemid 47030571)
    • (2007) Life Sciences , vol.81 , Issue.4 , pp. 280-287
    • Mirza, S.1    Sharma, G.2    Prasad, C.P.3    Parshad, R.4    Srivastava, A.5    Gupta, S.D.6    Ralhan, R.7
  • 34
    • 0035300429 scopus 로고    scopus 로고
    • Hypermethylation of the CpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 Locus, occurs in a large percentage of human breast cancers
    • Dammann R, Yang G, Pfeifer GP. Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res 2001; 61:3105-9. (Pubitemid 32691961)
    • (2001) Cancer Research , vol.61 , Issue.7 , pp. 3105-3109
    • Dammann, R.1    Yang, G.2    Pfeifer, G.P.3
  • 37
    • 2442696623 scopus 로고    scopus 로고
    • Molecular and cellular determinants of estrogen receptor alpha expression
    • DOI 10.1128/MCB.24.11.4605-4612.2004
    • Pinzone JJ, Stevenson H, Strobl JS, Berg PE. Molecular and cellular determinants of estrogen receptor alpha expression. Mol Cell Biol 2004; 24:4605-12. (Pubitemid 38668029)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.11 , pp. 4605-4612
    • Pinzone, J.J.1    Stevenson, H.2    Strobl, J.S.3    Berg, P.E.4
  • 40
    • 0033573202 scopus 로고    scopus 로고
    • TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage
    • DOI 10.1002/(SICI)1097-4644(19991215)75:4<566::AID-JCB3>3.0.CO;2-0
    • Lee MS, Lowe GN, Strong DD, Wergedal JE, Glackin CA. TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage. J Cell Biochem 1999; 75:566-77. (Pubitemid 29529912)
    • (1999) Journal of Cellular Biochemistry , vol.75 , Issue.4 , pp. 566-577
    • Lee, M.-S.1    Lowe, G.N.2    Strong, D.D.3    Wergedal, J.E.4    Glackin, C.A.5
  • 43
    • 0242439295 scopus 로고    scopus 로고
    • Methylation Profiling of Benign and Malignant Breast Lesions and Its Application to Cytopathology
    • DOI 10.1097/01.MP.0000095782.79895.E2
    • Pu RT, Laitala LE, Alli PM, Fackler MJ, Sukumar S, Clark DP. Methylation profiling of benign and malignant breast lesions and its application to cytopathology. Mod Pathol 2003; 16:1095-101. (Pubitemid 37414203)
    • (2003) Modern Pathology , vol.16 , Issue.11 , pp. 1095-1101
    • Pu, R.T.1    Laitala, L.E.2    Alli, P.M.3    Fackler, M.J.4    Sukumar, S.5    Clark, D.P.6
  • 44
    • 0031000554 scopus 로고    scopus 로고
    • Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells
    • Sweeney KJ, Sarcevic B, Sutherland RL, Musgrove EA. Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells. Oncogene 1997; 14:1329-40. (Pubitemid 27151990)
    • (1997) Oncogene , vol.14 , Issue.11 , pp. 1329-1340
    • Sweeney, K.J.1    Sarcevic, B.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 45
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2:76-83.
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    Del Barrio, M.G.6
  • 46
    • 16844383767 scopus 로고    scopus 로고
    • Distinct hypermethylation profile of primary breast cancer is associated with sentinel lymph node metastasis
    • DOI 10.1158/1078-0432.CCR-04-1810
    • Shinozaki M, Hoon DS, Giuliano AE, Hansen NM, Wang HJ, Turner R, et al. Distinct hypermethylation profile of primary breast cancer is associated with sentinel lymph node metastasis. Clin Cancer Res 2005; 11:2156-62. (Pubitemid 40490172)
    • (2005) Clinical Cancer Research , vol.11 , Issue.6 , pp. 2156-2162
    • Shinozaki, M.1    Hoon, D.S.B.2    Giuliano, A.E.3    Hansen, N.M.4    Wang, H.-J.5    Turner, R.6    Taback, B.7
  • 48
    • 31544435739 scopus 로고    scopus 로고
    • Breast cancer DNA methylation profiles in cancer cells and tumor stroma: Association with HER-2/neu status in primary breast cancer
    • DOI 10.1158/0008-5472.CAN-05-2508
    • Fiegl H, Millinger S, Goebel G, Muller-Holzner E, Marth C, Laird PW, et al. Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res 2006; 66:29-33. (Pubitemid 43166004)
    • (2006) Cancer Research , vol.66 , Issue.1 , pp. 29-33
    • Fiegl, H.1    Millinger, S.2    Goebel, G.3    Muller-Holzner, E.4    Marth, C.5    Laird, P.W.6    Widschwendter, M.7
  • 49
    • 33750467670 scopus 로고    scopus 로고
    • Studies on the methylation status of CpG sequences located in promoters of selected tumour suppressor genes in breast cancer cells
    • DOI 10.1080/15257770600890640, PII G52X55244L82041U
    • Fabianowska-Majewska K, Kordek R, Krawczyk B. Studies on the methylation status of CpG sequences located in promoters of selected tumour suppressor genes in breast cancer cells. Nucleosides Nucleotides Nucleic Acids 2006; 25:1025-8. (Pubitemid 44651841)
    • (2006) Nucleosides, Nucleotides and Nucleic Acids , vol.25 , Issue.9-11 , pp. 1025-1028
    • Fabianowska-Majewska, K.1    Kordek, R.2    Krawczyk, B.3
  • 51
    • 0037479867 scopus 로고    scopus 로고
    • Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: Relationships with abnormal E-cadherin and catenin expression and microsatellite instability
    • DOI 10.1002/ijc.11197
    • Sarrio D, Moreno-Bueno G, Hardisson D, Sanchez-Estevez C, Guo M, Herman JG, et al. Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer 2003; 106:208-15. (Pubitemid 36835173)
    • (2003) International Journal of Cancer , vol.106 , Issue.2 , pp. 208-215
    • Sarrio, D.1    Moreno-Bueno, G.2    Hardisson, D.3    Sanchez-Estevez, C.4    Guo, M.5    Herman, J.G.6    Gamallo, C.7    Esteller, M.8    Palacios, J.9
  • 52
    • 0038159962 scopus 로고    scopus 로고
    • Methylated DNA as a possible screening marker for neoplastic disease in several body fluids
    • Muller HM, Widschwendter M. Methylated DNA as a possible screening marker for neoplastic disease in several body fluids. Expert Rev Mol Diagn 2003; 3:443-58. (Pubitemid 36859292)
    • (2003) Expert Review of Molecular Diagnostics , vol.3 , Issue.4 , pp. 443-458
    • Muller, H.M.1    Widschwendter, M.2
  • 54
    • 18144411303 scopus 로고    scopus 로고
    • Role of the Ras-association domain family 1 tumor suppressor gene in human cancers
    • DOI 10.1158/0008-5472.CAN-04-4088
    • Agathanggelou A, Cooper WN, Latif F. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res 2005; 65:3497-508. (Pubitemid 40616319)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3497-3508
    • Agathanggelou, A.1    Cooper, W.N.2    Latif, F.3
  • 56
    • 3042825295 scopus 로고    scopus 로고
    • Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer
    • DOI 10.1158/0008-5472.CAN-03-3341
    • Fackler MJ, McVeigh M, Mehrotra J, Blum MA, Lange J, Lapides A, et al. Quantitative multiplex methylation-specific PCR assay for the detection of promoter hyper-methylation in multiple genes in breast cancer. Cancer Res 2004; 64:4442-52. (Pubitemid 38856915)
    • (2004) Cancer Research , vol.64 , Issue.13 , pp. 4442-4452
    • Fackler, M.J.1    McVeigh, M.2    Mehrotra, J.3    Blum, M.A.4    Lange, J.5    Lapides, A.6    Garrett, E.7    Argani, P.8    Sukamar, S.9
  • 59
    • 67649452451 scopus 로고    scopus 로고
    • Promoter methylation patterns of ATM ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers
    • Kontorovich T, Cohen Y, Nir U, Friedman E. Promoter methylation patterns of ATM ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers. Breast Cancer Res Treat 2009; 116:195-200.
    • (2009) Breast Cancer Res Treat , vol.116 , pp. 195-200
    • Kontorovich, T.1    Cohen, Y.2    Nir, U.3    Friedman, E.4
  • 60
    • 34248172540 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in ductal lavage fluid from healthy BRCA gene mutation carriers and mutation-negative controls
    • Locke I, Kote-Jarai Z, Fackler MJ, Bancroft E, Osin P, Nerurkar A, et al. Gene promoter hypermethylation in ductal lavage fluid from healthy BRCA gene mutation carriers and mutation-negative controls. Breast Cancer Res 2007; 9:20.
    • (2007) Breast Cancer Res , vol.9 , pp. 20
    • Locke, I.1    Kote-Jarai, Z.2    Fackler, M.J.3    Bancroft, E.4    Osin, P.5    Nerurkar, A.6
  • 62
    • 43049092333 scopus 로고    scopus 로고
    • Histopathological features of 'BRCAX' familial breast cancers in the kConFab resource
    • Loughrey M, Provan PJ, Byth K, Balleine RL. Histopathological features of 'BRCAX' familial breast cancers in the kConFab resource. Pathology 2008; 40:352-8.
    • (2008) Pathology , vol.40 , pp. 352-358
    • Loughrey, M.1    Provan, P.J.2    Byth, K.3    Balleine, R.L.4


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