The agrochemical fungicide triadimefon induces abnormalities in Xenopus laevis embryos

Reproductive Toxicology

Volumn 31, Issue 4, 2011, Pages 486-493

  Di Renzo, Francesca ^a   Bacchetta, Renato ^a   Sangiorgio, Lorenzo ^b   Bizzo, Andrea ^a   Menegola, Elena ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR   (Italy)

Author keywords

Amphibian; Azole; Branchial arches; CRABP; CYP26; Embryo; Larva; Malformation

Indexed keywords

CYTOCHROME P450 26A1; RETINOIC ACID BINDING PROTEIN; TRIADIMEFON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MALFORMATION; BRANCHIAL ARCH; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; EMBRYO; EMBRYOPATHY; FOREBRAIN; FUNCTIONAL MORPHOLOGY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; LARVAL STAGE; LONG TERM EXPOSURE; NEURULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RHOMBENCEPHALON; TISSUE DISTRIBUTION; XENOPUS LAEVIS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BLOTTING, WESTERN; CRANIOFACIAL ABNORMALITIES; CYTOCHROME P-450 ENZYME SYSTEM; EMBRYO, NONMAMMALIAN; FUNGICIDES, INDUSTRIAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; LARVA; MORPHOGENESIS; NEURULATION; POLYMERASE CHAIN REACTION; PROSENCEPHALON; RECEPTORS, RETINOIC ACID; RHOMBENCEPHALON; RNA, MESSENGER; TRIAZOLES; XENOPUS LAEVIS;

AMPHIBIA; RODENTIA; VERTEBRATA; XENOPUS LAEVIS;

EID: 79956360136     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.01.003     Document Type: Article

References (25)

1. Tomlin C.D.S. The pesticide manual 1997, British Crop Protection Council, Farnham, Surrey GU97PH, UK, pp. 1218-76.
2. Tiboni G.M. Second branchial arch anomalies induced by fluconazole, a bis-triazole antifungal agent, in cultured mouse embryos. Res Commun Chem Pathol Pharmacol 1993, 79:381-384.
3. Tiboni G.M., Giampietro F., Angelucci S., Moio P., Bellati U., Di Ilio C. Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole. Toxicol Lett 2003, 145:219-229.
4. Tiboni G.M., Marotta F., Carletti E. Fluconazole alters CYP26 gene expression in mouse embryos. Reprod Toxicol 2009, 27:199-202.
5. Menegola E., Broccia M.L., Di Renzo F., Prati M., Giavini E. In vitro teratogenic potential of two antifungal triazoles: triadimefon and triadimenol. In Vitro Cell Dev Biol Anim 2000, 36:88-95.
6. Menegola E., Broccia M.L., Di Renzo F., Giavini E. Antifungal triazoles induce malformations in vitro. Reprod Toxicol 2001, 15:421-427.
7. Menegola E., Broccia M.L., Di Renzo F., Giavini E. Pathogenic pathways in fluconazole-induced branchial arch malformations. Birth Defects Res A 2003, 67:116-124.
8. Menegola E., Broccia M.L., Di Renzo F., Massa V., Giavini E. Relationship between hindbrain segmentation, neural crest cell migration and branchial arch abnormalities in rat embryos exposed to fluconazole and retinoic acid in vitro. Reprod Toxicol 2004, 18:121-130.
9. Menegola E., Broccia M.L., Di Renzo F., Massa V., Giavini E. Study on the common teratogenic pathway elicited by the fungicides triazole-derivatives. Toxicol In Vitro 2005, 19:737-748.
10. Menegola E., Broccia M.L., Di Renzo F., Massa V., Giavini E. Craniofacial and axial skeletal defects induced by the fungicide triadimefon in the mouse. Birth Defects Res B 2005, 74:185-195.
11. Menegola E., Broccia M.L., Di Renzo F., Giavini E. Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects. Reprod Toxicol 2006, 22:186-195.
12. Menegola E., Broccia M.L., Di Renzo F., Giavini E. Dysmorphogenic effects of some fungicides derived from the imidazole on rat embryos cultured in vitro. Reprod Toxicol 2006, 21:74-82.
13. Di Renzo F., Broccia M.L., Giavini E., Menegola E., Citral an inhibitor of retinoic acid synthesis, attenuates the frequency and severity of branchial arch abnormalities induced by triazole-derivative fluconazole in rat embryos cultured in vitro. Reprod Toxicol 2007, 24:326-332.
14. Di Renzo F., Broccia M.L., Giavini E., Menegola E. Antifungal triazole derivative triadimefon induces ectopic maxillary cartilage by altering the morphogenesis of the first branchial arch. Birth Defects Res B 2007, 80:2-11.
15. Di Renzo F., Corsini E., Broccia M.L., Marinovich M., Galli C.L., Giavini E., et al. Molecular mechanism of teratogenic effects induced by the fungicide triadimefon: study of the expression of TGF-beta mRNA and TGF-beta and CRABPI proteins during rat in vitro development. Toxicol Appl Pharmacol 2009, 234:107-116.
16. Le Douarin N.M., Ziller C. Plasticity in neural crest cell differentiation. Curr Opin Cell Biol 1993, 5:1036-1043.
17. Noden D.M., Schneider R.A. Neural crest cells and the community of plan for craniofacial development: historical debates and current perspectives. Adv Exp Med Biol 2006, 589:1-23.
18. Marotta F., Tiboni G.M. Molecular aspects of azoles-induced teratogenesis. Expert Opin Drug Metab Toxicol 2010, 6:461-482.
19. Groppelli S., Pennati R., De Bernardi F., Menegola E., Giavini E., Sotgia C. Teratogenic effects of two antifungal triazoles, triadimefon and triadimenol, on Xenopus laevis development: craniofacial defects. Aquat Toxicol 2005, 73:370-381.
20. Papis E., Bernardini G., Gornati R., Prati M. Triadimefon causes branchial arch malformations in Xenopus laevis embryos. Environ Sci Pollut Res Int 2006, 13:251-255.
21. Papis E., Bernardini G., Gornati R., Menegola E., Prati M. Gene expression in Xenopus laevis embryos after triadimefon exposure. Gene Expr Patterns 2007, 7:137-142.
22. Nieuwkoop P.D., Faber J. Normal tables of Xenopus laevis Daudin 1956, North Holland, Amsterdam.
23. Thisse C., Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc 2008, 3:59-69.
24. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
25. Sadaghiani B., Thiébaud C.H. Neural crest development in the Xenopus laevis embryo, studied by interspecific transplantation and scanning electron microscopy. Dev Biol 1987, 124:91-110.