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Volumn 41, Issue 6, 2011, Pages 476-485

Effect of interferon-αα2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes

Author keywords

Hepatocyte; interferon 2b

Indexed keywords

ADIPOPHILIN; ALPHA2B INTERFERON; BREAST CANCER RESISTANCE PROTEIN; CARBOXYESTERASE 2; CARBOXYLESTERASE; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; GLUCURONOSYLTRANSFERASE 2B7; GLYCOPROTEIN; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING PEPTIDE 1B1; ORGANIC ANION TRANSPORTING PEPTIDE 1B3; ORGANIC ANION TRANSPORTING PEPTIDE 2B1; ORGANIC CATION TRANSPORTER 1; PHENOBARBITAL; PYRUVATE DEHYDROGENASE KINASE 4; RIFAMPICIN; STAT1 PROTEIN; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 2A1; UNCLASSIFIED DRUG;

EID: 79956352358     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.560971     Document Type: Article
Times cited : (20)

References (49)
  • 2
    • 34548090571 scopus 로고    scopus 로고
    • Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes
    • DOI 10.1124/dmd.107.015511
    • Aitken AE, Morgan ET. (2007). Gene-specifc efects of infammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Dispos 35:1687-1693. (Pubitemid 47296065)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.9 , pp. 1687-1693
    • Aitken, A.E.1    Morgan, E.T.2
  • 3
    • 29944432134 scopus 로고    scopus 로고
    • Transcriptional regulation of the PXR gene: Identification and characterization of a functional peroxisome proliferator-activated receptor α binding site within the proximal promoter of PXR
    • DOI 10.1124/dmd.105.006064
    • Aouabdi S, Gibson G, Plant N. (2006). Transcriptional regulation of the PXR gene: identifcation and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR. Drug Metab Dispos 34:138-144. (Pubitemid 43042655)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.1 , pp. 138-144
    • Aouabdi, S.1    Gibson, G.2    Plant, N.3
  • 5
    • 0036294598 scopus 로고    scopus 로고
    • Effect of interferon α-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C
    • DOI 10.1067/mcp.2002.124468
    • Becquemont L, Chazouilleres O, Serfaty L, Poirier JM, Broly F, Jaillon P, Poupon R, Funck-Brentano C. (2002). Efect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C. Clin Pharmacol Ter 71:488-495. (Pubitemid 34701356)
    • (2002) Clinical Pharmacology and Therapeutics , vol.71 , Issue.6 , pp. 488-495
    • Becquemont, L.1    Chazouilleres, O.2    Serfaty, L.3    Poirier, J.M.4    Broly, F.5    Jaillon, P.6    Poupon, R.7    Funck-Brentano, C.8
  • 6
    • 0030070481 scopus 로고    scopus 로고
    • Peroxisome proliferators activate Kupffer cells in vivo
    • Bojes HK, Turman RG. (1996). Peroxisome proliferators activate Kupfer cells in vivo. Cancer Res 56:1-4. (Pubitemid 26010375)
    • (1996) Cancer Research , vol.56 , Issue.1 , pp. 1-4
    • Bojes, H.K.1    Thurman, R.G.2
  • 9
    • 34249084393 scopus 로고    scopus 로고
    • CYP-mediated clozapine interactions: How predictable are they?
    • DOI 10.2174/138920007780655469
    • Chetty M, Murray M. (2007). CYP-mediated clozapine interactions: how predictable are they? Curr Drug Metab 8:307-313. (Pubitemid 46780060)
    • (2007) Current Drug Metabolism , vol.8 , Issue.4 , pp. 307-313
    • Chetty, M.1    Murray, M.2
  • 11
    • 33646863002 scopus 로고    scopus 로고
    • PPARα activators and fasting induce the expression of adipose differentiation-related protein in liver
    • DOI 10.1194/jlr.M500459-JLR200
    • Dalen KT, Ulven SM, Arntsen BM, Solaas K, Nebb HI. (2006). PPARalpha activators and fasting induce the expression of adipose diferentiation-related protein in liver. J Lipid Res 47:931-943. (Pubitemid 43778694)
    • (2006) Journal of Lipid Research , vol.47 , Issue.5 , pp. 931-943
    • Dalen, K.T.1    Ulven, S.M.2    Arntsen, B.M.3    Solaas, K.4    Nebb, H.I.5
  • 14
    • 0027411525 scopus 로고
    • The molecular cell biology of interferon-γ and its receptor
    • Farrar MA, Schreiber RD. (1993). Te molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 11:571-611. (Pubitemid 23115018)
    • (1993) Annual Review of Immunology , vol.11 , pp. 571-611
    • Farrar, M.A.1    Schreiber, R.D.2
  • 15
    • 12144260229 scopus 로고    scopus 로고
    • Control of hepatitis C: A medicinal chemistry perspective
    • DOI 10.1021/jm0400101
    • Gordon CP, Keller PA. (2005). Control of hepatitis C: a medicinal chemistry perspective. J Med Chem 48:1-20. (Pubitemid 40105243)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.1 , pp. 1-20
    • Gordon, C.P.1    Keller, P.A.2
  • 16
    • 33646896518 scopus 로고    scopus 로고
    • Drug-induced hepatitis in a patient with malignant melanoma treated with interferon alfa 2b adjuvantly who had been administered gemfibrozil in therapy
    • DOI 10.1385/MO:23:1:121
    • Grubisic-Cabo F, Vrdoljak E. (2006). Drug-induced hepatitis in a patient with malignant melanoma treated with interferon alfa 2b adjuvantly who had been administered gemfbrozil in therapy. Med Oncol 23:121-124. (Pubitemid 43787125)
    • (2006) Medical Oncology , vol.23 , Issue.1 , pp. 121-124
    • Grubisic-Cabo, F.1    Vrdoljak, E.2
  • 17
    • 0028929645 scopus 로고
    • Metabolism of theophylline by cDNA-expressed human cytochromes P-450
    • Ha HR, Chen J, Freiburghaus AU, Follath F. (1995). Metabolism of theophylline by cDNA-expressed human cytochromes P-450. Br J Clin Pharmacol 39:321-326.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 321-326
    • Ha, H.R.1    Chen, J.2    Freiburghaus, A.U.3    Follath, F.4
  • 18
    • 0031915809 scopus 로고    scopus 로고
    • Signal transduction in the interferon system
    • Haque SJ, Williams BR. (1998). Signal transduction in the interferon system. Semin Oncol 25:14-22. (Pubitemid 28093151)
    • (1998) Seminars in Oncology , vol.25 , Issue.1 SUPPL. , pp. 14-22
    • Haque, S.J.1    Williams, B.R.G.2
  • 19
    • 0034886485 scopus 로고    scopus 로고
    • Mouse hepatocyte response to peroxisome proliferators: Dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor α (PPARα)
    • DOI 10.1007/s002040100246
    • Hasmall S, James N, Hedley K, Olsen K, Roberts R. (2001). Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor alpha (PPARalpha). Arch Toxicol 75:357-361. (Pubitemid 32757417)
    • (2001) Archives of Toxicology , vol.75 , Issue.6 , pp. 357-361
    • Hasmall, S.1    James, N.2    Hedley, K.3    Olsen, K.4    Roberts, R.5
  • 20
    • 0032865199 scopus 로고    scopus 로고
    • The influence of interferon-α on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite in patients with multiple myeloma
    • Hassan M, Nilsson C, Olsson H, Lundin J, Osterborg A. (1999). Te infuence of interferon-alpha on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite in patients with multiple myeloma. Eur J Haematol 63:163-170. (Pubitemid 29406733)
    • (1999) European Journal of Haematology , vol.63 , Issue.3 , pp. 163-170
    • Hassan, M.1    Nilsson, C.2    Olsson, H.3    Lundin, J.4    Osterborg, A.5
  • 21
    • 0036023402 scopus 로고    scopus 로고
    • Differential effect of IFNα-2b on the cytochrome P450 enzyme system: A potential basis of IFN toxicity and its modulation by other drugs
    • Islam M, Frye R F, Richards TJ, Sbeitan I, Donnelly SS, Glue P, Agarwala SS, Kirkwood JM. (2002). Diferential efect of IFNalpha-2b on the cytochrome P450 enzyme system: a potential basis of IFN toxicity and its modulation by other drugs. Clin Cancer Res 8:2480-2487. (Pubitemid 34856329)
    • (2002) Clinical Cancer Research , vol.8 , Issue.8 , pp. 2480-2487
    • Islam, M.1    Frye, R.F.2    Richards, T.J.3    Sbeitan, I.4    Donnelly, S.S.5    Glue, P.6    Agarwala, S.S.7    Kirkwood, J.M.8
  • 23
    • 33748894676 scopus 로고    scopus 로고
    • Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
    • DOI 10.1124/dmd.106.010033
    • Jigorel E, Le Vee M, Boursier-Neyret C, Parmentier Y, Fardel O. (2006). Diferential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos 34:1756-1763. (Pubitemid 44427479)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1756-1763
    • Jigorel, E.1    Le Vee, M.2    Boursier-Neyret, C.3    Parmentier, Y.4    Fardel, O.5
  • 26
    • 17844378450 scopus 로고    scopus 로고
    • Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver
    • DOI 10.1124/dmd.104.003301
    • Kobayashi Y, Sakai R, Ohshiro N, Ohbayashi M, Kohyama N, Yamamoto T. (2005). Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos 33:619-622. (Pubitemid 40593874)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.5 , pp. 619-622
    • Kobayashi, Y.1    Sakai, R.2    Ohshiro, N.3    Ohbayashi, M.4    Kohyama, N.5    Yamamoto, T.6
  • 27
    • 38749136631 scopus 로고    scopus 로고
    • Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1β
    • DOI 10.1124/dmd.107.016907
    • Le Vee M, Gripon P, Stieger B, Fardel O. (2008). Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinfammatory cytokine interleukin 1beta. Drug Metab Dispos 36:217-222. (Pubitemid 351185762)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.2 , pp. 217-222
    • Le Vee, M.1    Gripon, P.2    Stieger, B.3    Fardel, O.4
  • 29
    • 0242584810 scopus 로고    scopus 로고
    • Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection
    • DOI 10.1002/jmv.10381
    • MacQuillan GC, Mamotte C, Reed WD, Jefrey GP, Allan JE. (2003). Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection. J Med Virol 70:219-227. (Pubitemid 36520630)
    • (2003) Journal of Medical Virology , vol.70 , Issue.2 , pp. 219-227
    • MacQuillan, G.C.1    Mamotte, C.2    Reed, W.D.3    Jeffrey, G.P.4    Allan, J.E.5
  • 30
    • 36148968010 scopus 로고    scopus 로고
    • Drug interaction studies of therapeutic proteins or monoclonal antibodies
    • DOI 10.1177/0091270007308616
    • Mahmood I, Green MD. (2007). Drug interaction studies of therapeutic proteins or monoclonal antibodies. J Clin Pharmacol 47:1540-1554. (Pubitemid 350115304)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.12 , pp. 1540-1554
    • Mahmood, I.1    Green, M.D.2
  • 31
    • 35548965586 scopus 로고    scopus 로고
    • The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver
    • DOI 10.1124/dmd.107.017269
    • Mano Y, Usui T, Kamimura H. (2007). Te UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfbrozil glucuronidation in the human liver. Drug Metab Dispos 35:2040-2044. (Pubitemid 350005193)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.11 , pp. 2040-2044
    • Mano, Y.1    Usui, T.2    Kamimura, H.3
  • 32
    • 0042468096 scopus 로고    scopus 로고
    • Impact of drug transporter studies on drug discovery and development
    • DOI 10.1124/pr.55.3.1
    • Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. (2003). Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 55:425-461. (Pubitemid 37013212)
    • (2003) Pharmacological Reviews , vol.55 , Issue.3 , pp. 425-461
    • Mizuno, N.1    Niwa, T.2    Yotsumoto, Y.3    Sugiyama, Y.4
  • 35
    • 50049122662 scopus 로고    scopus 로고
    • Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fbrosis in chronic hepatitis C patients
    • Nakai K, Tanaka H, Hanada K, Ogata H, Suzuki F, Kumada H, Miyajima A, Ishida S, Sunouchi M, Habano W, Kamikawa Y, Kubota K, Kita J, Ozawa S, Ohno Y. (2008). Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fbrosis in chronic hepatitis C patients. Drug Metab Dispos 36:1786-1793.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1786-1793
    • Nakai, K.1    Tanaka, H.2    Hanada, K.3    Ogata, H.4    Suzuki, F.5    Kumada, H.6    Miyajima, A.7    Ishida, S.8    Sunouchi, M.9    Habano, W.10    Kamikawa, Y.11    Kubota, K.12    Kita, J.13    Ozawa, S.14    Ohno, Y.15
  • 39
    • 0036211034 scopus 로고    scopus 로고
    • Interferon-α activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes
    • Radaeva S, Jaruga B, Hong F, Kim WH, Fan S, Cai H, Strom S, Liu Y, El-Assal O, Gao B. (2002). Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes. Gastroenterology 122:1020-1034. (Pubitemid 34267285)
    • (2002) Gastroenterology , vol.122 , Issue.4 , pp. 1020-1034
    • Radaeva, S.1    Jaruga, B.2    Hong, F.3    Kim, W.4    Fan, S.5    Cai, H.6    Strom, S.7    Liu, Y.8    ElAssal, O.9    Gao, B.10
  • 40
    • 0033047543 scopus 로고    scopus 로고
    • Role of kupffer cells in peroxisome proliferator-induced hepatocyte proliferation
    • DOI 10.1081/DMR-100101909
    • Rose ML, Rusyn I, Bojes HK, Germolec DR, Luster M, Turman RG. (1999). Role of Kupfer cells in peroxisome proliferator-induced hepatocyte proliferation. Drug Metab Rev 31:87-116. (Pubitemid 29106653)
    • (1999) Drug Metabolism Reviews , vol.31 , Issue.1 , pp. 87-116
    • Rose, M.L.1    Rusyn, I.2    Bojes, H.K.3    Germolec, D.R.4    Luster, M.5    Thurman, R.G.6
  • 41
    • 0035182921 scopus 로고    scopus 로고
    • Interferon alpha-associated agranulocytosis during clozapine treatment. Case report and status of current knowledge
    • Schäfer M, Schmidt F, Grunze H, Laakmann G, Loeschke K. (2001). [Interferon alpha-associated agranulocytosis during clozapine treatment. Case report and status of current knowledge]. Nervenarzt 72:872-875.
    • (2001) Nervenarzt , vol.72 , pp. 872-875
    • Schäfer, M.1    Schmidt, F.2    Grunze, H.3    Laakmann, G.4    Loeschke, K.5
  • 42
    • 0021684554 scopus 로고
    • 2 Interferon in patients with malignancies
    • DOI 10.1002/ajh.2830170406
    • Shah I, Band J, Samson M, Young J, Robinson R, Bailey B, Lerner AM, Prasad AS. (1984). Pharmacokinetics and tolerance of intravenous and intramuscular recombinant alpha 2 interferon in patients with malignancies. Am J Hematol 17:363-371. (Pubitemid 15201285)
    • (1984) American Journal of Hematology , vol.17 , Issue.4 , pp. 363-371
    • Shah, I.1    Band, J.2    Samson, M.3
  • 43
    • 0025739787 scopus 로고
    • Diferential efects of recombinant interferon alpha on constitutive and inducible cytochrome P450 isozymes in mouse liver
    • Stanley LA, Adams DJ, Balkwill FR, Grifn D, Wolf CR. (1991). Diferential efects of recombinant interferon alpha on constitutive and inducible cytochrome P450 isozymes in mouse liver. Biochem Pharmacol 42:311-320.
    • (1991) Biochem Pharmacol , vol.42 , pp. 311-320
    • Stanley, L.A.1    Adams, D.J.2    Balkwill, F.R.3    Grifn, D.4    Wolf, C.R.5
  • 45
    • 1342344700 scopus 로고    scopus 로고
    • Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes
    • DOI 10.1124/dmd.32.3.359
    • Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD. (2004). Kupfer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab Dispos 32:359-363. (Pubitemid 38263895)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.3 , pp. 359-363
    • Sunman, J.A.1    Hawke, R.L.2    LeCluyse, E.L.3    Kashuba, A.D.M.4
  • 46
    • 33845913538 scopus 로고    scopus 로고
    • Effects of ertiprotafib on hepatic cytochrome P450 and peroxisomal enzymes in rats and dogs, and in rat and human primary hepatocytes
    • DOI 10.1080/00498250600965115, PII U11QW62N365H0170
    • Tong Z, Chandrasekaran A, Jordan R, Markiewicz V, Li H, Xiang Q, Shen L, Scatina J. (2007). Efects of ertiprotafb on hepatic cytochrome P450 and peroxisomal enzymes in rats and dogs, and in rat and human primary hepatocytes. Xenobiotica 37: 1-18. (Pubitemid 46019700)
    • (2007) Xenobiotica , vol.37 , Issue.1 , pp. 1-18
    • Tong, Z.1    Chandrasekaran, A.2    Jordan, R.3    Markiewicz, V.4    Li, H.5    Xiang, Q.6    Shen, L.7    Scatina, J.8
  • 48
    • 33644514327 scopus 로고    scopus 로고
    • Potential drug - Drug interaction between interferon alfa-2b and gemfibrozil in a patient with malignant melanoma
    • DOI 10.1016/j.clinthera.2005.12.002, PII S0149291805003140
    • Wong SF, Jakowatz JG, Taheri R. (2005). Potential drug-drug interaction between interferon alfa-2b and gemfbrozil in a patient with malignant melanoma. Clin Ter 27:1942-1948. (Pubitemid 43293216)
    • (2005) Clinical Therapeutics , vol.27 , Issue.12 , pp. 1942-1948
    • Wong, S.-F.1    Jakowatz, J.G.2    Taheri, R.3
  • 49
    • 0035851148 scopus 로고    scopus 로고
    • Orphan nuclear receptors: The exotics of xenobiotics
    • Xie W, Evans RM. (2001). Orphan nuclear receptors: the exotics of xenobiotics. J Biol Chem 276:37739-37742.
    • (2001) J Biol Chem , vol.276 , pp. 37739-37742
    • Xie, W.1    Evans, R.M.2


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