Tolerability of combined modality therapy for rectal cancer in elderly patients aged 75 years and older

International Journal of Radiation Oncology Biology Physics

Volumn 81, Issue 5, 2011, Pages

  Margalit, Danielle N ^a   Mamon, Harvey J ^b   Ancukiewicz, Marek ^d   Kobayashi, Wendy ^d   Ryan, David P ^d   Blaszkowsky, Lawrence S ^d   Clark, Jeffrey ^d   Willett, Christopher G ^c   Hong, Theodore S ^d  

^a HARVARD RADIATION ONCOLOGY PROGRAM   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chemoradiation; Colorectal cancer; Combined modality therapy; Elderly; Treatment tolerability

Indexed keywords

CHEMORADIATION; COLORECTAL CANCER; COMBINED MODALITY THERAPY; ELDERLY; TREATMENT TOLERABILITY;

CHEMOTHERAPY; DISEASES; EPIDEMIOLOGY; HOSPITALS;

PATIENT TREATMENT;

CAPECITABINE; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; CLINICAL ARTICLE; COMORBIDITY; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG DOSE REDUCTION; ELDERLY CARE; FEMALE; FISHER EXACT TEST; HOSPITALIZATION; HUMAN; MALE; MANTEL HAENSZEL TEST; MEDICAL RECORD; MULTIMODALITY CANCER THERAPY; PHYSICAL TOLERANCE; POSTOPERATIVE CARE; PREDICTION; PREOPERATIVE CARE; PRIORITY JOURNAL; RADIATION DOSE; RECTUM CANCER; TREATMENT OUTCOME; UNITED STATES; VALIDATION PROCESS;

ADENOCARCINOMA; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CHEMORADIOTHERAPY; COMBINED MODALITY THERAPY; FEMALE; HOSPITALIZATION; HUMANS; MALE; NEOPLASM RECURRENCE, LOCAL; RADIOTHERAPY DOSAGE; RADIOTHERAPY, CONFORMAL; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 79956359847     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.12.056     Document Type: Article

References (33)

1. N.J. McCleary, J. Meyerhardt, and E. Green Impact of older age on the efficacy of newer adjuvant therapies in >12,500 patients (pts) with stage II/III colon cancer: Findings from the ACCENT Database J Clin Oncol 27 2009 4010 [Abstract]
2. T. Andre, C. Boni, and M. Navarro Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial J Clin Oncol 27 2009 3109 3116
3. S.A. Dobie, J.L. Warren, and B. Matthews Survival benefits and trends in use of adjuvant therapy among elderly stage II and III rectal cancer patients in the general population Cancer 112 2008 789 799 (Pubitemid 351240572)
4. J.F. Piccirillo, R.M. Tierney, and I. Costas Prognostic importance of comorbidity in a hospital-based cancer registry JAMA 291 2004 2441 2447 (Pubitemid 38669187)
5. W.L. Read, R.M. Tierney, and N.C. Page Differential prognostic impact of comorbidity J Clin Oncol 22 2004 3099 3103 (Pubitemid 41103722)
6. H. Rutten, M. den Dulk, and V. Lemmens Survival of elderly rectal cancer patients not improved: Analysis of population based data on the impact of TME surgery Eur J Cancer 43 2007 2295 2300 (Pubitemid 47539120)
7. J. Faivre, V.E. Lemmens, and V. Quipourt Management and survival of colorectal cancer in the elderly in population-based studies Eur J Cancer 43 2007 2279 2284 (Pubitemid 47539127)
8. R. Sauer, H. Becker, and W. Hohenberger Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 2004 1731 1740
9. J.F. Bosset, L. Collette, and G. Calais Chemotherapy with preoperative radiotherapy in rectal cancer N Engl J Med 355 2006 1114 1123 (Pubitemid 44394918)
10. K. Bujko, M.P. Nowacki, and A. Nasierowska-Guttmejer Sphincter preservation following preoperative radiotherapy for rectal cancer: Report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy Radiother Oncol 72 2004 15 24 (Pubitemid 38952855)
11. N. Wolmark, H.S. Wieand, and D.M. Hyams Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02 J Natl Cancer Inst 92 2000 388 396 (Pubitemid 30154820)
12. Miyamoto DT, Mamon HJ, Ryan DP, et al. Outcomes and tolerability of chemoradiation therapy for pancreatic cancer patients aged 75 years or older. Int J Radiat Oncol Biol Phys;77:1171-1177.
13. R.H. Mak, H.J. Mamon, and D.P. Ryan Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older Dis Esophagus 23 2010 316 323
14. Colorectal Cancer Collaborative Group Adjuvant radiotherapy for rectal cancer: A systematic overview of 8,507 patients from 22 randomised trials Lancet 358 2001 1291 1304
15. J.P. Gerard, T. Conroy, and F. Bonnetain Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: Results of FFCD 9203 J Clin Oncol 24 2006 4620 4625 (Pubitemid 46630960)
16. E. Kapiteijn, C.A. Marijnen, and I.D. Nagtegaal Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer N Engl J Med 345 2001 638 646
17. J. Folkesson, H. Birgisson, and L. Pahlman Swedish Rectal Cancer Trial: Long lasting benefits from radiotherapy on survival and local recurrence rate J Clin Oncol 23 2005 5644 5650
18. C. Camma, M. Giunta, and F. Fiorica Preoperative radiotherapy for resectable rectal cancer: A meta-analysis JAMA 284 2000 1008 1015 (Pubitemid 30659131)
19. A.I. Neugut, A.T. Fleischauer, and V. Sundararajan Use of adjuvant chemotherapy and radiation therapy for rectal cancer among the elderly: A population-based study J Clin Oncol 20 2002 2643 2650 (Pubitemid 34575636)
20. W.Y. Cheung, B.A. Neville, and C.C. Earle Etiology of delays in the initiation of adjuvant chemotherapy and their impact on outcomes for Stage II and III rectal cancer Dis Colon Rectum 52 2009 1054 1063 discussion 1064
21. D. Schrag, S.E. Gelfand, and P.B. Bach Who gets adjuvant treatment for stage II and III rectal cancer? Insight from Surveillance, Epidemiology, and End Results-Medicare J Clin Oncol 19 2001 3712 3718 (Pubitemid 32844782)
22. B. Jung, L. Pahlman, and R. Johansson Rectal cancer treatment and outcome in the elderly: An audit based on the Swedish Rectal Cancer Registry 1995-2004 BMC Cancer 9 2009 68
23. S.B. Yellen, D.F. Cella, and W.T. Leslie Age and clinical decision making in oncology patients J Natl Cancer Inst 86 1994 1766 1770 (Pubitemid 24373451)
24. J.H. Rose, E.E. O'Toole, and D. Einstadter Patient age, well-being, perspectives, and care practices in the early treatment phase for late-stage cancer J Gerontol A Biol Sci Med Sci 63 2008 960 968
25. M. Extermann, and A. Hurria Comprehensive geriatric assessment for older patients with cancer J Clin Oncol 25 2007 1824 1831 (Pubitemid 46860271)
26. A. Hurria, S. Gupta, and M. Zauderer Developing a cancer-specific geriatric assessment: A feasibility study Cancer 104 2005 1998 2005 (Pubitemid 41513186)
27. R.D. Madoff Rectal cancer: Optimum treatment leads to optimum results Lancet 373 2009 790 792
28. C.G. Willett, B.G. Czito, and J.C. Bendell Radiation therapy in stage II and III rectal cancer Clin Cancer Res 13 2007 6903s 6908s (Pubitemid 350206837)
29. D. Sebag-Montefiore, R.J. Stephens, and R. Steele Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): A multicentre, randomised trial Lancet 373 2009 811 820
30. K. Bujko, M.P. Nowacki, and A. Nasierowska-Guttmejer Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer Br J Surg 93 2006 1215 1223 (Pubitemid 44547018)
31. S. Ngan, R. Fisher, and D. Goldstein A randomized trial comparing local recurrence (LR) rates between short-course (SC) and long-course (LC) preoperative radiotherapy (RT) for clinical T3 rectal cancer: An Intergroup trial (TROG, AGITG, CSSANZ, RACS) J Clin Oncol 28 2010 3509 [Abstract]
32. C. Aschele, C. Pinto, and S. Cordio Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: Pathologic response analysis of the Studio Terapia Adiuvante Retto (STAR)-01 randomized phase III trial. 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition) J Clin Oncol 27 2009 4008 [Abstract]
33. J.P. Gerard, D. Azria, and S. Gourgou-Bourgade Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: Results of the phase III trial ACCORD 12/0405-Prodige 2 J Clin Oncol 28 2010 1638 1644