Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 19, 2011, Pages 7962-7967

  Memarzadeh, Sanaz ^a,b   Cai, Houjian ^c   Janzen, Deanna M ^a   Xin, Li ^d   Lukacs, Rita ^c   Riedinger, Mireille ^a   Zong, Yang ^c   DeGendt, Karel ^e   Verhoeven, Guido ^e   Huang, Jiaoti ^c   Witte, Owen N ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Tissue recombination; Tumor promoter; Tumor suppressor

Indexed keywords

ANDROGEN RECEPTOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROSTATIC INTRAEPITHELIAL NEOPLASIA; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CARCINOGENS; DNA PRIMERS; FIBROBLAST GROWTH FACTOR 10; HUMANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NEOPLASMS, HORMONE-DEPENDENT; PARACRINE COMMUNICATION; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANDROGEN; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 79956370342     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1105243108     Document Type: Article

References (46)

1. Rice LW (2010) Hormone prevention strategies for breast, endometrial and ovarian cancers. Gynecol Oncol 118:202-207.
2. Folkerd EJ, Dowsett M (2010) Influence of sex hormones on cancer progression. J Clin Oncol 28:4038-4044.
3. Lydon JP, Ge G, Kittrell FS, Medina D, O'Malley BW (1999) Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function. Cancer Res 59:4276-4284. (Pubitemid 29418743)
4. Bocchinfuso WP, Korach KS (1997) Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J Mammary Gland Biol Neoplasia 2:323-334.
5. Huggins C, Sr, Hoges CV (1941) Studies on prostatic cancer II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 43:209-223.
6. Kohli M, Tindall DJ (2010) New developments in the medical management of prostate cancer. Mayo Clin Proc 85:77-86.
7. Cunha GR (2008) Mesenchymal-epithelial interactions: Past, present, and future. Differentiation 76:578-586.
8. Cunha GR, Lung B (1978) The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice. J Exp Zool 205:181-193.
9. Tenniswood M (1986) Role of epithelial-stromal interactions in the control of gene expression in the prostate: an hypothesis. Prostate 9:375-385.
10. Le H, Arnold JT, McFann KK, Blackman MR (2006) DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab 290:E952-E960.
11. Lu W, Luo Y, Kan M, McKeehan WL (1999) Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate. J Biol Chem 274:12827-12834.
12. Yan G, Fukabori Y, Nikolaropoulos S, Wang F, McKeehan WL (1992) Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial- cell andromedin. Mol Endocrinol 6:2123-2128. (Pubitemid 23021561)
13. Thomson AA (2008) Mesenchymal mechanisms in prostate organogenesis. Differentiation 76:587-598.
14. Gao J, Arnold JT, Isaacs JT (2001) Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells. Cancer Res 61:5038-5044. (Pubitemid 32681532)
15. Vander Griend DJ, et al. (2010) Cell-autonomous intracellular androgen receptor signaling drives the growth of human prostate cancer initiating cells. Prostate 70:90-99.
16. Niu Y, et al. (2008) Androgen receptor is a tumor suppressor and proliferator in prostate cancer. Proc Natl Acad Sci USA 105:12182-12187.
17. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON (2010) Identification of a cell of origin for human prostate cancer. Science 329:568-571.
18. Lawson DA, et al. (2010) Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci USA 107:2610-2615.
19. Mulholland DJ, et al. (2009) Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res 69:8555-8562.
20. McNeal JE, Bostwick DG (1986) Intraductal dysplasia: A premalignant lesion of the prostate. Hum Pathol 17:64-71. (Pubitemid 16163546)
21. Abate-Shen C, Shen MM (2000) Molecular genetics of prostate cancer. Genes Dev 14:2410-2434.
22. Memarzadeh S, et al. (2007) Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell 12:572-585.
23. Xin L, Lawson DA, Witte ON (2005) The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci USA 102:6942-6947.
24. Xin L, et al. (2006) Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci USA 103:7789-7794.
25. Schlessinger J (2004) Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 306:1506-1507.
26. Liao Y, Hung MC (2010) Physiological regulation of Akt activity and stability. Am J Transl Res 2:19-42.
27. Acevedo VD, Ittmann M, Spencer DM (2009) Paths of FGFR-driven tumorigenesis. Cell Cycle 8:580-588.
28. Ahmed NN, et al. (1993) The proteins encoded by c-akt and v-akt differ in posttranslational modification, subcellular localizationand oncogenic potential. Oncogene 8:1957-1963.
29. Testa JR, Tsichlis PN (2005) AKT signaling in normal and malignant cells. Oncogene 24:7391-7393.
30. Andjelković M, et al. (1997) Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524.
31. Xin L, Ide H, Kim Y, Dubey P, Witte ON (2003) In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme. Proc Natl Acad Sci USA 100(Suppl 1):11896-11903.
32. Lyon MF, Hawkes SG (1970) X-linked gene for testicular feminization in the mouse. Nature 227:1217-1219.
33. He WW, Kumar MV, Tindall DJ (1991) A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res 19:2373-2378.
34. Jiao J, et al. (2007) Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. Cancer Res 67:6083-6091.
35. Hill R, Song Y, Cardiff RD, Van Dyke T (2005) Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 123:1001-1011.
36. Bierie B, Moses HL (2005) Under pressure: stromal fibroblasts change their ways. Cell 123:985-987.
37. De Gendt K, et al. (2004) A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci USA 101:1327-1332.
38. Lawson DA, Xin L, Lukacs RU, Cheng D, Witte ON (2007) Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci USA 104:181-186.
39. Li J, et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947.
40. Carnero A (2010) The PKB/AKT pathway in cancer. Curr Pharm Des 16:34-44.
41. Boormans JL, et al. (2010) E17K substitution in AKT1 in prostate cancer. Br J Cancer 102:1491-1494.
42. Ellem SJ, Risbridger GP (2007) Treating prostate cancer: A rationale for targeting local oestrogens. Nat Rev Cancer 7:621-627.
43. Niu Y, et al. (2008) Targeting the stromal androgen receptor in primary prostate tumors at earlier stages. Proc Natl Acad Sci USA 105:12188-12193.
44. Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60:277-300.
45. Thompson IM, et al. (2003) The influence of finasteride on the development of prostate cancer. N Engl J Med 349:215-224.
46. Andriole GL, et al.; REDUCE Study Group (2010) Effect of dutasteride on the risk of prostate cancer. N Engl J Med 362:1192-1202.